Click here to switch to the map view.

The map label for this gene is fabF [H]

Identifier: 123969351

GI number: 123969351

Start: 1550885

End: 1552129

Strand: Direct

Name: fabF [H]

Synonym: A9601_18191

Alternate gene names: 123969351

Gene position: 1550885-1552129 (Clockwise)

Preceding gene: 123969350

Following gene: 123969352

Centisome position: 92.87

GC content: 39.52

Gene sequence:

>1245_bases
ATGCCAAATTTCCATCGAGTAGTTGTTACTGGTATCGGAGCAGTCACTCCAATTGGTAATAACATTGATGAATATTTAGT
CGGTCTTCAAACAGGAACTAATGGGGTCTCAGGTATTACTCTCTTTGATCCTGAACAACATCCCTGCAAATTTGCGGCAG
AAGTAAAAAATCTTCAAACTGAAAATTTTATTGAAACTAAAGAATCCAAAAGATGGGATCGTTTTTCCCAGTTTGGAGTT
ATTGCTGCAAAGCAAGCCTTTAATGATTCCGGACTTGAAATTACTGAAGATAATGCATCAAGAATTGGAGTGATTATTGG
ATCTGGTGTTGGAGGCTTACTAACTATGGAAAGTCAAGCTCAAATATTGAGTCATAAAGGGGCTAAAAGAGTAAGCCCAT
TTACAGTCCCAATGATGATTCCAAACATGGCAACTGGATTGGCTGCAATCGCTTTGGGTGCAAAAGGACCAAGTTCCTCT
GTTTCCACCGCTTGCGCTGCCGGTTCAAATGCTATAGGTGATTCATTTAGACTACTCCAACTTGGAAAAGCAGATGCAAT
GATCTGTGGGGGAGCAGAAGCAAGTATTACGCCTCTCGGAGTAGCTGGTTTTGCCAGTGCCAAAGCTCTTTCTTCCAGAA
ATGACAGCCCTCAAACTGCTAGCAGACCTTTTGATGCAGAAAGAGATGGATTTGTTATTGGAGAAGGATCTGGAATTCTT
GTTTTAGAAACTTTAGAAAATGCACAAAAAAGGAATGCCAGAATTTATGGAGAAATAGTTGGATATGGGACAACATGTGA
TGCTCATCATATTACTGCTCCATCTCCTGGCGGTGTTGGAGGCGCCGAAGCTATTAAATTAGCAATTGAAGATGCTTGTC
TTAGCCTTGAAAAAGTTGACTACATAAATGCTCATGGAACAAGTACCTCAGCTAATGATAAAAATGAAACTTCTGCAATT
AAATCTATTTTTAAAGACAGATCTTACCTCATTCCTGTAAGCTCTACTAAGTCGATGACAGGTCATCTCTTAGGAGGCTC
AGGAGGTATAGAAGCTGTAGCTTGTATACTTTCTTTGACACATAATTTTATCCCTCCTACAATTAACTACGTCAATCGAG
ATCCTGATTGTGATCTTGATTATGTACCAAATAATGCAAGAGAAGCTCAAATAGGAGTTGCTCTTTCTAATTCTTTCGGC
TTTGGTGGTCACAATGTTTGCCTTGCTTTCAGCAAAATGAATTGA

Upstream 100 bases:

>100_bases
AGAAGCATTTGATATCGAAATTCCTGATGAAGCCGCTGAAGGAATCGCAACTGTTGGCGATGCAGTAAAATTCATCGAAG
AAAAAAAAGGTTAATAAAGA

Downstream 100 bases:

>100_bases
AGACAACCAATTCTGTATTTCCAACTTAACTTAATTTAAAACAATGGTCGCTGCATCTGTTTCATTAGAATCACTTTGTG
TAAATAGTATAAGAATGCTT

Product: 3-oxoacyl-[acyl-carrier-protein] synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 414; Mature: 413

Protein sequence:

>414_residues
MPNFHRVVVTGIGAVTPIGNNIDEYLVGLQTGTNGVSGITLFDPEQHPCKFAAEVKNLQTENFIETKESKRWDRFSQFGV
IAAKQAFNDSGLEITEDNASRIGVIIGSGVGGLLTMESQAQILSHKGAKRVSPFTVPMMIPNMATGLAAIALGAKGPSSS
VSTACAAGSNAIGDSFRLLQLGKADAMICGGAEASITPLGVAGFASAKALSSRNDSPQTASRPFDAERDGFVIGEGSGIL
VLETLENAQKRNARIYGEIVGYGTTCDAHHITAPSPGGVGGAEAIKLAIEDACLSLEKVDYINAHGTSTSANDKNETSAI
KSIFKDRSYLIPVSSTKSMTGHLLGGSGGIEAVACILSLTHNFIPPTINYVNRDPDCDLDYVPNNAREAQIGVALSNSFG
FGGHNVCLAFSKMN

Sequences:

>Translated_414_residues
MPNFHRVVVTGIGAVTPIGNNIDEYLVGLQTGTNGVSGITLFDPEQHPCKFAAEVKNLQTENFIETKESKRWDRFSQFGV
IAAKQAFNDSGLEITEDNASRIGVIIGSGVGGLLTMESQAQILSHKGAKRVSPFTVPMMIPNMATGLAAIALGAKGPSSS
VSTACAAGSNAIGDSFRLLQLGKADAMICGGAEASITPLGVAGFASAKALSSRNDSPQTASRPFDAERDGFVIGEGSGIL
VLETLENAQKRNARIYGEIVGYGTTCDAHHITAPSPGGVGGAEAIKLAIEDACLSLEKVDYINAHGTSTSANDKNETSAI
KSIFKDRSYLIPVSSTKSMTGHLLGGSGGIEAVACILSLTHNFIPPTINYVNRDPDCDLDYVPNNAREAQIGVALSNSFG
FGGHNVCLAFSKMN
>Mature_413_residues
PNFHRVVVTGIGAVTPIGNNIDEYLVGLQTGTNGVSGITLFDPEQHPCKFAAEVKNLQTENFIETKESKRWDRFSQFGVI
AAKQAFNDSGLEITEDNASRIGVIIGSGVGGLLTMESQAQILSHKGAKRVSPFTVPMMIPNMATGLAAIALGAKGPSSSV
STACAAGSNAIGDSFRLLQLGKADAMICGGAEASITPLGVAGFASAKALSSRNDSPQTASRPFDAERDGFVIGEGSGILV
LETLENAQKRNARIYGEIVGYGTTCDAHHITAPSPGGVGGAEAIKLAIEDACLSLEKVDYINAHGTSTSANDKNETSAIK
SIFKDRSYLIPVSSTKSMTGHLLGGSGGIEAVACILSLTHNFIPPTINYVNRDPDCDLDYVPNNAREAQIGVALSNSFGF
GGHNVCLAFSKMN

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=418, Percent_Identity=42.3444976076555, Blast_Score=316, Evalue=3e-86,
Organism=Homo sapiens, GI223972627, Length=150, Percent_Identity=45.3333333333333, Blast_Score=132, Evalue=7e-31,
Organism=Homo sapiens, GI41872631, Length=264, Percent_Identity=29.1666666666667, Blast_Score=90, Evalue=4e-18,
Organism=Escherichia coli, GI1787337, Length=410, Percent_Identity=49.7560975609756, Blast_Score=378, Evalue=1e-106,
Organism=Escherichia coli, GI1788663, Length=418, Percent_Identity=36.1244019138756, Blast_Score=227, Evalue=1e-60,
Organism=Caenorhabditis elegans, GI71983541, Length=416, Percent_Identity=33.6538461538462, Blast_Score=240, Evalue=8e-64,
Organism=Caenorhabditis elegans, GI71983535, Length=264, Percent_Identity=37.5, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI212642053, Length=341, Percent_Identity=27.8592375366569, Blast_Score=107, Evalue=8e-24,
Organism=Caenorhabditis elegans, GI17550940, Length=417, Percent_Identity=25.1798561151079, Blast_Score=84, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6320904, Length=443, Percent_Identity=37.020316027088, Blast_Score=265, Evalue=1e-71,
Organism=Drosophila melanogaster, GI24644341, Length=418, Percent_Identity=42.3444976076555, Blast_Score=310, Evalue=1e-84,
Organism=Drosophila melanogaster, GI221330659, Length=422, Percent_Identity=26.303317535545, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI19920632, Length=422, Percent_Identity=26.303317535545, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24581345, Length=420, Percent_Identity=23.0952380952381, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 43199; Mature: 43068

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: PS00606 B_KETOACYL_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPNFHRVVVTGIGAVTPIGNNIDEYLVGLQTGTNGVSGITLFDPEQHPCKFAAEVKNLQT
CCCCEEEEEEECCEECCCCCCHHHHEEEEECCCCCCCEEEEECCCCCCHHHHHHHHCCCC
ENFIETKESKRWDRFSQFGVIAAKQAFNDSGLEITEDNASRIGVIIGSGVGGLLTMESQA
CHHHHHHHHHHHHHHHHCCCEEEHHHCCCCCCEEECCCCCEEEEEEECCCCCEEEECHHH
QILSHKGAKRVSPFTVPMMIPNMATGLAAIALGAKGPSSSVSTACAAGSNAIGDSFRLLQ
HHHHHCCCCCCCCEEEEEECCCHHHHHHHEEECCCCCCCCHHHHHHCCCCCCCCCEEEEE
LGKADAMICGGAEASITPLGVAGFASAKALSSRNDSPQTASRPFDAERDGFVIGEGSGIL
ECCCCEEEECCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCCEE
VLETLENAQKRNARIYGEIVGYGTTCDAHHITAPSPGGVGGAEAIKLAIEDACLSLEKVD
EEEEHHHHHHCCCEEEEEEEECCCCCCCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHHE
YINAHGTSTSANDKNETSAIKSIFKDRSYLIPVSSTKSMTGHLLGGSGGIEAVACILSLT
EEECCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCEEEECCCCCHHHHHHHHHHH
HNFIPPTINYVNRDPDCDLDYVPNNAREAQIGVALSNSFGFGGHNVCLAFSKMN
HHCCCCCCHHCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCC
>Mature Secondary Structure 
PNFHRVVVTGIGAVTPIGNNIDEYLVGLQTGTNGVSGITLFDPEQHPCKFAAEVKNLQT
CCCEEEEEEECCEECCCCCCHHHHEEEEECCCCCCCEEEEECCCCCCHHHHHHHHCCCC
ENFIETKESKRWDRFSQFGVIAAKQAFNDSGLEITEDNASRIGVIIGSGVGGLLTMESQA
CHHHHHHHHHHHHHHHHCCCEEEHHHCCCCCCEEECCCCCEEEEEEECCCCCEEEECHHH
QILSHKGAKRVSPFTVPMMIPNMATGLAAIALGAKGPSSSVSTACAAGSNAIGDSFRLLQ
HHHHHCCCCCCCCEEEEEECCCHHHHHHHEEECCCCCCCCHHHHHHCCCCCCCCCEEEEE
LGKADAMICGGAEASITPLGVAGFASAKALSSRNDSPQTASRPFDAERDGFVIGEGSGIL
ECCCCEEEECCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCCEE
VLETLENAQKRNARIYGEIVGYGTTCDAHHITAPSPGGVGGAEAIKLAIEDACLSLEKVD
EEEEHHHHHHCCCEEEEEEEECCCCCCCCEECCCCCCCCCHHHHHHHHHHHHHHHHHHHE
YINAHGTSTSANDKNETSAIKSIFKDRSYLIPVSSTKSMTGHLLGGSGGIEAVACILSLT
EEECCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCEEEECCCCCHHHHHHHHHHH
HNFIPPTINYVNRDPDCDLDYVPNNAREAQIGVALSNSFGFGGHNVCLAFSKMN
HHCCCCCCHHCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231; 11152607 [H]