| Definition | Prochlorococcus marinus str. AS9601, complete genome. |
|---|---|
| Accession | NC_008816 |
| Length | 1,669,886 |
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The map label for this gene is topA [H]
Identifier: 123968028
GI number: 123968028
Start: 425643
End: 428249
Strand: Direct
Name: topA [H]
Synonym: A9601_04911
Alternate gene names: 123968028
Gene position: 425643-428249 (Clockwise)
Preceding gene: 123968025
Following gene: 123968029
Centisome position: 25.49
GC content: 35.56
Gene sequence:
>2607_bases TTGGATCACACACTTGTTATTGTTGAAAGTCCCACCAAAGCAAAAACTATAAGAAAGTTTTTGCCATCTAATTATGAAGT TCTCGCTTCAATGGGACATGTAAGAGATCTTCCAAAAGGAGCTGCTGAAATACCTGCTTCGGTTAAAAAGGAAAAATGGT CAAGGATAGGAGTTAATACAACAGAAGATTTTGAACCACTTTATATAGTTCCAAAAGATAAGAAAAAGGTTGTTAAAGAG TTAAAAGATGCATTGAAAGGTGCGACCCAGCTATTACTTGCAACTGATGAAGATAGAGAGGGAGAGAGTATTAGCTGGCA TCTCCTGCAAATTCTTAAGCCTAAAATACCAACTAAGAGAATGGTTTTTCATGAAATCACAAAAAAGGCAATTAATAAAG CTTTAGATCAAACAAGAGAAATTGATATGGAACTTGTTCAGGCTCAAGAAACAAGAAGAATCCTAGACAGGCTTTTTGGA TATGAATTATCTCCTTTACTTTGGAAGAAGGTAGCCCCCCGACTATCTGCTGGTCGTGTTCAATCTGTTTCTGTAAGACT TCTTGTTAGGAGAGAGAGAGAAAGAAGATCCTTTAAAAAAGCTAGTTACTGGGGGATTAAAGCTTCCTTAGTAAAAGATA ATATTACTTTCGAAACTAAATTATTCAGTTTAAAAGGTCAAAGAATTTGTAACGGTTCCGATTTCGACGAACAAACCGGT AAATTAAAAGAAGGAAACAAATCTTTAATAATTGGAGAAGAACAAGTAAATGATTTATTGAATACTTTTTCCTCTGAGGA TTGGTTAGTCTCAAAAATCGAAAAAAAGCCATCCACTCGTAAGCCAGTTCCTCCATTTACAACAAGCACATTACAACAAG AAGCAAATAGGAAGCTTCGTTTGTCTTCAAGAGAAACTATGAGATGTGCACAAGGGCTATATGAGAGAGGTTTCATAACA TATATGAGAACTGATTCAGTTCATCTCTCCGAACAAGCCACAAGAGCTGCTAGAGAATGTGTCAGTTCTATGTATGGGAA AGAATATTTATCTAACTCACCAAGACAATTTAATTCAACTGCAAGAAATGCTCAAGAAGCACACGAAGCTATTAGGCCTG CAGGTGAGGTATTTAAAACACCAAAGGAAACTAATTTAACTGGTAGAGACTTATCACTTTACGATTTAATTTGGAAAAGA ACTGTAGCTAGTCAAATGGCGGAAGCTAGGTTAACAATGATTAATGCTGAAATTAGCGTAGGGTATGGATTATTTAAATC GAGCGGGAAAAGTATTGATTTCCCAGGATTCTTCAGAGCTTATGTCGAGGGAAGTGATGATCCAAGTTCATCCCTTGAAC AACAAGAAATTATTCTCCCAAACTTAACAACTGGAACATGTCTTGAAGTTACTAGTAAGGAATCTACTTTTCATGAAACT AAGCCTCCTGCAAGATATACAGAGGCTGCATTAGTTAAAGTTCTTGAAAAAGAAGGGATTGGAAGACCCTCTACCTATGC CAGCATTATTGGGACCATAGTTGATAGAGGTTATGCGAATATATCTTCCAATACTTTGGCTCCAACGTTTACAGCTTTTG CTGTTACTGCTCTATTAGAAGAACATTTTCCTGATCTGGTTGATACTACTTTTACTGCAAAAATGGAATCTTCATTGGAT GAAATATCTTCAGGCAATCTTGAGTGGCTACCATACCTCGAAACTTTCTATAAAGGTAAAAATGGTTTGGAGATAAAGGT TCAGAAAACAGAGGGTAATATTGATGGTAAAGCTTATAGACAAGTTGATTTCGAAGACCTTCCTTGCGTAGTCAGAATAG GCTCAAACGGACCTTGGTTAGAGGGTACAAAAATTGATGAATCTGGAAATGAAATTCAGGCTAAAGGTAATCTTCCAATG GATATTACTCCTGGTGATTTAGACATTAAACAAGTTGATCAAATCTTAAGTGGCCCATCGGATCTTGGAACTGATCCAAA AACCGGGGAAAAAGTCTTTTTAAGATTTGGTCCTTATGGACCTTACGTTCAATTAGGAAATAATGATCAAGATAAAGCTA AACCAAGGAGAGCCTCATTACCCAAAGAGTTGAAAACTGATGACCTAACTCTAGATGAGGCTCTTGTACTTTTAAGTTTG CCTAGATTGTTAGGAGCTCATCCTGAAGGAGGAGTTGTTGAGGCTGATAGAGGAAGATTTGGCCCGTATATCAAATGGAT TAAAAATGAAAATGAATCTGAAAACAGATCCTTAAAGAAAGAGGATGATGTTTTTAGAGTTGATATAAAACGAGCATTAG AAATTCTTGCGATGCCAAAAATGGGTAGAGGTGGTCAAGAGGTACTTAAAGACTTTGGAAAACCAAAAGAATTTAAAGAA AAAATTCAAATATTAAATGGAAGATATGGCGTCTATTTAAAATGTGGCAAAACTAATGTATCGATTGCCAAAGATACTGA CATAGAAAAATTTACCATAGATGAAGCAGTATCTCTTTTAGAAGAAAAACTAAAAGATAAAAAAGGTGCAATTTTAAAGA AAACAAAGATTAGTAATAAAAAAACTTCAAGGAAAAAGAAAAGTTAG
Upstream 100 bases:
>100_bases GGTATGATTTTTGAAATTTTCAGAAGAAATTACTTGAAAAAGCTTCAAATAATCATAATATGCCCTAACTGAACAAAAAC ACCAATTTTTAAAATAAACC
Downstream 100 bases:
>100_bases AAAAAATATGATTTTAAAAAAAAAAGAACTTTTTTTATTAATTTTTTTAATTTTCTTGCAATCATGCTCTGGAGGGAGGA TTGGAAATTTTCTTGAAAGT
Product: DNA topoisomerase I
Products: NA
Alternate protein names: DNA topoisomerase I; Omega-protein; Relaxing enzyme; Swivelase; Untwisting enzyme [H]
Number of amino acids: Translated: 868; Mature: 868
Protein sequence:
>868_residues MDHTLVIVESPTKAKTIRKFLPSNYEVLASMGHVRDLPKGAAEIPASVKKEKWSRIGVNTTEDFEPLYIVPKDKKKVVKE LKDALKGATQLLLATDEDREGESISWHLLQILKPKIPTKRMVFHEITKKAINKALDQTREIDMELVQAQETRRILDRLFG YELSPLLWKKVAPRLSAGRVQSVSVRLLVRRERERRSFKKASYWGIKASLVKDNITFETKLFSLKGQRICNGSDFDEQTG KLKEGNKSLIIGEEQVNDLLNTFSSEDWLVSKIEKKPSTRKPVPPFTTSTLQQEANRKLRLSSRETMRCAQGLYERGFIT YMRTDSVHLSEQATRAARECVSSMYGKEYLSNSPRQFNSTARNAQEAHEAIRPAGEVFKTPKETNLTGRDLSLYDLIWKR TVASQMAEARLTMINAEISVGYGLFKSSGKSIDFPGFFRAYVEGSDDPSSSLEQQEIILPNLTTGTCLEVTSKESTFHET KPPARYTEAALVKVLEKEGIGRPSTYASIIGTIVDRGYANISSNTLAPTFTAFAVTALLEEHFPDLVDTTFTAKMESSLD EISSGNLEWLPYLETFYKGKNGLEIKVQKTEGNIDGKAYRQVDFEDLPCVVRIGSNGPWLEGTKIDESGNEIQAKGNLPM DITPGDLDIKQVDQILSGPSDLGTDPKTGEKVFLRFGPYGPYVQLGNNDQDKAKPRRASLPKELKTDDLTLDEALVLLSL PRLLGAHPEGGVVEADRGRFGPYIKWIKNENESENRSLKKEDDVFRVDIKRALEILAMPKMGRGGQEVLKDFGKPKEFKE KIQILNGRYGVYLKCGKTNVSIAKDTDIEKFTIDEAVSLLEEKLKDKKGAILKKTKISNKKTSRKKKS
Sequences:
>Translated_868_residues MDHTLVIVESPTKAKTIRKFLPSNYEVLASMGHVRDLPKGAAEIPASVKKEKWSRIGVNTTEDFEPLYIVPKDKKKVVKE LKDALKGATQLLLATDEDREGESISWHLLQILKPKIPTKRMVFHEITKKAINKALDQTREIDMELVQAQETRRILDRLFG YELSPLLWKKVAPRLSAGRVQSVSVRLLVRRERERRSFKKASYWGIKASLVKDNITFETKLFSLKGQRICNGSDFDEQTG KLKEGNKSLIIGEEQVNDLLNTFSSEDWLVSKIEKKPSTRKPVPPFTTSTLQQEANRKLRLSSRETMRCAQGLYERGFIT YMRTDSVHLSEQATRAARECVSSMYGKEYLSNSPRQFNSTARNAQEAHEAIRPAGEVFKTPKETNLTGRDLSLYDLIWKR TVASQMAEARLTMINAEISVGYGLFKSSGKSIDFPGFFRAYVEGSDDPSSSLEQQEIILPNLTTGTCLEVTSKESTFHET KPPARYTEAALVKVLEKEGIGRPSTYASIIGTIVDRGYANISSNTLAPTFTAFAVTALLEEHFPDLVDTTFTAKMESSLD EISSGNLEWLPYLETFYKGKNGLEIKVQKTEGNIDGKAYRQVDFEDLPCVVRIGSNGPWLEGTKIDESGNEIQAKGNLPM DITPGDLDIKQVDQILSGPSDLGTDPKTGEKVFLRFGPYGPYVQLGNNDQDKAKPRRASLPKELKTDDLTLDEALVLLSL PRLLGAHPEGGVVEADRGRFGPYIKWIKNENESENRSLKKEDDVFRVDIKRALEILAMPKMGRGGQEVLKDFGKPKEFKE KIQILNGRYGVYLKCGKTNVSIAKDTDIEKFTIDEAVSLLEEKLKDKKGAILKKTKISNKKTSRKKKS >Mature_868_residues MDHTLVIVESPTKAKTIRKFLPSNYEVLASMGHVRDLPKGAAEIPASVKKEKWSRIGVNTTEDFEPLYIVPKDKKKVVKE LKDALKGATQLLLATDEDREGESISWHLLQILKPKIPTKRMVFHEITKKAINKALDQTREIDMELVQAQETRRILDRLFG YELSPLLWKKVAPRLSAGRVQSVSVRLLVRRERERRSFKKASYWGIKASLVKDNITFETKLFSLKGQRICNGSDFDEQTG KLKEGNKSLIIGEEQVNDLLNTFSSEDWLVSKIEKKPSTRKPVPPFTTSTLQQEANRKLRLSSRETMRCAQGLYERGFIT YMRTDSVHLSEQATRAARECVSSMYGKEYLSNSPRQFNSTARNAQEAHEAIRPAGEVFKTPKETNLTGRDLSLYDLIWKR TVASQMAEARLTMINAEISVGYGLFKSSGKSIDFPGFFRAYVEGSDDPSSSLEQQEIILPNLTTGTCLEVTSKESTFHET KPPARYTEAALVKVLEKEGIGRPSTYASIIGTIVDRGYANISSNTLAPTFTAFAVTALLEEHFPDLVDTTFTAKMESSLD EISSGNLEWLPYLETFYKGKNGLEIKVQKTEGNIDGKAYRQVDFEDLPCVVRIGSNGPWLEGTKIDESGNEIQAKGNLPM DITPGDLDIKQVDQILSGPSDLGTDPKTGEKVFLRFGPYGPYVQLGNNDQDKAKPRRASLPKELKTDDLTLDEALVLLSL PRLLGAHPEGGVVEADRGRFGPYIKWIKNENESENRSLKKEDDVFRVDIKRALEILAMPKMGRGGQEVLKDFGKPKEFKE KIQILNGRYGVYLKCGKTNVSIAKDTDIEKFTIDEAVSLLEEKLKDKKGAILKKTKISNKKTSRKKKS
Specific function: The reaction catalyzed by topoisomerases leads to the conversion of one topological isomer of DNA to another [H]
COG id: COG0550
COG function: function code L; Topoisomerase IA
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 Toprim domain [H]
Homologues:
Organism=Homo sapiens, GI10835218, Length=519, Percent_Identity=25.0481695568401, Blast_Score=122, Evalue=1e-27, Organism=Homo sapiens, GI4507635, Length=615, Percent_Identity=22.7642276422764, Blast_Score=103, Evalue=6e-22, Organism=Escherichia coli, GI1787529, Length=593, Percent_Identity=40.4721753794266, Blast_Score=395, Evalue=1e-111, Organism=Escherichia coli, GI1788061, Length=628, Percent_Identity=22.9299363057325, Blast_Score=96, Evalue=1e-20, Organism=Caenorhabditis elegans, GI32563869, Length=576, Percent_Identity=23.9583333333333, Blast_Score=118, Evalue=1e-26, Organism=Caenorhabditis elegans, GI17555378, Length=525, Percent_Identity=24.3809523809524, Blast_Score=116, Evalue=4e-26, Organism=Saccharomyces cerevisiae, GI6323263, Length=518, Percent_Identity=22.972972972973, Blast_Score=97, Evalue=1e-20, Organism=Drosophila melanogaster, GI24585251, Length=470, Percent_Identity=27.0212765957447, Blast_Score=131, Evalue=2e-30,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR003601 - InterPro: IPR013497 - InterPro: IPR013824 - InterPro: IPR013825 - InterPro: IPR000380 - InterPro: IPR003602 - InterPro: IPR005733 - InterPro: IPR006171 [H]
Pfam domain/function: PF01131 Topoisom_bac; PF01751 Toprim [H]
EC number: =5.99.1.2 [H]
Molecular weight: Translated: 97527; Mature: 97527
Theoretical pI: Translated: 9.55; Mature: 9.55
Prosite motif: PS00396 TOPOISOMERASE_I_PROK
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.7 %Cys (Translated Protein) 1.5 %Met (Translated Protein) 2.2 %Cys+Met (Translated Protein) 0.7 %Cys (Mature Protein) 1.5 %Met (Mature Protein) 2.2 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MDHTLVIVESPTKAKTIRKFLPSNYEVLASMGHVRDLPKGAAEIPASVKKEKWSRIGVNT CCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHCCHHHHHHHHHHCCCCC TEDFEPLYIVPKDKKKVVKELKDALKGATQLLLATDEDREGESISWHLLQILKPKIPTKR CCCCCCEEEECCCHHHHHHHHHHHHHHHHEEEEECCCCCCCCCHHHHHHHHHCCCCCHHH MVFHEITKKAINKALDQTREIDMELVQAQETRRILDRLFGYELSPLLWKKVAPRLSAGRV HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCC QSVSVRLLVRRERERRSFKKASYWGIKASLVKDNITFETKLFSLKGQRICNGSDFDEQTG HHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCEEEEEEEEECCCCCCCCCCCCHHCC KLKEGNKSLIIGEEQVNDLLNTFSSEDWLVSKIEKKPSTRKPVPPFTTSTLQQEANRKLR CCCCCCCEEEECHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCEE LSSRETMRCAQGLYERGFITYMRTDSVHLSEQATRAARECVSSMYGKEYLSNSPRQFNST CCCHHHHHHHHHHHHCCCEEEEECCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH ARNAQEAHEAIRPAGEVFKTPKETNLTGRDLSLYDLIWKRTVASQMAEARLTMINAEISV HHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEECEEEC GYGLFKSSGKSIDFPGFFRAYVEGSDDPSSSLEQQEIILPNLTTGTCLEVTSKESTFHET CHHHHHCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCEECCCCCCCCEEEECCCCCCCCCC KPPARYTEAALVKVLEKEGIGRPSTYASIIGTIVDRGYANISSNTLAPTFTAFAVTALLE CCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHH EHFPDLVDTTFTAKMESSLDEISSGNLEWLPYLETFYKGKNGLEIKVQKTEGNIDGKAYR HHCCHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHCCCCCCEEEEEECCCCCCCHHEE QVDFEDLPCVVRIGSNGPWLEGTKIDESGNEIQAKGNLPMDITPGDLDIKQVDQILSGPS ECCCCCCCEEEEECCCCCCCCCCEECCCCCEEEECCCCCEECCCCCCCHHHHHHHHCCCH DLGTDPKTGEKVFLRFGPYGPYVQLGNNDQDKAKPRRASLPKELKTDDLTLDEALVLLSL HCCCCCCCCCEEEEEECCCCCEEEECCCCHHHCCCHHHCCCCCCCCCCCCHHHHHHHHHH PRLLGAHPEGGVVEADRGRFGPYIKWIKNENESENRSLKKEDDVFRVDIKRALEILAMPK HHHHCCCCCCCEEECCCCCCCCHHHHHCCCCCCHHCCCCCCCCCHHHHHHHHHHHHHCCC MGRGGQEVLKDFGKPKEFKEKIQILNGRYGVYLKCGKTNVSIAKDTDIEKFTIDEAVSLL CCCCHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEECCCCEEEECCCCCHHHHHHHHHHHH EEKLKDKKGAILKKTKISNKKTSRKKKS HHHHHHHCCCEEEEHHCCCCHHHHCCCC >Mature Secondary Structure MDHTLVIVESPTKAKTIRKFLPSNYEVLASMGHVRDLPKGAAEIPASVKKEKWSRIGVNT CCCEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHCCCCHHHCCHHHHHHHHHHCCCCC TEDFEPLYIVPKDKKKVVKELKDALKGATQLLLATDEDREGESISWHLLQILKPKIPTKR CCCCCCEEEECCCHHHHHHHHHHHHHHHHEEEEECCCCCCCCCHHHHHHHHHCCCCCHHH MVFHEITKKAINKALDQTREIDMELVQAQETRRILDRLFGYELSPLLWKKVAPRLSAGRV HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCC QSVSVRLLVRRERERRSFKKASYWGIKASLVKDNITFETKLFSLKGQRICNGSDFDEQTG HHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCEEEEEEEEECCCCCCCCCCCCHHCC KLKEGNKSLIIGEEQVNDLLNTFSSEDWLVSKIEKKPSTRKPVPPFTTSTLQQEANRKLR CCCCCCCEEEECHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCEE LSSRETMRCAQGLYERGFITYMRTDSVHLSEQATRAARECVSSMYGKEYLSNSPRQFNST CCCHHHHHHHHHHHHCCCEEEEECCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH ARNAQEAHEAIRPAGEVFKTPKETNLTGRDLSLYDLIWKRTVASQMAEARLTMINAEISV HHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEECEEEC GYGLFKSSGKSIDFPGFFRAYVEGSDDPSSSLEQQEIILPNLTTGTCLEVTSKESTFHET CHHHHHCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCEECCCCCCCCEEEECCCCCCCCCC KPPARYTEAALVKVLEKEGIGRPSTYASIIGTIVDRGYANISSNTLAPTFTAFAVTALLE CCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHH EHFPDLVDTTFTAKMESSLDEISSGNLEWLPYLETFYKGKNGLEIKVQKTEGNIDGKAYR HHCCHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHCCCCCCEEEEEECCCCCCCHHEE QVDFEDLPCVVRIGSNGPWLEGTKIDESGNEIQAKGNLPMDITPGDLDIKQVDQILSGPS ECCCCCCCEEEEECCCCCCCCCCEECCCCCEEEECCCCCEECCCCCCCHHHHHHHHCCCH DLGTDPKTGEKVFLRFGPYGPYVQLGNNDQDKAKPRRASLPKELKTDDLTLDEALVLLSL HCCCCCCCCCEEEEEECCCCCEEEECCCCHHHCCCHHHCCCCCCCCCCCCHHHHHHHHHH PRLLGAHPEGGVVEADRGRFGPYIKWIKNENESENRSLKKEDDVFRVDIKRALEILAMPK HHHHCCCCCCCEEECCCCCCCCHHHHHCCCCCCHHCCCCCCCCCHHHHHHHHHHHHHCCC MGRGGQEVLKDFGKPKEFKEKIQILNGRYGVYLKCGKTNVSIAKDTDIEKFTIDEAVSLL CCCCHHHHHHHCCCCHHHHHHHHHHCCCCEEEEEECCCCEEEECCCCCHHHHHHHHHHHH EEKLKDKKGAILKKTKISNKKTSRKKKS HHHHHHHCCCEEEEHHCCCCHHHHCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 7659748 [H]