Click here to switch to the map view.

The map label for this gene is mutSB [H]

Identifier: 123967774

GI number: 123967774

Start: 220393

End: 222804

Strand: Direct

Name: mutSB [H]

Synonym: A9601_02371

Alternate gene names: 123967774

Gene position: 220393-222804 (Clockwise)

Preceding gene: 123967773

Following gene: 123967775

Centisome position: 13.2

GC content: 31.51

Gene sequence:

>2412_bases
ATGCAAGAGAAAAGTTATTCTAAAAAATCATATTCAGATAACACCTTAGAAGAAGAATCTATAAACCTTTTAGAGTGGGA
TTCATTAAAAACGCATTTATCTTCGTTCGCCTCAACGGAAATGGGTAAACAATCAATTTTAAGTTTTGTTATACCTTCAG
AATACGAGGCATCTAAAAGACTTTTGAATGAAACTGTTGAAATTAATGAGCTAGAAAAAAATTTAGATAAATCAATTAGT
TTTTCTGGTGTTTTTGATATTAGTAGAAATATAGAAATTTGTTCGAAGGGAGGTGTAATTACATCTTCTGAGTTGTTAGA
AATAGCGAAAACAATTGCTGCAGCAAGAAATTTAAAAAAAATCTTATTAGATTTTGAACAAAGACCTTATATTTCATCAT
TCACAAAAAATTTAATTGACCATCAGAATATCGAAACGATTTTTAAAAAAGGCATTGAATCGAATGGAAGGATTTCAGAC
AATGCTAGTAATGAGTTATCTATTCTTAGAAAAGAATTTTTATCTAAGAAACTCGAAAGAAAAATATTAGTTGAGAAATT
TATTCAAAAGAATTTAGCTTATTTGCAAGATACTACTATTGGAGATCGGTATGGAAGGCCTGTTTTAGCAGTGAAAGTTA
ATTATGTAGATAAATTTAAGGGAATAATTCATGACTCTTCATCTTCAGGAAATACAGTATATTTCGAGCCTGAAAGTGTA
GTAACTAAAGGTAATAAGATTGCTTCTTTAGAGGCTAGGATCACAGCAGAAGAATTTAAATTACTTAAGAAATGGTCTCA
TGTTGTTAGTGATAATTCAAAAAATCTTATTGAAATGGCGTCCATTTTATTAAGATTAGAAAATGCCCTAACTCGTTCAA
GATATTCGAAATGGATTGGAGGTAAAACTCCTACATTTGAGAAAAATCCTATTATTTCTTTAATTGGTTTTTCTCATCCG
TTATTGATTTGGGAACATAAGAAAAAAGGAGCCCCTCCACCAGTAGCTGTCGATTTTTATATAAATCGAAATATTAAGGT
TGTAGCTATTACAGGCCCAAATACTGGAGGTAAAACAGCAGCTTTAAAAGGTTTGGGCTTGTCTTTACTTATGGCTAGAG
CAGGATTATTGATACCTTCAACTAATAATCCTATTATCCCTTTCTGTCCAAATATATATGTGGATATAGGAGATAATCAA
TCATTAGAAGAAAATTTATCTACCTTCAGTGGGCATATATCCCGCATAAAAGGGATATTAGATTCACTTGATTATAAGAA
AGGATTATCAGTTGTTTTGTTAGATGAGATTGGATCTGGTACAGATCCTCTTGAAGGAAGCGCTCTTGCGATGGCTTTAT
TAAAAGAATTTGCAAATAAATCTGATATCACTTTGGCAACTACACATTATGGAGATATTAAGGCTTTAAAATATAACGAC
TCGAGATTTGAAAACGTATCAGTTGCCTTTGATGAGGAATCTTTGAAGCCAAAATATATACTCAACTGGGGTATTCCTGG
GAGAAGTAATGCTTTGTCAATTTCAAAGAGAATTGGTCTCGATGAAAGCATACTCAATGAAGCTGCAAATTATCTAAAGC
CAAAAGAAGTTGACAACATTAACAGTATTATTAAAGGACTTGAGGAAGAGAGGATTAAACAACAAAATTCTGCAGAAGCT
GCTGCAGAATTGATTGCAAGGACTGAAATACTACATGATGAACTGAAGAGAAATTATGAACATCAAAAAATAAATGCTCA
AAAAATTCAAGAACTTGAAAGGTCTAAATTATCAAAACATATCATATCCGCTAAAAAAGAGGTGATAGATTTGATTAAAA
AATTAAGAGATAAAAATGTTAATGGAGAGGATACGAGAATTATTGGAAAAAGATTAAAGGAAATTGAGACGGAACATTTA
ACCCAAAAAAAATCTGAAAAGTCAATATCATGGAACCCTCAGGTAGGCGATTTTGTAAAGATTAAAAGTCTAAATAGTAC
GGGACAAATTGTAGATTTAGATAAAAAAGGTGGTTTTTACGAAGTTAAATGTGGTTCATTCAGAAGCACATTATCTGCAA
ATGACTTTGAAGGTATTAATGGAGAAAAGCCTAATTTCAAAATGTCAAAAATTGAGATCAAGGCTACAAGAGAGGATTTT
TCTTTTTCTAAAATTAGAACAAGTAAAAATACAATTGACGTAAGAGGATTAAGAGTGCATGAAGCCGAAATAATTATTGA
GGAGAAAATTAGAAGATTTCATGGACCACTATGGATTGTTCATGGAATTGGCACAGGAAAATTAAAGAAAGGACTAAGAA
ATTGGTTATCAGGTTTAAATTATGTTGATAAGATTGAAGATGCAGCCAACAACGAGGGTGGCCCTGGTTGCAGTATTGCG
TGGATAAAATAA

Upstream 100 bases:

>100_bases
CGGCATCTTTTTATATGAAGGATACTGAAGGAAACTGGCTTGAGATGCTTTATGTTCCTCCTGAAGGGATTCAATCGAAT
GTTTGATTCTTTTTTTTTGT

Downstream 100 bases:

>100_bases
AATTTAAAATACCTAGAAAACAATTTAATAAACGTATTAAGTGCAATTTATTGATCAAGCGAACATTATTCTTAAAGCTG
GAAAAGGTGGCAATGGAATA

Product: DNA mismatch repair protein MutS family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 803; Mature: 803

Protein sequence:

>803_residues
MQEKSYSKKSYSDNTLEEESINLLEWDSLKTHLSSFASTEMGKQSILSFVIPSEYEASKRLLNETVEINELEKNLDKSIS
FSGVFDISRNIEICSKGGVITSSELLEIAKTIAAARNLKKILLDFEQRPYISSFTKNLIDHQNIETIFKKGIESNGRISD
NASNELSILRKEFLSKKLERKILVEKFIQKNLAYLQDTTIGDRYGRPVLAVKVNYVDKFKGIIHDSSSSGNTVYFEPESV
VTKGNKIASLEARITAEEFKLLKKWSHVVSDNSKNLIEMASILLRLENALTRSRYSKWIGGKTPTFEKNPIISLIGFSHP
LLIWEHKKKGAPPPVAVDFYINRNIKVVAITGPNTGGKTAALKGLGLSLLMARAGLLIPSTNNPIIPFCPNIYVDIGDNQ
SLEENLSTFSGHISRIKGILDSLDYKKGLSVVLLDEIGSGTDPLEGSALAMALLKEFANKSDITLATTHYGDIKALKYND
SRFENVSVAFDEESLKPKYILNWGIPGRSNALSISKRIGLDESILNEAANYLKPKEVDNINSIIKGLEEERIKQQNSAEA
AAELIARTEILHDELKRNYEHQKINAQKIQELERSKLSKHIISAKKEVIDLIKKLRDKNVNGEDTRIIGKRLKEIETEHL
TQKKSEKSISWNPQVGDFVKIKSLNSTGQIVDLDKKGGFYEVKCGSFRSTLSANDFEGINGEKPNFKMSKIEIKATREDF
SFSKIRTSKNTIDVRGLRVHEAEIIIEEKIRRFHGPLWIVHGIGTGKLKKGLRNWLSGLNYVDKIEDAANNEGGPGCSIA
WIK

Sequences:

>Translated_803_residues
MQEKSYSKKSYSDNTLEEESINLLEWDSLKTHLSSFASTEMGKQSILSFVIPSEYEASKRLLNETVEINELEKNLDKSIS
FSGVFDISRNIEICSKGGVITSSELLEIAKTIAAARNLKKILLDFEQRPYISSFTKNLIDHQNIETIFKKGIESNGRISD
NASNELSILRKEFLSKKLERKILVEKFIQKNLAYLQDTTIGDRYGRPVLAVKVNYVDKFKGIIHDSSSSGNTVYFEPESV
VTKGNKIASLEARITAEEFKLLKKWSHVVSDNSKNLIEMASILLRLENALTRSRYSKWIGGKTPTFEKNPIISLIGFSHP
LLIWEHKKKGAPPPVAVDFYINRNIKVVAITGPNTGGKTAALKGLGLSLLMARAGLLIPSTNNPIIPFCPNIYVDIGDNQ
SLEENLSTFSGHISRIKGILDSLDYKKGLSVVLLDEIGSGTDPLEGSALAMALLKEFANKSDITLATTHYGDIKALKYND
SRFENVSVAFDEESLKPKYILNWGIPGRSNALSISKRIGLDESILNEAANYLKPKEVDNINSIIKGLEEERIKQQNSAEA
AAELIARTEILHDELKRNYEHQKINAQKIQELERSKLSKHIISAKKEVIDLIKKLRDKNVNGEDTRIIGKRLKEIETEHL
TQKKSEKSISWNPQVGDFVKIKSLNSTGQIVDLDKKGGFYEVKCGSFRSTLSANDFEGINGEKPNFKMSKIEIKATREDF
SFSKIRTSKNTIDVRGLRVHEAEIIIEEKIRRFHGPLWIVHGIGTGKLKKGLRNWLSGLNYVDKIEDAANNEGGPGCSIA
WIK
>Mature_803_residues
MQEKSYSKKSYSDNTLEEESINLLEWDSLKTHLSSFASTEMGKQSILSFVIPSEYEASKRLLNETVEINELEKNLDKSIS
FSGVFDISRNIEICSKGGVITSSELLEIAKTIAAARNLKKILLDFEQRPYISSFTKNLIDHQNIETIFKKGIESNGRISD
NASNELSILRKEFLSKKLERKILVEKFIQKNLAYLQDTTIGDRYGRPVLAVKVNYVDKFKGIIHDSSSSGNTVYFEPESV
VTKGNKIASLEARITAEEFKLLKKWSHVVSDNSKNLIEMASILLRLENALTRSRYSKWIGGKTPTFEKNPIISLIGFSHP
LLIWEHKKKGAPPPVAVDFYINRNIKVVAITGPNTGGKTAALKGLGLSLLMARAGLLIPSTNNPIIPFCPNIYVDIGDNQ
SLEENLSTFSGHISRIKGILDSLDYKKGLSVVLLDEIGSGTDPLEGSALAMALLKEFANKSDITLATTHYGDIKALKYND
SRFENVSVAFDEESLKPKYILNWGIPGRSNALSISKRIGLDESILNEAANYLKPKEVDNINSIIKGLEEERIKQQNSAEA
AAELIARTEILHDELKRNYEHQKINAQKIQELERSKLSKHIISAKKEVIDLIKKLRDKNVNGEDTRIIGKRLKEIETEHL
TQKKSEKSISWNPQVGDFVKIKSLNSTGQIVDLDKKGGFYEVKCGSFRSTLSANDFEGINGEKPNFKMSKIEIKATREDF
SFSKIRTSKNTIDVRGLRVHEAEIIIEEKIRRFHGPLWIVHGIGTGKLKKGLRNWLSGLNYVDKIEDAANNEGGPGCSIA
WIK

Specific function: This Protein Is Involved In The Repair Of Mismatches In DNA. It Is Possible That It Carries Out The Mismatch Recognition Step. This Protein Has A Weak Atpase Activity. [C]

COG id: COG1193

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Smr domain [H]

Homologues:

Organism=Homo sapiens, GI284813531, Length=257, Percent_Identity=28.7937743190661, Blast_Score=77, Evalue=8e-14,
Organism=Homo sapiens, GI36949366, Length=230, Percent_Identity=29.5652173913043, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI4504191, Length=237, Percent_Identity=25.7383966244726, Blast_Score=72, Evalue=2e-12,
Organism=Escherichia coli, GI1789089, Length=300, Percent_Identity=26.3333333333333, Blast_Score=84, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17534743, Length=238, Percent_Identity=28.5714285714286, Blast_Score=85, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17508445, Length=217, Percent_Identity=24.8847926267281, Blast_Score=83, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6319935, Length=193, Percent_Identity=32.1243523316062, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6324482, Length=267, Percent_Identity=26.5917602996255, Blast_Score=71, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24584320, Length=369, Percent_Identity=22.4932249322493, Blast_Score=77, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24664545, Length=336, Percent_Identity=23.8095238095238, Blast_Score=74, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005747
- InterPro:   IPR000432
- InterPro:   IPR007696
- InterPro:   IPR002625 [H]

Pfam domain/function: PF00488 MutS_V; PF01713 Smr [H]

EC number: NA

Molecular weight: Translated: 89988; Mature: 89988

Theoretical pI: Translated: 9.53; Mature: 9.53

Prosite motif: PS50828 SMR ; PS00486 DNA_MISMATCH_REPAIR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQEKSYSKKSYSDNTLEEESINLLEWDSLKTHLSSFASTEMGKQSILSFVIPSEYEASKR
CCCCCCCCCCCCCCCCCHHCCCEEEHHHHHHHHHHHHHHHHCHHHHHHHHCCCCHHHHHH
LLNETVEINELEKNLDKSISFSGVFDISRNIEICSKGGVITSSELLEIAKTIAAARNLKK
HHHHHHHHHHHHHHHHHCCCCCEEEECCCCCEEECCCCEECHHHHHHHHHHHHHHHHHHH
ILLDFEQRPYISSFTKNLIDHQNIETIFKKGIESNGRISDNASNELSILRKEFLSKKLER
HHHHCCCCCHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
KILVEKFIQKNLAYLQDTTIGDRYGRPVLAVKVNYVDKFKGIIHDSSSSGNTVYFEPESV
HHHHHHHHHHHHHHHHCCCCCHHCCCEEEEEEECHHHHHHHHEECCCCCCCEEEECCHHH
VTKGNKIASLEARITAEEFKLLKKWSHVVSDNSKNLIEMASILLRLENALTRSRYSKWIG
HHCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
GKTPTFEKNPIISLIGFSHPLLIWEHKKKGAPPPVAVDFYINRNIKVVAITGPNTGGKTA
CCCCCCCCCCCEEEECCCCCEEEEECCCCCCCCCEEEEEEECCCEEEEEEECCCCCCCHH
ALKGLGLSLLMARAGLLIPSTNNPIIPFCPNIYVDIGDNQSLEENLSTFSGHISRIKGIL
HHHHHHHHHHHHHCCEEEECCCCCEEEECCEEEEECCCCCCHHHHHHHHHHHHHHHHHHH
DSLDYKKGLSVVLLDEIGSGTDPLEGSALAMALLKEFANKSDITLATTHYGDIKALKYND
HHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCEEEEEECC
SRFENVSVAFDEESLKPKYILNWGIPGRSNALSISKRIGLDESILNEAANYLKPKEVDNI
CCCCEEEEEECCCCCCCCEEEECCCCCCCCCEEHHHHCCCCHHHHHHHHHHCCCCCHHHH
NSIIKGLEEERIKQQNSAEAAAELIARTEILHDELKRNYEHQKINAQKIQELERSKLSKH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCHHHHHHHHHHHHHHH
IISAKKEVIDLIKKLRDKNVNGEDTRIIGKRLKEIETEHLTQKKSEKSISWNPQVGDFVK
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEE
IKSLNSTGQIVDLDKKGGFYEVKCGSFRSTLSANDFEGINGEKPNFKMSKIEIKATREDF
EEECCCCCCEEEEECCCCEEEEECCCHHHCCCCCCCCCCCCCCCCCEEEEEEEEECCCCC
SFSKIRTSKNTIDVRGLRVHEAEIIIEEKIRRFHGPLWIVHGIGTGKLKKGLRNWLSGLN
CHHHHCCCCCCEEEEEEEEEHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHCC
YVDKIEDAANNEGGPGCSIAWIK
HHHHHHHHCCCCCCCCCEEEEEC
>Mature Secondary Structure
MQEKSYSKKSYSDNTLEEESINLLEWDSLKTHLSSFASTEMGKQSILSFVIPSEYEASKR
CCCCCCCCCCCCCCCCCHHCCCEEEHHHHHHHHHHHHHHHHCHHHHHHHHCCCCHHHHHH
LLNETVEINELEKNLDKSISFSGVFDISRNIEICSKGGVITSSELLEIAKTIAAARNLKK
HHHHHHHHHHHHHHHHHCCCCCEEEECCCCCEEECCCCEECHHHHHHHHHHHHHHHHHHH
ILLDFEQRPYISSFTKNLIDHQNIETIFKKGIESNGRISDNASNELSILRKEFLSKKLER
HHHHCCCCCHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
KILVEKFIQKNLAYLQDTTIGDRYGRPVLAVKVNYVDKFKGIIHDSSSSGNTVYFEPESV
HHHHHHHHHHHHHHHHCCCCCHHCCCEEEEEEECHHHHHHHHEECCCCCCCEEEECCHHH
VTKGNKIASLEARITAEEFKLLKKWSHVVSDNSKNLIEMASILLRLENALTRSRYSKWIG
HHCCCEEEEHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
GKTPTFEKNPIISLIGFSHPLLIWEHKKKGAPPPVAVDFYINRNIKVVAITGPNTGGKTA
CCCCCCCCCCCEEEECCCCCEEEEECCCCCCCCCEEEEEEECCCEEEEEEECCCCCCCHH
ALKGLGLSLLMARAGLLIPSTNNPIIPFCPNIYVDIGDNQSLEENLSTFSGHISRIKGIL
HHHHHHHHHHHHHCCEEEECCCCCEEEECCEEEEECCCCCCHHHHHHHHHHHHHHHHHHH
DSLDYKKGLSVVLLDEIGSGTDPLEGSALAMALLKEFANKSDITLATTHYGDIKALKYND
HHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCEEEEEECC
SRFENVSVAFDEESLKPKYILNWGIPGRSNALSISKRIGLDESILNEAANYLKPKEVDNI
CCCCEEEEEECCCCCCCCEEEECCCCCCCCCEEHHHHCCCCHHHHHHHHHHCCCCCHHHH
NSIIKGLEEERIKQQNSAEAAAELIARTEILHDELKRNYEHQKINAQKIQELERSKLSKH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCHHHHHHHHHHHHHHH
IISAKKEVIDLIKKLRDKNVNGEDTRIIGKRLKEIETEHLTQKKSEKSISWNPQVGDFVK
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEE
IKSLNSTGQIVDLDKKGGFYEVKCGSFRSTLSANDFEGINGEKPNFKMSKIEIKATREDF
EEECCCCCCEEEEECCCCEEEEECCCHHHCCCCCCCCCCCCCCCCCEEEEEEEEECCCCC
SFSKIRTSKNTIDVRGLRVHEAEIIIEEKIRRFHGPLWIVHGIGTGKLKKGLRNWLSGLN
CHHHHCCCCCCEEEEEEEEEHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHCC
YVDKIEDAANNEGGPGCSIAWIK
HHHHHHHHCCCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]