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The map label for this gene is ilvB [H]

Identifier: 123968117

GI number: 123968117

Start: 507621

End: 509384

Strand: Direct

Name: ilvB [H]

Synonym: A9601_05821

Alternate gene names: 123968117

Gene position: 507621-509384 (Clockwise)

Preceding gene: 123968116

Following gene: 123968118

Centisome position: 30.4

GC content: 36.68

Gene sequence:

>1764_bases
GTGACTCTTACTTCGAGATCCTTTTCAAAGGGTAGTTCAAAACATGAAAATCCAGTTTGGATAACTGGTGCAGATGCACT
AATGGATTCTTTAAAAATTCATGGGGTAAAAGTTATATTTGGATATCCTGGTGGAGCCATACTACCTATATATGACGCTG
TTCATAAGGCGGAACAAGAAGGTTGGTTAAAGCATTACATGGTAAGGCATGAACAAGGTGGTTCCCATGCCGCTGATGGA
TATGCAAGATCTACTGGTGAAGTAGGAGTATGTTTTGGTACCTCAGGTCCAGGTGCGACAAATTTGGTAACTGGAATTGC
AACTGCTCAAATGGATTCAGTCCCCCTAGTTGTAGTTACAGGCCAAGTCCCAAGACCTGCTATAGGGACAGACGCTTTTC
AAGAAACTGATATTTTTGGTATAACTCTTCCAATAGTGAAACATTCATGGGTAATAAGAAATCCTTCAGATATCGCGAAA
GTAGTTTCGGAAGCTTTTTTCATAGCCTCCTCTGGTAGACCTGGACCTGTTTTAATTGATATACCCAAAGATGTAGGTCA
GGAGTTCTTTAATTACCAAAGAGTTTTGCCTGGTGAGATTATTCCTAAAGGATTTAAAAGGAACGGAGATATTAATGATT
TCGATATTAATAAAGCAATTAAACTTATAGAAGATTCTGAAAGACCTCTTTTATATGTGGGAGGTGGGGCAATATCTTCA
GGAGCTCATGATGAAATAAGAACTTTGGCAAAGAATTATCAAATACCCGTAACTACAACCTTAATGGGTAAGGGCGCTTT
TGATGAAAAAGACAATTTATCAGTAGGGATGTTGGGAATGCACGGAACTGCTTACGCAAATTTTGCTGTTACAGAATGTG
ATCTTTTAATTGCTGTTGGAGCTAGATTCGATGATAGGGTTACAGGAAAATTAGATACTTTTGCGCCTAATGCAAAGGTA
ATTCATATAGATATTGACCCAGCAGAAGTTAATAAAAATAGACGCGTAGATGTTGCAATTGTTTCTGATGTTTCAAAAGC
TATTCTAAAAATTAATGAGCAATCTCTAAAAAATAAATTTACTTGTCGGACGAAAAACTGGTTAGAAAAAATTGATTTTT
GGAAAAATAAACACCCTTTATATGACCCGCCTAAAGAAGGAGAAATTTATCCACAGGAAGTTCTTTTAAAAGTGAGGGAA
CTTTCACCAGAAGCTTATGTCACTACAGATGTAGGACAACATCAAATGTGGGCTGCTCAATATCTTAGGAATTCTCCAAG
AAAATGGATTAGTAGTGCAGGCTTAGGAACTATGGGTTTTGGATTGCCAGCGGCAATTGGAGTAAAAGCAGCCTTACCTA
ATTCAGATGTAATTTGTATTGCAGGAGATGCAAGTGTATTAATGAATATTCAAGAATTAGGCACTTTATCTCAATATGGT
CTAAAGGTGAAATTGATTATTATCAATAATCGCTGGCAAGGGATGGTAAGACAATGGCAGGAAAGTTTCTACGATGAAAG
ATATTCCTCATCTGATATGAGTTGTGGTGAACCTGATTTTGTAAAACTTGCTGAATCTTTTGGAGTTAAAGGATACTTAA
TTTCTGATAGAAAACAATTACAGAATGAATTAAAAAGTGCGCTTGATCATGATGGCCCTGCCTTAATTAATATTCTTGTC
AGAAGAGGTGAAAATTGTTATCCAATGGTTCCTCCTGGTAAAAGTAATGCTCAAATGGTTGGATATGTTAATTGTGAAGA
TTAA

Upstream 100 bases:

>100_bases
ATTGAAAGATTTTCTGAATACATTTCTGACATTACATTTCTAAATGAGGCAAAAGTATTTAATTAAGTTTAAAATTTATA
GTAAATATTGAATTTCTTTA

Downstream 100 bases:

>100_bases
TTTTTTTTGAATTCTTCTTTTACAAAAAATTAACTTTAATATAATTCAAACCTTAGATATTTCTGAATTGAAAAAATTAT
CAAAATTTTTACTTATAATC

Product: acetolactate synthase 3 catalytic subunit

Products: NA

Alternate protein names: AHAS; Acetohydroxy-acid synthase large subunit; ALS [H]

Number of amino acids: Translated: 587; Mature: 586

Protein sequence:

>587_residues
MTLTSRSFSKGSSKHENPVWITGADALMDSLKIHGVKVIFGYPGGAILPIYDAVHKAEQEGWLKHYMVRHEQGGSHAADG
YARSTGEVGVCFGTSGPGATNLVTGIATAQMDSVPLVVVTGQVPRPAIGTDAFQETDIFGITLPIVKHSWVIRNPSDIAK
VVSEAFFIASSGRPGPVLIDIPKDVGQEFFNYQRVLPGEIIPKGFKRNGDINDFDINKAIKLIEDSERPLLYVGGGAISS
GAHDEIRTLAKNYQIPVTTTLMGKGAFDEKDNLSVGMLGMHGTAYANFAVTECDLLIAVGARFDDRVTGKLDTFAPNAKV
IHIDIDPAEVNKNRRVDVAIVSDVSKAILKINEQSLKNKFTCRTKNWLEKIDFWKNKHPLYDPPKEGEIYPQEVLLKVRE
LSPEAYVTTDVGQHQMWAAQYLRNSPRKWISSAGLGTMGFGLPAAIGVKAALPNSDVICIAGDASVLMNIQELGTLSQYG
LKVKLIIINNRWQGMVRQWQESFYDERYSSSDMSCGEPDFVKLAESFGVKGYLISDRKQLQNELKSALDHDGPALINILV
RRGENCYPMVPPGKSNAQMVGYVNCED

Sequences:

>Translated_587_residues
MTLTSRSFSKGSSKHENPVWITGADALMDSLKIHGVKVIFGYPGGAILPIYDAVHKAEQEGWLKHYMVRHEQGGSHAADG
YARSTGEVGVCFGTSGPGATNLVTGIATAQMDSVPLVVVTGQVPRPAIGTDAFQETDIFGITLPIVKHSWVIRNPSDIAK
VVSEAFFIASSGRPGPVLIDIPKDVGQEFFNYQRVLPGEIIPKGFKRNGDINDFDINKAIKLIEDSERPLLYVGGGAISS
GAHDEIRTLAKNYQIPVTTTLMGKGAFDEKDNLSVGMLGMHGTAYANFAVTECDLLIAVGARFDDRVTGKLDTFAPNAKV
IHIDIDPAEVNKNRRVDVAIVSDVSKAILKINEQSLKNKFTCRTKNWLEKIDFWKNKHPLYDPPKEGEIYPQEVLLKVRE
LSPEAYVTTDVGQHQMWAAQYLRNSPRKWISSAGLGTMGFGLPAAIGVKAALPNSDVICIAGDASVLMNIQELGTLSQYG
LKVKLIIINNRWQGMVRQWQESFYDERYSSSDMSCGEPDFVKLAESFGVKGYLISDRKQLQNELKSALDHDGPALINILV
RRGENCYPMVPPGKSNAQMVGYVNCED
>Mature_586_residues
TLTSRSFSKGSSKHENPVWITGADALMDSLKIHGVKVIFGYPGGAILPIYDAVHKAEQEGWLKHYMVRHEQGGSHAADGY
ARSTGEVGVCFGTSGPGATNLVTGIATAQMDSVPLVVVTGQVPRPAIGTDAFQETDIFGITLPIVKHSWVIRNPSDIAKV
VSEAFFIASSGRPGPVLIDIPKDVGQEFFNYQRVLPGEIIPKGFKRNGDINDFDINKAIKLIEDSERPLLYVGGGAISSG
AHDEIRTLAKNYQIPVTTTLMGKGAFDEKDNLSVGMLGMHGTAYANFAVTECDLLIAVGARFDDRVTGKLDTFAPNAKVI
HIDIDPAEVNKNRRVDVAIVSDVSKAILKINEQSLKNKFTCRTKNWLEKIDFWKNKHPLYDPPKEGEIYPQEVLLKVREL
SPEAYVTTDVGQHQMWAAQYLRNSPRKWISSAGLGTMGFGLPAAIGVKAALPNSDVICIAGDASVLMNIQELGTLSQYGL
KVKLIIINNRWQGMVRQWQESFYDERYSSSDMSCGEPDFVKLAESFGVKGYLISDRKQLQNELKSALDHDGPALINILVR
RGENCYPMVPPGKSNAQMVGYVNCED

Specific function: Valine and isoleucine biosynthesis; first step. [C]

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Homo sapiens, GI93004078, Length=568, Percent_Identity=27.112676056338, Blast_Score=167, Evalue=3e-41,
Organism=Homo sapiens, GI21361361, Length=604, Percent_Identity=25, Blast_Score=155, Evalue=9e-38,
Organism=Escherichia coli, GI87081685, Length=558, Percent_Identity=45.6989247311828, Blast_Score=494, Evalue=1e-141,
Organism=Escherichia coli, GI1790104, Length=565, Percent_Identity=42.8318584070797, Blast_Score=457, Evalue=1e-130,
Organism=Escherichia coli, GI1786717, Length=571, Percent_Identity=31.523642732049, Blast_Score=288, Evalue=5e-79,
Organism=Escherichia coli, GI1787096, Length=562, Percent_Identity=27.0462633451957, Blast_Score=189, Evalue=3e-49,
Organism=Escherichia coli, GI1788716, Length=549, Percent_Identity=24.7723132969035, Blast_Score=151, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17542570, Length=590, Percent_Identity=26.6101694915254, Blast_Score=140, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17531301, Length=578, Percent_Identity=23.8754325259516, Blast_Score=122, Evalue=8e-28,
Organism=Caenorhabditis elegans, GI17531299, Length=578, Percent_Identity=23.8754325259516, Blast_Score=121, Evalue=9e-28,
Organism=Saccharomyces cerevisiae, GI6323755, Length=590, Percent_Identity=41.864406779661, Blast_Score=431, Evalue=1e-121,
Organism=Saccharomyces cerevisiae, GI6320816, Length=488, Percent_Identity=23.3606557377049, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI19922626, Length=565, Percent_Identity=26.0176991150442, Blast_Score=177, Evalue=2e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012846
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR000399
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =2.2.1.6 [H]

Molecular weight: Translated: 64318; Mature: 64187

Theoretical pI: Translated: 6.70; Mature: 6.70

Prosite motif: PS00187 TPP_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLTSRSFSKGSSKHENPVWITGADALMDSLKIHGVKVIFGYPGGAILPIYDAVHKAEQE
CCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHEECEEEEEEECCCCCEEHHHHHHHHHHHH
GWLKHYMVRHEQGGSHAADGYARSTGEVGVCFGTSGPGATNLVTGIATAQMDSVPLVVVT
HHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCEEEEE
GQVPRPAIGTDAFQETDIFGITLPIVKHSWVIRNPSDIAKVVSEAFFIASSGRPGPVLID
CCCCCCCCCCCCCCCCCEEEEEEEHHCCEEEEECHHHHHHHHHHHEEEECCCCCCCEEEE
IPKDVGQEFFNYQRVLPGEIIPKGFKRNGDINDFDINKAIKLIEDSERPLLYVGGGAISS
CCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCEEEECCCCCCC
GAHDEIRTLAKNYQIPVTTTLMGKGAFDEKDNLSVGMLGMHGTAYANFAVTECDLLIAVG
CCHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCEEEEEECCCCEEEEEEEEEEEEEEEEC
ARFDDRVTGKLDTFAPNAKVIHIDIDPAEVNKNRRVDVAIVSDVSKAILKINEQSLKNKF
CCCCCCCCCCEECCCCCCEEEEEECCHHHCCCCCEEEEEEHHHHHHHHHHHCHHHHCCCE
TCRTKNWLEKIDFWKNKHPLYDPPKEGEIYPQEVLLKVRELSPEAYVTTDVGQHQMWAAQ
EECHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCHHHHHHH
YLRNSPRKWISSAGLGTMGFGLPAAIGVKAALPNSDVICIAGDASVLMNIQELGTLSQYG
HHHCCHHHHHHHCCCCCCCCCCHHHHCEEEECCCCCEEEEECCHHHHHHHHHHCCHHHCC
LKVKLIIINNRWQGMVRQWQESFYDERYSSSDMSCGEPDFVKLAESFGVKGYLISDRKQL
CEEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCEEEECCHHHH
QNELKSALDHDGPALINILVRRGENCYPMVPPGKSNAQMVGYVNCED
HHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCC
>Mature Secondary Structure 
TLTSRSFSKGSSKHENPVWITGADALMDSLKIHGVKVIFGYPGGAILPIYDAVHKAEQE
CCCCCCCCCCCCCCCCCEEEEEHHHHHHHHEECEEEEEEECCCCCEEHHHHHHHHHHHH
GWLKHYMVRHEQGGSHAADGYARSTGEVGVCFGTSGPGATNLVTGIATAQMDSVPLVVVT
HHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCEEEEE
GQVPRPAIGTDAFQETDIFGITLPIVKHSWVIRNPSDIAKVVSEAFFIASSGRPGPVLID
CCCCCCCCCCCCCCCCCEEEEEEEHHCCEEEEECHHHHHHHHHHHEEEECCCCCCCEEEE
IPKDVGQEFFNYQRVLPGEIIPKGFKRNGDINDFDINKAIKLIEDSERPLLYVGGGAISS
CCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCEEEECCCCCCC
GAHDEIRTLAKNYQIPVTTTLMGKGAFDEKDNLSVGMLGMHGTAYANFAVTECDLLIAVG
CCHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCEEEEEECCCCEEEEEEEEEEEEEEEEC
ARFDDRVTGKLDTFAPNAKVIHIDIDPAEVNKNRRVDVAIVSDVSKAILKINEQSLKNKF
CCCCCCCCCCEECCCCCCEEEEEECCHHHCCCCCEEEEEEHHHHHHHHHHHCHHHHCCCE
TCRTKNWLEKIDFWKNKHPLYDPPKEGEIYPQEVLLKVRELSPEAYVTTDVGQHQMWAAQ
EECHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCHHHHHHH
YLRNSPRKWISSAGLGTMGFGLPAAIGVKAALPNSDVICIAGDASVLMNIQELGTLSQYG
HHHCCHHHHHHHCCCCCCCCCCHHHHCEEEECCCCCEEEEECCHHHHHHHHHHCCHHHCC
LKVKLIIINNRWQGMVRQWQESFYDERYSSSDMSCGEPDFVKLAESFGVKGYLISDRKQL
CEEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCEEEECCHHHH
QNELKSALDHDGPALINILVRRGENCYPMVPPGKSNAQMVGYVNCED
HHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12917641 [H]