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The map label for this gene is purM [H]

Identifier: 123967009

GI number: 123967009

Start: 1562333

End: 1563376

Strand: Reverse

Name: purM [H]

Synonym: P9515_17761

Alternate gene names: 123967009

Gene position: 1563376-1562333 (Counterclockwise)

Preceding gene: 123967011

Following gene: 123967008

Centisome position: 91.74

GC content: 30.46

Gene sequence:

>1044_bases
ATGGATTACAAAACATCAGGAGTTGACATAAAAGCTGGAAGAGAATTTGTCTCAGAAATTAAACAAGCTGTTGAGTCAAC
TCATTCATCTAATGTAATCGAAGGGATAGGCGGGTTTGGCGGCCTATTCAAAATACCTCTTGAGGGTTTAAAAAAACCTA
TTTTAGTTTCAGGAACTGATGGTGTTGGGACAAAACTAGAGTTGGCACAAAGTAAGAACTTTCATTTCGAAGTAGGTATT
GATTTGGTCGCAATGTGTATGAACGACATAATTACAACTGGTGCAAAACCGCTATTTTTTCTTGATTATATTGCTACAGG
GAAGCTTGAAAAAAATCAATTATTAGAAGTTGTTAAAGGTATTTCTTATAGTTGCTTAGAAAATAACTGCTCTTTACTTG
GAGGAGAAACTGCAGAAATGCCTGGATTTTATTCAAAGAATAAGTATGATTTAGCAGGATTTTGTGTGGGAATAGTTGAT
GAGGAAAAATTAATTAATGGTAAAAAAATAGGTGAAAATGATTTGATAATTGCATTACAAAGTAATGGTATTCATAGTAA
TGGATTTAGTTTAGTCAGAAAAATTATTGAAAATAATGATCAAATTCATAAGAAATTTGAAAAAATGTATCACTTAGATT
TTTATAGTCAATTACTACAGCCCACGAAAATTTACTTTAAGCTCATAAATCAAATTTTATCTCAGAATATTGAAATTAAG
GGCATGTCTCATATAACTGGAGGAGGAATTCCTGAAAATTTACCAAGATGTATGTCTGCCGATTTTATTCCTTACATAGA
TACGAAGTCTTGGGATATTCCGGTTTTATTTAAATATTTAAAGGATGTTGGTCAGATTCCTGAAAAGGATTTTTGGAATA
CATTTAATCTAGGGGTTGGATTTTGTTTAATAATTGATAAGAAATTTAAGGATGAGATTTTAAATATTTGTGAAGATAAT
GATGTGAAAAGTTGGGTCTTAGGGAAGGTTCTTAAGAAAGATAATTCAAAAGAGAATGAATTTTTACCTGAAATATTAAT
TTAG

Upstream 100 bases:

>100_bases
TTCACTTTTTTAAAAAATAAATCTATTTAATAAATAATTACTGGACAAAAGCGATCTACGGAGGAACATCTATATAGGAC
AATTCTATCATTTTTACTTC

Downstream 100 bases:

>100_bases
ATCTCTCGTATTAACTTTTATTGAGAAATTACAAATTAAATTTAACTACACAAATGAAAAAGTTAGGTGTAATATAATAG
GACTACCGCCGAGTTATATC

Product: phosphoribosylaminoimidazole synthetase

Products: NA

Alternate protein names: AIR synthase; AIRS; Phosphoribosyl-aminoimidazole synthetase [H]

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MDYKTSGVDIKAGREFVSEIKQAVESTHSSNVIEGIGGFGGLFKIPLEGLKKPILVSGTDGVGTKLELAQSKNFHFEVGI
DLVAMCMNDIITTGAKPLFFLDYIATGKLEKNQLLEVVKGISYSCLENNCSLLGGETAEMPGFYSKNKYDLAGFCVGIVD
EEKLINGKKIGENDLIIALQSNGIHSNGFSLVRKIIENNDQIHKKFEKMYHLDFYSQLLQPTKIYFKLINQILSQNIEIK
GMSHITGGGIPENLPRCMSADFIPYIDTKSWDIPVLFKYLKDVGQIPEKDFWNTFNLGVGFCLIIDKKFKDEILNICEDN
DVKSWVLGKVLKKDNSKENEFLPEILI

Sequences:

>Translated_347_residues
MDYKTSGVDIKAGREFVSEIKQAVESTHSSNVIEGIGGFGGLFKIPLEGLKKPILVSGTDGVGTKLELAQSKNFHFEVGI
DLVAMCMNDIITTGAKPLFFLDYIATGKLEKNQLLEVVKGISYSCLENNCSLLGGETAEMPGFYSKNKYDLAGFCVGIVD
EEKLINGKKIGENDLIIALQSNGIHSNGFSLVRKIIENNDQIHKKFEKMYHLDFYSQLLQPTKIYFKLINQILSQNIEIK
GMSHITGGGIPENLPRCMSADFIPYIDTKSWDIPVLFKYLKDVGQIPEKDFWNTFNLGVGFCLIIDKKFKDEILNICEDN
DVKSWVLGKVLKKDNSKENEFLPEILI
>Mature_347_residues
MDYKTSGVDIKAGREFVSEIKQAVESTHSSNVIEGIGGFGGLFKIPLEGLKKPILVSGTDGVGTKLELAQSKNFHFEVGI
DLVAMCMNDIITTGAKPLFFLDYIATGKLEKNQLLEVVKGISYSCLENNCSLLGGETAEMPGFYSKNKYDLAGFCVGIVD
EEKLINGKKIGENDLIIALQSNGIHSNGFSLVRKIIENNDQIHKKFEKMYHLDFYSQLLQPTKIYFKLINQILSQNIEIK
GMSHITGGGIPENLPRCMSADFIPYIDTKSWDIPVLFKYLKDVGQIPEKDFWNTFNLGVGFCLIIDKKFKDEILNICEDN
DVKSWVLGKVLKKDNSKENEFLPEILI

Specific function: De novo purine biosynthesis; fifth step. [C]

COG id: COG0150

COG function: function code F; Phosphoribosylaminoimidazole (AIR) synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=336, Percent_Identity=42.5595238095238, Blast_Score=276, Evalue=3e-74,
Organism=Homo sapiens, GI209869995, Length=336, Percent_Identity=42.5595238095238, Blast_Score=276, Evalue=3e-74,
Organism=Homo sapiens, GI209869993, Length=336, Percent_Identity=42.5595238095238, Blast_Score=276, Evalue=3e-74,
Organism=Escherichia coli, GI1788845, Length=338, Percent_Identity=42.603550295858, Blast_Score=293, Evalue=1e-80,
Organism=Caenorhabditis elegans, GI17567511, Length=351, Percent_Identity=37.8917378917379, Blast_Score=216, Evalue=1e-56,
Organism=Saccharomyces cerevisiae, GI6321203, Length=339, Percent_Identity=38.9380530973451, Blast_Score=249, Evalue=4e-67,
Organism=Drosophila melanogaster, GI24582400, Length=302, Percent_Identity=36.0927152317881, Blast_Score=190, Evalue=1e-48,

Paralogues:

None

Copy number: 180 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR004733
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.3.1 [H]

Molecular weight: Translated: 38812; Mature: 38812

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDYKTSGVDIKAGREFVSEIKQAVESTHSSNVIEGIGGFGGLFKIPLEGLKKPILVSGTD
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCEECCHHHCCCCEEEECCC
GVGTKLELAQSKNFHFEVGIDLVAMCMNDIITTGAKPLFFLDYIATGKLEKNQLLEVVKG
CCCCEEEECCCCCCEEEEHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHC
ISYSCLENNCSLLGGETAEMPGFYSKNKYDLAGFCVGIVDEEKLINGKKIGENDLIIALQ
CCHHHHHCCCCEECCCCCCCCCCCCCCCCCHHHEEEEECCHHHHCCCCCCCCCCEEEEEE
SNGIHSNGFSLVRKIIENNDQIHKKFEKMYHLDFYSQLLQPTKIYFKLINQILSQNIEIK
CCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
GMSHITGGGIPENLPRCMSADFIPYIDTKSWDIPVLFKYLKDVGQIPEKDFWNTFNLGVG
ECCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHCCCCE
FCLIIDKKFKDEILNICEDNDVKSWVLGKVLKKDNSKENEFLPEILI
EEEEECCHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHCCHHHCC
>Mature Secondary Structure
MDYKTSGVDIKAGREFVSEIKQAVESTHSSNVIEGIGGFGGLFKIPLEGLKKPILVSGTD
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCEECCHHHCCCCEEEECCC
GVGTKLELAQSKNFHFEVGIDLVAMCMNDIITTGAKPLFFLDYIATGKLEKNQLLEVVKG
CCCCEEEECCCCCCEEEEHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHC
ISYSCLENNCSLLGGETAEMPGFYSKNKYDLAGFCVGIVDEEKLINGKKIGENDLIIALQ
CCHHHHHCCCCEECCCCCCCCCCCCCCCCCHHHEEEEECCHHHHCCCCCCCCCCEEEEEE
SNGIHSNGFSLVRKIIENNDQIHKKFEKMYHLDFYSQLLQPTKIYFKLINQILSQNIEIK
CCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEE
GMSHITGGGIPENLPRCMSADFIPYIDTKSWDIPVLFKYLKDVGQIPEKDFWNTFNLGVG
ECCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHCCCCE
FCLIIDKKFKDEILNICEDNDVKSWVLGKVLKKDNSKENEFLPEILI
EEEEECCHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCHHCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12917642 [H]