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The map label for this gene is nadB [H]

Identifier: 123967653

GI number: 123967653

Start: 114423

End: 116090

Strand: Direct

Name: nadB [H]

Synonym: A9601_01161

Alternate gene names: 123967653

Gene position: 114423-116090 (Clockwise)

Preceding gene: 123967652

Following gene: 123967655

Centisome position: 6.85

GC content: 33.75

Gene sequence:

>1668_bases
ATGTTAAGGCCTCCATTTTCGCAAGAACCGATACCAATCAACAATTGGGATGTAATCGTTATAGGCGCTGGAGCAGCTGG
CCTTATGACTTGTCTTGAATTACCCTCAAATTTAAAAGTGCTTCTTTTAAATAGAAATACTAGTAAGATATCTTCCAGTA
GATGGGCTCAAGGCGGAATTGCATCTGTTGTTAGACAAGATGATTCATTTGATCTTCATGCTGAGGATACTTTAAAAGCA
GGTGATGGATTATGTGATTTTCAAGCTGTAGAAATGTTAGTTAAAGAAGCTCCAGGATGTGTAGAAAGGTTGCAGAATTT
AGGGATGATTTTTGATCAAAGCTCTGATCAACTAGCTACTACCTTGGAAGCAGCCCATTCACGAAGAAGAGTCTTACATG
TTAAAGATCGTACTGGAAGAGCATTAGTTGAAGTTCTAGAAGATCATATTGAAAATGAAAAAAATATTCTTCATTGCAGG
GGTGTAAGAGTAACTGAACTTCTCATTGAGAATAAAGAATGTAGAGGAGTTCAGGTTCTTGATGGAGCAAATTTATATTG
GATTAAATCTAGAGCTGTTGTTTTGGCTACAGGTGGGGGTGGGCACTTATTTACAAATACAACGAATCCTGCTCAATCCT
CTGGTGAAGGGATTGCTCTTGCATGGAAAGCAGGAGCTGCTATCGAAGATTTAGAGTTCGTGCAATTTCATCCAACAGCT
TTAAAATTTTATGGTGCACCTTGCTTCTTAATATCTGAGGCGCTTAGAGGGGAAGGAGCGATATTAGTTGATAAAAATGG
TGAAAGTCCAGTTAAAAATCTTGAAAATCGTGATCTAGCAACTAGAGATCAGGTAAGTAGAGCAATTATGAAAAATATGC
ATGATAATAATGTAGACCATGTTGGCTTAGATCTTCGTTATATTGACCCAGAAAAAATTGTAGAGCGCTTCCCTACGATC
TTAAGTCGATGTCAGGATTATGGCGTTAACCCTTTAAATGAGGTTATTCCAGTAGCTCCTGCAGCTCATTATTGGATGGG
AGGTGTTAAAACTGATCTAAATGCATCTTCAACAAGAAAAGGATTATATGCCGTTGGAGAAGTTGCTTCTACAGGTGTGC
ATGGTGCTAATAGACTGGCAAGTAATTCATTGATGGAGTGTCTTGTTTTCGCAAGAAAAATGTCTTCAATTGTTTTGAAT
GACTTTTCTAAATTTGAAAAATTTGATAGATCATTTCAAGAGTTTAATATTGAAGATCCTAAAGAACATCAAATTTCTAT
AATTGCTGAAAAAATTGATGAACTAAGAAAACTTTGTTGGTTAAATTTAGGTGTATCGCGAAATAAGGTAAATATGAGTA
AATTTTTAAATTATATTCAAAATGATATAGATAAATTAAATAAAAATGATTTACTAAATAGTCTTGAAAAAATAAAATTT
GATCAAAAAATAAAACTTAGTGAACGTAATAGAAGAGCATTAAATCTTTTACTTGATTTAAAGAATAGACAAATAACAAC
AATAACTTTATTAAAAGCTTGTCTCTTTAGAGAAGAAAGTAGAGGAGGGCATTATAGAGATGATTTCCCTGATAAAGATA
AAAATTGGGAATGCCATACTAGACAACAGTTAGATCAAAAAATTCAAAAAAGATTTATTAAAAATTAA

Upstream 100 bases:

>100_bases
CACTCTTAGTTTCTGGTTACGTAATTCAAACGACATTAATTGTTGATGGTATTTTTATTGTTTTAGCAATTCTGCAACCA
ACTTTTAGTGGATTGGTTTA

Downstream 100 bases:

>100_bases
GATCTCCATGATAGTCGGTTTTTGTCGCTAATTCATTTAAGTCACGCGTACCACTAATAATTTCTCCATTGATTTCCCAA
GAAGGAAATCCACTTATTCC

Product: L-aspartate oxidase

Products: NA

Alternate protein names: LASPO; Quinolinate synthase B [H]

Number of amino acids: Translated: 555; Mature: 555

Protein sequence:

>555_residues
MLRPPFSQEPIPINNWDVIVIGAGAAGLMTCLELPSNLKVLLLNRNTSKISSSRWAQGGIASVVRQDDSFDLHAEDTLKA
GDGLCDFQAVEMLVKEAPGCVERLQNLGMIFDQSSDQLATTLEAAHSRRRVLHVKDRTGRALVEVLEDHIENEKNILHCR
GVRVTELLIENKECRGVQVLDGANLYWIKSRAVVLATGGGGHLFTNTTNPAQSSGEGIALAWKAGAAIEDLEFVQFHPTA
LKFYGAPCFLISEALRGEGAILVDKNGESPVKNLENRDLATRDQVSRAIMKNMHDNNVDHVGLDLRYIDPEKIVERFPTI
LSRCQDYGVNPLNEVIPVAPAAHYWMGGVKTDLNASSTRKGLYAVGEVASTGVHGANRLASNSLMECLVFARKMSSIVLN
DFSKFEKFDRSFQEFNIEDPKEHQISIIAEKIDELRKLCWLNLGVSRNKVNMSKFLNYIQNDIDKLNKNDLLNSLEKIKF
DQKIKLSERNRRALNLLLDLKNRQITTITLLKACLFREESRGGHYRDDFPDKDKNWECHTRQQLDQKIQKRFIKN

Sequences:

>Translated_555_residues
MLRPPFSQEPIPINNWDVIVIGAGAAGLMTCLELPSNLKVLLLNRNTSKISSSRWAQGGIASVVRQDDSFDLHAEDTLKA
GDGLCDFQAVEMLVKEAPGCVERLQNLGMIFDQSSDQLATTLEAAHSRRRVLHVKDRTGRALVEVLEDHIENEKNILHCR
GVRVTELLIENKECRGVQVLDGANLYWIKSRAVVLATGGGGHLFTNTTNPAQSSGEGIALAWKAGAAIEDLEFVQFHPTA
LKFYGAPCFLISEALRGEGAILVDKNGESPVKNLENRDLATRDQVSRAIMKNMHDNNVDHVGLDLRYIDPEKIVERFPTI
LSRCQDYGVNPLNEVIPVAPAAHYWMGGVKTDLNASSTRKGLYAVGEVASTGVHGANRLASNSLMECLVFARKMSSIVLN
DFSKFEKFDRSFQEFNIEDPKEHQISIIAEKIDELRKLCWLNLGVSRNKVNMSKFLNYIQNDIDKLNKNDLLNSLEKIKF
DQKIKLSERNRRALNLLLDLKNRQITTITLLKACLFREESRGGHYRDDFPDKDKNWECHTRQQLDQKIQKRFIKN
>Mature_555_residues
MLRPPFSQEPIPINNWDVIVIGAGAAGLMTCLELPSNLKVLLLNRNTSKISSSRWAQGGIASVVRQDDSFDLHAEDTLKA
GDGLCDFQAVEMLVKEAPGCVERLQNLGMIFDQSSDQLATTLEAAHSRRRVLHVKDRTGRALVEVLEDHIENEKNILHCR
GVRVTELLIENKECRGVQVLDGANLYWIKSRAVVLATGGGGHLFTNTTNPAQSSGEGIALAWKAGAAIEDLEFVQFHPTA
LKFYGAPCFLISEALRGEGAILVDKNGESPVKNLENRDLATRDQVSRAIMKNMHDNNVDHVGLDLRYIDPEKIVERFPTI
LSRCQDYGVNPLNEVIPVAPAAHYWMGGVKTDLNASSTRKGLYAVGEVASTGVHGANRLASNSLMECLVFARKMSSIVLN
DFSKFEKFDRSFQEFNIEDPKEHQISIIAEKIDELRKLCWLNLGVSRNKVNMSKFLNYIQNDIDKLNKNDLLNSLEKIKF
DQKIKLSERNRRALNLLLDLKNRQITTITLLKACLFREESRGGHYRDDFPDKDKNWECHTRQQLDQKIQKRFIKN

Specific function: Catalyzes the oxidation of L-aspartate to iminoaspartate [H]

COG id: COG0029

COG function: function code H; Aspartate oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=518, Percent_Identity=31.6602316602317, Blast_Score=213, Evalue=5e-55,
Organism=Escherichia coli, GI1788928, Length=547, Percent_Identity=36.3802559414991, Blast_Score=310, Evalue=2e-85,
Organism=Escherichia coli, GI1790597, Length=377, Percent_Identity=35.5437665782493, Blast_Score=212, Evalue=5e-56,
Organism=Escherichia coli, GI1786942, Length=574, Percent_Identity=30.4878048780488, Blast_Score=204, Evalue=9e-54,
Organism=Caenorhabditis elegans, GI17550100, Length=561, Percent_Identity=32.0855614973262, Blast_Score=209, Evalue=3e-54,
Organism=Caenorhabditis elegans, GI17505833, Length=566, Percent_Identity=30.3886925795053, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI71986328, Length=420, Percent_Identity=28.5714285714286, Blast_Score=107, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6322416, Length=583, Percent_Identity=30.8747855917667, Blast_Score=198, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6322701, Length=529, Percent_Identity=30.0567107750473, Blast_Score=191, Evalue=3e-49,
Organism=Saccharomyces cerevisiae, GI6322511, Length=462, Percent_Identity=27.7056277056277, Blast_Score=104, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6320788, Length=481, Percent_Identity=26.8191268191268, Blast_Score=101, Evalue=3e-22,
Organism=Drosophila melanogaster, GI17137288, Length=597, Percent_Identity=30.1507537688442, Blast_Score=205, Evalue=6e-53,
Organism=Drosophila melanogaster, GI24655642, Length=597, Percent_Identity=30.1507537688442, Blast_Score=205, Evalue=6e-53,
Organism=Drosophila melanogaster, GI24655647, Length=597, Percent_Identity=30.1507537688442, Blast_Score=205, Evalue=6e-53,
Organism=Drosophila melanogaster, GI24663005, Length=520, Percent_Identity=30.1923076923077, Blast_Score=181, Evalue=1e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR005288 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.4.3.16 [H]

Molecular weight: Translated: 62430; Mature: 62430

Theoretical pI: Translated: 7.54; Mature: 7.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRPPFSQEPIPINNWDVIVIGAGAAGLMTCLELPSNLKVLLLNRNTSKISSSRWAQGGI
CCCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHCCCCCEEEEEECCCHHHHHHHCCCCCH
ASVVRQDDSFDLHAEDTLKAGDGLCDFQAVEMLVKEAPGCVERLQNLGMIFDQSSDQLAT
HHHHHCCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHCCHHHHHHHHCCEEEECCCHHHHH
TLEAAHSRRRVLHVKDRTGRALVEVLEDHIENEKNILHCRGVRVTELLIENKECRGVQVL
HHHHHHHHCEEEEECCCCHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHCCCCCCCEEEE
DGANLYWIKSRAVVLATGGGGHLFTNTTNPAQSSGEGIALAWKAGAAIEDLEFVQFHPTA
CCCCEEEEECCEEEEEECCCCEEEECCCCCCCCCCCCEEEEEECCCCHHCCHHEEECCHH
LKFYGAPCFLISEALRGEGAILVDKNGESPVKNLENRDLATRDQVSRAIMKNMHDNNVDH
HHHCCCHHHHHHHHHCCCCEEEEECCCCCHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCE
VGLDLRYIDPEKIVERFPTILSRCQDYGVNPLNEVIPVAPAAHYWMGGVKTDLNASSTRK
EEEEEEECCHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCHHHHHCCCCCCCCCCCHHCC
GLYAVGEVASTGVHGANRLASNSLMECLVFARKMSSIVLNDFSKFEKFDRSFQEFNIEDP
CHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
KEHQISIIAEKIDELRKLCWLNLGVSRNKVNMSKFLNYIQNDIDKLNKNDLLNSLEKIKF
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCC
DQKIKLSERNRRALNLLLDLKNRQITTITLLKACLFREESRGGHYRDDFPDKDKNWECHT
CCCCCCCHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHH
RQQLDQKIQKRFIKN
HHHHHHHHHHHHCCC
>Mature Secondary Structure
MLRPPFSQEPIPINNWDVIVIGAGAAGLMTCLELPSNLKVLLLNRNTSKISSSRWAQGGI
CCCCCCCCCCCCCCCCCEEEECCCHHHHHHHHHCCCCCEEEEEECCCHHHHHHHCCCCCH
ASVVRQDDSFDLHAEDTLKAGDGLCDFQAVEMLVKEAPGCVERLQNLGMIFDQSSDQLAT
HHHHHCCCCCCCCCCHHHHCCCCCCHHHHHHHHHHHCCHHHHHHHHCCEEEECCCHHHHH
TLEAAHSRRRVLHVKDRTGRALVEVLEDHIENEKNILHCRGVRVTELLIENKECRGVQVL
HHHHHHHHCEEEEECCCCHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHCCCCCCCEEEE
DGANLYWIKSRAVVLATGGGGHLFTNTTNPAQSSGEGIALAWKAGAAIEDLEFVQFHPTA
CCCCEEEEECCEEEEEECCCCEEEECCCCCCCCCCCCEEEEEECCCCHHCCHHEEECCHH
LKFYGAPCFLISEALRGEGAILVDKNGESPVKNLENRDLATRDQVSRAIMKNMHDNNVDH
HHHCCCHHHHHHHHHCCCCEEEEECCCCCHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCE
VGLDLRYIDPEKIVERFPTILSRCQDYGVNPLNEVIPVAPAAHYWMGGVKTDLNASSTRK
EEEEEEECCHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCHHHHHCCCCCCCCCCCHHCC
GLYAVGEVASTGVHGANRLASNSLMECLVFARKMSSIVLNDFSKFEKFDRSFQEFNIEDP
CHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
KEHQISIIAEKIDELRKLCWLNLGVSRNKVNMSKFLNYIQNDIDKLNKNDLLNSLEKIKF
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCC
DQKIKLSERNRRALNLLLDLKNRQITTITLLKACLFREESRGGHYRDDFPDKDKNWECHT
CCCCCCCHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHH
RQQLDQKIQKRFIKN
HHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]