Click here to switch to the map view.

The map label for this gene is ribB [H]

Identifier: 123968501

GI number: 123968501

Start: 834087

End: 835811

Strand: Reverse

Name: ribB [H]

Synonym: A9601_09681

Alternate gene names: 123968501

Gene position: 835811-834087 (Counterclockwise)

Preceding gene: 123968503

Following gene: 123968496

Centisome position: 50.05

GC content: 32.58

Gene sequence:

>1725_bases
ATGAAAGAAACAAGTCCCAAATCAAATAATGGAACAATTTTGGATATAAATGAATCTTTTAAAATTGAATTTGATCCTAT
CAGCGATGCGTTGGCAGCCATAAGAAATGGTGAATGCATAATTGTTGTAGATGATGAAAGAAGAGAAAATGAAGGAGATC
TAATATGTGCGGCTCAGTTTGCTACTCCACAGCAAATTAATTTTATGGCAACTGAGGGACGTGGACTTATATGCCTAGCA
ATGCAAGGCGAAAAACTTGATTCTTTAGATTTGCCATTAATGGTAGATAGAAATACAGATGAAAATCAAACCGCTTTTAC
GATATCAATTGATGCTGGACCTGAAAATAATGTTACTACTGGAATTTCTGCTGAAGACAGGGCAAAGACAATTCAAGTTG
CTATAAACCCAAAGACAAAACCAGATGATTTGAGAAGGCCAGGACATATTTTTCCATTAAGAGCTAAGAAAGGTGGAGTA
TTAAAAAGAGCAGGTCATACTGAAGCGGCAGTAGATATTGCGGCGATGTCAGGTCTTTATCCCGCTGGAGTTATTTGCGA
AATACAAAATCCTGATGGTTCCATGTCAAGACTTCCTCAACTTAAAGAGTATGCAAAACAGTGGGGAATGAAATTAATAT
CCATAGCTGATTTAATTAGTTATCGTTTCCAAACTGAGAGATTTGTATTTAGAAAATCCGATGCGGTACTTCCAAGTATT
TTTGGTAATTTCAAAGCTTATGGATATGTTAATGAACTTGATGGTTCAGAGCACGTTGCATTAGTTAAACAAAAATCATT
CAAATTAAGCGAACCTGTATTAGTAAGAATGCATTCAGAGTGCTTGACTGGCGATGCTTTTGGATCTTTACGTTGTGATT
GTAGACCCCAATTAGAGGCTGCCTTATCAAGGATAGAAAAGGAGGAAGAGGGGGTTGTTGTTTACTTAAGGCAAGAAGGC
AGAGGTATTGGTCTAATAAATAAATTAAAAGCTTATAGTTTGCAGGATGGTGGATTAGACACTGTAGAAGCTAATGAAAA
ATTAGGTTTTCCAGCTGATCTCAGAAATTACGGAGTTGGAGCACAGATATTAACCGATCTAGGTATAAAAAAACTAAAAT
TACTTACAAATAATCCCAGAAAGATTGCTGGATTAGGTGGTTATGGAATAGAAGTTATTGAGAGAGTTCCATTAGTAATT
TGTCCAAACGATAATAATGCAGAATATTTGAGTGTAAAAAAAACGAAGCTAGGTCACATGATTGATGAAGATAATTCTAA
TTCAAGAAATATCGATCCATTTATATCAATATTTCTTGACGGAAAATATAAATCTATTGATCTAGTTCCAATAAAAAATA
ACGTTATTAAATTCTGTAGTGATAAGAAAATTAATATTAAACTTGAAAGTACTCCAAGATTATTGGCTTTTTGGAATCGA
CCAAAATTAGTTTGGCGAATTTTACATGATAAGAATAGAACCAATTCCAACATTACTAATGAAGAGATAAAGAATATAGA
ATTATTTATTCAATTTTTATCCAATTATGAAAATAGTACAAAGATTGGAATTATTGTTTCTAGAAACATTGAACAAGCAT
TACACCCAAAAAGTAGTATCAAATTAATCAATACTAAATTTTCAATAAATAATGAAATCTTGTATTCATCTACAAGAAAA
TTTAATCTAGATAAAGAGACATTTAGTATTGTTTTTGAGAGCTAA

Upstream 100 bases:

>100_bases
TGCAACATTCATTTCTTTGAATTGGCAGACTTTGAGATAGGATTATAAAGTGTTGAATTTAAGGTAACTAAAACACTATT
TTTCTATATTGATAGGAATA

Downstream 100 bases:

>100_bases
AAACTATTTTAAAGTTGCCTTTAAAATTTTTGACCCATTAGTAAGCTTTAGCACTACATCCATATCATCAGTCTTACCAA
AAACTGTATGAACTCCATCG

Product: bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II/unknown domain fusion protein

Products: NA

Alternate protein names: 3,4-dihydroxy-2-butanone 4-phosphate synthase; DHBP synthase; GTP cyclohydrolase-2; GTP cyclohydrolase II [H]

Number of amino acids: Translated: 574; Mature: 574

Protein sequence:

>574_residues
MKETSPKSNNGTILDINESFKIEFDPISDALAAIRNGECIIVVDDERRENEGDLICAAQFATPQQINFMATEGRGLICLA
MQGEKLDSLDLPLMVDRNTDENQTAFTISIDAGPENNVTTGISAEDRAKTIQVAINPKTKPDDLRRPGHIFPLRAKKGGV
LKRAGHTEAAVDIAAMSGLYPAGVICEIQNPDGSMSRLPQLKEYAKQWGMKLISIADLISYRFQTERFVFRKSDAVLPSI
FGNFKAYGYVNELDGSEHVALVKQKSFKLSEPVLVRMHSECLTGDAFGSLRCDCRPQLEAALSRIEKEEEGVVVYLRQEG
RGIGLINKLKAYSLQDGGLDTVEANEKLGFPADLRNYGVGAQILTDLGIKKLKLLTNNPRKIAGLGGYGIEVIERVPLVI
CPNDNNAEYLSVKKTKLGHMIDEDNSNSRNIDPFISIFLDGKYKSIDLVPIKNNVIKFCSDKKINIKLESTPRLLAFWNR
PKLVWRILHDKNRTNSNITNEEIKNIELFIQFLSNYENSTKIGIIVSRNIEQALHPKSSIKLINTKFSINNEILYSSTRK
FNLDKETFSIVFES

Sequences:

>Translated_574_residues
MKETSPKSNNGTILDINESFKIEFDPISDALAAIRNGECIIVVDDERRENEGDLICAAQFATPQQINFMATEGRGLICLA
MQGEKLDSLDLPLMVDRNTDENQTAFTISIDAGPENNVTTGISAEDRAKTIQVAINPKTKPDDLRRPGHIFPLRAKKGGV
LKRAGHTEAAVDIAAMSGLYPAGVICEIQNPDGSMSRLPQLKEYAKQWGMKLISIADLISYRFQTERFVFRKSDAVLPSI
FGNFKAYGYVNELDGSEHVALVKQKSFKLSEPVLVRMHSECLTGDAFGSLRCDCRPQLEAALSRIEKEEEGVVVYLRQEG
RGIGLINKLKAYSLQDGGLDTVEANEKLGFPADLRNYGVGAQILTDLGIKKLKLLTNNPRKIAGLGGYGIEVIERVPLVI
CPNDNNAEYLSVKKTKLGHMIDEDNSNSRNIDPFISIFLDGKYKSIDLVPIKNNVIKFCSDKKINIKLESTPRLLAFWNR
PKLVWRILHDKNRTNSNITNEEIKNIELFIQFLSNYENSTKIGIIVSRNIEQALHPKSSIKLINTKFSINNEILYSSTRK
FNLDKETFSIVFES
>Mature_574_residues
MKETSPKSNNGTILDINESFKIEFDPISDALAAIRNGECIIVVDDERRENEGDLICAAQFATPQQINFMATEGRGLICLA
MQGEKLDSLDLPLMVDRNTDENQTAFTISIDAGPENNVTTGISAEDRAKTIQVAINPKTKPDDLRRPGHIFPLRAKKGGV
LKRAGHTEAAVDIAAMSGLYPAGVICEIQNPDGSMSRLPQLKEYAKQWGMKLISIADLISYRFQTERFVFRKSDAVLPSI
FGNFKAYGYVNELDGSEHVALVKQKSFKLSEPVLVRMHSECLTGDAFGSLRCDCRPQLEAALSRIEKEEEGVVVYLRQEG
RGIGLINKLKAYSLQDGGLDTVEANEKLGFPADLRNYGVGAQILTDLGIKKLKLLTNNPRKIAGLGGYGIEVIERVPLVI
CPNDNNAEYLSVKKTKLGHMIDEDNSNSRNIDPFISIFLDGKYKSIDLVPIKNNVIKFCSDKKINIKLESTPRLLAFWNR
PKLVWRILHDKNRTNSNITNEEIKNIELFIQFLSNYENSTKIGIIVSRNIEQALHPKSSIKLINTKFSINNEILYSSTRK
FNLDKETFSIVFES

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0108

COG function: function code H; 3,4-dihydroxy-2-butanone 4-phosphate synthase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the central section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1789420, Length=209, Percent_Identity=47.3684210526316, Blast_Score=214, Evalue=2e-56,
Organism=Escherichia coli, GI1787533, Length=193, Percent_Identity=50.259067357513, Blast_Score=196, Evalue=3e-51,
Organism=Saccharomyces cerevisiae, GI6320695, Length=206, Percent_Identity=42.2330097087379, Blast_Score=163, Evalue=7e-41,
Organism=Saccharomyces cerevisiae, GI6319438, Length=191, Percent_Identity=41.8848167539267, Blast_Score=134, Evalue=4e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12; =3.5.4.25 [H]

Molecular weight: Translated: 64120; Mature: 64120

Theoretical pI: Translated: 7.42; Mature: 7.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKETSPKSNNGTILDINESFKIEFDPISDALAAIRNGECIIVVDDERRENEGDLICAAQF
CCCCCCCCCCCEEEEECCCEEEEECCHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEEEC
ATPQQINFMATEGRGLICLAMQGEKLDSLDLPLMVDRNTDENQTAFTISIDAGPENNVTT
CCCCEEEEEEECCCCEEEEEECCCCCCCCCCCEEEECCCCCCCEEEEEEEECCCCCCEEC
GISAEDRAKTIQVAINPKTKPDDLRRPGHIFPLRAKKGGVLKRAGHTEAAVDIAAMSGLY
CCCCCCCCEEEEEEECCCCCHHHCCCCCCEEEEECCCCCCEEECCCCHHHEEHHHHCCCC
PAGVICEIQNPDGSMSRLPQLKEYAKQWGMKLISIADLISYRFQTERFVFRKSDAVLPSI
CCCEEEEEECCCCHHHHCHHHHHHHHHHCCHHHHHHHHHHHHHCCCEEEEECCCCCHHHH
FGNFKAYGYVNELDGSEHVALVKQKSFKLSEPVLVRMHSECLTGDAFGSLRCDCRPQLEA
HCCCEEEEEEECCCCCCEEEEEEECCCCCCCCEEEEEEHHHCCCCCCCCEEECCCHHHHH
ALSRIEKEEEGVVVYLRQEGRGIGLINKLKAYSLQDGGLDTVEANEKLGFPADLRNYGVG
HHHHHCCCCCCEEEEEEECCCCCCCHHHHEEEEECCCCCCEEECCCCCCCCHHHHHCCCC
AQILTDLGIKKLKLLTNNPRKIAGLGGYGIEVIERVPLVICPNDNNAEYLSVKKTKLGHM
HHHHHHCCCEEEEEEECCCCEEEECCCCHHHHHHHCCEEEECCCCCCEEEEEEHHHHCCE
IDEDNSNSRNIDPFISIFLDGKYKSIDLVPIKNNVIKFCSDKKINIKLESTPRLLAFWNR
ECCCCCCCCCCCCEEEEEECCCCCEEEEEECCCCCEECCCCCEEEEEECCCCCEEEEECC
PKLVWRILHDKNRTNSNITNEEIKNIELFIQFLSNYENSTKIGIIVSRNIEQALHPKSSI
CCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEEECCHHHHHCCCCCE
KLINTKFSINNEILYSSTRKFNLDKETFSIVFES
EEEEEEEECCCEEEEECCCEECCCCCEEEEEECC
>Mature Secondary Structure
MKETSPKSNNGTILDINESFKIEFDPISDALAAIRNGECIIVVDDERRENEGDLICAAQF
CCCCCCCCCCCEEEEECCCEEEEECCHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEEEC
ATPQQINFMATEGRGLICLAMQGEKLDSLDLPLMVDRNTDENQTAFTISIDAGPENNVTT
CCCCEEEEEEECCCCEEEEEECCCCCCCCCCCEEEECCCCCCCEEEEEEEECCCCCCEEC
GISAEDRAKTIQVAINPKTKPDDLRRPGHIFPLRAKKGGVLKRAGHTEAAVDIAAMSGLY
CCCCCCCCEEEEEEECCCCCHHHCCCCCCEEEEECCCCCCEEECCCCHHHEEHHHHCCCC
PAGVICEIQNPDGSMSRLPQLKEYAKQWGMKLISIADLISYRFQTERFVFRKSDAVLPSI
CCCEEEEEECCCCHHHHCHHHHHHHHHHCCHHHHHHHHHHHHHCCCEEEEECCCCCHHHH
FGNFKAYGYVNELDGSEHVALVKQKSFKLSEPVLVRMHSECLTGDAFGSLRCDCRPQLEA
HCCCEEEEEEECCCCCCEEEEEEECCCCCCCCEEEEEEHHHCCCCCCCCEEECCCHHHHH
ALSRIEKEEEGVVVYLRQEGRGIGLINKLKAYSLQDGGLDTVEANEKLGFPADLRNYGVG
HHHHHCCCCCCEEEEEEECCCCCCCHHHHEEEEECCCCCCEEECCCCCCCCHHHHHCCCC
AQILTDLGIKKLKLLTNNPRKIAGLGGYGIEVIERVPLVICPNDNNAEYLSVKKTKLGHM
HHHHHHCCCEEEEEEECCCCEEEECCCCHHHHHHHCCEEEECCCCCCEEEEEEHHHHCCE
IDEDNSNSRNIDPFISIFLDGKYKSIDLVPIKNNVIKFCSDKKINIKLESTPRLLAFWNR
ECCCCCCCCCCCCEEEEEECCCCCEEEEEECCCCCEECCCCCEEEEEECCCCCEEEEECC
PKLVWRILHDKNRTNSNITNEEIKNIELFIQFLSNYENSTKIGIIVSRNIEQALHPKSSI
CCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEEECCHHHHHCCCCCE
KLINTKFSINNEILYSSTRKFNLDKETFSIVFES
EEEEEEEECCCEEEEECCCEECCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]