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The map label for this gene is wzb [C]

Identifier: 123967011

GI number: 123967011

Start: 1565003

End: 1565476

Strand: Reverse

Name: wzb [C]

Synonym: P9515_17781

Alternate gene names: 123967011

Gene position: 1565476-1565003 (Counterclockwise)

Preceding gene: 123967012

Following gene: 123967009

Centisome position: 91.86

GC content: 31.01

Gene sequence:

>474_bases
ATGAAAAAACAATCTGTCCTTTTTGTATGTTTAGGTAATATCTGCAGGTCTCCAGCTGCTGAAGCAATTTTTATTAATTT
AATTAATAAAAAAGGATTTAATAATAATTTTATAGTTGATTCAGCCGGAACTGGTGGTTGGCACATAGGTAAGAAAGCTG
ATAATAGAATGAGAAAAGCGGCACATAAAAGAGGTTTGGAAATTTTAAGTAGAGCTAGACAAATTAATTCTAAAGATTTT
GAGATATTTAACTATATAGTTGCAATGGATGACTCTAATTTTGAAAATATTAGCGCCCTTAAATCTAGAAAATCATTATC
TGATTTTTCATCAATAAACAAGATACAAAATTTTAGATCTGTTTTTGAAGAAACAGAAGTGCCTGATCCTTATTTTGGCG
GCGATGATGGATTTGATCACGTCCTTGATATCTTAGAAGACTCTGTAAGTGGCTTCTTGAATACGATTTGTTGA

Upstream 100 bases:

>100_bases
CCAATGTTATCAAGTTTATTTGGCAAAGATTTTACTGAATCCTTAATTAATAAAGTATTATTTTCCACTAATAAAGTTTA
TAATTAAGTTTTGAAATTAG

Downstream 100 bases:

>100_bases
GTTATTCAATTTGAATCTCTTTAGGAATTTTGAAATTGTAAATATTAATAATTTTTTCTACGACTTCATTTATAGAATAT
CCGTCAGTGATCAGTTCAAT

Product: low molecular weight phosphotyrosine protein phosphatase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 157; Mature: 157

Protein sequence:

>157_residues
MKKQSVLFVCLGNICRSPAAEAIFINLINKKGFNNNFIVDSAGTGGWHIGKKADNRMRKAAHKRGLEILSRARQINSKDF
EIFNYIVAMDDSNFENISALKSRKSLSDFSSINKIQNFRSVFEETEVPDPYFGGDDGFDHVLDILEDSVSGFLNTIC

Sequences:

>Translated_157_residues
MKKQSVLFVCLGNICRSPAAEAIFINLINKKGFNNNFIVDSAGTGGWHIGKKADNRMRKAAHKRGLEILSRARQINSKDF
EIFNYIVAMDDSNFENISALKSRKSLSDFSSINKIQNFRSVFEETEVPDPYFGGDDGFDHVLDILEDSVSGFLNTIC
>Mature_157_residues
MKKQSVLFVCLGNICRSPAAEAIFINLINKKGFNNNFIVDSAGTGGWHIGKKADNRMRKAAHKRGLEILSRARQINSKDF
EIFNYIVAMDDSNFENISALKSRKSLSDFSSINKIQNFRSVFEETEVPDPYFGGDDGFDHVLDILEDSVSGFLNTIC

Specific function: Dephosphorylates Wzc. Required For The Extracellular Polysaccharide Colanic Acid Synthesis. Probably Involved In The Export Of Colanic Acid From The Cell To Medium. [C]

COG id: COG0394

COG function: function code T; Protein-tyrosine-phosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the low molecular weight phosphotyrosine protein phosphatase family [H]

Homologues:

Organism=Homo sapiens, GI4757714, Length=152, Percent_Identity=38.8157894736842, Blast_Score=108, Evalue=2e-24,
Organism=Homo sapiens, GI6005988, Length=152, Percent_Identity=36.1842105263158, Blast_Score=108, Evalue=3e-24,
Organism=Homo sapiens, GI96304457, Length=79, Percent_Identity=45.5696202531646, Blast_Score=78, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6325330, Length=142, Percent_Identity=35.9154929577465, Blast_Score=92, Evalue=4e-20,
Organism=Drosophila melanogaster, GI78706766, Length=137, Percent_Identity=35.7664233576642, Blast_Score=93, Evalue=7e-20,
Organism=Drosophila melanogaster, GI78706768, Length=137, Percent_Identity=35.7664233576642, Blast_Score=93, Evalue=7e-20,
Organism=Drosophila melanogaster, GI78711846, Length=143, Percent_Identity=37.0629370629371, Blast_Score=91, Evalue=2e-19,
Organism=Drosophila melanogaster, GI78706764, Length=129, Percent_Identity=35.6589147286822, Blast_Score=91, Evalue=4e-19,
Organism=Drosophila melanogaster, GI78706770, Length=141, Percent_Identity=34.7517730496454, Blast_Score=91, Evalue=4e-19,
Organism=Drosophila melanogaster, GI78706772, Length=141, Percent_Identity=34.7517730496454, Blast_Score=91, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24648069, Length=97, Percent_Identity=38.1443298969072, Blast_Score=72, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000106
- InterPro:   IPR017867 [H]

Pfam domain/function: PF01451 LMWPc [H]

EC number: =3.1.3.48 [H]

Molecular weight: Translated: 17603; Mature: 17603

Theoretical pI: Translated: 7.44; Mature: 7.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKQSVLFVCLGNICRSPAAEAIFINLINKKGFNNNFIVDSAGTGGWHIGKKADNRMRKA
CCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCHHHHHHHHH
AHKRGLEILSRARQINSKDFEIFNYIVAMDDSNFENISALKSRKSLSDFSSINKIQNFRS
HHHHHHHHHHHHHHCCCCHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VFEETEVPDPYFGGDDGFDHVLDILEDSVSGFLNTIC
HHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKKQSVLFVCLGNICRSPAAEAIFINLINKKGFNNNFIVDSAGTGGWHIGKKADNRMRKA
CCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCHHHHHHHHH
AHKRGLEILSRARQINSKDFEIFNYIVAMDDSNFENISALKSRKSLSDFSSINKIQNFRS
HHHHHHHHHHHHHHCCCCHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VFEETEVPDPYFGGDDGFDHVLDILEDSVSGFLNTIC
HHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]