Click here to switch to the map view.

The map label for this gene is ispA [C]

Identifier: 123968708

GI number: 123968708

Start: 990189

End: 991091

Strand: Direct

Name: ispA [C]

Synonym: A9601_11751

Alternate gene names: 123968708

Gene position: 990189-991091 (Clockwise)

Preceding gene: 123968707

Following gene: 123968709

Centisome position: 59.3

GC content: 37.65

Gene sequence:

>903_bases
ATGACTGAAGTTATAAATAATATTTCTGATTTTGAAAAATATCTTAAAAACACAAAAAAGGTTGTAGAAGAAGCACTTGA
TTTTTCCTTGGGTCCTGAGAATCCAGAAATATTAAGGGAATCAATGAGATATTCCCTTTTAGCTGGAGGGAAAAGAATAC
GTCCAATTTTATGTTTAGCATCTTGCTCACTGGCAGGAGGAGAACCCTCTCTTGCTGTTCCTACTGCAGTAGCAATAGAA
ATGATCCATACAATGTCCTTGATTCATGATGATCTGCCCGCCATGGATAATGATGACTTGAGGAGAGGTAGGCCGACAAA
TCATAAAGTTTATGGAGATGCAATAGCTATTCTTGCAGGTGATGCTTTATTGACCAGGGCCTTTGAAATGGTCTCTTTAA
GAAGTCCAGGAGTTGATCCAACTAGATTATTAAATGTAGTTGGTGAACTTTCTTTAGTTGCTGGGGCACCAGGTTTAGTG
GGAGGACAAGTAGTTGATTTAGAATGCGAAGGCAAGGAGGTTGACCTTAAAACTCTCGAATATATTCATCTTCATAAGAC
TGGGGCTTTATTAAAAGCTTGCGTAAGAACAGGCGCGATGATCGCAGGCGCAAACGAAAAACTATTACATGCTCTGACAA
CATATGCAGAGGGTATTGGATTAGCCTTCCAGATAATAGATGATATTCTTGATTTAACTTCAAGTAGTGAAAAGCTTGGT
AAAACTGCCGGGAAAGATCTTTTAGCTGACAAAACTACTTACCCTAAATTACTTGGAATGGAGGAATCAAAGAAAAGAGC
ATTTGATTTAGTTGAAAAAGCAAAAAAAGCAATTGAACCTTGGGGGCCAGATGCAAAGTATTTAATATCATTAGCCGATT
TCATTACAAATAGAGATAGATAA

Upstream 100 bases:

>100_bases
ACTATTTTTAGCTGGCAAAAACAATTTGGTTTATCATCAACTCTTAATGACCTTTTGCCATAAACTCCAAGATGCAAAAT
TTTTTTACTAACGGTATAAA

Downstream 100 bases:

>100_bases
ATAGTTTAAATTTATGTCTGATTTTTTTGCCTTTTTTAATAATTCAGTTCTTTTTTGGAGTTTATTATCCTGTTTACTGG
CTCAATTTTTTAAAATTTTA

Product: polyprenyl synthetase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 300; Mature: 299

Protein sequence:

>300_residues
MTEVINNISDFEKYLKNTKKVVEEALDFSLGPENPEILRESMRYSLLAGGKRIRPILCLASCSLAGGEPSLAVPTAVAIE
MIHTMSLIHDDLPAMDNDDLRRGRPTNHKVYGDAIAILAGDALLTRAFEMVSLRSPGVDPTRLLNVVGELSLVAGAPGLV
GGQVVDLECEGKEVDLKTLEYIHLHKTGALLKACVRTGAMIAGANEKLLHALTTYAEGIGLAFQIIDDILDLTSSSEKLG
KTAGKDLLADKTTYPKLLGMEESKKRAFDLVEKAKKAIEPWGPDAKYLISLADFITNRDR

Sequences:

>Translated_300_residues
MTEVINNISDFEKYLKNTKKVVEEALDFSLGPENPEILRESMRYSLLAGGKRIRPILCLASCSLAGGEPSLAVPTAVAIE
MIHTMSLIHDDLPAMDNDDLRRGRPTNHKVYGDAIAILAGDALLTRAFEMVSLRSPGVDPTRLLNVVGELSLVAGAPGLV
GGQVVDLECEGKEVDLKTLEYIHLHKTGALLKACVRTGAMIAGANEKLLHALTTYAEGIGLAFQIIDDILDLTSSSEKLG
KTAGKDLLADKTTYPKLLGMEESKKRAFDLVEKAKKAIEPWGPDAKYLISLADFITNRDR
>Mature_299_residues
TEVINNISDFEKYLKNTKKVVEEALDFSLGPENPEILRESMRYSLLAGGKRIRPILCLASCSLAGGEPSLAVPTAVAIEM
IHTMSLIHDDLPAMDNDDLRRGRPTNHKVYGDAIAILAGDALLTRAFEMVSLRSPGVDPTRLLNVVGELSLVAGAPGLVG
GQVVDLECEGKEVDLKTLEYIHLHKTGALLKACVRTGAMIAGANEKLLHALTTYAEGIGLAFQIIDDILDLTSSSEKLGK
TAGKDLLADKTTYPKLLGMEESKKRAFDLVEKAKKAIEPWGPDAKYLISLADFITNRDR

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=235, Percent_Identity=29.3617021276596, Blast_Score=90, Evalue=2e-18,
Organism=Escherichia coli, GI1786623, Length=302, Percent_Identity=44.7019867549669, Blast_Score=200, Evalue=1e-52,
Organism=Escherichia coli, GI1789578, Length=233, Percent_Identity=32.618025751073, Blast_Score=119, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17505681, Length=191, Percent_Identity=30.8900523560209, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24651612, Length=218, Percent_Identity=31.1926605504587, Blast_Score=91, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 32526; Mature: 32395

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEVINNISDFEKYLKNTKKVVEEALDFSLGPENPEILRESMRYSLLAGGKRIRPILCLA
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHH
SCSLAGGEPSLAVPTAVAIEMIHTMSLIHDDLPAMDNDDLRRGRPTNHKVYGDAIAILAG
HCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCEEHHCCHHHHHH
DALLTRAFEMVSLRSPGVDPTRLLNVVGELSLVAGAPGLVGGQVVDLECEGKEVDLKTLE
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCHHHHH
YIHLHKTGALLKACVRTGAMIAGANEKLLHALTTYAEGIGLAFQIIDDILDLTSSSEKLG
HHHHHHHHHHHHHHHHHCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
KTAGKDLLADKTTYPKLLGMEESKKRAFDLVEKAKKAIEPWGPDAKYLISLADFITNRDR
HHHCHHHHCCCCCCHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TEVINNISDFEKYLKNTKKVVEEALDFSLGPENPEILRESMRYSLLAGGKRIRPILCLA
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHH
SCSLAGGEPSLAVPTAVAIEMIHTMSLIHDDLPAMDNDDLRRGRPTNHKVYGDAIAILAG
HCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCEEHHCCHHHHHH
DALLTRAFEMVSLRSPGVDPTRLLNVVGELSLVAGAPGLVGGQVVDLECEGKEVDLKTLE
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCHHHHH
YIHLHKTGALLKACVRTGAMIAGANEKLLHALTTYAEGIGLAFQIIDDILDLTSSSEKLG
HHHHHHHHHHHHHHHHHCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
KTAGKDLLADKTTYPKLLGMEESKKRAFDLVEKAKKAIEPWGPDAKYLISLADFITNRDR
HHHCHHHHCCCCCCHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8486607; 7918490 [H]