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The map label for this gene is aroE

Identifier: 123967129

GI number: 123967129

Start: 1689679

End: 1690536

Strand: Direct

Name: aroE

Synonym: P9515_18961

Alternate gene names: 123967129

Gene position: 1689679-1690536 (Clockwise)

Preceding gene: 123967127

Following gene: 123967130

Centisome position: 99.15

GC content: 28.79

Gene sequence:

>858_bases
ATGATTACAAGTAATACATCTTTTCTTGCTTTAATTGGAAACCCAGTAAGCCACTCTTTATCTCCAATCATGCAAAATGC
AGCTATAAAATATTTAGGTCTTGATTTAATTTACATAGCAATTCCCTGTAAAAATGAAGACTTAGAAATTGTTGTAAATT
CTCTAAAAAAAATGAATTGTAAAGGCTTAAATATTACAATTCCATTTAAAAAGAAAGTATTTGATCTCTGCAGTGAAATA
TCACCAGTTGCAAAAAAAATACAGGCTATAAATACTCTTAAACTTAAAAATGATAATAATTGGAGTGGTACAAATACTGA
TATTGAAGGGTTTATCTACCCTTTAAAAAACCTAAATTTAACAAACAAAAATTCGATAATTTTGGGTTCTGGAGGCGCTG
CAAGATCAGTAATTCAAGGTCTTATAGATTTAAAATTATCGAAAATCACCATTATCTCAAGGAATAATAACTCTTTAAAT
GAGCTAATTACCCTTTTTAAAAATGACATCAAAATAGAGGGAATACTAAATACTAATGATGAAATTGGTAACTTAATTGA
AGAAACAGATTTAATAGTCAATACAACTCCAATAGGAATGAGTCAAACCTCAGATAATGATGCAATACCATTTGGGCAAT
CGTCTTGGGAAACTATTGATTCAAATACAATTGTTTATGATCTTATTTACAATCCTTCACCTACTCCTTTTTTAAAGTTT
TGCGATAGAAAAGGATGTATGACTATAGATGGTACTCAAATGCTAATTGCTCAAGGAGCAAAATCATTATCATTTTGGAC
AAATGGTTTAGAAGTACCTTTTGAAGTAATGCATGATGCACTAAAAAAATATCTTTAA

Upstream 100 bases:

>100_bases
TAATATTCTCCATAATCGGTCATTGACGACATTATTGTTACTCTAAAACGAGGTGTGGTTCCCGAACAGATCACAATTTT
TTTTAAAAATTTCTCTAAAA

Downstream 100 bases:

>100_bases
CCAGATAAAAAGCTCATTATTATTAAGAATATGACCTTGATAATGTATCGTATGTAATGTACAGACGCTCATTAACAAAT
TTACGAGCCAAAGACCTTGT

Product: shikimate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 285; Mature: 285

Protein sequence:

>285_residues
MITSNTSFLALIGNPVSHSLSPIMQNAAIKYLGLDLIYIAIPCKNEDLEIVVNSLKKMNCKGLNITIPFKKKVFDLCSEI
SPVAKKIQAINTLKLKNDNNWSGTNTDIEGFIYPLKNLNLTNKNSIILGSGGAARSVIQGLIDLKLSKITIISRNNNSLN
ELITLFKNDIKIEGILNTNDEIGNLIEETDLIVNTTPIGMSQTSDNDAIPFGQSSWETIDSNTIVYDLIYNPSPTPFLKF
CDRKGCMTIDGTQMLIAQGAKSLSFWTNGLEVPFEVMHDALKKYL

Sequences:

>Translated_285_residues
MITSNTSFLALIGNPVSHSLSPIMQNAAIKYLGLDLIYIAIPCKNEDLEIVVNSLKKMNCKGLNITIPFKKKVFDLCSEI
SPVAKKIQAINTLKLKNDNNWSGTNTDIEGFIYPLKNLNLTNKNSIILGSGGAARSVIQGLIDLKLSKITIISRNNNSLN
ELITLFKNDIKIEGILNTNDEIGNLIEETDLIVNTTPIGMSQTSDNDAIPFGQSSWETIDSNTIVYDLIYNPSPTPFLKF
CDRKGCMTIDGTQMLIAQGAKSLSFWTNGLEVPFEVMHDALKKYL
>Mature_285_residues
MITSNTSFLALIGNPVSHSLSPIMQNAAIKYLGLDLIYIAIPCKNEDLEIVVNSLKKMNCKGLNITIPFKKKVFDLCSEI
SPVAKKIQAINTLKLKNDNNWSGTNTDIEGFIYPLKNLNLTNKNSIILGSGGAARSVIQGLIDLKLSKITIISRNNNSLN
ELITLFKNDIKIEGILNTNDEIGNLIEETDLIVNTTPIGMSQTSDNDAIPFGQSSWETIDSNTIVYDLIYNPSPTPFLKF
CDRKGCMTIDGTQMLIAQGAKSLSFWTNGLEVPFEVMHDALKKYL

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; fourth step. [C]

COG id: COG0169

COG function: function code E; Shikimate 5-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1787983, Length=296, Percent_Identity=27.3648648648649, Blast_Score=128, Evalue=4e-31,
Organism=Escherichia coli, GI1789675, Length=260, Percent_Identity=33.0769230769231, Blast_Score=122, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6320332, Length=290, Percent_Identity=28.2758620689655, Blast_Score=94, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROE_PROM5 (A2BZ92)

Other databases:

- EMBL:   CP000552
- RefSeq:   YP_001012210.1
- ProteinModelPortal:   A2BZ92
- SMR:   A2BZ92
- STRING:   A2BZ92
- GeneID:   4720546
- GenomeReviews:   CP000552_GR
- KEGG:   pmc:P9515_18961
- eggNOG:   COG0169
- HOGENOM:   HBG553408
- OMA:   NEDLEIV
- ProtClustDB:   PRK00258
- GO:   GO:0005737
- HAMAP:   MF_00222
- InterPro:   IPR016040
- InterPro:   IPR011342
- InterPro:   IPR013708
- InterPro:   IPR022893
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR00507

Pfam domain/function: PF01488 Shikimate_DH; PF08501 Shikimate_dh_N

EC number: =1.1.1.25

Molecular weight: Translated: 31449; Mature: 31449

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: NA

Important sites: ACT_SITE 70-70

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITSNTSFLALIGNPVSHSLSPIMQNAAIKYLGLDLIYIAIPCKNEDLEIVVNSLKKMNC
CCCCCCCEEEEECCCHHHHHHHHHHHHHHHHCCEEEEEEEEECCCCCHHHHHHHHHHCCC
KGLNITIPFKKKVFDLCSEISPVAKKIQAINTLKLKNDNNWSGTNTDIEGFIYPLKNLNL
CCEEEEECHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCEEEEECCCCCC
TNKNSIILGSGGAARSVIQGLIDLKLSKITIISRNNNSLNELITLFKNDIKIEGILNTND
CCCCEEEEECCCHHHHHHHHHHHCEEEEEEEEECCCCCHHHHHHHHHCCEEEEEEECCCH
EIGNLIEETDLIVNTTPIGMSQTSDNDAIPFGQSSWETIDSNTIVYDLIYNPSPTPFLKF
HHHHHHHHCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCHHHHH
CDRKGCMTIDGTQMLIAQGAKSLSFWTNGLEVPFEVMHDALKKYL
HCCCCCEEECCCHHHHHCCCCHHHHHCCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MITSNTSFLALIGNPVSHSLSPIMQNAAIKYLGLDLIYIAIPCKNEDLEIVVNSLKKMNC
CCCCCCCEEEEECCCHHHHHHHHHHHHHHHHCCEEEEEEEEECCCCCHHHHHHHHHHCCC
KGLNITIPFKKKVFDLCSEISPVAKKIQAINTLKLKNDNNWSGTNTDIEGFIYPLKNLNL
CCEEEEECHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCEEEEECCCCCC
TNKNSIILGSGGAARSVIQGLIDLKLSKITIISRNNNSLNELITLFKNDIKIEGILNTND
CCCCEEEEECCCHHHHHHHHHHHCEEEEEEEEECCCCCHHHHHHHHHCCEEEEEEECCCH
EIGNLIEETDLIVNTTPIGMSQTSDNDAIPFGQSSWETIDSNTIVYDLIYNPSPTPFLKF
HHHHHHHHCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCCHHHHH
CDRKGCMTIDGTQMLIAQGAKSLSFWTNGLEVPFEVMHDALKKYL
HCCCCCEEECCCHHHHHCCCCHHHHHCCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA