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The map label for this gene is acoA [H]

Identifier: 123969019

GI number: 123969019

Start: 1268563

End: 1269636

Strand: Direct

Name: acoA [H]

Synonym: A9601_14871

Alternate gene names: 123969019

Gene position: 1268563-1269636 (Clockwise)

Preceding gene: 123969013

Following gene: 123969022

Centisome position: 75.97

GC content: 38.36

Gene sequence:

>1074_bases
ATGTTAACAAATCAAAACTTCGTTAAGGTATTTTTCTTGGAAACACACGTAGAGAGAATCTCAAATCTTCAAGACATAAA
AAAAGCCGAATTAGATCGAGAAACCGGATTATTCCTTTATGAAGACATGACGCTTGGTCGTAGATTTGAAGATAAGTGTG
CAGAAATGTATTACAGGGGGAAAATGTTTGGTTTCGTTCATTTATATAACGGTCAAGAGGCTATAAGCACAGGAGTAATT
GGCGCCATGAAAAAGAAACATGATTGGTTTTGTAGTACCTATCGCGATCATGTTCATGCACTAAGTGCGGGTGTTCCCTC
ATTTGAAGTAATGAGTGAACTTTTTGGTAAATCCACTGGTTGTAGCAAAGGCCGAGGTGGATCCATGCACTTATTTTCAA
GAGAGCATCACCTACTAGGAGGATATGCATTTATTGGAGAGGGAATTCCTGTTGCCTTAGGGGCAGCCTTTTCAAGTAAA
TACAAAAAGGAAGTTGCTGGAAATAGTAATAGTGATGCTGTAACTGCAGCATTTTTTGGGGATGGGACTTGCAATAATGG
GCAGTTTTTTGAATGTTTAAATATGGCCCAGTTATGGAAATTACCCATAATTTTTGTTGTTGAGAATAATAAATGGGCTA
TTGGTATGGCTCATGATAGAGCTACTAGTAATCCTGAAATCTGGAGAAAAGCGTCTGCTTTTGGCATGCACGGTGAGGAA
GTTGATGGAATGGATGTATTAGCAGTAAGAGGGGCAGCACAAAGAGCAATTGAGCGAGCTAGGGCAGGAGAAGGTCCCAC
ACTTTTAGAATGTTTAACTTATAGATATAGAGGGCATTCTCTTGCAGATCCAGATGAATTAAGGTCTGAAAAAGAGAAGG
AGTTTTGGGGAAAAAGAGACCCTATTAAGAAATTAGCTCAAGAAATTATTGACGGTAAATTCGCTACGGAAGAAGAATTA
AAAATTATTGAAAAGAAGATTGATGCTGAAATAGCGGAGTCAGTTAAAAATGCAATTGAAGCTCCTGAACCTCCTTCAGA
AGAATTAACCAAATATATTTGGGCAGAAGATTAG

Upstream 100 bases:

>100_bases
TGAAAATTCTTAGACAAATTTTATCAAGTTAAAAAATTTTTTCACAAGGTCTTACAGAGTTATTAAAAAAAATCATGAAA
ATCGCCCATCACGGCTTAGA

Downstream 100 bases:

>100_bases
ATTAAATACCGCTAGGTAATTTTCTGGTTAAATTCCTTAATTTTCTTAGTGCCTTAAGTTCAACTTGTCTTACTCTTTCT
CTAGAAACTTCTAATAATCT

Product: pyruvate dehydrogenase E1 alpha subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 357; Mature: 357

Protein sequence:

>357_residues
MLTNQNFVKVFFLETHVERISNLQDIKKAELDRETGLFLYEDMTLGRRFEDKCAEMYYRGKMFGFVHLYNGQEAISTGVI
GAMKKKHDWFCSTYRDHVHALSAGVPSFEVMSELFGKSTGCSKGRGGSMHLFSREHHLLGGYAFIGEGIPVALGAAFSSK
YKKEVAGNSNSDAVTAAFFGDGTCNNGQFFECLNMAQLWKLPIIFVVENNKWAIGMAHDRATSNPEIWRKASAFGMHGEE
VDGMDVLAVRGAAQRAIERARAGEGPTLLECLTYRYRGHSLADPDELRSEKEKEFWGKRDPIKKLAQEIIDGKFATEEEL
KIIEKKIDAEIAESVKNAIEAPEPPSEELTKYIWAED

Sequences:

>Translated_357_residues
MLTNQNFVKVFFLETHVERISNLQDIKKAELDRETGLFLYEDMTLGRRFEDKCAEMYYRGKMFGFVHLYNGQEAISTGVI
GAMKKKHDWFCSTYRDHVHALSAGVPSFEVMSELFGKSTGCSKGRGGSMHLFSREHHLLGGYAFIGEGIPVALGAAFSSK
YKKEVAGNSNSDAVTAAFFGDGTCNNGQFFECLNMAQLWKLPIIFVVENNKWAIGMAHDRATSNPEIWRKASAFGMHGEE
VDGMDVLAVRGAAQRAIERARAGEGPTLLECLTYRYRGHSLADPDELRSEKEKEFWGKRDPIKKLAQEIIDGKFATEEEL
KIIEKKIDAEIAESVKNAIEAPEPPSEELTKYIWAED
>Mature_357_residues
MLTNQNFVKVFFLETHVERISNLQDIKKAELDRETGLFLYEDMTLGRRFEDKCAEMYYRGKMFGFVHLYNGQEAISTGVI
GAMKKKHDWFCSTYRDHVHALSAGVPSFEVMSELFGKSTGCSKGRGGSMHLFSREHHLLGGYAFIGEGIPVALGAAFSSK
YKKEVAGNSNSDAVTAAFFGDGTCNNGQFFECLNMAQLWKLPIIFVVENNKWAIGMAHDRATSNPEIWRKASAFGMHGEE
VDGMDVLAVRGAAQRAIERARAGEGPTLLECLTYRYRGHSLADPDELRSEKEKEFWGKRDPIKKLAQEIIDGKFATEEEL
KIIEKKIDAEIAESVKNAIEAPEPPSEELTKYIWAED

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4885543, Length=329, Percent_Identity=38.6018237082067, Blast_Score=227, Evalue=1e-59,
Organism=Homo sapiens, GI291084742, Length=329, Percent_Identity=37.9939209726444, Blast_Score=209, Evalue=2e-54,
Organism=Homo sapiens, GI4505685, Length=329, Percent_Identity=37.9939209726444, Blast_Score=209, Evalue=2e-54,
Organism=Homo sapiens, GI291084744, Length=336, Percent_Identity=37.202380952381, Blast_Score=203, Evalue=2e-52,
Organism=Homo sapiens, GI291084757, Length=329, Percent_Identity=34.6504559270517, Blast_Score=172, Evalue=3e-43,
Organism=Homo sapiens, GI11386135, Length=328, Percent_Identity=28.0487804878049, Blast_Score=108, Evalue=6e-24,
Organism=Homo sapiens, GI258645172, Length=333, Percent_Identity=28.2282282282282, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI17536047, Length=326, Percent_Identity=38.3435582822086, Blast_Score=219, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI32564172, Length=326, Percent_Identity=38.3435582822086, Blast_Score=218, Evalue=3e-57,
Organism=Caenorhabditis elegans, GI86563355, Length=312, Percent_Identity=27.5641025641026, Blast_Score=112, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI86563357, Length=312, Percent_Identity=27.5641025641026, Blast_Score=112, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6321026, Length=323, Percent_Identity=38.6996904024768, Blast_Score=214, Evalue=2e-56,
Organism=Drosophila melanogaster, GI24639748, Length=363, Percent_Identity=37.7410468319559, Blast_Score=219, Evalue=2e-57,
Organism=Drosophila melanogaster, GI24639744, Length=310, Percent_Identity=38.3870967741935, Blast_Score=206, Evalue=3e-53,
Organism=Drosophila melanogaster, GI28571106, Length=310, Percent_Identity=38.3870967741935, Blast_Score=206, Evalue=3e-53,
Organism=Drosophila melanogaster, GI24639740, Length=310, Percent_Identity=38.3870967741935, Blast_Score=205, Evalue=4e-53,
Organism=Drosophila melanogaster, GI24639746, Length=291, Percent_Identity=39.5189003436426, Blast_Score=199, Evalue=2e-51,
Organism=Drosophila melanogaster, GI21355903, Length=339, Percent_Identity=25.9587020648968, Blast_Score=95, Evalue=6e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017597 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 40076; Mature: 40076

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTNQNFVKVFFLETHVERISNLQDIKKAELDRETGLFLYEDMTLGRRFEDKCAEMYYRG
CCCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCHHCCEEEEECCHHCCHHHHHHHHHHHHC
KMFGFVHLYNGQEAISTGVIGAMKKKHDWFCSTYRDHVHALSAGVPSFEVMSELFGKSTG
CEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCC
CSKGRGGSMHLFSREHHLLGGYAFIGEGIPVALGAAFSSKYKKEVAGNSNSDAVTAAFFG
CCCCCCCCEEEECCCCHHCCCCCEECCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEEC
DGTCNNGQFFECLNMAQLWKLPIIFVVENNKWAIGMAHDRATSNPEIWRKASAFGMHGEE
CCCCCCCHHHHHHHHHHHHCCCEEEEEECCEEEEEECCCCCCCCHHHHHHHHHCCCCCCC
VDGMDVLAVRGAAQRAIERARAGEGPTLLECLTYRYRGHSLADPDELRSEKEKEFWGKRD
CCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCC
PIKKLAQEIIDGKFATEEELKIIEKKIDAEIAESVKNAIEAPEPPSEELTKYIWAED
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCC
>Mature Secondary Structure
MLTNQNFVKVFFLETHVERISNLQDIKKAELDRETGLFLYEDMTLGRRFEDKCAEMYYRG
CCCCCCEEEEEHHHHHHHHHHHHHHHHHHHCCHHCCEEEEECCHHCCHHHHHHHHHHHHC
KMFGFVHLYNGQEAISTGVIGAMKKKHDWFCSTYRDHVHALSAGVPSFEVMSELFGKSTG
CEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCC
CSKGRGGSMHLFSREHHLLGGYAFIGEGIPVALGAAFSSKYKKEVAGNSNSDAVTAAFFG
CCCCCCCCEEEECCCCHHCCCCCEECCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEEC
DGTCNNGQFFECLNMAQLWKLPIIFVVENNKWAIGMAHDRATSNPEIWRKASAFGMHGEE
CCCCCCCHHHHHHHHHHHHCCCEEEEEECCEEEEEECCCCCCCCHHHHHHHHHCCCCCCC
VDGMDVLAVRGAAQRAIERARAGEGPTLLECLTYRYRGHSLADPDELRSEKEKEFWGKRD
CCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCC
PIKKLAQEIIDGKFATEEELKIIEKKIDAEIAESVKNAIEAPEPPSEELTKYIWAED
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10796014; 11481430 [H]