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The map label for this gene is hemH [H]

Identifier: 123968116

GI number: 123968116

Start: 506309

End: 507484

Strand: Direct

Name: hemH [H]

Synonym: A9601_05811

Alternate gene names: 123968116

Gene position: 506309-507484 (Clockwise)

Preceding gene: 161353818

Following gene: 123968117

Centisome position: 30.32

GC content: 36.22

Gene sequence:

>1176_bases
ATGGATAAAATAGGCGTCTTACTAATGAATTTAGGAGGGCCTGAACGCATTACTGATGTAGGCCCATTCTTATACAATCT
TTTTTCTGATCCAGAAATAATCAGGACGCCTTTTCCTGTTTTTCAAAAGCCCCTAGCTTGGTTAATTAGTACGCTGAGGA
GTACTACTTCACAACAGGCTTATCTTTCTATAGGTGGAGGTTCTCCTATCAGAAGGATAACTGAACAACAAGCGAGAGAA
TTACAATCTAAATTACGGGATAAAGGACTTAATGCTACTACCTATATTGCCATGAGATATTGGCATCCTTTTACTGAATC
AGCAATAGCTGATATGAAAGCCGACGGCATAGATCAAGTTGTTGTAATACCTTTGTATCCACATTTTTCGATAAGTACTA
GTGGTTCGAGCTTTAGGGAATTAAAAAAATTGAGGGATGCTGATGATGAATTTAAGAGGGTTCCAATGAGATGTGTTAGG
AGTTGGTTCAGTCAATCAGGTTATTTAAAGTCTATGGTTGAATTAATTTCTGAACAAATTTCACTTTGTGAATTGCCTTC
AAAAGCGCATATATTTTTTACTGCTCATGGAGTTCCTAAGAGTTACGTAGAGGAAGCTGGAGACCCTTACAAACAACAAA
TTGAAGATTGTTCTCTCTTAATAATAAATGAGCTGGAAAAATGTTTAGGACATACTAACCCTCATACACTTTCTTATCAA
AGTAGAGTTGGTCCTGTTGAATGGTTGAAGCCTTATACAGAAGAAGTGTTAGCTGATCTTGGAAGATCAAATGTTAATGA
TCTGATTGTGGTTCCAATAAGTTTTGTTGGAGAGCATATTGAAACATTGCAAGAAATTGATATTGAATATAAAGAAATTG
CTGAAAAGGCTGGTATTAAAAACTTTCGGAGAGTTAAAGCTTTAAATACTCATCCTACTTTTATTGAAGGTCTAAGTGAT
CTCGTGATTTCCTGTTTGGAAGGGCCTCAAGTTAATTTAGAGGAGGCTTCTAAGTTGCCTGAAAAAGTTAAACTTTATCC
CCAAGAAAAGTGGCAATGGGGTTGGAATAATAGTTCAGAGGTGTGGAACGGAAGGGTGGCAATGATTATTTTTCTTGTGC
TTTTTATTGAACTTATTTCAGGCTCTGGACCTCTACATAAACTTGGCATTTTATAA

Upstream 100 bases:

>100_bases
CATTGACATTATTAATTTCCTGAATTAAGTTCATTTACTTATATAATTGTCCATATAATGACGTTTTGTATGTTGATTTT
CAATCTCCATAAATTTTAAG

Downstream 100 bases:

>100_bases
AGAACAATTGATTTTTACTTGAAAAAAATTAAATCTATTGAAAGATTTTCTGAATACATTTCTGACATTACATTTCTAAA
TGAGGCAAAAGTATTTAATT

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase [H]

Number of amino acids: Translated: 391; Mature: 391

Protein sequence:

>391_residues
MDKIGVLLMNLGGPERITDVGPFLYNLFSDPEIIRTPFPVFQKPLAWLISTLRSTTSQQAYLSIGGGSPIRRITEQQARE
LQSKLRDKGLNATTYIAMRYWHPFTESAIADMKADGIDQVVVIPLYPHFSISTSGSSFRELKKLRDADDEFKRVPMRCVR
SWFSQSGYLKSMVELISEQISLCELPSKAHIFFTAHGVPKSYVEEAGDPYKQQIEDCSLLIINELEKCLGHTNPHTLSYQ
SRVGPVEWLKPYTEEVLADLGRSNVNDLIVVPISFVGEHIETLQEIDIEYKEIAEKAGIKNFRRVKALNTHPTFIEGLSD
LVISCLEGPQVNLEEASKLPEKVKLYPQEKWQWGWNNSSEVWNGRVAMIIFLVLFIELISGSGPLHKLGIL

Sequences:

>Translated_391_residues
MDKIGVLLMNLGGPERITDVGPFLYNLFSDPEIIRTPFPVFQKPLAWLISTLRSTTSQQAYLSIGGGSPIRRITEQQARE
LQSKLRDKGLNATTYIAMRYWHPFTESAIADMKADGIDQVVVIPLYPHFSISTSGSSFRELKKLRDADDEFKRVPMRCVR
SWFSQSGYLKSMVELISEQISLCELPSKAHIFFTAHGVPKSYVEEAGDPYKQQIEDCSLLIINELEKCLGHTNPHTLSYQ
SRVGPVEWLKPYTEEVLADLGRSNVNDLIVVPISFVGEHIETLQEIDIEYKEIAEKAGIKNFRRVKALNTHPTFIEGLSD
LVISCLEGPQVNLEEASKLPEKVKLYPQEKWQWGWNNSSEVWNGRVAMIIFLVLFIELISGSGPLHKLGIL
>Mature_391_residues
MDKIGVLLMNLGGPERITDVGPFLYNLFSDPEIIRTPFPVFQKPLAWLISTLRSTTSQQAYLSIGGGSPIRRITEQQARE
LQSKLRDKGLNATTYIAMRYWHPFTESAIADMKADGIDQVVVIPLYPHFSISTSGSSFRELKKLRDADDEFKRVPMRCVR
SWFSQSGYLKSMVELISEQISLCELPSKAHIFFTAHGVPKSYVEEAGDPYKQQIEDCSLLIINELEKCLGHTNPHTLSYQ
SRVGPVEWLKPYTEEVLADLGRSNVNDLIVVPISFVGEHIETLQEIDIEYKEIAEKAGIKNFRRVKALNTHPTFIEGLSD
LVISCLEGPQVNLEEASKLPEKVKLYPQEKWQWGWNNSSEVWNGRVAMIIFLVLFIELISGSGPLHKLGIL

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499021, Length=331, Percent_Identity=34.7432024169184, Blast_Score=189, Evalue=4e-48,
Organism=Homo sapiens, GI60499025, Length=331, Percent_Identity=34.7432024169184, Blast_Score=189, Evalue=5e-48,
Organism=Escherichia coli, GI1786681, Length=327, Percent_Identity=30.5810397553517, Blast_Score=128, Evalue=6e-31,
Organism=Saccharomyces cerevisiae, GI6324750, Length=336, Percent_Identity=36.6071428571429, Blast_Score=196, Evalue=5e-51,
Organism=Drosophila melanogaster, GI17864156, Length=335, Percent_Identity=32.2388059701493, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI24651774, Length=260, Percent_Identity=29.6153846153846, Blast_Score=126, Evalue=2e-29,
Organism=Drosophila melanogaster, GI45552018, Length=142, Percent_Identity=40.8450704225352, Blast_Score=114, Evalue=9e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 44252; Mature: 44252

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKIGVLLMNLGGPERITDVGPFLYNLFSDPEIIRTPFPVFQKPLAWLISTLRSTTSQQA
CCCCEEEEEECCCCHHHHHHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHHHCCCCCE
YLSIGGGSPIRRITEQQARELQSKLRDKGLNATTYIAMRYWHPFTESAIADMKADGIDQV
EEEECCCCHHHHHHHHHHHHHHHHHHHCCCCHHEEEEEHHCCCHHHHHHHHHCCCCCCCE
VVIPLYPHFSISTSGSSFRELKKLRDADDEFKRVPMRCVRSWFSQSGYLKSMVELISEQI
EEEEECCCCEECCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
SLCELPSKAHIFFTAHGVPKSYVEEAGDPYKQQIEDCSLLIINELEKCLGHTNPHTLSYQ
HHHCCCCCCEEEEEECCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEECHH
SRVGPVEWLKPYTEEVLADLGRSNVNDLIVVPISFVGEHIETLQEIDIEYKEIAEKAGIK
HCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHCCHHHHHHHHHCCH
NFRRVKALNTHPTFIEGLSDLVISCLEGPQVNLEEASKLPEKVKLYPQEKWQWGWNNSSE
HHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHCCCHHHCCCCCHHCCCCCCCCCH
VWNGRVAMIIFLVLFIELISGSGPLHKLGIL
HHCCHHHHHHHHHHHHHHHCCCCCCHHCCCC
>Mature Secondary Structure
MDKIGVLLMNLGGPERITDVGPFLYNLFSDPEIIRTPFPVFQKPLAWLISTLRSTTSQQA
CCCCEEEEEECCCCHHHHHHHHHHHHHHCCCHHHCCCCHHHHHHHHHHHHHHHHCCCCCE
YLSIGGGSPIRRITEQQARELQSKLRDKGLNATTYIAMRYWHPFTESAIADMKADGIDQV
EEEECCCCHHHHHHHHHHHHHHHHHHHCCCCHHEEEEEHHCCCHHHHHHHHHCCCCCCCE
VVIPLYPHFSISTSGSSFRELKKLRDADDEFKRVPMRCVRSWFSQSGYLKSMVELISEQI
EEEEECCCCEECCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHH
SLCELPSKAHIFFTAHGVPKSYVEEAGDPYKQQIEDCSLLIINELEKCLGHTNPHTLSYQ
HHHCCCCCCEEEEEECCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEECHH
SRVGPVEWLKPYTEEVLADLGRSNVNDLIVVPISFVGEHIETLQEIDIEYKEIAEKAGIK
HCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHCCHHHHHHHHHCCH
NFRRVKALNTHPTFIEGLSDLVISCLEGPQVNLEEASKLPEKVKLYPQEKWQWGWNNSSE
HHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHCCCHHHCCCCCHHCCCCCCCCCH
VWNGRVAMIIFLVLFIELISGSGPLHKLGIL
HHCCHHHHHHHHHHHHHHHCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA