Click here to switch to the map view.

The map label for this gene is gnd [H]

Identifier: 123968365

GI number: 123968365

Start: 721853

End: 723271

Strand: Direct

Name: gnd [H]

Synonym: A9601_08321

Alternate gene names: 123968365

Gene position: 721853-723271 (Clockwise)

Preceding gene: 123968364

Following gene: 123968366

Centisome position: 43.23

GC content: 36.43

Gene sequence:

>1419_bases
ATGTCCAAGGCACATTTTGGTTTAATAGGTCTTGGTGTTATGGGCGAAAACTTAGTTCTTAACGCAGAGAGAAATGGATT
TTCTAGTGTAGTTTTTAATAGGACTTACTCAAAAACTGAGGAATTTTTGCAAGGTCGTGGCCTTGGTAAGAGTATAGAGG
GAGCTGAAACTCTTCAAGAATTTGTTAATAAGCTTGAGAGACCTAGAAGAATTCTCATGATGGTAAAAGCTGGGCCAGCA
ACAGATGCTGTCATTGATAATATTTCTGGATATCTCGAGGAAGGAGATTTATTAATAGATGGCGGTAATTCTCAATTTAA
AGATACAGAAAGAAGGGTGAATACCCTTGAAAGTAAAAGTTTTGGATACATTGGGATGGGAGTCTCTGGAGGTGCCAAAG
GAGCTCTAGAGGGTCCAAGTATGATGCCCGGTGGTACTAAGGCTTCATATGATGCAATAGAAAGCTTACTAACGAAAATG
GCTGCCAAAGTTGAAGACGGACCATGTGTTGCATATGTTGGCCCAGGAGGCTCAGGTCATTTTGTAAAAACTGTTCATAA
CGGAATTGAATATGGAATTGAACAAATACTTGCAGAAGCTTATGACCTTATGAAGAGAGTCAAAGGTATGAATGGACAGC
AGATGTCAGAGGTATTTGGTATTTGGAATAATACTGATGAATTAGCTTCTTATCTTGTTGAGATAACAGAGATTTGTCTA
AATACAAAAGATGAGATGACTGGAGATGATGTCGTGGAAAAAATATTAGATAAAGCTGGCCAGAAAGGTACAGGTCTATG
GACTGTTGTAAGTGCTCTAGAACTGGGGGTATCAGTCCCAACTATTTATGCATCTTTAAATGCAAGAGTAATGAGTTCTT
TAAAAGAGCAACGTACTGAGATTGAAAAAACTATTCCATCTAAAGATATAGAGGATTTTGATTTAGGAAATATATCAGAT
GGAATGAAACCTTTATTTGATGCTGTAGTCCTTGCCACAATTGCTAGCTATGCCCAAGGTATGGATATTTTAAGAGAAGC
ATCTGCAGTATATAACTATGGTTTGAATATGCCGTCAATTGCACAAATATGGAAAGGTGGTTGCATAATTAGATCAAAAT
TATTAAGTAAAATTCAAGATGCTTATAACAAAGACCCTGATCTAAAAAATTTAATTTTTGATGATTGGTTTAACAATGAA
ATTGCGACAAGATTAGATAACTTAGCTAAGGTGGTTTCTCTATCCACAAAGGCAGGTATACCAGTCCCATGTTTATCCAG
TACTTTAGATTATTTGAATAGTTATAGAACTAATAGACTTCCTCAGAATCTTGTTCAGGCAATGAGAGACTGTTTTGGCT
CCCATACATATGAAAGAATTGATAGGGAAGGTAGTTTTCATACTGAATGGATGAAATGA

Upstream 100 bases:

>100_bases
TTAATTCTTTTCGATCATTTTTCGCTGACATAAGTATTTTTTTTTGAGCAATTTTGTTGAGTTGGATGCACACTATATTT
ATTGAGTTTTTTAATTTTTT

Downstream 100 bases:

