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The map label for this gene is yycF [H]

Identifier: 123967041

GI number: 123967041

Start: 1593166

End: 1593912

Strand: Reverse

Name: yycF [H]

Synonym: P9515_18081

Alternate gene names: 123967041

Gene position: 1593912-1593166 (Counterclockwise)

Preceding gene: 123967042

Following gene: 123967040

Centisome position: 93.53

GC content: 37.88

Gene sequence:

>747_bases
ATGTCAAAAGCAAGCATTTTAGTTGTTGATGATGAACCAGCTGTATTGAAAGTATTAGTTACTAGACTTCAATTGGCTGG
ATATCAAGTTCACCAAGCTACTAATGGAGAAGAAGCTCTTGAAGCTTTTCATAGAGAATCTCCAGATTTAATAGTTCTTG
ATGTGATGCTTCCCAAAATGGATGGATTTGCAGTTTGCAGAAGAATCAGAGCTGAATCGGTAGTACCTATAATATTTTTA
ACTGCTTTAGAGGCTATTTCTGAAAGGGTAGCTGGTTTAGATTTAGGAGCTGACGATTATTTGTCAAAACCATTTAGTCC
TAAGGAATTAGAAGCCAGAATAGCCACAATCTTGAGGCGGATGGGTCCCAGTATTACAGTTACTGAAACTAAAGAGGTCC
CTTCTGGTAAAGGTGTGATGAAATTCGGAAATCTTGTAGTTGATACTAATAGAAGACAAGTTTCTAGAGCTGGAGAAAGA
ATTAGCTTAACTTATACTGAATTTAGTCTTCTTGAACTTTTATTTGATGAACCAGGTAAGGTAGTTCCAAGAGCTGAAAT
ACTTGAGCAACTTTGGGGATATCCTCCTCGACGCGCAGCTGATTTAAGAGTTGTAGATGTTTATGTAGCTAGACTTAGAG
GAAAGCTAGAGCCTGATCCCAGAAATCCAGAGTTAATTCTTACTGTTAGAGGAATAGGTTATGCTTCTCAAAGAGTTGGA
GAAACAGCAACATCTTTGGCAAGTTGA

Upstream 100 bases:

>100_bases
AGGGGGCATAATGTTATATTTTTAATTGTTAGATTATATTTACAGGATGTTCATTGCAAAATAAATTTGCTTTGAATTAT
TTGCAAAAATTTTTTTTTCG

Downstream 100 bases:

>100_bases
TCCTAAGTCTGATAGTTTGATTAAATAAAACATAAATATTGAGTTAAATTTTGTCTGAAATAAGAGAAGCTCGCTTATTA
AAAGCTAATTCACTAATTAA

Product: two-component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 248; Mature: 247

Protein sequence:

>248_residues
MSKASILVVDDEPAVLKVLVTRLQLAGYQVHQATNGEEALEAFHRESPDLIVLDVMLPKMDGFAVCRRIRAESVVPIIFL
TALEAISERVAGLDLGADDYLSKPFSPKELEARIATILRRMGPSITVTETKEVPSGKGVMKFGNLVVDTNRRQVSRAGER
ISLTYTEFSLLELLFDEPGKVVPRAEILEQLWGYPPRRAADLRVVDVYVARLRGKLEPDPRNPELILTVRGIGYASQRVG
ETATSLAS

Sequences:

>Translated_248_residues
MSKASILVVDDEPAVLKVLVTRLQLAGYQVHQATNGEEALEAFHRESPDLIVLDVMLPKMDGFAVCRRIRAESVVPIIFL
TALEAISERVAGLDLGADDYLSKPFSPKELEARIATILRRMGPSITVTETKEVPSGKGVMKFGNLVVDTNRRQVSRAGER
ISLTYTEFSLLELLFDEPGKVVPRAEILEQLWGYPPRRAADLRVVDVYVARLRGKLEPDPRNPELILTVRGIGYASQRVG
ETATSLAS
>Mature_247_residues
SKASILVVDDEPAVLKVLVTRLQLAGYQVHQATNGEEALEAFHRESPDLIVLDVMLPKMDGFAVCRRIRAESVVPIIFLT
ALEAISERVAGLDLGADDYLSKPFSPKELEARIATILRRMGPSITVTETKEVPSGKGVMKFGNLVVDTNRRQVSRAGERI
SLTYTEFSLLELLFDEPGKVVPRAEILEQLWGYPPRRAADLRVVDVYVARLRGKLEPDPRNPELILTVRGIGYASQRVGE
TATSLAS

Specific function: Member of the two-component regulatory system YycG/YycF involved in the regulation of the ftsAZ operon, the yocH, ykvT, cwlO, lytE, ydjM, yjeA, yoeB genes and the tagAB and tagDEF operons. Probably phosphorylates YycF. Binds to the ftsAZ P1 promoter seque

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=230, Percent_Identity=42.1739130434783, Blast_Score=160, Evalue=6e-41,
Organism=Escherichia coli, GI1788394, Length=230, Percent_Identity=39.1304347826087, Blast_Score=150, Evalue=7e-38,
Organism=Escherichia coli, GI1786911, Length=230, Percent_Identity=38.695652173913, Blast_Score=147, Evalue=5e-37,
Organism=Escherichia coli, GI1789809, Length=231, Percent_Identity=38.0952380952381, Blast_Score=145, Evalue=2e-36,
Organism=Escherichia coli, GI87082012, Length=230, Percent_Identity=35.6521739130435, Blast_Score=137, Evalue=8e-34,
Organism=Escherichia coli, GI1790860, Length=240, Percent_Identity=35, Blast_Score=137, Evalue=9e-34,
Organism=Escherichia coli, GI1786599, Length=232, Percent_Identity=36.2068965517241, Blast_Score=135, Evalue=2e-33,
Organism=Escherichia coli, GI1790863, Length=235, Percent_Identity=32.7659574468085, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI1789402, Length=230, Percent_Identity=35.6521739130435, Blast_Score=126, Evalue=1e-30,
Organism=Escherichia coli, GI1787375, Length=233, Percent_Identity=35.6223175965665, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1790552, Length=233, Percent_Identity=34.7639484978541, Blast_Score=121, Evalue=6e-29,
Organism=Escherichia coli, GI1787229, Length=232, Percent_Identity=33.1896551724138, Blast_Score=118, Evalue=3e-28,
Organism=Escherichia coli, GI2367329, Length=230, Percent_Identity=38.2608695652174, Blast_Score=118, Evalue=4e-28,
Organism=Escherichia coli, GI145693140, Length=234, Percent_Identity=34.1880341880342, Blast_Score=111, Evalue=4e-26,
Organism=Escherichia coli, GI1788550, Length=106, Percent_Identity=39.622641509434, Blast_Score=84, Evalue=9e-18,
Organism=Escherichia coli, GI1790299, Length=110, Percent_Identity=35.4545454545455, Blast_Score=72, Evalue=4e-14,
Organism=Escherichia coli, GI1788713, Length=116, Percent_Identity=37.9310344827586, Blast_Score=70, Evalue=9e-14,
Organism=Escherichia coli, GI1790437, Length=114, Percent_Identity=35.9649122807018, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI145693157, Length=102, Percent_Identity=37.2549019607843, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1789149, Length=201, Percent_Identity=27.8606965174129, Blast_Score=66, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 27395; Mature: 27264

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKASILVVDDEPAVLKVLVTRLQLAGYQVHQATNGEEALEAFHRESPDLIVLDVMLPKM
CCCCEEEEECCCCHHHHHHHHHHHHHCCCEECCCCHHHHHHHHHCCCCCEEEEEEECCCC
DGFAVCRRIRAESVVPIIFLTALEAISERVAGLDLGADDYLSKPFSPKELEARIATILRR
CHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCHHHHHHHHHHHHHH
MGPSITVTETKEVPSGKGVMKFGNLVVDTNRRQVSRAGERISLTYTEFSLLELLFDEPGK
HCCCEEEEECCCCCCCCCCEEECCEEEECCHHHHHHCCCEEEEEEHHHHHHHHHHCCCCC
VVPRAEILEQLWGYPPRRAADLRVVDVYVARLRGKLEPDPRNPELILTVRGIGYASQRVG
CCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCHHHHHHH
ETATSLAS
HHHHHHCC
>Mature Secondary Structure 
SKASILVVDDEPAVLKVLVTRLQLAGYQVHQATNGEEALEAFHRESPDLIVLDVMLPKM
CCCEEEEECCCCHHHHHHHHHHHHHCCCEECCCCHHHHHHHHHCCCCCEEEEEEECCCC
DGFAVCRRIRAESVVPIIFLTALEAISERVAGLDLGADDYLSKPFSPKELEARIATILRR
CHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHCCCCCHHHHHHHHHHHHHH
MGPSITVTETKEVPSGKGVMKFGNLVVDTNRRQVSRAGERISLTYTEFSLLELLFDEPGK
HCCCEEEEECCCCCCCCCCEEECCEEEECCHHHHHHCCCEEEEEEHHHHHHHHHHCCCCC
VVPRAEILEQLWGYPPRRAADLRVVDVYVARLRGKLEPDPRNPELILTVRGIGYASQRVG
CCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCHHHHHHH
ETATSLAS
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7584024; 9384377; 9829949; 10878122 [H]