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The map label for this gene is elaC [H]

Identifier: 123969082

GI number: 123969082

Start: 1329266

End: 1330204

Strand: Direct

Name: elaC [H]

Synonym: A9601_15501

Alternate gene names: 123969082

Gene position: 1329266-1330204 (Clockwise)

Preceding gene: 123969080

Following gene: 123969083

Centisome position: 79.6

GC content: 33.76

Gene sequence:

>939_bases
GTGAATATCACCTTCTTAGGAACAAGCTCAGGTGTCCCATCCTTAACGAGAAATGTTTCTTCCCTAGCACTTAAATTATC
ACAGTCAGCAGAAGTTTGGCTTTTTGATTGTGGAGAGGGAACGCAACATCAAATAATGAAAAGTAATATTAAATCTTCAC
AAATCAAGAAAATATTTATTACACATATGCATGGTGACCATATTTATGGTTTGCCTGGACTTTTGGCTACCTTAGGTTTA
TCAGGCAATAGTGAGGGTATTGAAATTTACGGTCCTTCAGAGTTGCGAAGTTTTATAAATTCAGCACTTAAAAGTAGTTT
TTGCAAATTGTCATTCCCATTGCATTTTGTGGAAGTTGAAAATTTTGCATTAAAAAATAAAATTCTATTTGAAAACAACA
AAATAAAAGTAAATTGCGCCTGCCTTAAACATAAAATACCTGCTTATGGTTATAGGGTTAGTGAAAAAGATAAGCCAGGT
GTATTTGATATCAAAAAAGCAGAGTCTCTAAAAATAGCACCTGGACCAATTTATTCAGAACTGCAACAAGGTAAAAAAGT
CGTATTACCAGACGGAAGGACATTTGATGGAAAAGAATTCTGTGGACCGCCTAGAGAAGGAGAAAGTTTTGTTTATTGCA
CAGATACAGTCTTTAGCGAATCAGCTGTTTCACTATCGAAAAATGCCGATTTACTCGTACATGAATCAACATTTTCTCAG
ACGGATGAGAGAATGGCCTATGAAAAATTACATTCCACTACAATTATGGCTGCCAAAACAGCATTATTATCTAATACAAA
AAAATTGATTATTACTCATTTAAGTCCAAGATATACTAATAAAAATTCAATTACACCAGGTGATTTGCTTAAAGAGGCGC
AAAAAGTTTTCCCAAATACTCATCTTGCCAAAGATTTCCTAACTGCAGAAATAAAATAA

Upstream 100 bases:

>100_bases
TTTAAGTATCACTTTGTTTAAAAACAAATGCTTAATTTGCCTAAGTTTGACTAAAAGTCTAAATTTAATCCAGATATAAA
AATAAAAATATCATAAATAA

Downstream 100 bases:

>100_bases
ACTGCAACAGTTCGTTAGCAGGAGCGCTGTAAATGGCCAACCCATGAAATAATAGTCTTAGGTTTTTCTATTTGATGTCG
ATCGAAATGGTCTCTATTTT

Product: metallo-beta-lactamase superfamily protein

Products: NA

Alternate protein names: RNase Z; tRNA 3 endonuclease; tRNase Z [H]

Number of amino acids: Translated: 312; Mature: 312

Protein sequence:

>312_residues
MNITFLGTSSGVPSLTRNVSSLALKLSQSAEVWLFDCGEGTQHQIMKSNIKSSQIKKIFITHMHGDHIYGLPGLLATLGL
SGNSEGIEIYGPSELRSFINSALKSSFCKLSFPLHFVEVENFALKNKILFENNKIKVNCACLKHKIPAYGYRVSEKDKPG
VFDIKKAESLKIAPGPIYSELQQGKKVVLPDGRTFDGKEFCGPPREGESFVYCTDTVFSESAVSLSKNADLLVHESTFSQ
TDERMAYEKLHSTTIMAAKTALLSNTKKLIITHLSPRYTNKNSITPGDLLKEAQKVFPNTHLAKDFLTAEIK

Sequences:

>Translated_312_residues
MNITFLGTSSGVPSLTRNVSSLALKLSQSAEVWLFDCGEGTQHQIMKSNIKSSQIKKIFITHMHGDHIYGLPGLLATLGL
SGNSEGIEIYGPSELRSFINSALKSSFCKLSFPLHFVEVENFALKNKILFENNKIKVNCACLKHKIPAYGYRVSEKDKPG
VFDIKKAESLKIAPGPIYSELQQGKKVVLPDGRTFDGKEFCGPPREGESFVYCTDTVFSESAVSLSKNADLLVHESTFSQ
TDERMAYEKLHSTTIMAAKTALLSNTKKLIITHLSPRYTNKNSITPGDLLKEAQKVFPNTHLAKDFLTAEIK
>Mature_312_residues
MNITFLGTSSGVPSLTRNVSSLALKLSQSAEVWLFDCGEGTQHQIMKSNIKSSQIKKIFITHMHGDHIYGLPGLLATLGL
SGNSEGIEIYGPSELRSFINSALKSSFCKLSFPLHFVEVENFALKNKILFENNKIKVNCACLKHKIPAYGYRVSEKDKPG
VFDIKKAESLKIAPGPIYSELQQGKKVVLPDGRTFDGKEFCGPPREGESFVYCTDTVFSESAVSLSKNADLLVHESTFSQ
TDERMAYEKLHSTTIMAAKTALLSNTKKLIITHLSPRYTNKNSITPGDLLKEAQKVFPNTHLAKDFLTAEIK

Specific function: Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA [H]

COG id: COG1234

COG function: function code R; Metal-dependent hydrolases of the beta-lactamase superfamily III

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RNase Z family [H]

Homologues:

Organism=Homo sapiens, GI8922122, Length=361, Percent_Identity=37.1191135734072, Blast_Score=211, Evalue=8e-55,
Organism=Escherichia coli, GI87082078, Length=308, Percent_Identity=40.5844155844156, Blast_Score=249, Evalue=2e-67,
Organism=Drosophila melanogaster, GI24652403, Length=222, Percent_Identity=25.6756756756757, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR013471 [H]

Pfam domain/function: PF00753 Lactamase_B [H]

EC number: =3.1.26.11 [H]

Molecular weight: Translated: 34496; Mature: 34496

Theoretical pI: Translated: 9.12; Mature: 9.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNITFLGTSSGVPSLTRNVSSLALKLSQSAEVWLFDCGEGTQHQIMKSNIKSSQIKKIFI
CEEEEEECCCCCCHHHHHHHHHHEEECCCCCEEEEECCCCCHHHHHHHCCCHHHEEEEEE
THMHGDHIYGLPGLLATLGLSGNSEGIEIYGPSELRSFINSALKSSFCKLSFPLHFVEVE
EEECCCEEECCHHHHHHHCCCCCCCCEEEECHHHHHHHHHHHHHHHHEEEECCEEEEEEC
NFALKNKILFENNKIKVNCACLKHKIPAYGYRVSEKDKPGVFDIKKAESLKIAPGPIYSE
CEEECCEEEEECCEEEEEEEEEECCCCCCCEEECCCCCCCEEEECCCCCEEECCCHHHHH
LQQGKKVVLPDGRTFDGKEFCGPPREGESFVYCTDTVFSESAVSLSKNADLLVHESTFSQ
HHCCCEEECCCCCCCCCHHHCCCCCCCCEEEEEECCHHCCCHHHHCCCCCEEEECCHHHH
TDERMAYEKLHSTTIMAAKTALLSNTKKLIITHLSPRYTNKNSITPGDLLKEAQKVFPNT
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCC
HLAKDFLTAEIK
HHHHHHHHCCCC
>Mature Secondary Structure
MNITFLGTSSGVPSLTRNVSSLALKLSQSAEVWLFDCGEGTQHQIMKSNIKSSQIKKIFI
CEEEEEECCCCCCHHHHHHHHHHEEECCCCCEEEEECCCCCHHHHHHHCCCHHHEEEEEE
THMHGDHIYGLPGLLATLGLSGNSEGIEIYGPSELRSFINSALKSSFCKLSFPLHFVEVE
EEECCCEEECCHHHHHHHCCCCCCCCEEEECHHHHHHHHHHHHHHHHEEEECCEEEEEEC
NFALKNKILFENNKIKVNCACLKHKIPAYGYRVSEKDKPGVFDIKKAESLKIAPGPIYSE
CEEECCEEEEECCEEEEEEEEEECCCCCCCEEECCCCCCCEEEECCCCCEEECCCHHHHH
LQQGKKVVLPDGRTFDGKEFCGPPREGESFVYCTDTVFSESAVSLSKNADLLVHESTFSQ
HHCCCEEECCCCCCCCCHHHCCCCCCCCEEEEEECCHHCCCHHHHCCCCCEEEECCHHHH
TDERMAYEKLHSTTIMAAKTALLSNTKKLIITHLSPRYTNKNSITPGDLLKEAQKVFPNT
HHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCC
HLAKDFLTAEIK
HHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA