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The map label for this gene is pepP [H]

Identifier: 123969176

GI number: 123969176

Start: 1388760

End: 1390085

Strand: Reverse

Name: pepP [H]

Synonym: A9601_16441

Alternate gene names: 123969176

Gene position: 1390085-1388760 (Counterclockwise)

Preceding gene: 123969181

Following gene: 123969175

Centisome position: 83.24

GC content: 35.52

Gene sequence:

>1326_bases
ATGTTTAAACCTGAAAATAAAGTTTTTGAAGAAAGAAGAGAAGTCTTCCTCAATAAATTAAATGGAAAAGCTGCTATTAT
CCCCGGTGCTAATCTCGTAAAGCATCATGCTGATTGTGAATATCCTTTTAGACAAGATAGTAATTTTTGGTATTTAACCG
GTTTTGATGAGCCGGATGCAATCGCCCTTTTCTTATCGCATAAGCCAAAGGGAGAGAGATTTATTATGTTTGTTGCTCCT
AAAGATGTTATCAGCGAAGTCTGGCATGGCTTTAGATGGGGTTTAGAAGGCGCTGAAAAAGAGTTTAATGCGGATAAGGC
TCACTCAGTAAATGAATTCAGAGATTTACTCCCAGCTTATATAAATGGTTCCGATGAACTTGTTTTTTCTATTGGTAAGC
ATCCATCAGTTGAGAAAATAATACTTGAAATTTTTTCACAACAACTTGAAAATCGCTCAAGATTAGGCATTGGTGGAAAT
TCTATAAAATCTCCAGAAATTTACTTAAATGAGATGAGATTAATTAAAAGTGAATTTGAAATTAAGAGAATGAGAAAGGC
TATACAAATCTCAGCCGAAGCTCATGAACTAGTTAGAGAATCTATCTCATCAAAGAAAAATGAAAGACAAATTCAGGGTC
TACTAGAGGGATTCTTTCTGGAAAAAGGGGCGAGAGGTCCAGCTTATAACTCAATTGTTGCATCAGGAGATAATGCGTGT
ATTTTGCATTACACTTCAAATAATTCACCACTGAAGAAGGAAGATTTATTATTGGTTGATGCTGGCTGCTCACTAATTGA
TTATTACAATGGAGACATAACAAGAACTATACCAATAGGTGGCAAATTTTCTAATGAGCAAAAAGTTATCTATGAAATTG
TATTGAGAGCGCAGAAAAATGCAATTAAAAGTGCTGTAAAGGGATCGAATTCTAGTGCTGTTCATAATGTCGCTTTGACA
ATTCTTATAGAAGGATTAAAAGAAATTGGGTTATTGTCGGGCAGTACTGAGGAGATAATTGATAATCAATCTTATAAGCA
TCTTTACATGCATAGAACTGGACATTGGCTAGGCTTAGATGTTCATGATGTTGGAGCATACAGAATGGGAGACTATGAAG
TGCCATTACAGAATGGAATGATTCTTACGGTTGAACCTGGGATCTACATAAGTGATAGGATCCCAGTCTCTGAGGGACAA
CCCCCTATAGATGAGAAATGGAAAGGCATAGGGATAAGAATTGAAGACGATGTCCTTGTAAATGATACAAACCCAGAAGT
TTTAAGTATTGCAGCACTAAAAGAAATTTCTGATTTAGAATTTTGA

Upstream 100 bases:

>100_bases
ACTAAACCGTAAACACTTGGTTCCATTAAAATAGATTAAGTACTAAATCTGTATTAATTCATTCTTCCATTTTTTTTTTA
AACACGCCAATACACAATCT

Downstream 100 bases:

>100_bases
AATTTGACTTATCAAGTTAATAGATTTATTTTTTATTAAGTTAAAGCTCAAAAATGAATAAGTCCGATTCATATGATTCG
AAACTCTCTCAAGCAAGAGG

Product: putative aminopeptidase P

Products: NA

Alternate protein names: Aminoacylproline aminopeptidase; Aminopeptidase P II; APP-II; X-Pro aminopeptidase [H]

Number of amino acids: Translated: 441; Mature: 441

Protein sequence:

>441_residues
MFKPENKVFEERREVFLNKLNGKAAIIPGANLVKHHADCEYPFRQDSNFWYLTGFDEPDAIALFLSHKPKGERFIMFVAP
KDVISEVWHGFRWGLEGAEKEFNADKAHSVNEFRDLLPAYINGSDELVFSIGKHPSVEKIILEIFSQQLENRSRLGIGGN
SIKSPEIYLNEMRLIKSEFEIKRMRKAIQISAEAHELVRESISSKKNERQIQGLLEGFFLEKGARGPAYNSIVASGDNAC
ILHYTSNNSPLKKEDLLLVDAGCSLIDYYNGDITRTIPIGGKFSNEQKVIYEIVLRAQKNAIKSAVKGSNSSAVHNVALT
ILIEGLKEIGLLSGSTEEIIDNQSYKHLYMHRTGHWLGLDVHDVGAYRMGDYEVPLQNGMILTVEPGIYISDRIPVSEGQ
PPIDEKWKGIGIRIEDDVLVNDTNPEVLSIAALKEISDLEF

Sequences:

>Translated_441_residues
MFKPENKVFEERREVFLNKLNGKAAIIPGANLVKHHADCEYPFRQDSNFWYLTGFDEPDAIALFLSHKPKGERFIMFVAP
KDVISEVWHGFRWGLEGAEKEFNADKAHSVNEFRDLLPAYINGSDELVFSIGKHPSVEKIILEIFSQQLENRSRLGIGGN
SIKSPEIYLNEMRLIKSEFEIKRMRKAIQISAEAHELVRESISSKKNERQIQGLLEGFFLEKGARGPAYNSIVASGDNAC
ILHYTSNNSPLKKEDLLLVDAGCSLIDYYNGDITRTIPIGGKFSNEQKVIYEIVLRAQKNAIKSAVKGSNSSAVHNVALT
ILIEGLKEIGLLSGSTEEIIDNQSYKHLYMHRTGHWLGLDVHDVGAYRMGDYEVPLQNGMILTVEPGIYISDRIPVSEGQ
PPIDEKWKGIGIRIEDDVLVNDTNPEVLSIAALKEISDLEF
>Mature_441_residues
MFKPENKVFEERREVFLNKLNGKAAIIPGANLVKHHADCEYPFRQDSNFWYLTGFDEPDAIALFLSHKPKGERFIMFVAP
KDVISEVWHGFRWGLEGAEKEFNADKAHSVNEFRDLLPAYINGSDELVFSIGKHPSVEKIILEIFSQQLENRSRLGIGGN
SIKSPEIYLNEMRLIKSEFEIKRMRKAIQISAEAHELVRESISSKKNERQIQGLLEGFFLEKGARGPAYNSIVASGDNAC
ILHYTSNNSPLKKEDLLLVDAGCSLIDYYNGDITRTIPIGGKFSNEQKVIYEIVLRAQKNAIKSAVKGSNSSAVHNVALT
ILIEGLKEIGLLSGSTEEIIDNQSYKHLYMHRTGHWLGLDVHDVGAYRMGDYEVPLQNGMILTVEPGIYISDRIPVSEGQ
PPIDEKWKGIGIRIEDDVLVNDTNPEVLSIAALKEISDLEF

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=412, Percent_Identity=33.7378640776699, Blast_Score=219, Evalue=5e-57,
Organism=Homo sapiens, GI149589008, Length=467, Percent_Identity=27.6231263383298, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI260593665, Length=300, Percent_Identity=33, Blast_Score=152, Evalue=6e-37,
Organism=Homo sapiens, GI260593663, Length=249, Percent_Identity=32.9317269076305, Blast_Score=125, Evalue=5e-29,
Organism=Escherichia coli, GI1789275, Length=439, Percent_Identity=36.4464692482916, Blast_Score=291, Evalue=4e-80,
Organism=Escherichia coli, GI1788728, Length=261, Percent_Identity=31.0344827586207, Blast_Score=105, Evalue=8e-24,
Organism=Escherichia coli, GI1790282, Length=311, Percent_Identity=28.9389067524116, Blast_Score=94, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17508215, Length=476, Percent_Identity=27.7310924369748, Blast_Score=141, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI71989583, Length=277, Percent_Identity=30.6859205776173, Blast_Score=122, Evalue=5e-28,
Organism=Saccharomyces cerevisiae, GI6320922, Length=446, Percent_Identity=34.304932735426, Blast_Score=228, Evalue=2e-60,
Organism=Saccharomyces cerevisiae, GI6321118, Length=421, Percent_Identity=30.4038004750594, Blast_Score=165, Evalue=1e-41,
Organism=Drosophila melanogaster, GI19920384, Length=406, Percent_Identity=32.2660098522167, Blast_Score=184, Evalue=1e-46,
Organism=Drosophila melanogaster, GI21357079, Length=436, Percent_Identity=29.8165137614679, Blast_Score=162, Evalue=4e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000994
- InterPro:   IPR007865
- InterPro:   IPR001131 [H]

Pfam domain/function: PF05195 AMP_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.11.9 [H]

Molecular weight: Translated: 49602; Mature: 49602

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKPENKVFEERREVFLNKLNGKAAIIPGANLVKHHADCEYPFRQDSNFWYLTGFDEPDA
CCCCCHHHHHHHHHHHHHHCCCCEEEECCCHHHHHCCCCCCCCCCCCCEEEEECCCCCCE
IALFLSHKPKGERFIMFVAPKDVISEVWHGFRWGLEGAEKEFNADKAHSVNEFRDLLPAY
EEEEEECCCCCCEEEEEECCHHHHHHHHHHHHCCCCCCHHHCCCCHHCCHHHHHHHHHHH
INGSDELVFSIGKHPSVEKIILEIFSQQLENRSRLGIGGNSIKSPEIYLNEMRLIKSEFE
CCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
IKRMRKAIQISAEAHELVRESISSKKNERQIQGLLEGFFLEKGARGPAYNSIVASGDNAC
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCEE
ILHYTSNNSPLKKEDLLLVDAGCSLIDYYNGDITRTIPIGGKFSNEQKVIYEIVLRAQKN
EEEECCCCCCCCCCCEEEEECCCCEEEEECCCEEEEEECCCCCCCCHHHHHHHHHHHHHH
AIKSAVKGSNSSAVHNVALTILIEGLKEIGLLSGSTEEIIDNQSYKHLYMHRTGHWLGLD
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCEEEEEEECCCEEEEE
VHDVGAYRMGDYEVPLQNGMILTVEPGIYISDRIPVSEGQPPIDEKWKGIGIRIEDDVLV
EECCCCEECCCEECCCCCCEEEEECCCEEEECCCCCCCCCCCCCCCCCCCCEEEECCEEE
NDTNPEVLSIAALKEISDLEF
ECCCCCEEEHHHHHHHHCCCC
>Mature Secondary Structure
MFKPENKVFEERREVFLNKLNGKAAIIPGANLVKHHADCEYPFRQDSNFWYLTGFDEPDA
CCCCCHHHHHHHHHHHHHHCCCCEEEECCCHHHHHCCCCCCCCCCCCCEEEEECCCCCCE
IALFLSHKPKGERFIMFVAPKDVISEVWHGFRWGLEGAEKEFNADKAHSVNEFRDLLPAY
EEEEEECCCCCCEEEEEECCHHHHHHHHHHHHCCCCCCHHHCCCCHHCCHHHHHHHHHHH
INGSDELVFSIGKHPSVEKIILEIFSQQLENRSRLGIGGNSIKSPEIYLNEMRLIKSEFE
CCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
IKRMRKAIQISAEAHELVRESISSKKNERQIQGLLEGFFLEKGARGPAYNSIVASGDNAC
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCEE
ILHYTSNNSPLKKEDLLLVDAGCSLIDYYNGDITRTIPIGGKFSNEQKVIYEIVLRAQKN
EEEECCCCCCCCCCCEEEEECCCCEEEEECCCEEEEEECCCCCCCCHHHHHHHHHHHHHH
AIKSAVKGSNSSAVHNVALTILIEGLKEIGLLSGSTEEIIDNQSYKHLYMHRTGHWLGLD
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCEEEEEEECCCEEEEE
VHDVGAYRMGDYEVPLQNGMILTVEPGIYISDRIPVSEGQPPIDEKWKGIGIRIEDDVLV
EECCCCEECCCEECCCCCCEEEEECCCEEEECCCCCCCCCCCCCCCCCCCCEEEECCEEE
NDTNPEVLSIAALKEISDLEF
ECCCCCEEEHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]