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The map label for this gene is purM [H]

Identifier: 123969330

GI number: 123969330

Start: 1530614

End: 1531657

Strand: Reverse

Name: purM [H]

Synonym: A9601_17981

Alternate gene names: 123969330

Gene position: 1531657-1530614 (Counterclockwise)

Preceding gene: 123969332

Following gene: 123969329

Centisome position: 91.72

GC content: 29.98

Gene sequence:

>1044_bases
ATGGATTACAAAACATCAGGTGTTGATATAGAAGCTGGGCGAGAATTTGTTTCCGAAATTAAACAGGCAGTTGAAGGAAC
ACATACATCTAATGTGATTGAGGGTATTGGTGGGTTTGGAGGTTTGTTTAGAATTCCTATCGATAGTTTTAAAAAACCAG
TTCTTGTTTCAGGAACTGATGGTGTTGGAACAAAATTAGAATTAGCCCAAAGTAAAAACTTCCACTTTGAGGTTGGTATT
GATTTAGTTGCTATGTGTATGAATGATATTATTACAAGTGGGGCAAAACCTTTATTTTTTTTGGATTATATTGCTACTGG
TAAACTTGATAAGAATCAATTATTGAGGGTTGTTAAGGGAATTTCACATGGCTGCGGAGAAAATAACTGTTCATTACTCG
GCGGAGAAACTGCTGAGATGCCTGGATTTTATTCAAAAAATAAGTATGATCTTGCAGGATTTTGTGTTGGAATAGTTGAT
GAGGATAAGCTTATTAATGGTAAAAAAGTATCTGAAAATGACTTAATAATTGCTTTAAAAAGTAATGGAGTTCATAGTAA
CGGCTTTAGTTTAGTAAGAAAAATTATTCAAAATAATAATCAAATAGATAAAGAATTTGAAAAAGTTTTTCACTTAAATT
TTTATGATGAGTTATTGAAACCTACAAAAATTTATAATAATGTGATTAACCAAATGTTAACTGAAAATATAGAAATTAAA
GCAATGTCTCATATTACTGGGGGAGGAATTCCAGAAAATTTACCAAGATGTATGCCTTCTGATTTTATTCCTTATGTAGA
TACCGGTTCTTGGGAAATACCTATTATATTTAAATTCCTCAAAGAGAAAGGATCGATTCCTGAAAAAGATTTTTGGAATA
CTTTCAATCTTGGAGTAGGATTTTGTTTAATTATTGATAAACAATTTAAGGATCCGATATTAAATATCTGTAAAGATAAT
GAAATAGATAGTTGGGAAATTGGAAAGATAGTTCGAAAAAATGATTCAACGATTAGTAAATTTTTGCCAGAAATTTTAAC
TTAA

Upstream 100 bases:

>100_bases
ACTTTGTTTTTAAAAAATAAATCTATTTGATAAATAATTACTGGACAAAATCAATCTTAGGAGGAAGATCTATATAGAGA
AAGTCTATCATTTTTATTTC

Downstream 100 bases:

>100_bases
ATTTTTTTATCTTCTTTTAATGAGTTTTAAAAAATTATTTTTTATACCCAAATGAAAAAGTTAGGTGTAATATAATAAAA
TTACCGCCGAATTATATCGG

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MDYKTSGVDIEAGREFVSEIKQAVEGTHTSNVIEGIGGFGGLFRIPIDSFKKPVLVSGTDGVGTKLELAQSKNFHFEVGI
DLVAMCMNDIITSGAKPLFFLDYIATGKLDKNQLLRVVKGISHGCGENNCSLLGGETAEMPGFYSKNKYDLAGFCVGIVD
EDKLINGKKVSENDLIIALKSNGVHSNGFSLVRKIIQNNNQIDKEFEKVFHLNFYDELLKPTKIYNNVINQMLTENIEIK
AMSHITGGGIPENLPRCMPSDFIPYVDTGSWEIPIIFKFLKEKGSIPEKDFWNTFNLGVGFCLIIDKQFKDPILNICKDN
EIDSWEIGKIVRKNDSTISKFLPEILT

Sequences:

>Translated_347_residues
MDYKTSGVDIEAGREFVSEIKQAVEGTHTSNVIEGIGGFGGLFRIPIDSFKKPVLVSGTDGVGTKLELAQSKNFHFEVGI
DLVAMCMNDIITSGAKPLFFLDYIATGKLDKNQLLRVVKGISHGCGENNCSLLGGETAEMPGFYSKNKYDLAGFCVGIVD
EDKLINGKKVSENDLIIALKSNGVHSNGFSLVRKIIQNNNQIDKEFEKVFHLNFYDELLKPTKIYNNVINQMLTENIEIK
AMSHITGGGIPENLPRCMPSDFIPYVDTGSWEIPIIFKFLKEKGSIPEKDFWNTFNLGVGFCLIIDKQFKDPILNICKDN
EIDSWEIGKIVRKNDSTISKFLPEILT
>Mature_347_residues
MDYKTSGVDIEAGREFVSEIKQAVEGTHTSNVIEGIGGFGGLFRIPIDSFKKPVLVSGTDGVGTKLELAQSKNFHFEVGI
DLVAMCMNDIITSGAKPLFFLDYIATGKLDKNQLLRVVKGISHGCGENNCSLLGGETAEMPGFYSKNKYDLAGFCVGIVD
EDKLINGKKVSENDLIIALKSNGVHSNGFSLVRKIIQNNNQIDKEFEKVFHLNFYDELLKPTKIYNNVINQMLTENIEIK
AMSHITGGGIPENLPRCMPSDFIPYVDTGSWEIPIIFKFLKEKGSIPEKDFWNTFNLGVGFCLIIDKQFKDPILNICKDN
EIDSWEIGKIVRKNDSTISKFLPEILT

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=340, Percent_Identity=43.2352941176471, Blast_Score=290, Evalue=1e-78,
Organism=Homo sapiens, GI209869995, Length=340, Percent_Identity=43.2352941176471, Blast_Score=290, Evalue=1e-78,
Organism=Homo sapiens, GI209869993, Length=340, Percent_Identity=43.2352941176471, Blast_Score=290, Evalue=1e-78,
Organism=Escherichia coli, GI1788845, Length=336, Percent_Identity=45.5357142857143, Blast_Score=309, Evalue=2e-85,
Organism=Caenorhabditis elegans, GI17567511, Length=350, Percent_Identity=37.1428571428571, Blast_Score=213, Evalue=1e-55,
Organism=Saccharomyces cerevisiae, GI6321203, Length=337, Percent_Identity=40.9495548961424, Blast_Score=252, Evalue=6e-68,
Organism=Drosophila melanogaster, GI24582400, Length=266, Percent_Identity=38.3458646616541, Blast_Score=192, Evalue=3e-49,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 38591; Mature: 38591

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDYKTSGVDIEAGREFVSEIKQAVEGTHTSNVIEGIGGFGGLFRIPIDSFKKPVLVSGTD
CCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCEEECCHHHCCCCEEEECCC
GVGTKLELAQSKNFHFEVGIDLVAMCMNDIITSGAKPLFFLDYIATGKLDKNQLLRVVKG
CCCCEEEEECCCCCEEEEHHHHHHHHHHHHHHCCCCCEEEEEHHHCCCCCHHHHHHHHHH
ISHGCGENNCSLLGGETAEMPGFYSKNKYDLAGFCVGIVDEDKLINGKKVSENDLIIALK
HHCCCCCCCCEEECCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCEECCCCEEEEEE
SNGVHSNGFSLVRKIIQNNNQIDKEFEKVFHLNFYDELLKPTKIYNNVINQMLTENIEIK
CCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHCHHHHHHHHHHHHHHCCCEEE
AMSHITGGGIPENLPRCMPSDFIPYVDTGSWEIPIIFKFLKEKGSIPEKDFWNTFNLGVG
EEECCCCCCCCHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHCCCCCCCCCE
FCLIIDKQFKDPILNICKDNEIDSWEIGKIVRKNDSTISKFLPEILT
EEEEEECHHCCHHHHHHCCCCCCCCHHHHHHHCCCCHHHHHHHHHCC
>Mature Secondary Structure
MDYKTSGVDIEAGREFVSEIKQAVEGTHTSNVIEGIGGFGGLFRIPIDSFKKPVLVSGTD
CCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCEEECCHHHCCCCEEEECCC
GVGTKLELAQSKNFHFEVGIDLVAMCMNDIITSGAKPLFFLDYIATGKLDKNQLLRVVKG
CCCCEEEEECCCCCEEEEHHHHHHHHHHHHHHCCCCCEEEEEHHHCCCCCHHHHHHHHHH
ISHGCGENNCSLLGGETAEMPGFYSKNKYDLAGFCVGIVDEDKLINGKKVSENDLIIALK
HHCCCCCCCCEEECCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCCCCEECCCCEEEEEE
SNGVHSNGFSLVRKIIQNNNQIDKEFEKVFHLNFYDELLKPTKIYNNVINQMLTENIEIK
CCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHCHHHHHHHHHHHHHHCCCEEE
AMSHITGGGIPENLPRCMPSDFIPYVDTGSWEIPIIFKFLKEKGSIPEKDFWNTFNLGVG
EEECCCCCCCCHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHHCCCCCCCCCE
FCLIIDKQFKDPILNICKDNEIDSWEIGKIVRKNDSTISKFLPEILT
EEEEEECHHCCHHHHHHCCCCCCCCHHHHHHHCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA