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The map label for this gene is glmU [H]

Identifier: 123968972

GI number: 123968972

Start: 1225367

End: 1226077

Strand: Direct

Name: glmU [H]

Synonym: A9601_14401

Alternate gene names: 123968972

Gene position: 1225367-1226077 (Clockwise)

Preceding gene: 123968971

Following gene: 123968973

Centisome position: 73.38

GC content: 27.85

Gene sequence:

>711_bases
ATGAAAAATGAATATAAGGCTTTATTACTATCTGCAGGTCTTGGTACAAGATTAAGACCTCTTACAAATGATATTCCAAA
GTGTTTAGTAGAAATAAATAACAAGCCAATTTTACATATGTGGCTTGATAAACTTCAAAATTTAGAAATTAATTCAGTAC
TTATCAATACGCACTATCTTGCGAACAAAGTGTATGAATCAATCCAAAGGTGGAATAGCAAAAATCTTAAGGTTTATACT
ATTTATGAAAAAGAACTTATTGGAACGGCAGGAACATTAATTAATAATCTCAGCTTTTTTAAAGGTTCAAAAGGTTTAAT
TTTGCATGCAGATAATGTCACAGATGATGATTTAAAGGAGTTAATCAAAGCTCACAAAAATAGGCCCTCTAAAGCATTAA
TTACTATGCTTACTTTCGAAACAGAAAATCCCGAGCAATGTGGAGTAATAGAATTAGATAATAATAATTTAGTAAAAGGT
TTTTATGAAAAAATATCAAATCCTCCTACAAAATTAGCAAATGGAGCAATTTATGCTTTTGATGAAGATTTTATAGAATA
CTTATCAAATTTTAATCTTGAGCATGGTGATATAAGTTTAGATATTATACCTAAAATTAATGGTAGGATATTTACTTATA
AAACTAACTCAAATTTCATTGATATTGGCACTCATACTAATTTGAAGAAGGCTAGAGAATTATGGAAATAA

Upstream 100 bases:

>100_bases
AGGATTATTGAATGCCTTTATAAAATAAAATCTTTATTTTTTTAAATTATAGAATTTAAATTCTTTTATTAAAATTATTT
ACTTAAATTATTTTTAAAAA

Downstream 100 bases:

>100_bases
AGTCCAAAGAAAATAATAATTTTACAAACTTTGCAAATATTTATTTGAAGAATTTAAATAATGTATTTGATGAAAATATT
TTGGAAAGAATACAAGATTT

Product: putative sugar-phosphate nucleotidyl transferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 236; Mature: 236

Protein sequence:

>236_residues
MKNEYKALLLSAGLGTRLRPLTNDIPKCLVEINNKPILHMWLDKLQNLEINSVLINTHYLANKVYESIQRWNSKNLKVYT
IYEKELIGTAGTLINNLSFFKGSKGLILHADNVTDDDLKELIKAHKNRPSKALITMLTFETENPEQCGVIELDNNNLVKG
FYEKISNPPTKLANGAIYAFDEDFIEYLSNFNLEHGDISLDIIPKINGRIFTYKTNSNFIDIGTHTNLKKARELWK

Sequences:

>Translated_236_residues
MKNEYKALLLSAGLGTRLRPLTNDIPKCLVEINNKPILHMWLDKLQNLEINSVLINTHYLANKVYESIQRWNSKNLKVYT
IYEKELIGTAGTLINNLSFFKGSKGLILHADNVTDDDLKELIKAHKNRPSKALITMLTFETENPEQCGVIELDNNNLVKG
FYEKISNPPTKLANGAIYAFDEDFIEYLSNFNLEHGDISLDIIPKINGRIFTYKTNSNFIDIGTHTNLKKARELWK
>Mature_236_residues
MKNEYKALLLSAGLGTRLRPLTNDIPKCLVEINNKPILHMWLDKLQNLEINSVLINTHYLANKVYESIQRWNSKNLKVYT
IYEKELIGTAGTLINNLSFFKGSKGLILHADNVTDDDLKELIKAHKNRPSKALITMLTFETENPEQCGVIELDNNNLVKG
FYEKISNPPTKLANGAIYAFDEDFIEYLSNFNLEHGDISLDIIPKINGRIFTYKTNSNFIDIGTHTNLKKARELWK

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetyl-glucosamine (UDP- GlcNAc). Responsible for the acetylation of GlcN-1-P to GlcNAc-1- P, and for the uridyl transfer from UTP to GlcNAc-1-P, to produce UDP-GlcN

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=225, Percent_Identity=25.3333333333333, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI11761619, Length=225, Percent_Identity=25.3333333333333, Blast_Score=76, Evalue=2e-14,
Organism=Escherichia coli, GI1788351, Length=234, Percent_Identity=26.4957264957265, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1789837, Length=235, Percent_Identity=27.6595744680851, Blast_Score=73, Evalue=1e-14,
Organism=Escherichia coli, GI1790224, Length=244, Percent_Identity=23.7704918032787, Blast_Score=68, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI133931050, Length=236, Percent_Identity=27.5423728813559, Blast_Score=87, Evalue=7e-18,
Organism=Saccharomyces cerevisiae, GI6320148, Length=188, Percent_Identity=28.1914893617021, Blast_Score=77, Evalue=3e-15,
Organism=Drosophila melanogaster, GI21355443, Length=229, Percent_Identity=29.6943231441048, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24644084, Length=229, Percent_Identity=29.6943231441048, Blast_Score=92, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 26998; Mature: 26998

Theoretical pI: Translated: 8.20; Mature: 8.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNEYKALLLSAGLGTRLRPLTNDIPKCLVEINNKPILHMWLDKLQNLEINSVLINTHYL
CCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCEEEEEEEEHHHH
ANKVYESIQRWNSKNLKVYTIYEKELIGTAGTLINNLSFFKGSKGLILHADNVTDDDLKE
HHHHHHHHHHCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHH
LIKAHKNRPSKALITMLTFETENPEQCGVIELDNNNLVKGFYEKISNPPTKLANGAIYAF
HHHHHCCCCCHHEEEEEEEECCCCCCCCEEEECCCCHHHHHHHHHCCCCHHHHCCEEEEE
DEDFIEYLSNFNLEHGDISLDIIPKINGRIFTYKTNSNFIDIGTHTNLKKARELWK
CHHHHHHHHHCCCCCCCEEEEEEECCCCEEEEEECCCCEEEECCCCCHHHHHHHCC
>Mature Secondary Structure
MKNEYKALLLSAGLGTRLRPLTNDIPKCLVEINNKPILHMWLDKLQNLEINSVLINTHYL
CCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHCCCEEEEEEEEHHHH
ANKVYESIQRWNSKNLKVYTIYEKELIGTAGTLINNLSFFKGSKGLILHADNVTDDDLKE
HHHHHHHHHHCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHH
LIKAHKNRPSKALITMLTFETENPEQCGVIELDNNNLVKGFYEKISNPPTKLANGAIYAF
HHHHHCCCCCHHEEEEEEEECCCCCCCCEEEECCCCHHHHHHHHHCCCCHHHHCCEEEEE
DEDFIEYLSNFNLEHGDISLDIIPKINGRIFTYKTNSNFIDIGTHTNLKKARELWK
CHHHHHHHHHCCCCCCCEEEEEEECCCCEEEEEECCCCEEEECCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]