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The map label for this gene is pepP [H]

Identifier: 123966854

GI number: 123966854

Start: 1416011

End: 1417336

Strand: Reverse

Name: pepP [H]

Synonym: P9515_16211

Alternate gene names: 123966854

Gene position: 1417336-1416011 (Counterclockwise)

Preceding gene: 123966859

Following gene: 123966853

Centisome position: 83.17

GC content: 33.56

Gene sequence:

>1326_bases
ATGTTTAAAACTAATACAAAAATTTTTGAAGAAAGAAGAGAAATTTTCCTAAAAAAATTAAATGGTAAAGCTGCCATCAT
TTCAAGCTCAAGTTTAGTTAATCATCATGCTGATTGTGAATACCCTTTTAGACAAGATAGTAATTTTTGGTATCTTACTG
GATTTGATGAGCCTGATTCAATTGCTCTTTTCTTGTCTAATAAGCCAAAAGGTGAAAGGTACATCTTGTTTGTTGCCCCA
AAAGACATTATTAGCGAGGTCTGGCATGGCTTTAGATGGGGTGTAGAGGGCGCTGAAAGAGAATTCAAGGCAGATAAAGC
CCACTCAATTAGTGATTTTAAGCGTTTACTTCCAGTTTATATTAGTGATTCAGAAGACATCGTATATTCACAAAACAAAC
ATTCCAAATTTGAAAAAATAGTTTTGGAAATATTCTCAAAACAAATTGAAGCTCGTTCAAAAGAAGGAAAAGAAGAAATT
AATATAGAATCCCCAGAAATTTATCTCAATGAGATGCGCTTAATTAAAAGTGATTTTGAGATCAGTAGGATGAGAGAGGC
AACTCAAATTTCTGCCGAAGCTCATGAATTAGTTAGGGAATCTATTTCATTAAAAAAAAATGAAAGACAAATTCAGGGAT
TAATAGAAGGATTCTTTTTAGAAAAAGGTGCAAGAGGACCAGCTTATAACTCAATAGTTGCTTCAGGCGATAATGCCTGC
ATTTTGCATTACACATTAAATAACTCTGACTTAAATAAAGGAGATCTATTATTGGTGGACGCAGGATGTTCATTAATGGA
TTATTACAATGGGGACATAACAAGAACTATTCCGATAGGAGGGAAGTTTTCTAAAGAGCAGAAAATTATATATGAAATTG
TTTTAGAAGCACAAAAAAACGCAATTAAGCATTCTGTAAAAGGTTCTAATACTACTAATGTTCATAATGTTGCTTTGAGA
ATTTTGGTAGATGGATTAAAGGAAATTGGACTGTTGAGAGGAGATACTGATGGAATAATTGAAAACGGATCTTATAAACA
TCTTTATATGCATAGAACTGGACATTGGCTTGGTTTAGACGTTCATGATGTTGGGGCTTACAGGATGGGAGAATATGATG
TTCCATTACAGAATGGCATGATACTTACTGTTGAACCGGGTATCTATATAAGTGATAGGATCCCAGTCCCCGAAGGACAA
CCTAGTATTGATGAAAAATGGAAAGGTATTGGAATAAGAATAGAAGATGACATTCTTGTAAAAGAAAAAGAACCAGAAAT
TCTTAGCATCGCTGCGCTGAAAGAAATTTCTGATTTAGAGTATTGA

Upstream 100 bases:

>100_bases
AATTAGAATGTAAACACTTGGTTCCATTTAAATTGATTAGTTTTAAATATCTTTTAATTCATTCTTCCACTTTTTTACAA
AACCCGCCAATTGACAATTT

Downstream 100 bases:

>100_bases
ATATTTGACTTATCCAATTAATGGTTTTATTTTTTTATTAGTATAAAAATTAAAAATGGATAAATCAAATTCTTATGATT
CCAAATTATCTCAAGCAAGA

Product: putative aminopeptidase P

Products: NA

Alternate protein names: Aminoacylproline aminopeptidase; Aminopeptidase P II; APP-II; X-Pro aminopeptidase [H]

Number of amino acids: Translated: 441; Mature: 441

Protein sequence:

>441_residues
MFKTNTKIFEERREIFLKKLNGKAAIISSSSLVNHHADCEYPFRQDSNFWYLTGFDEPDSIALFLSNKPKGERYILFVAP
KDIISEVWHGFRWGVEGAEREFKADKAHSISDFKRLLPVYISDSEDIVYSQNKHSKFEKIVLEIFSKQIEARSKEGKEEI
NIESPEIYLNEMRLIKSDFEISRMREATQISAEAHELVRESISLKKNERQIQGLIEGFFLEKGARGPAYNSIVASGDNAC
ILHYTLNNSDLNKGDLLLVDAGCSLMDYYNGDITRTIPIGGKFSKEQKIIYEIVLEAQKNAIKHSVKGSNTTNVHNVALR
ILVDGLKEIGLLRGDTDGIIENGSYKHLYMHRTGHWLGLDVHDVGAYRMGEYDVPLQNGMILTVEPGIYISDRIPVPEGQ
PSIDEKWKGIGIRIEDDILVKEKEPEILSIAALKEISDLEY

Sequences:

>Translated_441_residues
MFKTNTKIFEERREIFLKKLNGKAAIISSSSLVNHHADCEYPFRQDSNFWYLTGFDEPDSIALFLSNKPKGERYILFVAP
KDIISEVWHGFRWGVEGAEREFKADKAHSISDFKRLLPVYISDSEDIVYSQNKHSKFEKIVLEIFSKQIEARSKEGKEEI
NIESPEIYLNEMRLIKSDFEISRMREATQISAEAHELVRESISLKKNERQIQGLIEGFFLEKGARGPAYNSIVASGDNAC
ILHYTLNNSDLNKGDLLLVDAGCSLMDYYNGDITRTIPIGGKFSKEQKIIYEIVLEAQKNAIKHSVKGSNTTNVHNVALR
ILVDGLKEIGLLRGDTDGIIENGSYKHLYMHRTGHWLGLDVHDVGAYRMGEYDVPLQNGMILTVEPGIYISDRIPVPEGQ
PSIDEKWKGIGIRIEDDILVKEKEPEILSIAALKEISDLEY
>Mature_441_residues
MFKTNTKIFEERREIFLKKLNGKAAIISSSSLVNHHADCEYPFRQDSNFWYLTGFDEPDSIALFLSNKPKGERYILFVAP
KDIISEVWHGFRWGVEGAEREFKADKAHSISDFKRLLPVYISDSEDIVYSQNKHSKFEKIVLEIFSKQIEARSKEGKEEI
NIESPEIYLNEMRLIKSDFEISRMREATQISAEAHELVRESISLKKNERQIQGLIEGFFLEKGARGPAYNSIVASGDNAC
ILHYTLNNSDLNKGDLLLVDAGCSLMDYYNGDITRTIPIGGKFSKEQKIIYEIVLEAQKNAIKHSVKGSNTTNVHNVALR
ILVDGLKEIGLLRGDTDGIIENGSYKHLYMHRTGHWLGLDVHDVGAYRMGEYDVPLQNGMILTVEPGIYISDRIPVPEGQ
PSIDEKWKGIGIRIEDDILVKEKEPEILSIAALKEISDLEY

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=430, Percent_Identity=33.4883720930233, Blast_Score=228, Evalue=1e-59,
Organism=Homo sapiens, GI149589008, Length=480, Percent_Identity=28.125, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI260593665, Length=305, Percent_Identity=33.1147540983607, Blast_Score=148, Evalue=8e-36,
Organism=Homo sapiens, GI260593663, Length=249, Percent_Identity=32.5301204819277, Blast_Score=121, Evalue=2e-27,
Organism=Escherichia coli, GI1789275, Length=447, Percent_Identity=36.4653243847875, Blast_Score=304, Evalue=6e-84,
Organism=Escherichia coli, GI1788728, Length=277, Percent_Identity=29.9638989169675, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1790282, Length=460, Percent_Identity=25.2173913043478, Blast_Score=90, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17508215, Length=474, Percent_Identity=26.7932489451477, Blast_Score=141, Evalue=8e-34,
Organism=Caenorhabditis elegans, GI71989583, Length=355, Percent_Identity=28.7323943661972, Blast_Score=125, Evalue=6e-29,
Organism=Saccharomyces cerevisiae, GI6320922, Length=446, Percent_Identity=33.1838565022422, Blast_Score=207, Evalue=3e-54,
Organism=Saccharomyces cerevisiae, GI6321118, Length=443, Percent_Identity=29.3453724604966, Blast_Score=166, Evalue=8e-42,
Organism=Drosophila melanogaster, GI19920384, Length=406, Percent_Identity=31.0344827586207, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI21357079, Length=446, Percent_Identity=29.8206278026906, Blast_Score=159, Evalue=5e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000994
- InterPro:   IPR007865
- InterPro:   IPR001131 [H]

Pfam domain/function: PF05195 AMP_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.11.9 [H]

Molecular weight: Translated: 50147; Mature: 50147

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKTNTKIFEERREIFLKKLNGKAAIISSSSLVNHHADCEYPFRQDSNFWYLTGFDEPDS
CCCCCHHHHHHHHHHHHHHCCCCEEEEECCHHHCCCCCCCCCCCCCCCEEEEECCCCCCC
IALFLSNKPKGERYILFVAPKDIISEVWHGFRWGVEGAEREFKADKAHSISDFKRLLPVY
EEEEECCCCCCCEEEEEECCHHHHHHHHHHHCCCCCCHHHHHCCCCCCCHHHHHHHCEEE
ISDSEDIVYSQNKHSKFEKIVLEIFSKQIEARSKEGKEEINIESPEIYLNEMRLIKSDFE
ECCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEHHHHHHHHCCCH
ISRMREATQISAEAHELVRESISLKKNERQIQGLIEGFFLEKGARGPAYNSIVASGDNAC
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCEE
ILHYTLNNSDLNKGDLLLVDAGCSLMDYYNGDITRTIPIGGKFSKEQKIIYEIVLEAQKN
EEEEEECCCCCCCCCEEEEECCCCEEECCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHH
AIKHSVKGSNTTNVHNVALRILVDGLKEIGLLRGDTDGIIENGSYKHLYMHRTGHWLGLD
HHHHHCCCCCCCCHHHHHHHHHHHHHHHHCEECCCCCCEEECCCEEEEEEEECCCEEEEE
VHDVGAYRMGEYDVPLQNGMILTVEPGIYISDRIPVPEGQPSIDEKWKGIGIRIEDDILV
EECCCCEECCCCCCCCCCCEEEEECCCEEEECCCCCCCCCCCCCHHHCCCCEEEECCEEE
KEKEPEILSIAALKEISDLEY
ECCCCCEEEHHHHHHHHCCCC
>Mature Secondary Structure
MFKTNTKIFEERREIFLKKLNGKAAIISSSSLVNHHADCEYPFRQDSNFWYLTGFDEPDS
CCCCCHHHHHHHHHHHHHHCCCCEEEEECCHHHCCCCCCCCCCCCCCCEEEEECCCCCCC
IALFLSNKPKGERYILFVAPKDIISEVWHGFRWGVEGAEREFKADKAHSISDFKRLLPVY
EEEEECCCCCCCEEEEEECCHHHHHHHHHHHCCCCCCHHHHHCCCCCCCHHHHHHHCEEE
ISDSEDIVYSQNKHSKFEKIVLEIFSKQIEARSKEGKEEINIESPEIYLNEMRLIKSDFE
ECCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEHHHHHHHHCCCH
ISRMREATQISAEAHELVRESISLKKNERQIQGLIEGFFLEKGARGPAYNSIVASGDNAC
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCEE
ILHYTLNNSDLNKGDLLLVDAGCSLMDYYNGDITRTIPIGGKFSKEQKIIYEIVLEAQKN
EEEEEECCCCCCCCCEEEEECCCCEEECCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHH
AIKHSVKGSNTTNVHNVALRILVDGLKEIGLLRGDTDGIIENGSYKHLYMHRTGHWLGLD
HHHHHCCCCCCCCHHHHHHHHHHHHHHHHCEECCCCCCEEECCCEEEEEEEECCCEEEEE
VHDVGAYRMGEYDVPLQNGMILTVEPGIYISDRIPVPEGQPSIDEKWKGIGIRIEDDILV
EECCCCEECCCCCCCCCCCEEEEECCCEEEECCCCCCCCCCCCCHHHCCCCEEEECCEEE
KEKEPEILSIAALKEISDLEY
ECCCCCEEEHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]