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The map label for this gene is ffh [H]

Identifier: 123969017

GI number: 123969017

Start: 1264800

End: 1266296

Strand: Reverse

Name: ffh [H]

Synonym: A9601_14851

Alternate gene names: 123969017

Gene position: 1266296-1264800 (Counterclockwise)

Preceding gene: 123969018

Following gene: 123969016

Centisome position: 75.83

GC content: 36.54

Gene sequence:

>1497_bases
ATGTTTGATGAACTCTCGTCACGCTTTGAAGACGCAGTAAAGGGTTTAAGAGGCGAAGCAAAAATTAGTGAAAATAATAT
AAACGATGCCTTGAAGGAGGTAAAAAGAGCACTCCTTGATGCAGATGTTAGTTTGTCTGTAGTAAAAGAGTTTATTTCAG
ATGTCAAAGATAAAGCTATTGGGGAAGAAGTAGTTAGGGGTGTAAACCCAGGTCAAAAATTTATTGAAGTTGTAAATAAA
GAGTTGATTAACATTATGGGGAATGAAAATTCTCCATTAAACGAAAATGAAAAAAGTCCTACAGTCATTTTGATGGCTGG
ACTTCAGGGAGCTGGTAAAACAACTGCAACAGGAAAATTAGGACTTTATTTAAAGGAAAAAGATAAAAAAGTTCTTTTGG
TGGCTGCAGATATTTATCGACCAGCAGCTGTAGAGCAGCTTAAAACATTGGGAAGTCAATATGAATTGGAAGTTTTTTCA
GCTAAAGAAAAAAATAGCAAACCAGAAGAAATAGCAAAGGAAGCATTGAATTTTGCTAATGAAAATGATTTTAATTCGAT
AATTATTGATACCGCAGGAAGACTGCAAATTGATGATTCCATGATGAGTGAAATGGTTCGAATAAAAGAAGTTTCTAATC
CTGATGAGATTTTGCTTGTAGTTGATTCAATGATTGGGCAAGAAGCTGCAGACTTAACAAAATCATTTCATGAAAAAGTA
GGAATCACAGGGGCGATATTAACTAAGTTGGATGGCGACTCAAGAGGTGGAGCTGCTTTATCGATAAGAAAAATAAGTGG
TAAACCAATCAAATTTATAGGTGTAGGTGAAAAAATAGAGGCATTGCAACCATTTCATCCAGAGAGAATGGCCAGCAGAA
TTTTAGGCATGGGCGATGTATTGACACTTGTTGAAAAAGCACAAAAAGAAGTTGAACTTGCTGATGCAGAAGCGATGCAA
AAGAAACTTCAAGAAGCGACTTTTGATTTTAATGATTTTGTAAAGCAAATGAGATTAATTAAAAGAATGGGTTCACTTGG
TGGATTGATTAAATTGATTCCTGGAATGAATAAAATAGATGATGGGATGATAAAAGATGGAGAAGATCAACTTAAGAAAA
TAGAATCTATGATCTCGTCAATGACTCTTGAGGAGAAACAAAAACCCGAAGTTCTTGCCGCTCACCCCTCAAGAAGACAA
AGAATCGCTCAAGGTAGCGGTTATGAAGCAAAAGATGTAGATAAAGTTTTAGCCGATTTTCAAAGAATGAGAGGTTTTAT
GAAACAAATGTCTAACGGAGGGATGCCAGGAATGGGAGGAATGCCAGGAATGGGAGGTATGCCAGGAATGGGAGGAATGC
CAGGAATGGGAGGAATGCCAGGAATGGGAGGAATGCCAGGAATGGGAGGTATGCCAGGAATGGGAGGTATGAGTGGTAAT
AGGCAAATGAAAAAACAAAAAAATAATAAAAAGAAAAAAGGTTTTGCTGATTTATAG

Upstream 100 bases:

>100_bases
TGGGCTTTTCAAATAAATCGTGGAAATTGGTTGATTTCGTGAGCGGCTTGTAATTACAAACTTCAAGATCATCTATAATA
ATTAAAATTACTTTTTAATA

Downstream 100 bases:

>100_bases
TTTCTATATTTTTACCTTTAAATGATATTATTATTTAAAACGCATTAATTTAAGATGATTAAATTGCGCCTTAAGCGCTT
TGGAAAGAAAAAAGAGGCAA

Product: signal recognition particle protein (SRP54)

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 498; Mature: 498

Protein sequence:

>498_residues
MFDELSSRFEDAVKGLRGEAKISENNINDALKEVKRALLDADVSLSVVKEFISDVKDKAIGEEVVRGVNPGQKFIEVVNK
ELINIMGNENSPLNENEKSPTVILMAGLQGAGKTTATGKLGLYLKEKDKKVLLVAADIYRPAAVEQLKTLGSQYELEVFS
AKEKNSKPEEIAKEALNFANENDFNSIIIDTAGRLQIDDSMMSEMVRIKEVSNPDEILLVVDSMIGQEAADLTKSFHEKV
GITGAILTKLDGDSRGGAALSIRKISGKPIKFIGVGEKIEALQPFHPERMASRILGMGDVLTLVEKAQKEVELADAEAMQ
KKLQEATFDFNDFVKQMRLIKRMGSLGGLIKLIPGMNKIDDGMIKDGEDQLKKIESMISSMTLEEKQKPEVLAAHPSRRQ
RIAQGSGYEAKDVDKVLADFQRMRGFMKQMSNGGMPGMGGMPGMGGMPGMGGMPGMGGMPGMGGMPGMGGMPGMGGMSGN
RQMKKQKNNKKKKGFADL

Sequences:

>Translated_498_residues
MFDELSSRFEDAVKGLRGEAKISENNINDALKEVKRALLDADVSLSVVKEFISDVKDKAIGEEVVRGVNPGQKFIEVVNK
ELINIMGNENSPLNENEKSPTVILMAGLQGAGKTTATGKLGLYLKEKDKKVLLVAADIYRPAAVEQLKTLGSQYELEVFS
AKEKNSKPEEIAKEALNFANENDFNSIIIDTAGRLQIDDSMMSEMVRIKEVSNPDEILLVVDSMIGQEAADLTKSFHEKV
GITGAILTKLDGDSRGGAALSIRKISGKPIKFIGVGEKIEALQPFHPERMASRILGMGDVLTLVEKAQKEVELADAEAMQ
KKLQEATFDFNDFVKQMRLIKRMGSLGGLIKLIPGMNKIDDGMIKDGEDQLKKIESMISSMTLEEKQKPEVLAAHPSRRQ
RIAQGSGYEAKDVDKVLADFQRMRGFMKQMSNGGMPGMGGMPGMGGMPGMGGMPGMGGMPGMGGMPGMGGMPGMGGMSGN
RQMKKQKNNKKKKGFADL
>Mature_498_residues
MFDELSSRFEDAVKGLRGEAKISENNINDALKEVKRALLDADVSLSVVKEFISDVKDKAIGEEVVRGVNPGQKFIEVVNK
ELINIMGNENSPLNENEKSPTVILMAGLQGAGKTTATGKLGLYLKEKDKKVLLVAADIYRPAAVEQLKTLGSQYELEVFS
AKEKNSKPEEIAKEALNFANENDFNSIIIDTAGRLQIDDSMMSEMVRIKEVSNPDEILLVVDSMIGQEAADLTKSFHEKV
GITGAILTKLDGDSRGGAALSIRKISGKPIKFIGVGEKIEALQPFHPERMASRILGMGDVLTLVEKAQKEVELADAEAMQ
KKLQEATFDFNDFVKQMRLIKRMGSLGGLIKLIPGMNKIDDGMIKDGEDQLKKIESMISSMTLEEKQKPEVLAAHPSRRQ
RIAQGSGYEAKDVDKVLADFQRMRGFMKQMSNGGMPGMGGMPGMGGMPGMGGMPGMGGMPGMGGMPGMGGMPGMGGMSGN
RQMKKQKNNKKKKGFADL

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=507, Percent_Identity=33.7278106508876, Blast_Score=249, Evalue=4e-66,
Organism=Homo sapiens, GI226371618, Length=385, Percent_Identity=35.0649350649351, Blast_Score=219, Evalue=4e-57,
Organism=Homo sapiens, GI89061728, Length=159, Percent_Identity=42.1383647798742, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI295424842, Length=315, Percent_Identity=25.3968253968254, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI23308697, Length=315, Percent_Identity=25.3968253968254, Blast_Score=114, Evalue=2e-25,
Organism=Escherichia coli, GI1788963, Length=427, Percent_Identity=48.9461358313817, Blast_Score=419, Evalue=1e-118,
Organism=Escherichia coli, GI1789874, Length=251, Percent_Identity=36.2549800796813, Blast_Score=155, Evalue=5e-39,
Organism=Caenorhabditis elegans, GI17539958, Length=432, Percent_Identity=29.3981481481481, Blast_Score=220, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI193206261, Length=299, Percent_Identity=29.4314381270903, Blast_Score=122, Evalue=5e-28,
Organism=Saccharomyces cerevisiae, GI6325345, Length=483, Percent_Identity=32.0910973084886, Blast_Score=248, Evalue=2e-66,
Organism=Saccharomyces cerevisiae, GI6320498, Length=325, Percent_Identity=24.6153846153846, Blast_Score=95, Evalue=3e-20,
Organism=Drosophila melanogaster, GI17647949, Length=442, Percent_Identity=30.9954751131222, Blast_Score=223, Evalue=3e-58,
Organism=Drosophila melanogaster, GI24641198, Length=259, Percent_Identity=30.1158301158301, Blast_Score=116, Evalue=3e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 54054; Mature: 54054

Theoretical pI: Translated: 7.73; Mature: 7.73

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
7.0 %Met     (Translated Protein)
7.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
7.0 %Met     (Mature Protein)
7.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDELSSRFEDAVKGLRGEAKISENNINDALKEVKRALLDADVSLSVVKEFISDVKDKAI
CCHHHHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
GEEVVRGVNPGQKFIEVVNKELINIMGNENSPLNENEKSPTVILMAGLQGAGKTTATGKL
HHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCE
GLYLKEKDKKVLLVAADIYRPAAVEQLKTLGSQYELEVFSAKEKNSKPEEIAKEALNFAN
EEEEECCCCEEEEEEHHHHCHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHCCC
ENDFNSIIIDTAGRLQIDDSMMSEMVRIKEVSNPDEILLVVDSMIGQEAADLTKSFHEKV
CCCCCEEEEECCCCEEECHHHHHHHHHHHHCCCCCCEEEEHHHHHCHHHHHHHHHHHHHH
GITGAILTKLDGDSRGGAALSIRKISGKPIKFIGVGEKIEALQPFHPERMASRILGMGDV
CCCHHHHEECCCCCCCCCEEEEEECCCCCEEEEECCCHHHHHCCCCHHHHHHHHHCCHHH
LTLVEKAQKEVELADAEAMQKKLQEATFDFNDFVKQMRLIKRMGSLGGLIKLIPGMNKID
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCC
DGMIKDGEDQLKKIESMISSMTLEEKQKPEVLAAHPSRRQRIAQGSGYEAKDVDKVLADF
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHCCCCCCHHHHHHHHHHH
QRMRGFMKQMSNGGMPGMGGMPGMGGMPGMGGMPGMGGMPGMGGMPGMGGMPGMGGMSGN
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
RQMKKQKNNKKKKGFADL
HHHHHHHCCHHCCCCCCC
>Mature Secondary Structure
MFDELSSRFEDAVKGLRGEAKISENNINDALKEVKRALLDADVSLSVVKEFISDVKDKAI
CCHHHHHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
GEEVVRGVNPGQKFIEVVNKELINIMGNENSPLNENEKSPTVILMAGLQGAGKTTATGKL
HHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCE
GLYLKEKDKKVLLVAADIYRPAAVEQLKTLGSQYELEVFSAKEKNSKPEEIAKEALNFAN
EEEEECCCCEEEEEEHHHHCHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHCCC
ENDFNSIIIDTAGRLQIDDSMMSEMVRIKEVSNPDEILLVVDSMIGQEAADLTKSFHEKV
CCCCCEEEEECCCCEEECHHHHHHHHHHHHCCCCCCEEEEHHHHHCHHHHHHHHHHHHHH
GITGAILTKLDGDSRGGAALSIRKISGKPIKFIGVGEKIEALQPFHPERMASRILGMGDV
CCCHHHHEECCCCCCCCCEEEEEECCCCCEEEEECCCHHHHHCCCCHHHHHHHHHCCHHH
LTLVEKAQKEVELADAEAMQKKLQEATFDFNDFVKQMRLIKRMGSLGGLIKLIPGMNKID
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCC
DGMIKDGEDQLKKIESMISSMTLEEKQKPEVLAAHPSRRQRIAQGSGYEAKDVDKVLADF
CCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEECCCHHHHHHHCCCCCCHHHHHHHHHHH
QRMRGFMKQMSNGGMPGMGGMPGMGGMPGMGGMPGMGGMPGMGGMPGMGGMPGMGGMSGN
HHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
RQMKKQKNNKKKKGFADL
HHHHHHHCCHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]