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The map label for this gene is clpB2 [H]

Identifier: 123967762

GI number: 123967762

Start: 208224

End: 210986

Strand: Reverse

Name: clpB2 [H]

Synonym: A9601_02251

Alternate gene names: 123967762

Gene position: 210986-208224 (Counterclockwise)

Preceding gene: 123967764

Following gene: 123967761

Centisome position: 12.63

GC content: 31.2

Gene sequence:

>2763_bases
ATGAGAGAAACACTTACATCCAGTCCTGAACTATTTAGCGATATTAGTTGGAATCTTCTTTTATTAGGGGAAGAAACCGC
AAAAAAATGGGATCATAGCGAATTTAATATTGAACACATAATTCATACATTGTTCTCATCAAGTGAATTCTTTGCCTTCA
TTGAAAAATTATCAATCGACCAAGATACAGTTTTAGACATAACAGAAGATTTTTTAGAAGAGACACCAACAAATGAGTCA
GATATTTTTACTATCGGAGAAGATTTAGAAATTTTATTAGATAACGCGAATCAGATTAAAACTCAATGGGGATCGAGATT
AATAGAAATCCCTCATTTACTAATTGCTCTTGGAAGAGATTTAAGAATTGGAAATTATGTTTTTGAAGAAGGAAACCTTT
CAATGGAAAAATTAGAGGAAGAATTAAAGTTTTTCCCAAATATTAATCAATCAAAAGATTCTTTTAATTATGGGAATGTA
ATTGAAATAAATAATCAATCCAATTTTGAATCAAACAATGAGACTAACGAGACTTTTGTAAAAGAAGAAAAATTTAAAAA
AGCTATTGTTCCATTACAGAAAAGTGAACTTCAAATTGAAACAAAACAAGTTGGAAAAGATGAAAATGCTCTTTCAATTT
ATGGAAAAGATTTAACAGAATCAGCTAAAAAAGGGTTACTGGATCCCGTTTTAGGAAGAGAAAATGAGATCAATAATTTA
ATGAGGGTACTCTGCAGAAGAAACAAAAATAACCCTATACTTATTGGCAATCCTGGAGTTGGTAAAACCTCAATTGCAAA
ATTACTTGCTCAATTAATTGTAGACAAAAAAGTTCCTGATACTTTAAAGGACTTAAAAATTATTTCACTTGACTTAGGTG
CATTAGTTTCTGGGACTAAATTTAGAGGTCAACTAGAGGAAAGACTAAGCTTAATAATGCAGGAACTAAATAATCCAAAC
CAAGGAATGATCCTATTTATTGATGAAATTCACTCAATATTAAGTTCTGACAGATCTTCTACCGACATCAGTAATATCTT
AAAACCTTTACTAGCTGAAGGAGAACTTAGATGTATCGGTACAACTACACCTGAGAAATTTCGTGAAACTATTGAAAAAG
ATCAGGCATTAAATAATTGCTTTCAAAAGATAACTGTTAATGAACCTTCAGTAGAATTAAGCGCAAAAATATTACAAGGG
ATCAAAAAGAAATATGAATCACATCATGGCATAAAAATTTCTGAAGAGGCTGTAAACTATTCTGCAAAATTGGCCGATAG
ATACATCAGCGATAAATGTCTCCCTGATAGTGCAATAGATTTAATTGATGAAGCAGCCGCACAGTTAAAAATCGAGTCTA
ATAATATGCCTCAAATCATTCTCCAACAAGAAAACAAACTTAATACTATCGATGAAAAATTGAATAATTTGCAAGGAGAC
AATATCGAAGCTCAAGAAAAACTATTGAATAATAGACAACAATCAGAGGCAAAATTGAACGTTCTTTTAGAAAATTGGAA
CAATTTACGTGAAGAGATGGAGGAATTATCCATTTTAATGAAAGAAGAAGATAAGCTAACCAAACAAATCAAAGATAAAT
CAAATCGCGAAATTGAAAATGATCTAGATTATTTAGAAAAGCTTGAAGAAGAGTTAAGTAAAATAGAGAATGAAATACAA
AAACTTGAAGAGAACTTTACTAAAATAAAGAAAAATAGAAATTTCCCTTTTAAATATCAAGTTGAACCTGATGATATTGC
AGATGTTATATCGAAAATCACAGGTATTCCAATTTCTAAAGTAGTTTCAAATGAACGTAAGAAATTAGTCAATCTAGAAA
CAGAACTAAGTGAAAAAGTTATTGGACAAGAAAAAGCCATAGAAGTTGTTTCTGCTGCAATTAGAAGAGCTCGAGTTGGC
ATGAAAAGTCCCAAAAGACCTATTGGATCTTTTTTATTTATGGGTCCTACTGGTGTTGGTAAAACAGAATTAGCAAAATC
TCTTGCAACAGTTTTATTTGATGAAGAAGACGCACTTTTAAGATTAGACATGAGTGAATATATGGAGAAAAATGCCGTAG
CAAGACTTTTAGGAGCTCCCCCAGGTTATATTGGTTATGAAGAGGGAGGTCAATTAACTGAAGCTGTAAGACGTAAACCC
TACTCAGTAATACTTCTTGACGAGATAGAAAAAGCTCATGCAGAAGTATTTAATATCCTTTTGCAAGTCTTAGATGAAGG
AAGATTAACGGACTCTCAAGGAAGGACCGTAGATTTCAAAAATACGGTAATCATTATGACAAGTAACCTAGCTGGTAAAT
CTATACTGGAGTATTCACAAAAAATTTCTAAAAGTGAGGGAAAGTTAGAAAAAGATCAACAAACCCTAGATGATTCAATT
AGTAATGCATTGTCTTCAATTTTTAGACCTGAATTTTTAAATAGAATTGACGAAGTGGTAAAGTTTGATCCACTTTCTAT
TGATGAACTTCAAAAAATAATCATTCTACAAACAGAAGATTTAAAGAACCTGCTACTTGAGCAGAAAATAAATATCGCTA
TAGACAAAAAAGTTATCAATAAAATTGCAAACGATTCTTACGAACCTGAATATGGTGCTAGGCCACTTAGCAGGGAACTT
AGAAGACAAATAGAAAATCCCTTGGCTGCAAAACTTTTAGAGGATAGTTTCAAAAATAAAAAAAATATAACAATTAAACT
TAACCCTACTAAAAAAGATGAGATCGTTTTCAAACCTAGCTGA

Upstream 100 bases:

>100_bases
ATTTTCAAATTCATCTTACAATTTGAAAATTATTGGATGATTATTAATGCAGATCTTATTTAGAATATTAATTAATAATC
AACTATAGTTTTTATAGTTT

Downstream 100 bases:

>100_bases
GGAGTAAATCAATAAGCTAAAATAAAAACTAAAGCATAAAGCTTAATTTCAAAAAAATTTTGTGACAAGTCCTACTACTA
ATAAAGAACCTCTTAAAAAG

Product: putative ATP-dependent Clp protease, Hsp 100, ATP-binding subunit ClpB

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 920; Mature: 920

Protein sequence:

>920_residues
MRETLTSSPELFSDISWNLLLLGEETAKKWDHSEFNIEHIIHTLFSSSEFFAFIEKLSIDQDTVLDITEDFLEETPTNES
DIFTIGEDLEILLDNANQIKTQWGSRLIEIPHLLIALGRDLRIGNYVFEEGNLSMEKLEEELKFFPNINQSKDSFNYGNV
IEINNQSNFESNNETNETFVKEEKFKKAIVPLQKSELQIETKQVGKDENALSIYGKDLTESAKKGLLDPVLGRENEINNL
MRVLCRRNKNNPILIGNPGVGKTSIAKLLAQLIVDKKVPDTLKDLKIISLDLGALVSGTKFRGQLEERLSLIMQELNNPN
QGMILFIDEIHSILSSDRSSTDISNILKPLLAEGELRCIGTTTPEKFRETIEKDQALNNCFQKITVNEPSVELSAKILQG
IKKKYESHHGIKISEEAVNYSAKLADRYISDKCLPDSAIDLIDEAAAQLKIESNNMPQIILQQENKLNTIDEKLNNLQGD
NIEAQEKLLNNRQQSEAKLNVLLENWNNLREEMEELSILMKEEDKLTKQIKDKSNREIENDLDYLEKLEEELSKIENEIQ
KLEENFTKIKKNRNFPFKYQVEPDDIADVISKITGIPISKVVSNERKKLVNLETELSEKVIGQEKAIEVVSAAIRRARVG
MKSPKRPIGSFLFMGPTGVGKTELAKSLATVLFDEEDALLRLDMSEYMEKNAVARLLGAPPGYIGYEEGGQLTEAVRRKP
YSVILLDEIEKAHAEVFNILLQVLDEGRLTDSQGRTVDFKNTVIIMTSNLAGKSILEYSQKISKSEGKLEKDQQTLDDSI
SNALSSIFRPEFLNRIDEVVKFDPLSIDELQKIIILQTEDLKNLLLEQKINIAIDKKVINKIANDSYEPEYGARPLSREL
RRQIENPLAAKLLEDSFKNKKNITIKLNPTKKDEIVFKPS

Sequences:

>Translated_920_residues
MRETLTSSPELFSDISWNLLLLGEETAKKWDHSEFNIEHIIHTLFSSSEFFAFIEKLSIDQDTVLDITEDFLEETPTNES
DIFTIGEDLEILLDNANQIKTQWGSRLIEIPHLLIALGRDLRIGNYVFEEGNLSMEKLEEELKFFPNINQSKDSFNYGNV
IEINNQSNFESNNETNETFVKEEKFKKAIVPLQKSELQIETKQVGKDENALSIYGKDLTESAKKGLLDPVLGRENEINNL
MRVLCRRNKNNPILIGNPGVGKTSIAKLLAQLIVDKKVPDTLKDLKIISLDLGALVSGTKFRGQLEERLSLIMQELNNPN
QGMILFIDEIHSILSSDRSSTDISNILKPLLAEGELRCIGTTTPEKFRETIEKDQALNNCFQKITVNEPSVELSAKILQG
IKKKYESHHGIKISEEAVNYSAKLADRYISDKCLPDSAIDLIDEAAAQLKIESNNMPQIILQQENKLNTIDEKLNNLQGD
NIEAQEKLLNNRQQSEAKLNVLLENWNNLREEMEELSILMKEEDKLTKQIKDKSNREIENDLDYLEKLEEELSKIENEIQ
KLEENFTKIKKNRNFPFKYQVEPDDIADVISKITGIPISKVVSNERKKLVNLETELSEKVIGQEKAIEVVSAAIRRARVG
MKSPKRPIGSFLFMGPTGVGKTELAKSLATVLFDEEDALLRLDMSEYMEKNAVARLLGAPPGYIGYEEGGQLTEAVRRKP
YSVILLDEIEKAHAEVFNILLQVLDEGRLTDSQGRTVDFKNTVIIMTSNLAGKSILEYSQKISKSEGKLEKDQQTLDDSI
SNALSSIFRPEFLNRIDEVVKFDPLSIDELQKIIILQTEDLKNLLLEQKINIAIDKKVINKIANDSYEPEYGARPLSREL
RRQIENPLAAKLLEDSFKNKKNITIKLNPTKKDEIVFKPS
>Mature_920_residues
MRETLTSSPELFSDISWNLLLLGEETAKKWDHSEFNIEHIIHTLFSSSEFFAFIEKLSIDQDTVLDITEDFLEETPTNES
DIFTIGEDLEILLDNANQIKTQWGSRLIEIPHLLIALGRDLRIGNYVFEEGNLSMEKLEEELKFFPNINQSKDSFNYGNV
IEINNQSNFESNNETNETFVKEEKFKKAIVPLQKSELQIETKQVGKDENALSIYGKDLTESAKKGLLDPVLGRENEINNL
MRVLCRRNKNNPILIGNPGVGKTSIAKLLAQLIVDKKVPDTLKDLKIISLDLGALVSGTKFRGQLEERLSLIMQELNNPN
QGMILFIDEIHSILSSDRSSTDISNILKPLLAEGELRCIGTTTPEKFRETIEKDQALNNCFQKITVNEPSVELSAKILQG
IKKKYESHHGIKISEEAVNYSAKLADRYISDKCLPDSAIDLIDEAAAQLKIESNNMPQIILQQENKLNTIDEKLNNLQGD
NIEAQEKLLNNRQQSEAKLNVLLENWNNLREEMEELSILMKEEDKLTKQIKDKSNREIENDLDYLEKLEEELSKIENEIQ
KLEENFTKIKKNRNFPFKYQVEPDDIADVISKITGIPISKVVSNERKKLVNLETELSEKVIGQEKAIEVVSAAIRRARVG
MKSPKRPIGSFLFMGPTGVGKTELAKSLATVLFDEEDALLRLDMSEYMEKNAVARLLGAPPGYIGYEEGGQLTEAVRRKP
YSVILLDEIEKAHAEVFNILLQVLDEGRLTDSQGRTVDFKNTVIIMTSNLAGKSILEYSQKISKSEGKLEKDQQTLDDSI
SNALSSIFRPEFLNRIDEVVKFDPLSIDELQKIIILQTEDLKNLLLEQKINIAIDKKVINKIANDSYEPEYGARPLSREL
RRQIENPLAAKLLEDSFKNKKNITIKLNPTKKDEIVFKPS

Specific function: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=323, Percent_Identity=37.4613003095975, Blast_Score=210, Evalue=6e-54,
Organism=Escherichia coli, GI1788943, Length=721, Percent_Identity=45.7697642163662, Blast_Score=612, Evalue=1e-176,
Organism=Escherichia coli, GI1787109, Length=340, Percent_Identity=42.6470588235294, Blast_Score=265, Evalue=1e-71,
Organism=Saccharomyces cerevisiae, GI6320464, Length=708, Percent_Identity=42.2316384180791, Blast_Score=545, Evalue=1e-155,
Organism=Saccharomyces cerevisiae, GI6323002, Length=930, Percent_Identity=34.5161290322581, Blast_Score=502, Evalue=1e-142,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 104550; Mature: 104550

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRETLTSSPELFSDISWNLLLLGEETAKKWDHSEFNIEHIIHTLFSSSEFFAFIEKLSID
CCCCCCCCCHHHHCCCCCEEEEECHHHHHCCCCCCCHHHHHHHHHCCHHHHHHHHHHCCC
QDTVLDITEDFLEETPTNESDIFTIGEDLEILLDNANQIKTQWGSRLIEIPHLLIALGRD
CHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCC
LRIGNYVFEEGNLSMEKLEEELKFFPNINQSKDSFNYGNVIEINNQSNFESNNETNETFV
CEECCEEEECCCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCHHHHH
KEEKFKKAIVPLQKSELQIETKQVGKDENALSIYGKDLTESAKKGLLDPVLGRENEINNL
HHHHHHHHHCCCCHHHHEEEHHHCCCCCCCEEEECCHHHHHHHCCCCCHHCCCCHHHHHH
MRVLCRRNKNNPILIGNPGVGKTSIAKLLAQLIVDKKVPDTLKDLKIISLDLGALVSGTK
HHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCHHHHCCEEEEEEHHHHHCCCH
FRGQLEERLSLIMQELNNPNQGMILFIDEIHSILSSDRSSTDISNILKPLLAEGELRCIG
HHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHCCCCCCHHHHHHHHHHCCCCEEEEE
TTTPEKFRETIEKDQALNNCFQKITVNEPSVELSAKILQGIKKKYESHHGIKISEEAVNY
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEHHHHHH
SAKLADRYISDKCLPDSAIDLIDEAAAQLKIESNNMPQIILQQENKLNTIDEKLNNLQGD
HHHHHHHHHHCCCCCHHHHHHHHHHHHHEEECCCCCCEEEEECCCCCHHHHHHHHCCCCC
NIEAQEKLLNNRQQSEAKLNVLLENWNNLREEMEELSILMKEEDKLTKQIKDKSNREIEN
CCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
DLDYLEKLEEELSKIENEIQKLEENFTKIKKNRNFPFKYQVEPDDIADVISKITGIPISK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHCCCCHHH
VVSNERKKLVNLETELSEKVIGQEKAIEVVSAAIRRARVGMKSPKRPIGSFLFMGPTGVG
HHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCC
KTELAKSLATVLFDEEDALLRLDMSEYMEKNAVARLLGAPPGYIGYEEGGQLTEAVRRKP
HHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCC
YSVILLDEIEKAHAEVFNILLQVLDEGRLTDSQGRTVDFKNTVIIMTSNLAGKSILEYSQ
CEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCEEEEEECCCCHHHHHHHHH
KISKSEGKLEKDQQTLDDSISNALSSIFRPEFLNRIDEVVKFDPLSIDELQKIIILQTED
HHHHHCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCHHHHHHHHEEECHH
LKNLLLEQKINIAIDKKVINKIANDSYEPEYGARPLSRELRRQIENPLAAKLLEDSFKNK
HHHHHHHHHCCCEECHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCHHHHHHHHHHHCCC
KNITIKLNPTKKDEIVFKPS
CCEEEEECCCCCCCEEECCC
>Mature Secondary Structure
MRETLTSSPELFSDISWNLLLLGEETAKKWDHSEFNIEHIIHTLFSSSEFFAFIEKLSID
CCCCCCCCCHHHHCCCCCEEEEECHHHHHCCCCCCCHHHHHHHHHCCHHHHHHHHHHCCC
QDTVLDITEDFLEETPTNESDIFTIGEDLEILLDNANQIKTQWGSRLIEIPHLLIALGRD
CHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCC
LRIGNYVFEEGNLSMEKLEEELKFFPNINQSKDSFNYGNVIEINNQSNFESNNETNETFV
CEECCEEEECCCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEECCCCCCCCCCCCHHHHH
KEEKFKKAIVPLQKSELQIETKQVGKDENALSIYGKDLTESAKKGLLDPVLGRENEINNL
HHHHHHHHHCCCCHHHHEEEHHHCCCCCCCEEEECCHHHHHHHCCCCCHHCCCCHHHHHH
MRVLCRRNKNNPILIGNPGVGKTSIAKLLAQLIVDKKVPDTLKDLKIISLDLGALVSGTK
HHHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCHHHHCCEEEEEEHHHHHCCCH
FRGQLEERLSLIMQELNNPNQGMILFIDEIHSILSSDRSSTDISNILKPLLAEGELRCIG
HHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHHHHHCCCCCCHHHHHHHHHHCCCCEEEEE
TTTPEKFRETIEKDQALNNCFQKITVNEPSVELSAKILQGIKKKYESHHGIKISEEAVNY
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEHHHHHH
SAKLADRYISDKCLPDSAIDLIDEAAAQLKIESNNMPQIILQQENKLNTIDEKLNNLQGD
HHHHHHHHHHCCCCCHHHHHHHHHHHHHEEECCCCCCEEEEECCCCCHHHHHHHHCCCCC
NIEAQEKLLNNRQQSEAKLNVLLENWNNLREEMEELSILMKEEDKLTKQIKDKSNREIEN
CCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHH
DLDYLEKLEEELSKIENEIQKLEENFTKIKKNRNFPFKYQVEPDDIADVISKITGIPISK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHCCCCHHH
VVSNERKKLVNLETELSEKVIGQEKAIEVVSAAIRRARVGMKSPKRPIGSFLFMGPTGVG
HHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCCCC
KTELAKSLATVLFDEEDALLRLDMSEYMEKNAVARLLGAPPGYIGYEEGGQLTEAVRRKP
HHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHCCC
YSVILLDEIEKAHAEVFNILLQVLDEGRLTDSQGRTVDFKNTVIIMTSNLAGKSILEYSQ
CEEEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCEEEEEECCCCHHHHHHHHH
KISKSEGKLEKDQQTLDDSISNALSSIFRPEFLNRIDEVVKFDPLSIDELQKIIILQTED
HHHHHCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCHHHHHHHHEEECHH
LKNLLLEQKINIAIDKKVINKIANDSYEPEYGARPLSRELRRQIENPLAAKLLEDSFKNK
HHHHHHHHHCCCEECHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHCHHHHHHHHHHHCCC
KNITIKLNPTKKDEIVFKPS
CCEEEEECCCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12917641 [H]