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The map label for this gene is ndk [H]

Identifier: 123967584

GI number: 123967584

Start: 50925

End: 51383

Strand: Direct

Name: ndk [H]

Synonym: A9601_00471

Alternate gene names: 123967584

Gene position: 50925-51383 (Clockwise)

Preceding gene: 123967582

Following gene: 123967586

Centisome position: 3.05

GC content: 35.08

Gene sequence:

>459_bases
ATGACCAAAGAGAGAACCTTTATTGCAATTAAACCAGATGGAGTTCAAAGAGGATATGTTTCTGAGATTCTTGGCAGATT
TGAAAAAAAAGGATTTAAATTGGTTGGATTAAAGCAATTAATTCCTTCAAAAGAACTTGCTCAAAATCATTATGGAGTAC
ATAGAGAAAGACCCTTTTTTGGTGATTTAGTAGACTTTATTTCAAGTGGTCCTGTTGTAGCAATGGTGTGGGAAGGCGAA
GGAGTTATTTTGAGTGCTAGAAAACTAATAGGTGCAACAAAACCTCTGGAAGCAGAGCCTGGAACAATTAGAGGTGATTT
AGCTATTGATATTGGGAGGAATATTATTCATGGTTCTGATGGAGAAGATACAGCAAAATTTGAAATTAATCTATGGTTTA
ACGAAGAGGAATTATGTGAGTGGGAAACTTCTGATTCGAAATGGCGATCTGAAAATTAA

Upstream 100 bases:

>100_bases
ATGTTTTTGAAAATAACTTAAAACAATATCTTTTATTTTAATGATTACTTGCCAAGTTACCACCCAAAAGTTGAATATAC
ATAGAGTGATTATTAACTAA

Downstream 100 bases:

>100_bases
AATTTAAATCGCAAATCTATCTAAACTAAATTTTTCTAAAAAGCTTTTCTCTATTTCTTTGAGATTTTTATTTTGAACTA
TTTTCAAAAGAAGATCACTT

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase [H]

Number of amino acids: Translated: 152; Mature: 151

Protein sequence:

>152_residues
MTKERTFIAIKPDGVQRGYVSEILGRFEKKGFKLVGLKQLIPSKELAQNHYGVHRERPFFGDLVDFISSGPVVAMVWEGE
GVILSARKLIGATKPLEAEPGTIRGDLAIDIGRNIIHGSDGEDTAKFEINLWFNEEELCEWETSDSKWRSEN

Sequences:

>Translated_152_residues
MTKERTFIAIKPDGVQRGYVSEILGRFEKKGFKLVGLKQLIPSKELAQNHYGVHRERPFFGDLVDFISSGPVVAMVWEGE
GVILSARKLIGATKPLEAEPGTIRGDLAIDIGRNIIHGSDGEDTAKFEINLWFNEEELCEWETSDSKWRSEN
>Mature_151_residues
TKERTFIAIKPDGVQRGYVSEILGRFEKKGFKLVGLKQLIPSKELAQNHYGVHRERPFFGDLVDFISSGPVVAMVWEGEG
VILSARKLIGATKPLEAEPGTIRGDLAIDIGRNIIHGSDGEDTAKFEINLWFNEEELCEWETSDSKWRSEN

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate [H]

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family [H]

Homologues:

Organism=Homo sapiens, GI37693993, Length=148, Percent_Identity=58.1081081081081, Blast_Score=182, Evalue=1e-46,
Organism=Homo sapiens, GI38045913, Length=148, Percent_Identity=56.0810810810811, Blast_Score=175, Evalue=1e-44,
Organism=Homo sapiens, GI4557797, Length=148, Percent_Identity=56.0810810810811, Blast_Score=175, Evalue=2e-44,
Organism=Homo sapiens, GI66392203, Length=148, Percent_Identity=55.4054054054054, Blast_Score=171, Evalue=2e-43,
Organism=Homo sapiens, GI66392227, Length=148, Percent_Identity=55.4054054054054, Blast_Score=171, Evalue=3e-43,
Organism=Homo sapiens, GI66392205, Length=148, Percent_Identity=55.4054054054054, Blast_Score=171, Evalue=3e-43,
Organism=Homo sapiens, GI4505409, Length=148, Percent_Identity=55.4054054054054, Blast_Score=171, Evalue=3e-43,
Organism=Homo sapiens, GI66392192, Length=148, Percent_Identity=55.4054054054054, Blast_Score=171, Evalue=3e-43,
Organism=Homo sapiens, GI4826862, Length=140, Percent_Identity=50.7142857142857, Blast_Score=157, Evalue=4e-39,
Organism=Homo sapiens, GI7019465, Length=134, Percent_Identity=32.8358208955224, Blast_Score=74, Evalue=3e-14,
Organism=Homo sapiens, GI37574614, Length=134, Percent_Identity=32.8358208955224, Blast_Score=74, Evalue=4e-14,
Organism=Homo sapiens, GI5031951, Length=140, Percent_Identity=32.1428571428571, Blast_Score=69, Evalue=2e-12,
Organism=Escherichia coli, GI1788866, Length=139, Percent_Identity=44.6043165467626, Blast_Score=122, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17506807, Length=140, Percent_Identity=54.2857142857143, Blast_Score=166, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI17507605, Length=87, Percent_Identity=41.3793103448276, Blast_Score=65, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322783, Length=145, Percent_Identity=57.2413793103448, Blast_Score=185, Evalue=3e-48,
Organism=Drosophila melanogaster, GI45549037, Length=149, Percent_Identity=57.0469798657718, Blast_Score=178, Evalue=1e-45,
Organism=Drosophila melanogaster, GI18860097, Length=135, Percent_Identity=32.5925925925926, Blast_Score=79, Evalue=9e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001564
- InterPro:   IPR023005 [H]

Pfam domain/function: PF00334 NDK [H]

EC number: =2.7.4.6 [H]

Molecular weight: Translated: 17106; Mature: 16974

Theoretical pI: Translated: 5.09; Mature: 5.09

Prosite motif: PS00469 NDP_KINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKERTFIAIKPDGVQRGYVSEILGRFEKKGFKLVGLKQLIPSKELAQNHYGVHRERPFF
CCCCCEEEEECCCCCCCCHHHHHHHHHHHCCEEEECHHHHCCCHHHHHHHCCCCCCCCCH
GDLVDFISSGPVVAMVWEGEGVILSARKLIGATKPLEAEPGTIRGDLAIDIGRNIIHGSD
HHHHHHHCCCCEEEEEECCCCEEEECHHHHCCCCCCCCCCCEEECEEEEECCCCEEECCC
GEDTAKFEINLWFNEEELCEWETSDSKWRSEN
CCCEEEEEEEEEECHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
TKERTFIAIKPDGVQRGYVSEILGRFEKKGFKLVGLKQLIPSKELAQNHYGVHRERPFF
CCCCEEEEECCCCCCCCHHHHHHHHHHHCCEEEECHHHHCCCHHHHHHHCCCCCCCCCH
GDLVDFISSGPVVAMVWEGEGVILSARKLIGATKPLEAEPGTIRGDLAIDIGRNIIHGSD
HHHHHHHCCCCEEEEEECCCCEEEECHHHHCCCCCCCCCCCEEECEEEEECCCCEEECCC
GEDTAKFEINLWFNEEELCEWETSDSKWRSEN
CCCEEEEEEEEEECHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA