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The map label for this gene is clpP4 [H]

Identifier: 123967079

GI number: 123967079

Start: 1633777

End: 1634391

Strand: Direct

Name: clpP4 [H]

Synonym: P9515_18461

Alternate gene names: 123967079

Gene position: 1633777-1634391 (Clockwise)

Preceding gene: 123967078

Following gene: 123967080

Centisome position: 95.87

GC content: 36.59

Gene sequence:

>615_bases
ATGAGTCCTCTTGAAAGTGTCAATAACACGAAATCTGCTATTCCTACTGTTGTGGAACAATCTGGAAGAGGAGAAAGAGC
ATTTGATATTTATTCGAGATTATTAAGGGAAAGAATAATATTTTTAGGAACCGGAATTAACGATCAGGTAACAGATTCAC
TTGTTGCACAACTTCTATTTCTAGAAGCCGAAGATCCTGACAAAGATATTCAAATATATATCAATTCTCCCGGTGGTTCT
GTTACTGCAGGATTAGCTATTTACGACACGATGCAACAGATCTCTCCAGATGTTGTCACGATCTGCTTTGGCGTGGCTGC
AAGTATGGGGGCATTCCTTCTTTCTGGTGGCGCAAAAGGGAAAAGGTTGGCTTTGCCTAATTCAAGAATTATGATTCACC
AGCCTCTTGGAGGTGCTCAAGGCCAAGCAGTAGAAATTGAGATACAAGCAAAAGAAATATTATTTCTCAAAAAAACTTTA
AATTCTCTTTTGTCAGAACATACTGGTCAATCTTTAGAAAAAATTAATGAAGATACTGAAAGAGATTATTTTCTGTCACC
TGAGGAAGCTGTGCAATATGGATTAATTGATAAAGTTATAAAAAATGACAAGTAA

Upstream 100 bases:

>100_bases
TTTATAAAAAATTTAACTAATCAAGAAAAAAACTTCTAAATTAGATATAAAAGAGATTAATTTAGTGAATTCTAAACAAA
AACATTTAATACACAGCTCA

Downstream 100 bases:

>100_bases
AACTAATATTTTAAGAATATGATGACGAATCCAAATTTATAAGCAATCCTAATAATAAGGGATAGTTACCCTTTTTTATT
TTTCACAAGCTTTGATAATC

Product: Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp 4 [H]

Number of amino acids: Translated: 204; Mature: 203

Protein sequence:

>204_residues
MSPLESVNNTKSAIPTVVEQSGRGERAFDIYSRLLRERIIFLGTGINDQVTDSLVAQLLFLEAEDPDKDIQIYINSPGGS
VTAGLAIYDTMQQISPDVVTICFGVAASMGAFLLSGGAKGKRLALPNSRIMIHQPLGGAQGQAVEIEIQAKEILFLKKTL
NSLLSEHTGQSLEKINEDTERDYFLSPEEAVQYGLIDKVIKNDK

Sequences:

>Translated_204_residues
MSPLESVNNTKSAIPTVVEQSGRGERAFDIYSRLLRERIIFLGTGINDQVTDSLVAQLLFLEAEDPDKDIQIYINSPGGS
VTAGLAIYDTMQQISPDVVTICFGVAASMGAFLLSGGAKGKRLALPNSRIMIHQPLGGAQGQAVEIEIQAKEILFLKKTL
NSLLSEHTGQSLEKINEDTERDYFLSPEEAVQYGLIDKVIKNDK
>Mature_203_residues
SPLESVNNTKSAIPTVVEQSGRGERAFDIYSRLLRERIIFLGTGINDQVTDSLVAQLLFLEAEDPDKDIQIYINSPGGSV
TAGLAIYDTMQQISPDVVTICFGVAASMGAFLLSGGAKGKRLALPNSRIMIHQPLGGAQGQAVEIEIQAKEILFLKKTLN
SLLSEHTGQSLEKINEDTERDYFLSPEEAVQYGLIDKVIKNDK

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=187, Percent_Identity=59.8930481283422, Blast_Score=230, Evalue=8e-61,
Organism=Escherichia coli, GI1786641, Length=189, Percent_Identity=65.6084656084656, Blast_Score=271, Evalue=2e-74,
Organism=Caenorhabditis elegans, GI17538017, Length=190, Percent_Identity=54.2105263157895, Blast_Score=216, Evalue=5e-57,
Organism=Drosophila melanogaster, GI20129427, Length=189, Percent_Identity=56.0846560846561, Blast_Score=229, Evalue=1e-60,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 22241; Mature: 22109

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: PS00381 CLP_PROTEASE_SER ; PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPLESVNNTKSAIPTVVEQSGRGERAFDIYSRLLRERIIFLGTGINDQVTDSLVAQLLF
CCCHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHH
LEAEDPDKDIQIYINSPGGSVTAGLAIYDTMQQISPDVVTICFGVAASMGAFLLSGGAKG
HCCCCCCCCEEEEEECCCCCEEHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCC
KRLALPNSRIMIHQPLGGAQGQAVEIEIQAKEILFLKKTLNSLLSEHTGQSLEKINEDTE
CEEECCCCEEEEECCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCC
RDYFLSPEEAVQYGLIDKVIKNDK
CCCCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SPLESVNNTKSAIPTVVEQSGRGERAFDIYSRLLRERIIFLGTGINDQVTDSLVAQLLF
CCHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHH
LEAEDPDKDIQIYINSPGGSVTAGLAIYDTMQQISPDVVTICFGVAASMGAFLLSGGAKG
HCCCCCCCCEEEEEECCCCCEEHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCC
KRLALPNSRIMIHQPLGGAQGQAVEIEIQAKEILFLKKTLNSLLSEHTGQSLEKINEDTE
CEEECCCCEEEEECCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCC
RDYFLSPEEAVQYGLIDKVIKNDK
CCCCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA