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The map label for this gene is hemD [H]

Identifier: 123967668

GI number: 123967668

Start: 124764

End: 125561

Strand: Direct

Name: hemD [H]

Synonym: A9601_01311

Alternate gene names: 123967668

Gene position: 124764-125561 (Clockwise)

Preceding gene: 123967667

Following gene: 123967671

Centisome position: 7.47

GC content: 31.08

Gene sequence:

>798_bases
ATGCCAAAAGTTGATCTACCCCTTGATCAAAGAAATATAATTATTACTCGATCAAAAGAAGGGATATTGGATATAAAAAA
GATATTCATAAGCAAGGGCGCTAATGTATTTGATTTACCTGCAATAAGTATTGGTGATCCAGATGATTTGAATCCTCTTG
ACGAAGCATTAAATCAAATAAATGATTTTCATTGGATTATTTTTTCCAGTAGTAATGGGATCAAATTTGTGGATAAAAGA
CTTAGATACTTTAATAGTTCATTAAAAGAATGTTCTAAAAAAACAAAAATCGCCGTAGTCGGAGAAAAAACCTCAAAAAC
TCTTGATGATTTTGGGATTAAGGCTGATTTCATACCTCCAGAATTTGTTGCTGAAAGTTTAATTGATAATTTCCCAGTAT
CTGGTTATGGACTTCGAGTTTTTGTACCAAGAGTTCAAACAGGTGGTAGGGATTTCATTGCAGATCAATTTAGAAAGGCT
GGTTCTCGTGTATTTGAGGTTGCTGCATATGAGACTAGATGTCCTGAATCAATTCCGGAAGAAACAATTGATATTATTTC
TAATCGAAAAGTTGATGCAATTATTTTCTCAAGTGGTAAAACCGTAGTAAATGCTGCTTTTTTACTAGAAAAAAATCTTG
GTAAAAAATGGTTAGAATATTTTGATCAAATTAAGTTATTAACTATTGGACCTCAGACAACAAAAATATGTAACAAGATT
TTTGGAAGATTTGATAGTCAGGCACAAAAATATACTTTTGAAGGACTACTAGATGTAGCAATTAATATTTTTAGTTAG

Upstream 100 bases:

>100_bases
ATTTTTAAAGACGATGTTGTTCTTGATAAAGGATTATCAGTCTTGAAACTTCTCGATGAATTAAAAAATAAAAATCAAAA
TCATAATGTTGAGGACAAGG

Downstream 100 bases:

>100_bases
AAAAATTTTTTGTATAGTTCTTTTCAACTAAATCTTTGAACCTATCAATATTGGCCTGTAATTCGTTTGTAACCATTTTG
CCTAAAATATTTTCTTCCAT

Product: putative uroporphyrinogen III synthase

Products: NA

Alternate protein names: UROS; Hydroxymethylbilane hydrolyase [cyclizing]; Uroporphyrinogen-III cosynthase [H]

Number of amino acids: Translated: 265; Mature: 264

Protein sequence:

>265_residues
MPKVDLPLDQRNIIITRSKEGILDIKKIFISKGANVFDLPAISIGDPDDLNPLDEALNQINDFHWIIFSSSNGIKFVDKR
LRYFNSSLKECSKKTKIAVVGEKTSKTLDDFGIKADFIPPEFVAESLIDNFPVSGYGLRVFVPRVQTGGRDFIADQFRKA
GSRVFEVAAYETRCPESIPEETIDIISNRKVDAIIFSSGKTVVNAAFLLEKNLGKKWLEYFDQIKLLTIGPQTTKICNKI
FGRFDSQAQKYTFEGLLDVAINIFS

Sequences:

>Translated_265_residues
MPKVDLPLDQRNIIITRSKEGILDIKKIFISKGANVFDLPAISIGDPDDLNPLDEALNQINDFHWIIFSSSNGIKFVDKR
LRYFNSSLKECSKKTKIAVVGEKTSKTLDDFGIKADFIPPEFVAESLIDNFPVSGYGLRVFVPRVQTGGRDFIADQFRKA
GSRVFEVAAYETRCPESIPEETIDIISNRKVDAIIFSSGKTVVNAAFLLEKNLGKKWLEYFDQIKLLTIGPQTTKICNKI
FGRFDSQAQKYTFEGLLDVAINIFS
>Mature_264_residues
PKVDLPLDQRNIIITRSKEGILDIKKIFISKGANVFDLPAISIGDPDDLNPLDEALNQINDFHWIIFSSSNGIKFVDKRL
RYFNSSLKECSKKTKIAVVGEKTSKTLDDFGIKADFIPPEFVAESLIDNFPVSGYGLRVFVPRVQTGGRDFIADQFRKAG
SRVFEVAAYETRCPESIPEETIDIISNRKVDAIIFSSGKTVVNAAFLLEKNLGKKWLEYFDQIKLLTIGPQTTKICNKIF
GRFDSQAQKYTFEGLLDVAINIFS

Specific function: Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III [H]

COG id: COG1587

COG function: function code H; Uroporphyrinogen-III synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen-III synthase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003754 [H]

Pfam domain/function: PF02602 HEM4 [H]

EC number: =4.2.1.75 [H]

Molecular weight: Translated: 29815; Mature: 29683

Theoretical pI: Translated: 8.02; Mature: 8.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
0.4 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKVDLPLDQRNIIITRSKEGILDIKKIFISKGANVFDLPAISIGDPDDLNPLDEALNQI
CCCCCCCCCCCCEEEEECCCCHHHHHHHHHHCCCCEEECCEECCCCCCCCCHHHHHHHHC
NDFHWIIFSSSNGIKFVDKRLRYFNSSLKECSKKTKIAVVGEKTSKTLDDFGIKADFIPP
CCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCEEEEEECCHHHHHHHCCCEECCCCH
EFVAESLIDNFPVSGYGLRVFVPRVQTGGRDFIADQFRKAGSRVFEVAAYETRCPESIPE
HHHHHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
ETIDIISNRKVDAIIFSSGKTVVNAAFLLEKNLGKKWLEYFDQIKLLTIGPQTTKICNKI
HHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHCCHHHHHHHHCEEEEEECCHHHHHHHHH
FGRFDSQAQKYTFEGLLDVAINIFS
HHCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PKVDLPLDQRNIIITRSKEGILDIKKIFISKGANVFDLPAISIGDPDDLNPLDEALNQI
CCCCCCCCCCCEEEEECCCCHHHHHHHHHHCCCCEEECCEECCCCCCCCCHHHHHHHHC
NDFHWIIFSSSNGIKFVDKRLRYFNSSLKECSKKTKIAVVGEKTSKTLDDFGIKADFIPP
CCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCEEEEEECCHHHHHHHCCCEECCCCH
EFVAESLIDNFPVSGYGLRVFVPRVQTGGRDFIADQFRKAGSRVFEVAAYETRCPESIPE
HHHHHHHHHCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHH
ETIDIISNRKVDAIIFSSGKTVVNAAFLLEKNLGKKWLEYFDQIKLLTIGPQTTKICNKI
HHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHCCHHHHHHHHCEEEEEECCHHHHHHHHH
FGRFDSQAQKYTFEGLLDVAINIFS
HHCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8123787 [H]