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The map label for this gene is gadB [H]

Identifier: 123968476

GI number: 123968476

Start: 811812

End: 813197

Strand: Direct

Name: gadB [H]

Synonym: A9601_09431

Alternate gene names: 123968476

Gene position: 811812-813197 (Clockwise)

Preceding gene: 123968474

Following gene: 123968477

Centisome position: 48.61

GC content: 31.24

Gene sequence:

>1386_bases
ATGGCTGAAGATTTAATTAATAATAAAAATATATATTTTCCCTCATATTTAGGGACTAATGACAAATTGAATATTCTTTT
AAATAGAGCAAGTAAAACTCTTTGTGACTGGTTCTCTAAATCTGATAAAAATGGTCCTTTACCTTTTGATGAGAGCTTCA
AGTGCATTATGCCTGCGGAGGATGGCAACTCTGAAGAAGATTTGTTTTCTGAGATTGAATCTCTTTTGAATAATTCATTT
AATCCCGTTCATCCCGGCTCACTAGCTCACCTTGATCCCCCACCTTTAATTTTCTCTATATTGGGAGATTTAATTGCTGC
TGGTTTAAATAATAATCTTCTCGCTTACGAATTATCACCAAGTGTAACTTTGCTTGAGGAATCATTATGCAAATGGTTTG
CCAAAAAAATAGGGTTTAATGATTTCTCAGGGGGTATAGCTGCAAGCGGAGGTACATTAAGTAATCTGAATGCACTTATA
GCAGCTAGAAATAATGCTGGATTAGGTACAAATCCTGATTCTGTATTACTAGTTAGTGAAGATGCTCATTCATCCTTCGT
TAAATGTATAAGAGTAATGGGTCTTGATACTTCGAATCTTGTCAGGATTAAAACTGATAATCAAGGTCGAATGGATATAA
ACGAGCTCAGAAAGTCTTTAGAAAAATGTTCAATAGAAAATAAAAAAATTTTTGCTATTGTTGCCACCCTTGGGACAACT
GTAAGAGGAGCAATTGACCCGATTAAAGAAATTGGTGAAATCTGTAAGCAAAGAAATATATGGTTACATATTGATGGTTC
AATTGGAGGGATTTTTGCAATAACTTCTATTCCAATAGAAGGTTTAAATAATATTAATCAGGCTAATTCGATAACGATAA
ATCCACAAAAAATTATTGGTATTACAAAGACTTCATCTTTGTTATTGGTATCAAATATGAGTACTTTAGAAAATACTTTT
AATACTGGACTACCATACATATCATCTAAAGAAAATATTATAAATAGAGGAGAGATAGGCATACAAGGTTCTAGACCTGC
AGAGGTTATAAAATTATGGCTTGGGTTACGTTTTTTAGGTATGAATGGAATAGAAAATATATTAAAGTCATCAATTAAAA
GAAAAGATTTTTTTATAAGAAATATTAGTAGCAATAAATTTGATATATATTCAGGTCCTCTTCATATCGTTTCATTCTTA
CCAAAGAAACTTGAGCCAAAAGACTCTGATGCATGGACTCAAACTAAAGTTAATGAACTAATTAACAATAATTTTATGCT
TTCTAGACCAAAATTTAAAGGTAAATATTTTTTACGGGTTGTAATGGGAAATTACAATACAAAAGAATCCCATATAGAGG
AACTTTTGAGACTTTTAAATGCTTAA

Upstream 100 bases:

>100_bases
ATTTGTTTTTCTTTGTTGATCTTCATTACTATTTCCATTTTCAAAAATATATCTCATTTACCAATATTGAGAATACAATT
ACTAATAGATATTTTATCTG

Downstream 100 bases:

>100_bases
ATAGTGAATATGGGCAGACCAAAAATTATTGCAATTGTAACAGGGTTTATATCTATAGCTATTTGTATTGCTTATTTACT
CTTAATAACTATCTTTGATT

Product: pyridoxal-dependent decarboxylase family protein

Products: NA

Alternate protein names: DABA decarboxylase; DABA-DC [H]

Number of amino acids: Translated: 461; Mature: 460

Protein sequence:

>461_residues
MAEDLINNKNIYFPSYLGTNDKLNILLNRASKTLCDWFSKSDKNGPLPFDESFKCIMPAEDGNSEEDLFSEIESLLNNSF
NPVHPGSLAHLDPPPLIFSILGDLIAAGLNNNLLAYELSPSVTLLEESLCKWFAKKIGFNDFSGGIAASGGTLSNLNALI
AARNNAGLGTNPDSVLLVSEDAHSSFVKCIRVMGLDTSNLVRIKTDNQGRMDINELRKSLEKCSIENKKIFAIVATLGTT
VRGAIDPIKEIGEICKQRNIWLHIDGSIGGIFAITSIPIEGLNNINQANSITINPQKIIGITKTSSLLLVSNMSTLENTF
NTGLPYISSKENIINRGEIGIQGSRPAEVIKLWLGLRFLGMNGIENILKSSIKRKDFFIRNISSNKFDIYSGPLHIVSFL
PKKLEPKDSDAWTQTKVNELINNNFMLSRPKFKGKYFLRVVMGNYNTKESHIEELLRLLNA

Sequences:

>Translated_461_residues
MAEDLINNKNIYFPSYLGTNDKLNILLNRASKTLCDWFSKSDKNGPLPFDESFKCIMPAEDGNSEEDLFSEIESLLNNSF
NPVHPGSLAHLDPPPLIFSILGDLIAAGLNNNLLAYELSPSVTLLEESLCKWFAKKIGFNDFSGGIAASGGTLSNLNALI
AARNNAGLGTNPDSVLLVSEDAHSSFVKCIRVMGLDTSNLVRIKTDNQGRMDINELRKSLEKCSIENKKIFAIVATLGTT
VRGAIDPIKEIGEICKQRNIWLHIDGSIGGIFAITSIPIEGLNNINQANSITINPQKIIGITKTSSLLLVSNMSTLENTF
NTGLPYISSKENIINRGEIGIQGSRPAEVIKLWLGLRFLGMNGIENILKSSIKRKDFFIRNISSNKFDIYSGPLHIVSFL
PKKLEPKDSDAWTQTKVNELINNNFMLSRPKFKGKYFLRVVMGNYNTKESHIEELLRLLNA
>Mature_460_residues
AEDLINNKNIYFPSYLGTNDKLNILLNRASKTLCDWFSKSDKNGPLPFDESFKCIMPAEDGNSEEDLFSEIESLLNNSFN
PVHPGSLAHLDPPPLIFSILGDLIAAGLNNNLLAYELSPSVTLLEESLCKWFAKKIGFNDFSGGIAASGGTLSNLNALIA
ARNNAGLGTNPDSVLLVSEDAHSSFVKCIRVMGLDTSNLVRIKTDNQGRMDINELRKSLEKCSIENKKIFAIVATLGTTV
RGAIDPIKEIGEICKQRNIWLHIDGSIGGIFAITSIPIEGLNNINQANSITINPQKIIGITKTSSLLLVSNMSTLENTFN
TGLPYISSKENIINRGEIGIQGSRPAEVIKLWLGLRFLGMNGIENILKSSIKRKDFFIRNISSNKFDIYSGPLHIVSFLP
KKLEPKDSDAWTQTKVNELINNNFMLSRPKFKGKYFLRVVMGNYNTKESHIEELLRLLNA

Specific function: Unknown

COG id: COG0076

COG function: function code E; Glutamate decarboxylase and related PLP-dependent proteins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the group II decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI58331246, Length=498, Percent_Identity=26.9076305220884, Blast_Score=159, Evalue=6e-39,
Organism=Homo sapiens, GI197276620, Length=401, Percent_Identity=27.431421446384, Blast_Score=155, Evalue=9e-38,
Organism=Homo sapiens, GI4503875, Length=401, Percent_Identity=27.431421446384, Blast_Score=155, Evalue=9e-38,
Organism=Homo sapiens, GI197383062, Length=339, Percent_Identity=27.7286135693215, Blast_Score=153, Evalue=4e-37,
Organism=Homo sapiens, GI194294551, Length=401, Percent_Identity=24.9376558603491, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI92110055, Length=355, Percent_Identity=28.4507042253521, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI4503281, Length=346, Percent_Identity=23.6994219653179, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI132814448, Length=346, Percent_Identity=23.6994219653179, Blast_Score=97, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI71993058, Length=335, Percent_Identity=27.7611940298507, Blast_Score=147, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17555682, Length=335, Percent_Identity=27.7611940298507, Blast_Score=147, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI71993062, Length=335, Percent_Identity=27.7611940298507, Blast_Score=146, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI17534819, Length=389, Percent_Identity=24.6786632390745, Blast_Score=96, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17534817, Length=408, Percent_Identity=24.7549019607843, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI17136594, Length=336, Percent_Identity=28.2738095238095, Blast_Score=155, Evalue=5e-38,
Organism=Drosophila melanogaster, GI24657193, Length=425, Percent_Identity=27.0588235294118, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24657185, Length=425, Percent_Identity=27.0588235294118, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI24657188, Length=425, Percent_Identity=27.0588235294118, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI21356415, Length=371, Percent_Identity=27.2237196765499, Blast_Score=132, Evalue=7e-31,
Organism=Drosophila melanogaster, GI28573972, Length=436, Percent_Identity=26.1467889908257, Blast_Score=114, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24652373, Length=362, Percent_Identity=25.1381215469613, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI17136190, Length=379, Percent_Identity=23.7467018469657, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24585135, Length=375, Percent_Identity=23.4666666666667, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24586044, Length=368, Percent_Identity=23.6413043478261, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI221476190, Length=352, Percent_Identity=23.5795454545455, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24585143, Length=352, Percent_Identity=23.5795454545455, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24585139, Length=352, Percent_Identity=23.5795454545455, Blast_Score=74, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002129
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR021115 [H]

Pfam domain/function: PF00282 Pyridoxal_deC [H]

EC number: =4.1.1.86 [H]

Molecular weight: Translated: 50952; Mature: 50821

Theoretical pI: Translated: 7.83; Mature: 7.83

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEDLINNKNIYFPSYLGTNDKLNILLNRASKTLCDWFSKSDKNGPLPFDESFKCIMPAE
CCCHHCCCCCEEECCCCCCCCCEEEEEEHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECC
DGNSEEDLFSEIESLLNNSFNPVHPGSLAHLDPPPLIFSILGDLIAAGLNNNLLAYELSP
CCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCC
SVTLLEESLCKWFAKKIGFNDFSGGIAASGGTLSNLNALIAARNNAGLGTNPDSVLLVSE
CHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCHHCCEEEEEECCCCCCCCCCCCEEEEEC
DAHSSFVKCIRVMGLDTSNLVRIKTDNQGRMDINELRKSLEKCSIENKKIFAIVATLGTT
CHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCEEEEEEEHHCCH
VRGAIDPIKEIGEICKQRNIWLHIDGSIGGIFAITSIPIEGLNNINQANSITINPQKIIG
HHHHHHHHHHHHHHHHHCCEEEEEECCCCCEEEEEECCHHCCCCCCCCCEEEECHHHEEE
ITKTSSLLLVSNMSTLENTFNTGLPYISSKENIINRGEIGIQGSRPAEVIKLWLGLRFLG
EECCCCEEEEECCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHC
MNGIENILKSSIKRKDFFIRNISSNKFDIYSGPLHIVSFLPKKLEPKDSDAWTQTKVNEL
CHHHHHHHHHHHHHHHHEEEECCCCCEEEECCHHHHHHHHHHHCCCCCCCCHHHHHHHHH
INNNFMLSRPKFKGKYFLRVVMGNYNTKESHIEELLRLLNA
HCCCEEEECCCCCCEEEEEEEECCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
AEDLINNKNIYFPSYLGTNDKLNILLNRASKTLCDWFSKSDKNGPLPFDESFKCIMPAE
CCHHCCCCCEEECCCCCCCCCEEEEEEHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECC
DGNSEEDLFSEIESLLNNSFNPVHPGSLAHLDPPPLIFSILGDLIAAGLNNNLLAYELSP
CCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCC
SVTLLEESLCKWFAKKIGFNDFSGGIAASGGTLSNLNALIAARNNAGLGTNPDSVLLVSE
CHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCHHCCEEEEEECCCCCCCCCCCCEEEEEC
DAHSSFVKCIRVMGLDTSNLVRIKTDNQGRMDINELRKSLEKCSIENKKIFAIVATLGTT
CHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCEEEEEEEHHCCH
VRGAIDPIKEIGEICKQRNIWLHIDGSIGGIFAITSIPIEGLNNINQANSITINPQKIIG
HHHHHHHHHHHHHHHHHCCEEEEEECCCCCEEEEEECCHHCCCCCCCCCEEEECHHHEEE
ITKTSSLLLVSNMSTLENTFNTGLPYISSKENIINRGEIGIQGSRPAEVIKLWLGLRFLG
EECCCCEEEEECCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHC
MNGIENILKSSIKRKDFFIRNISSNKFDIYSGPLHIVSFLPKKLEPKDSDAWTQTKVNEL
CHHHHHHHHHHHHHHHHEEEECCCCCEEEECCHHHHHHHHHHHCCCCCCCCHHHHHHHHH
INNNFMLSRPKFKGKYFLRVVMGNYNTKESHIEELLRLLNA
HCCCEEEECCCCCCEEEEEEEECCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8772175 [H]