>100_bases
TTGAAAAGGTCAAAAATGGATACACCTTAAATATATGCAAAGACAAGTTAGAACTATCAACAGCGGTTTTTAAGTTTATT
CAAAGCCATATTATTCATAC

Product: 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 472; Mature: 471

Protein sequence:

>472_residues
MSKAHFGLIGLGVMGENLVLNAERNGFSSVVFNRTYSKTEEFLQGRGLGKSIEGAETLQEFVNKLERPRRILMMVKAGPA
TDAVIDNISGYLEEGDLLIDGGNSQFKDTERRVNTLESKSFGYIGMGVSGGAKGALEGPSMMPGGTKASYDAIESLLTKM
AAKVEDGPCVAYVGPGGSGHFVKTVHNGIEYGIEQILAEAYDLMKRVKGMNGQQMSEVFGIWNNTDELASYLVEITEICL
NTKDEMTGDDVVEKILDKAGQKGTGLWTVVSALELGVSVPTIYASLNARVMSSLKEQRTEIEKTIPSKDIEDFDLGNISD
GMKPLFDAVVLATIASYAQGMDILREASAVYNYGLNMPSIAQIWKGGCIIRSKLLSKIQDAYNKDPDLKNLIFDDWFNNE
IATRLDNLAKVVSLSTKAGIPVPCLSSTLDYLNSYRTNRLPQNLVQAMRDCFGSHTYERIDREGSFHTEWMK

Sequences:

>Translated_472_residues
MSKAHFGLIGLGVMGENLVLNAERNGFSSVVFNRTYSKTEEFLQGRGLGKSIEGAETLQEFVNKLERPRRILMMVKAGPA
TDAVIDNISGYLEEGDLLIDGGNSQFKDTERRVNTLESKSFGYIGMGVSGGAKGALEGPSMMPGGTKASYDAIESLLTKM
AAKVEDGPCVAYVGPGGSGHFVKTVHNGIEYGIEQILAEAYDLMKRVKGMNGQQMSEVFGIWNNTDELASYLVEITEICL
NTKDEMTGDDVVEKILDKAGQKGTGLWTVVSALELGVSVPTIYASLNARVMSSLKEQRTEIEKTIPSKDIEDFDLGNISD
GMKPLFDAVVLATIASYAQGMDILREASAVYNYGLNMPSIAQIWKGGCIIRSKLLSKIQDAYNKDPDLKNLIFDDWFNNE
IATRLDNLAKVVSLSTKAGIPVPCLSSTLDYLNSYRTNRLPQNLVQAMRDCFGSHTYERIDREGSFHTEWMK
>Mature_471_residues
SKAHFGLIGLGVMGENLVLNAERNGFSSVVFNRTYSKTEEFLQGRGLGKSIEGAETLQEFVNKLERPRRILMMVKAGPAT
DAVIDNISGYLEEGDLLIDGGNSQFKDTERRVNTLESKSFGYIGMGVSGGAKGALEGPSMMPGGTKASYDAIESLLTKMA
AKVEDGPCVAYVGPGGSGHFVKTVHNGIEYGIEQILAEAYDLMKRVKGMNGQQMSEVFGIWNNTDELASYLVEITEICLN
TKDEMTGDDVVEKILDKAGQKGTGLWTVVSALELGVSVPTIYASLNARVMSSLKEQRTEIEKTIPSKDIEDFDLGNISDG
MKPLFDAVVLATIASYAQGMDILREASAVYNYGLNMPSIAQIWKGGCIIRSKLLSKIQDAYNKDPDLKNLIFDDWFNNEI
ATRLDNLAKVVSLSTKAGIPVPCLSSTLDYLNSYRTNRLPQNLVQAMRDCFGSHTYERIDREGSFHTEWMK

Specific function: Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH [H]

COG id: COG0362

COG function: function code G; 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=472, Percent_Identity=45.9745762711864, Blast_Score=413, Evalue=1e-115,
Organism=Escherichia coli, GI1788341, Length=472, Percent_Identity=47.6694915254237, Blast_Score=440, Evalue=1e-124,
Organism=Caenorhabditis elegans, GI17542558, Length=472, Percent_Identity=44.4915254237288, Blast_Score=416, Evalue=1e-116,
Organism=Saccharomyces cerevisiae, GI6321977, Length=455, Percent_Identity=46.1538461538462, Blast_Score=418, Evalue=1e-117,
Organism=Saccharomyces cerevisiae, GI6321695, Length=469, Percent_Identity=44.136460554371, Blast_Score=418, Evalue=1e-117,
Organism=Drosophila melanogaster, GI24639279, Length=471, Percent_Identity=44.1613588110403, Blast_Score=389, Evalue=1e-108,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR006114
- InterPro:   IPR006113
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR012284
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: =1.1.1.44 [H]

Molecular weight: Translated: 51726; Mature: 51594

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: PS00461 6PGD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKAHFGLIGLGVMGENLVLNAERNGFSSVVFNRTYSKTEEFLQGRGLGKSIEGAETLQE
CCCCCCCEEEECCCCCCEEEECCCCCCHHHHHHCHHHHHHHHHHCCCCCCCCCHHHHHHH
FVNKLERPRRILMMVKAGPATDAVIDNISGYLEEGDLLIDGGNSQFKDTERRVNTLESKS
HHHHHHCCHHEEEEEECCCCHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHCCC
FGYIGMGVSGGAKGALEGPSMMPGGTKASYDAIESLLTKMAAKVEDGPCVAYVGPGGSGH
CCEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCC
FVKTVHNGIEYGIEQILAEAYDLMKRVKGMNGQQMSEVFGIWNNTDELASYLVEITEICL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHH
NTKDEMTGDDVVEKILDKAGQKGTGLWTVVSALELGVSVPTIYASLNARVMSSLKEQRTE
CCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
IEKTIPSKDIEDFDLGNISDGMKPLFDAVVLATIASYAQGMDILREASAVYNYGLNMPSI
HHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
AQIWKGGCIIRSKLLSKIQDAYNKDPDLKNLIFDDWFNNEIATRLDNLAKVVSLSTKAGI
HHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCC
PVPCLSSTLDYLNSYRTNRLPQNLVQAMRDCFGSHTYERIDREGSFHTEWMK
CCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
SKAHFGLIGLGVMGENLVLNAERNGFSSVVFNRTYSKTEEFLQGRGLGKSIEGAETLQE
CCCCCCEEEECCCCCCEEEECCCCCCHHHHHHCHHHHHHHHHHCCCCCCCCCHHHHHHH
FVNKLERPRRILMMVKAGPATDAVIDNISGYLEEGDLLIDGGNSQFKDTERRVNTLESKS
HHHHHHCCHHEEEEEECCCCHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHCCC
FGYIGMGVSGGAKGALEGPSMMPGGTKASYDAIESLLTKMAAKVEDGPCVAYVGPGGSGH
CCEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCC
FVKTVHNGIEYGIEQILAEAYDLMKRVKGMNGQQMSEVFGIWNNTDELASYLVEITEICL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHH
NTKDEMTGDDVVEKILDKAGQKGTGLWTVVSALELGVSVPTIYASLNARVMSSLKEQRTE
CCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
IEKTIPSKDIEDFDLGNISDGMKPLFDAVVLATIASYAQGMDILREASAVYNYGLNMPSI
HHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
AQIWKGGCIIRSKLLSKIQDAYNKDPDLKNLIFDDWFNNEIATRLDNLAKVVSLSTKAGI
HHHHCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCC
PVPCLSSTLDYLNSYRTNRLPQNLVQAMRDCFGSHTYERIDREGSFHTEWMK
CCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2113917 [H]