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The map label for this gene is ndhD [H]

Identifier: 123967704

GI number: 123967704

Start: 156647

End: 158251

Strand: Direct

Name: ndhD [H]

Synonym: A9601_01671

Alternate gene names: 123967704

Gene position: 156647-158251 (Clockwise)

Preceding gene: 123967703

Following gene: 123967705

Centisome position: 9.38

GC content: 35.14

Gene sequence:

>1605_bases
ATGTTGGGAACTTTGGGCGCTGGATTGTCTAATTTTCCTTGGTTATCTGCTTCAATTTTATTCCCAATTGGTAGTGCATT
TGTGATACCTTTTTTTCCAGATAAAGGGGATGGCAAAGAGGTGAGATGGTTTGCATTGTCTATTGCATTAATTACTTTTT
TAATAACTGTAGGTTCATACATAAATGGCTTTGATATTAGTAATGAAAATGTTCAACTTAAAGAAAATATTAGTTGGCTC
CCTGATTTAGGTCTTACTTGGTCTGTTGGCGCTGATGGTATGTCTATGCCGTTAATATTATTGACTAGTTTTATAACTGC
TTTAGCAGTTCTTGCTGCATGGCCAGTAAAGTTCAAACCAAAGTTATTTTTCTTTTTAATATTGGTTATGGATGGTGGGC
AAATCGCTGTGTTTGCCGTACAAGATATGCTTTTATTCTTTCTAACTTGGGAACTTGAGTTAATTCCTGTTTATTTATTA
CTCGCTATATGGGGTGGCAAAAATCGACAATATGCTGCGACAAAATTCATTATCTATACAGCTGGTAGTTCTATCTTTAT
TCTTCTTGCCGCGTTAGCAATGGGTTTCTATGGTACAGAAATTCCTAACTTTGAGTTTTCTCACTTGGCAGCTCAAGATT
TTAGTCAAAAATTCCAAATTTTATGCTATGTAGGGCTTTTAATTGCATTTGGTGTGAAACTTCCAATAGTACCCCTGCAT
ACTTGGCTTCCAGATGCTCATGGAGAGGCTACAGCTCCAGTTCATATGCTTCTAGCGGGAATTTTATTAAAGATGGGAGG
ATATGCTCTTTTAAGATTTAATGCACAATTATTACCCGTCGCTCATGCTCAATTTGCTCCATTATTGATAGTTCTAGGGG
TAGTCAATATCATTTATGCTGCATTAACTTCTTTTGCTCAAAGAAATCTTAAAAGAAAAATTGCATATAGTTCGATAAGT
CATATGGGTTTCGTTCTTATTGGAATAGGCAGTTTCAGTAGCCTTGGAACAAGTGGAGCTATGCTGCAAATGGTTAGTCA
TGGATTAATCGGTGCAAGTTTATTTTTTCTTGTTGGTGCTACCTATGACAGAACAAAAACTCTTAAACTTGATGAAATGA
GTGGTGTAGGACAAAAAATGAGAATCATGTTTGCCTTATGGACTGCTTGCTCATTGGCTTCTCTTGCTTTGCCTGGTATG
AGCGGATTTGTTTCCGAATTGATGGTTTTTACAGGATTTGTTACTGATGAAGTGTATACTCTTCCTTTTAGGGTAGTGAT
GGCTTCTTTAGCAGCTATCGGTGTAATACTTACTCCTATTTATCTACTTTCAATGTTACGAGAAATTTTCTTTGGTAAAG
AAAATCCTAAATTAATAGAAGAACGAAAACTCATAGATGCAGAGCCAAGGGAAGTTTATATTATTGCCTGTTTACTTTTA
CCGATTATTGGAATAGGTTTATACCCAAGATTAGTTACTGAAAGTTATATTGCATCTATCAATAATTTAGTCGATAGAGA
TTTAACTGCCATTAAAAGTGCTGCTAAAGCAAATATTTTTTCAGGAACTAAAAAAAATGATATCCTAAAAGCTCCAACAA
TATAA

Upstream 100 bases:

>100_bases
GTCCATTGGGGTGAAAAAATACAGAAAATTTCTAGACTTTATTTAAGATAAATTTCTTATTAAATTGAGTACTTATTTTT
ATACACATTTTGCGACACAA

Downstream 100 bases:

>100_bases
TTTTTTAAATTAATGCAATATTGTTTGGCATTAAATAAATTAAAAGATATCTTGTGAGTAGATTTTATCTATTTTAAAAT
AACTTATTTCAATCCTATTG

Product: NAD(P)H-quinone oxidoreductase subunit 4

Products: NAD+; ubiquinol

Alternate protein names: NAD(P)H dehydrogenase I, chain 4; NDH-1, chain 4 [H]

Number of amino acids: Translated: 534; Mature: 534

Protein sequence:

>534_residues
MLGTLGAGLSNFPWLSASILFPIGSAFVIPFFPDKGDGKEVRWFALSIALITFLITVGSYINGFDISNENVQLKENISWL
PDLGLTWSVGADGMSMPLILLTSFITALAVLAAWPVKFKPKLFFFLILVMDGGQIAVFAVQDMLLFFLTWELELIPVYLL
LAIWGGKNRQYAATKFIIYTAGSSIFILLAALAMGFYGTEIPNFEFSHLAAQDFSQKFQILCYVGLLIAFGVKLPIVPLH
TWLPDAHGEATAPVHMLLAGILLKMGGYALLRFNAQLLPVAHAQFAPLLIVLGVVNIIYAALTSFAQRNLKRKIAYSSIS
HMGFVLIGIGSFSSLGTSGAMLQMVSHGLIGASLFFLVGATYDRTKTLKLDEMSGVGQKMRIMFALWTACSLASLALPGM
SGFVSELMVFTGFVTDEVYTLPFRVVMASLAAIGVILTPIYLLSMLREIFFGKENPKLIEERKLIDAEPREVYIIACLLL
PIIGIGLYPRLVTESYIASINNLVDRDLTAIKSAAKANIFSGTKKNDILKAPTI

Sequences:

>Translated_534_residues
MLGTLGAGLSNFPWLSASILFPIGSAFVIPFFPDKGDGKEVRWFALSIALITFLITVGSYINGFDISNENVQLKENISWL
PDLGLTWSVGADGMSMPLILLTSFITALAVLAAWPVKFKPKLFFFLILVMDGGQIAVFAVQDMLLFFLTWELELIPVYLL
LAIWGGKNRQYAATKFIIYTAGSSIFILLAALAMGFYGTEIPNFEFSHLAAQDFSQKFQILCYVGLLIAFGVKLPIVPLH
TWLPDAHGEATAPVHMLLAGILLKMGGYALLRFNAQLLPVAHAQFAPLLIVLGVVNIIYAALTSFAQRNLKRKIAYSSIS
HMGFVLIGIGSFSSLGTSGAMLQMVSHGLIGASLFFLVGATYDRTKTLKLDEMSGVGQKMRIMFALWTACSLASLALPGM
SGFVSELMVFTGFVTDEVYTLPFRVVMASLAAIGVILTPIYLLSMLREIFFGKENPKLIEERKLIDAEPREVYIIACLLL
PIIGIGLYPRLVTESYIASINNLVDRDLTAIKSAAKANIFSGTKKNDILKAPTI
>Mature_534_residues
MLGTLGAGLSNFPWLSASILFPIGSAFVIPFFPDKGDGKEVRWFALSIALITFLITVGSYINGFDISNENVQLKENISWL
PDLGLTWSVGADGMSMPLILLTSFITALAVLAAWPVKFKPKLFFFLILVMDGGQIAVFAVQDMLLFFLTWELELIPVYLL
LAIWGGKNRQYAATKFIIYTAGSSIFILLAALAMGFYGTEIPNFEFSHLAAQDFSQKFQILCYVGLLIAFGVKLPIVPLH
TWLPDAHGEATAPVHMLLAGILLKMGGYALLRFNAQLLPVAHAQFAPLLIVLGVVNIIYAALTSFAQRNLKRKIAYSSIS
HMGFVLIGIGSFSSLGTSGAMLQMVSHGLIGASLFFLVGATYDRTKTLKLDEMSGVGQKMRIMFALWTACSLASLALPGM
SGFVSELMVFTGFVTDEVYTLPFRVVMASLAAIGVILTPIYLLSMLREIFFGKENPKLIEERKLIDAEPREVYIIACLLL
PIIGIGLYPRLVTESYIASINNLVDRDLTAIKSAAKANIFSGTKKNDILKAPTI

Specific function: NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton tran

COG id: COG1008

COG function: function code C; NADH:ubiquinone oxidoreductase subunit 4 (chain M)

Gene ontology:

Cell location: Cellular thylakoid membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 4 family [H]

Homologues:

Organism=Homo sapiens, GI251831116, Length=378, Percent_Identity=29.8941798941799, Blast_Score=133, Evalue=4e-31,
Organism=Escherichia coli, GI1788613, Length=517, Percent_Identity=36.5570599613153, Blast_Score=295, Evalue=6e-81,
Organism=Escherichia coli, GI1788831, Length=268, Percent_Identity=30.5970149253731, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1788827, Length=304, Percent_Identity=23.6842105263158, Blast_Score=93, Evalue=5e-20,
Organism=Escherichia coli, GI1788614, Length=450, Percent_Identity=23.5555555555556, Blast_Score=73, Evalue=5e-14,
Organism=Escherichia coli, GI2367154, Length=203, Percent_Identity=27.0935960591133, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI145693160, Length=384, Percent_Identity=24.4791666666667, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1788829, Length=267, Percent_Identity=28.4644194756554, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022997
- InterPro:   IPR010227
- InterPro:   IPR001750
- InterPro:   IPR003918 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: 1.6.5.3

Molecular weight: Translated: 58331; Mature: 58331

Theoretical pI: Translated: 8.67; Mature: 8.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLGTLGAGLSNFPWLSASILFPIGSAFVIPFFPDKGDGKEVRWFALSIALITFLITVGSY
CCCCCCCCCCCCCCCHHHHHEECCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHH
INGFDISNENVQLKENISWLPDLGLTWSVGADGMSMPLILLTSFITALAVLAAWPVKFKP
CCCCCCCCCCEEECCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCC
KLFFFLILVMDGGQIAVFAVQDMLLFFLTWELELIPVYLLLAIWGGKNRQYAATKFIIYT
HHHHHHHHEECCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEE
AGSSIFILLAALAMGFYGTEIPNFEFSHLAAQDFSQKFQILCYVGLLIAFGVKLPIVPLH
CCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHH
TWLPDAHGEATAPVHMLLAGILLKMGGYALLRFNAQLLPVAHAQFAPLLIVLGVVNIIYA
HHCCCCCCCCCCHHHHHHHHHHHHHCCEEEEEECCCEEEEHHHHHHHHHHHHHHHHHHHH
ALTSFAQRNLKRKIAYSSISHMGFVLIGIGSFSSLGTSGAMLQMVSHGLIGASLFFLVGA
HHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCHHHHHHHHCCHHHHHHHHHHCC
TYDRTKTLKLDEMSGVGQKMRIMFALWTACSLASLALPGMSGFVSELMVFTGFVTDEVYT
CCCCCEEEEEHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHH
LPFRVVMASLAAIGVILTPIYLLSMLREIFFGKENPKLIEERKLIDAEPREVYIIACLLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCCEEHHHHHHH
PIIGIGLYPRLVTESYIASINNLVDRDLTAIKSAAKANIFSGTKKNDILKAPTI
HHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure
MLGTLGAGLSNFPWLSASILFPIGSAFVIPFFPDKGDGKEVRWFALSIALITFLITVGSY
CCCCCCCCCCCCCCCHHHHHEECCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHH
INGFDISNENVQLKENISWLPDLGLTWSVGADGMSMPLILLTSFITALAVLAAWPVKFKP
CCCCCCCCCCEEECCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCC
KLFFFLILVMDGGQIAVFAVQDMLLFFLTWELELIPVYLLLAIWGGKNRQYAATKFIIYT
HHHHHHHHEECCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEE
AGSSIFILLAALAMGFYGTEIPNFEFSHLAAQDFSQKFQILCYVGLLIAFGVKLPIVPLH
CCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHH
TWLPDAHGEATAPVHMLLAGILLKMGGYALLRFNAQLLPVAHAQFAPLLIVLGVVNIIYA
HHCCCCCCCCCCHHHHHHHHHHHHHCCEEEEEECCCEEEEHHHHHHHHHHHHHHHHHHHH
ALTSFAQRNLKRKIAYSSISHMGFVLIGIGSFSSLGTSGAMLQMVSHGLIGASLFFLVGA
HHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCHHHHHHHHCCHHHHHHHHHHCC
TYDRTKTLKLDEMSGVGQKMRIMFALWTACSLASLALPGMSGFVSELMVFTGFVTDEVYT
CCCCCEEEEEHHHHCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCHHHH
LPFRVVMASLAAIGVILTPIYLLSMLREIFFGKENPKLIEERKLIDAEPREVYIIACLLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCCEEHHHHHHH
PIIGIGLYPRLVTESYIASINNLVDRDLTAIKSAAKANIFSGTKKNDILKAPTI
HHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NADH; H+; ubiquinone

Specific reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA