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The map label for this gene is ubiB [C]

Identifier: 123967764

GI number: 123967764

Start: 212547

End: 214214

Strand: Reverse

Name: ubiB [C]

Synonym: A9601_02271

Alternate gene names: 123967764

Gene position: 214214-212547 (Counterclockwise)

Preceding gene: 123967765

Following gene: 123967762

Centisome position: 12.83

GC content: 32.91

Gene sequence:

>1668_bases
ATGAGTTATCACATTTTTCATTATCGTTTAAAAAAATTGAAGAGGGCCTTTGTTATTTGGATAACTCTGATTTCGCTTTT
AATAAATTTATGGATAGATAATATTAGATTTACAATTTTCCAAACTAAGAATAATGAAAAAAGTAGGGTTCAAATTAAGA
GAGCTAGGTGGTTTACTAATCAATTAATAAAGCTTGGATCAGCATTTATTAAAATTGGACAATTATTATCAGCGAGGCCT
GATTTAATTCCTAATACCTGGATACAGGAATTGTCTAAATTGCAGGATCAAGTTCCTAATTTTTCATTTACGCAAGTTGA
AGAGACTATTAGAAATGAACTAGGGTCTAAGTTTAATGAAATAGATCAAATAATATGTGATCCGGTTGGATCAGCATCAC
TAGCTCAGGTTCATAGGGCGACTCTAAAAGATGGTAAGACAGTAGTTTTTAAAGTTCAAAGACCCAATTTAAAAGAATTA
TTTATTATCGATTTGGGCATAATGCAGCAAATAGCAGGATTATTGCAGAAAAATAAGAATTTGAGTAGAGGTAGAAACTG
GGTTGAGATTGCTAAAGAGTGTAGGAAAGTTCTGATGAAAGAACTTGATTTTAATTGCGAAGCGCAATATGCAGCAAGAT
TTAGGCAGCAATTTCTTGATGATGAAAATGTTGAAGTTCCTGAAGTAATTTGGGATATGAGCAGTGAAAAAGTACTTTGT
TTAAGTTATGTAGAAGGGACAAAAATAAGCGATTTAGAAAAATTAAAATCACAAGAAATTGATTTACCTAAAATTGCAGA
GATAGGTGCAATCAGCTACTTAAAACAATTAGTAAATTACGGTTTTTTTCATGCAGATCCTCATCCAGGGAATTTAGCAG
TTTCAAGTGAAGGTAAATTAATTTTTTATGATTTTGGAATGATGGGGAACATCTCAAATAATCTTCAAAAAAGATTAGGG
GGGATGGTTAAGGCTGCTGCTCTTAGAGACGCCTCATCACTAGTTAGTCAATTACAACAAGCTGGGCTAATTTCAAAAGA
TATAGATGTAGGACCAGTCAGAAGATTAGTCAGATTGATGCTTAAAGAAGCCTTAACTCCTCCATTTAGTCCTAATATTA
TTGAAAAATTATCTGGAGATTTATACGAACTGGTTTATGAAACGCCATTTCAACTGCCAGTAGATTTAATCTTTGTGATG
AGAGCTTTATCAACTTTTGAAGGAGTTGGTAGAATGCTTGATCCAGGGTTTAACCTTGTATCAGTTACCAAGCCTTATTT
AATAGAACTTATGACTTCAAATAATCAAAGTCCCAACGATTTAATTAACCAATTTGGAAGGCAAGTAGGCGAACTAGGAT
CGAAAGCTGTTGGAATTCCCAAAAGAATAGATGAAAGTTTAGAAAGATTAGAACAGGGAGATTTACAATTGCAAATAAGA
ATGGGCGAGTCTGATAGGCAATTCAAAAAAATGTTTACGGCTCAAAAAACTTTAGGCCATTCAATTCTAATAGGAAGCTT
ATCAATTGCATCCGCTTTACTTGTATCCAATAAACAAAATAATTTTGCATTGTTGCCACTCTTTTTTGCACTACCAATAA
GTATTGATTGGATAAAGTGCCAATTAAGTATGAGAAAAGGCTCACGTTTAGAAAAACTTAAGCGCTAA

Upstream 100 bases:

>100_bases
ATACTTATCAAGATTCAAAAATAAAAAAAGCTTTAAATGAAATTGAAGGTATCAATAAGCAAATTGATCTGTTTAATAAA
ACTTTAAATAATCAAATTAA

Downstream 100 bases:

>100_bases
AAAAACTATATATTTTTAGGACCTAAACCTAGAGCTCCAGCGAATCTTGCTTGATTTCCTAATTCCTCCTCAATTTTTAA
AAGCCTATTATATTTTGCAA

Product: putative kinase

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 555; Mature: 554

Protein sequence:

>555_residues
MSYHIFHYRLKKLKRAFVIWITLISLLINLWIDNIRFTIFQTKNNEKSRVQIKRARWFTNQLIKLGSAFIKIGQLLSARP
DLIPNTWIQELSKLQDQVPNFSFTQVEETIRNELGSKFNEIDQIICDPVGSASLAQVHRATLKDGKTVVFKVQRPNLKEL
FIIDLGIMQQIAGLLQKNKNLSRGRNWVEIAKECRKVLMKELDFNCEAQYAARFRQQFLDDENVEVPEVIWDMSSEKVLC
LSYVEGTKISDLEKLKSQEIDLPKIAEIGAISYLKQLVNYGFFHADPHPGNLAVSSEGKLIFYDFGMMGNISNNLQKRLG
GMVKAAALRDASSLVSQLQQAGLISKDIDVGPVRRLVRLMLKEALTPPFSPNIIEKLSGDLYELVYETPFQLPVDLIFVM
RALSTFEGVGRMLDPGFNLVSVTKPYLIELMTSNNQSPNDLINQFGRQVGELGSKAVGIPKRIDESLERLEQGDLQLQIR
MGESDRQFKKMFTAQKTLGHSILIGSLSIASALLVSNKQNNFALLPLFFALPISIDWIKCQLSMRKGSRLEKLKR

Sequences:

>Translated_555_residues
MSYHIFHYRLKKLKRAFVIWITLISLLINLWIDNIRFTIFQTKNNEKSRVQIKRARWFTNQLIKLGSAFIKIGQLLSARP
DLIPNTWIQELSKLQDQVPNFSFTQVEETIRNELGSKFNEIDQIICDPVGSASLAQVHRATLKDGKTVVFKVQRPNLKEL
FIIDLGIMQQIAGLLQKNKNLSRGRNWVEIAKECRKVLMKELDFNCEAQYAARFRQQFLDDENVEVPEVIWDMSSEKVLC
LSYVEGTKISDLEKLKSQEIDLPKIAEIGAISYLKQLVNYGFFHADPHPGNLAVSSEGKLIFYDFGMMGNISNNLQKRLG
GMVKAAALRDASSLVSQLQQAGLISKDIDVGPVRRLVRLMLKEALTPPFSPNIIEKLSGDLYELVYETPFQLPVDLIFVM
RALSTFEGVGRMLDPGFNLVSVTKPYLIELMTSNNQSPNDLINQFGRQVGELGSKAVGIPKRIDESLERLEQGDLQLQIR
MGESDRQFKKMFTAQKTLGHSILIGSLSIASALLVSNKQNNFALLPLFFALPISIDWIKCQLSMRKGSRLEKLKR
>Mature_554_residues
SYHIFHYRLKKLKRAFVIWITLISLLINLWIDNIRFTIFQTKNNEKSRVQIKRARWFTNQLIKLGSAFIKIGQLLSARPD
LIPNTWIQELSKLQDQVPNFSFTQVEETIRNELGSKFNEIDQIICDPVGSASLAQVHRATLKDGKTVVFKVQRPNLKELF
IIDLGIMQQIAGLLQKNKNLSRGRNWVEIAKECRKVLMKELDFNCEAQYAARFRQQFLDDENVEVPEVIWDMSSEKVLCL
SYVEGTKISDLEKLKSQEIDLPKIAEIGAISYLKQLVNYGFFHADPHPGNLAVSSEGKLIFYDFGMMGNISNNLQKRLGG
MVKAAALRDASSLVSQLQQAGLISKDIDVGPVRRLVRLMLKEALTPPFSPNIIEKLSGDLYELVYETPFQLPVDLIFVMR
ALSTFEGVGRMLDPGFNLVSVTKPYLIELMTSNNQSPNDLINQFGRQVGELGSKAVGIPKRIDESLERLEQGDLQLQIRM
GESDRQFKKMFTAQKTLGHSILIGSLSIASALLVSNKQNNFALLPLFFALPISIDWIKCQLSMRKGSRLEKLKR

Specific function: Required, Probably Indirectly, For The Hydroxylation Of 2-Octaprenylphenol To 2-Octaprenyl-6-Hydroxy-Phenol, The Fourth Step In Ubiquinone Biosynthesis. Specific For Aerobically Grown Log-Phase Cells. [C]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the protein kinase superfamily. ADCK protein kinase family [H]

Homologues:

Organism=Homo sapiens, GI40254938, Length=267, Percent_Identity=31.8352059925094, Blast_Score=145, Evalue=1e-34,
Organism=Homo sapiens, GI41393593, Length=354, Percent_Identity=28.5310734463277, Blast_Score=133, Evalue=5e-31,
Organism=Homo sapiens, GI217035081, Length=201, Percent_Identity=32.8358208955224, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI34147522, Length=283, Percent_Identity=26.1484098939929, Blast_Score=80, Evalue=7e-15,
Organism=Homo sapiens, GI27363457, Length=275, Percent_Identity=24.7272727272727, Blast_Score=74, Evalue=3e-13,
Organism=Homo sapiens, GI217416386, Length=237, Percent_Identity=25.3164556962025, Blast_Score=69, Evalue=9e-12,
Organism=Escherichia coli, GI2367309, Length=510, Percent_Identity=27.2549019607843, Blast_Score=166, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI17559152, Length=261, Percent_Identity=32.5670498084291, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI32565180, Length=294, Percent_Identity=25.8503401360544, Blast_Score=85, Evalue=8e-17,
Organism=Saccharomyces cerevisiae, GI6323282, Length=251, Percent_Identity=31.0756972111554, Blast_Score=108, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6321319, Length=293, Percent_Identity=27.9863481228669, Blast_Score=103, Evalue=8e-23,
Organism=Saccharomyces cerevisiae, GI6325148, Length=432, Percent_Identity=23.1481481481481, Blast_Score=77, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24662575, Length=394, Percent_Identity=28.1725888324873, Blast_Score=140, Evalue=3e-33,
Organism=Drosophila melanogaster, GI22024280, Length=304, Percent_Identity=29.6052631578947, Blast_Score=131, Evalue=2e-30,
Organism=Drosophila melanogaster, GI18859849, Length=261, Percent_Identity=27.2030651340996, Blast_Score=78, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR000719 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 63110; Mature: 62978

Theoretical pI: Translated: 9.87; Mature: 9.87

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYHIFHYRLKKLKRAFVIWITLISLLINLWIDNIRFTIFQTKNNEKSRVQIKRARWFTN
CCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEEECCCCHHHHHHHHHHHHHH
QLIKLGSAFIKIGQLLSARPDLIPNTWIQELSKLQDQVPNFSFTQVEETIRNELGSKFNE
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
IDQIICDPVGSASLAQVHRATLKDGKTVVFKVQRPNLKELFIIDLGIMQQIAGLLQKNKN
HHHHHHCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCEEEEEHHHHHHHHHHHHHCCCC
LSRGRNWVEIAKECRKVLMKELDFNCEAQYAARFRQQFLDDENVEVPEVIWDMSSEKVLC
HHHCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCEEE
LSYVEGTKISDLEKLKSQEIDLPKIAEIGAISYLKQLVNYGFFHADPHPGNLAVSSEGKL
EEECCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCEECCCCCCCEEECCCCCE
IFYDFGMMGNISNNLQKRLGGMVKAAALRDASSLVSQLQQAGLISKDIDVGPVRRLVRLM
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
LKEALTPPFSPNIIEKLSGDLYELVYETPFQLPVDLIFVMRALSTFEGVGRMLDPGFNLV
HHHHCCCCCCCHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEE
SVTKPYLIELMTSNNQSPNDLINQFGRQVGELGSKAVGIPKRIDESLERLEQGDLQLQIR
EECCHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCEEEEEE
MGESDRQFKKMFTAQKTLGHSILIGSLSIASALLVSNKQNNFALLPLFFALPISIDWIKC
ECCCHHHHHHHHHHHHHHCCHHEEHHHHHHHHHHHCCCCCCEEHHHHHHHHCCCEEEHEE
QLSMRKGSRLEKLKR
EEEHHCCCHHHHHCC
>Mature Secondary Structure 
SYHIFHYRLKKLKRAFVIWITLISLLINLWIDNIRFTIFQTKNNEKSRVQIKRARWFTN
CEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEEEECCCCHHHHHHHHHHHHHH
QLIKLGSAFIKIGQLLSARPDLIPNTWIQELSKLQDQVPNFSFTQVEETIRNELGSKFNE
HHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
IDQIICDPVGSASLAQVHRATLKDGKTVVFKVQRPNLKELFIIDLGIMQQIAGLLQKNKN
HHHHHHCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCCEEEEEHHHHHHHHHHHHHCCCC
LSRGRNWVEIAKECRKVLMKELDFNCEAQYAARFRQQFLDDENVEVPEVIWDMSSEKVLC
HHHCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCEEE
LSYVEGTKISDLEKLKSQEIDLPKIAEIGAISYLKQLVNYGFFHADPHPGNLAVSSEGKL
EEECCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCEECCCCCCCEEECCCCCE
IFYDFGMMGNISNNLQKRLGGMVKAAALRDASSLVSQLQQAGLISKDIDVGPVRRLVRLM
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
LKEALTPPFSPNIIEKLSGDLYELVYETPFQLPVDLIFVMRALSTFEGVGRMLDPGFNLV
HHHHCCCCCCCHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEE
SVTKPYLIELMTSNNQSPNDLINQFGRQVGELGSKAVGIPKRIDESLERLEQGDLQLQIR
EECCHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCEEEEEE
MGESDRQFKKMFTAQKTLGHSILIGSLSIASALLVSNKQNNFALLPLFFALPISIDWIKC
ECCCHHHHHHHHHHHHHHCCHHEEHHHHHHHHHHHCCCCCCEEHHHHHHHHCCCEEEHEE
QLSMRKGSRLEKLKR
EEEHHCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]