Click here to switch to the map view.

The map label for this gene is dnaX [H]

Identifier: 123967081

GI number: 123967081

Start: 1635916

End: 1637703

Strand: Direct

Name: dnaX [H]

Synonym: P9515_18481

Alternate gene names: 123967081

Gene position: 1635916-1637703 (Clockwise)

Preceding gene: 123967080

Following gene: 123967084

Centisome position: 95.99

GC content: 28.24

Gene sequence:

>1788_bases
ATGCTTAATATACATAAACCTTTTCATCAAAAATATAGGCCTAGCAACCTTGATGAGCTAGTTGGTCAAGAATTTATATC
AATAACCCTTAAACAAGCACTAATATCTAAGAAAATTGCACCTGCTTATCTGTTTAATGGGCCTAGAGGAACTGGAAAGA
CATCAAGTGCACGAATATTTGCAAAATCATTAAATTGTCTATCATGTGAACAGCCTACGGCTAATCCTTGTGGCAAATGC
GAATTATGTAAACAAATTGCAGATGGTAATGCCCTTGATATTATTGAAATTGATGCTGCTTCTAATACTGGGGTTGATAA
TATAAGAGAAATAATAGATGGAGCAAGATTCACTCCTACTCAAGCCAGGTGGAAAGTATACGTTATCGATGAATGTCATA
TGCTCTCAACTGCAGCATCAAATGCTTTACTCAAAACTATTGAAGAACCTCCCGAAAGAGTTGTTTTTATTCTTGCTACT
ACAAATCCGGAAAGAGTAATAAATACTATTCAAAGTAGGTGTCAAAAATTCGATTTTAAAAGAATCAGCTCAAATACTAT
TTTCCACAACCTTTCAGAAATAGCGAATAAAGAATCAATTAAATTTGAAGATCAAGCACTAAAATTAATTGCAAAAAGAT
CTAATGGTGGAATGCGTGATGCACAAAGTTTACTAGATCAATTAAGTCTTCTTCCTAATGGCGTAACTACTAAAAATGTT
CAAAACTTACTTGGAGAAGTATCCGAAAATGATTTAATTAATTTAATAAATGCCTTAATTTACAATGAACCAGAGTCGTT
ATTAATTAGTTGCAATCAATTATATGATTCAGGAAATGAACCTCATGAGATATTAGTTGGTTTATTAAATATTACTAGAG
ACCTATTATTGAAAACTTTAAATAACAATTATTCAGATATTTTCTATACCTCCATTGACTTTCAAAATGAATTAAATAAA
TTTTCTAAAAACATTAGTAAAATGAGGATAATTGATTGGCATAACAAGCTTAAAAATATTGATTATCAAATCAAAACAAG
TGATAATCCAAAATTATGGTTAGAAGTACATTTAACAAGCCTTATTGAAAATAAGATCGAAGACAACATAGTTAATAATG
GACAAAGTAATAAAGAGACTTTAAATCAAAAGGTTATTAATAAAGATGAATTAATTAATAAAACAATCATTTCTAAAAAT
GCAAATCAAACTGAATCAGAAGATATTAATAAAAAGGAATTAATTAATAATCAAGATATTCAGCCTAATTATGAAAATGC
AAATCAAACTGAATCAGAAGATATTAATAAAAAGGAATTAATTAATAATCAAGATATTCAGCCTAATTATGAGCATGCAA
ATCAAACTGACTTTTTAAAAGAAAAGTGGGAGCTAATTCTATCTAAATTAGAATTGCCTTCGACAAGAATGTTACTTTCT
CAGCAAGCAGAACTAGCAAGTATTGATTCGAATGAAGTTTTAATAGCATTATCTCCCAACTGGGAAAACATGATCAAAAG
TCGAAAAATAATAATTGAAAATGCTGTAAAAAAAGTTTGTGGAGATAAAGTAAAACTTAACTTTTCTAGCAAAAAAATTA
ATATTAATAATACTGCAAAATCTCAAGAGAAAATAATTAAAAAATCAACTAGTAATAGGGAAATACAAAATACCAATTTT
CAAAATTCCAACACCCCTATAGAAAAACCTCAAAAAGAATTTTATGATGACAATTCCAAAAATCTAGCAAATTTTTTTAA
CGGAGAAATTATTGATTTGGATGAATAA

Upstream 100 bases:

>100_bases
AAACTTCCTGCAGGTTCACATAGGATTATTAAAGAATCTGCATAAAAGTAAGGTTAACTCTCTATGATTTCAAGATTATT
CATATAATTAATAATCATAA

Downstream 100 bases:

>100_bases
GTTAAACACCAGTATGAAGTGTTTTCTTCCAGAGAATCTTTTTCGGAAAAATAGACATTTTTATTGTCACCCAGGGTATT
ACAACAAACCAATGAGACAA

Product: DNA polymerase, gamma and tau subunits

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 595; Mature: 595

Protein sequence:

>595_residues
MLNIHKPFHQKYRPSNLDELVGQEFISITLKQALISKKIAPAYLFNGPRGTGKTSSARIFAKSLNCLSCEQPTANPCGKC
ELCKQIADGNALDIIEIDAASNTGVDNIREIIDGARFTPTQARWKVYVIDECHMLSTAASNALLKTIEEPPERVVFILAT
TNPERVINTIQSRCQKFDFKRISSNTIFHNLSEIANKESIKFEDQALKLIAKRSNGGMRDAQSLLDQLSLLPNGVTTKNV
QNLLGEVSENDLINLINALIYNEPESLLISCNQLYDSGNEPHEILVGLLNITRDLLLKTLNNNYSDIFYTSIDFQNELNK
FSKNISKMRIIDWHNKLKNIDYQIKTSDNPKLWLEVHLTSLIENKIEDNIVNNGQSNKETLNQKVINKDELINKTIISKN
ANQTESEDINKKELINNQDIQPNYENANQTESEDINKKELINNQDIQPNYEHANQTDFLKEKWELILSKLELPSTRMLLS
QQAELASIDSNEVLIALSPNWENMIKSRKIIIENAVKKVCGDKVKLNFSSKKININNTAKSQEKIIKKSTSNREIQNTNF
QNSNTPIEKPQKEFYDDNSKNLANFFNGEIIDLDE

Sequences:

>Translated_595_residues
MLNIHKPFHQKYRPSNLDELVGQEFISITLKQALISKKIAPAYLFNGPRGTGKTSSARIFAKSLNCLSCEQPTANPCGKC
ELCKQIADGNALDIIEIDAASNTGVDNIREIIDGARFTPTQARWKVYVIDECHMLSTAASNALLKTIEEPPERVVFILAT
TNPERVINTIQSRCQKFDFKRISSNTIFHNLSEIANKESIKFEDQALKLIAKRSNGGMRDAQSLLDQLSLLPNGVTTKNV
QNLLGEVSENDLINLINALIYNEPESLLISCNQLYDSGNEPHEILVGLLNITRDLLLKTLNNNYSDIFYTSIDFQNELNK
FSKNISKMRIIDWHNKLKNIDYQIKTSDNPKLWLEVHLTSLIENKIEDNIVNNGQSNKETLNQKVINKDELINKTIISKN
ANQTESEDINKKELINNQDIQPNYENANQTESEDINKKELINNQDIQPNYEHANQTDFLKEKWELILSKLELPSTRMLLS
QQAELASIDSNEVLIALSPNWENMIKSRKIIIENAVKKVCGDKVKLNFSSKKININNTAKSQEKIIKKSTSNREIQNTNF
QNSNTPIEKPQKEFYDDNSKNLANFFNGEIIDLDE
>Mature_595_residues
MLNIHKPFHQKYRPSNLDELVGQEFISITLKQALISKKIAPAYLFNGPRGTGKTSSARIFAKSLNCLSCEQPTANPCGKC
ELCKQIADGNALDIIEIDAASNTGVDNIREIIDGARFTPTQARWKVYVIDECHMLSTAASNALLKTIEEPPERVVFILAT
TNPERVINTIQSRCQKFDFKRISSNTIFHNLSEIANKESIKFEDQALKLIAKRSNGGMRDAQSLLDQLSLLPNGVTTKNV
QNLLGEVSENDLINLINALIYNEPESLLISCNQLYDSGNEPHEILVGLLNITRDLLLKTLNNNYSDIFYTSIDFQNELNK
FSKNISKMRIIDWHNKLKNIDYQIKTSDNPKLWLEVHLTSLIENKIEDNIVNNGQSNKETLNQKVINKDELINKTIISKN
ANQTESEDINKKELINNQDIQPNYENANQTESEDINKKELINNQDIQPNYEHANQTDFLKEKWELILSKLELPSTRMLLS
QQAELASIDSNEVLIALSPNWENMIKSRKIIIENAVKKVCGDKVKLNFSSKKININNTAKSQEKIIKKSTSNREIQNTNF
QNSNTPIEKPQKEFYDDNSKNLANFFNGEIIDLDE

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4506491, Length=311, Percent_Identity=28.2958199356913, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI31881687, Length=311, Percent_Identity=28.2958199356913, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI6677723, Length=256, Percent_Identity=26.953125, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI194306571, Length=253, Percent_Identity=26.8774703557312, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI194306567, Length=253, Percent_Identity=26.8774703557312, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI31563534, Length=218, Percent_Identity=26.605504587156, Blast_Score=87, Evalue=5e-17,
Organism=Homo sapiens, GI194306569, Length=272, Percent_Identity=22.4264705882353, Blast_Score=69, Evalue=9e-12,
Organism=Escherichia coli, GI1786676, Length=293, Percent_Identity=41.6382252559727, Blast_Score=237, Evalue=2e-63,
Organism=Escherichia coli, GI1787119, Length=240, Percent_Identity=26.25, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1787341, Length=132, Percent_Identity=37.1212121212121, Blast_Score=63, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI71986063, Length=295, Percent_Identity=26.1016949152542, Blast_Score=93, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17541988, Length=258, Percent_Identity=27.1317829457364, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17554730, Length=229, Percent_Identity=27.5109170305677, Blast_Score=89, Evalue=9e-18,
Organism=Saccharomyces cerevisiae, GI6322528, Length=307, Percent_Identity=28.0130293159609, Blast_Score=101, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6324039, Length=222, Percent_Identity=28.3783783783784, Blast_Score=85, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6324478, Length=333, Percent_Identity=22.8228228228228, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI17647857, Length=336, Percent_Identity=23.8095238095238, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI19921076, Length=262, Percent_Identity=27.0992366412214, Blast_Score=96, Evalue=1e-19,
Organism=Drosophila melanogaster, GI18859927, Length=233, Percent_Identity=30.4721030042918, Blast_Score=91, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR008921
- InterPro:   IPR022754
- InterPro:   IPR012763 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 67640; Mature: 67640

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNIHKPFHQKYRPSNLDELVGQEFISITLKQALISKKIAPAYLFNGPRGTGKTSSARIF
CCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHEECCCCCCCCCCCHHHH
AKSLNCLSCEQPTANPCGKCELCKQIADGNALDIIEIDAASNTGVDNIREIIDGARFTPT
HHHCCCCCCCCCCCCCCCHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHCCCCCCCC
QARWKVYVIDECHMLSTAASNALLKTIEEPPERVVFILATTNPERVINTIQSRCQKFDFK
CCCEEEEEECCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHCCHH
RISSNTIFHNLSEIANKESIKFEDQALKLIAKRSNGGMRDAQSLLDQLSLLPNGVTTKNV
HHCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCHHHH
QNLLGEVSENDLINLINALIYNEPESLLISCNQLYDSGNEPHEILVGLLNITRDLLLKTL
HHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
NNNYSDIFYTSIDFQNELNKFSKNISKMRIIDWHNKLKNIDYQIKTSDNPKLWLEVHLTS
CCCCCEEEEEEECHHHHHHHHHHHHHHEEEEEHHHHHCCCCEEEEECCCCEEEEEEEHHH
LIENKIEDNIVNNGQSNKETLNQKVINKDELINKTIISKNANQTESEDINKKELINNQDI
HHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHCCCCCCCCHHCCCHHHHCCCCCC
QPNYENANQTESEDINKKELINNQDIQPNYEHANQTDFLKEKWELILSKLELPSTRMLLS
CCCCCCCCCCCHHCCCHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHH
QQAELASIDSNEVLIALSPNWENMIKSRKIIIENAVKKVCGDKVKLNFSSKKININNTAK
HHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCEEECCCCHH
SQEKIIKKSTSNREIQNTNFQNSNTPIEKPQKEFYDDNSKNLANFFNGEIIDLDE
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCHHHHHHCCEEEECCC
>Mature Secondary Structure
MLNIHKPFHQKYRPSNLDELVGQEFISITLKQALISKKIAPAYLFNGPRGTGKTSSARIF
CCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHEECCCCCCCCCCCHHHH
AKSLNCLSCEQPTANPCGKCELCKQIADGNALDIIEIDAASNTGVDNIREIIDGARFTPT
HHHCCCCCCCCCCCCCCCHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHCCCCCCCC
QARWKVYVIDECHMLSTAASNALLKTIEEPPERVVFILATTNPERVINTIQSRCQKFDFK
CCCEEEEEECCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHCCHH
RISSNTIFHNLSEIANKESIKFEDQALKLIAKRSNGGMRDAQSLLDQLSLLPNGVTTKNV
HHCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCHHHH
QNLLGEVSENDLINLINALIYNEPESLLISCNQLYDSGNEPHEILVGLLNITRDLLLKTL
HHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHH
NNNYSDIFYTSIDFQNELNKFSKNISKMRIIDWHNKLKNIDYQIKTSDNPKLWLEVHLTS
CCCCCEEEEEEECHHHHHHHHHHHHHHEEEEEHHHHHCCCCEEEEECCCCEEEEEEEHHH
LIENKIEDNIVNNGQSNKETLNQKVINKDELINKTIISKNANQTESEDINKKELINNQDI
HHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHCCCCCCCCHHCCCHHHHCCCCCC
QPNYENANQTESEDINKKELINNQDIQPNYEHANQTDFLKEKWELILSKLELPSTRMLLS
CCCCCCCCCCCHHCCCHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHH
QQAELASIDSNEVLIALSPNWENMIKSRKIIIENAVKKVCGDKVKLNFSSKKININNTAK
HHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCEEECCCCHH
SQEKIIKKSTSNREIQNTNFQNSNTPIEKPQKEFYDDNSKNLANFFNGEIIDLDE
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCHHHHHHCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2124672; 7584024; 9384377; 2452406; 2468993; 1698458 [H]