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The map label for this gene is groEL [H]

Identifier: 123966848

GI number: 123966848

Start: 1411077

End: 1412711

Strand: Reverse

Name: groEL [H]

Synonym: P9515_16151

Alternate gene names: 123966848

Gene position: 1412711-1411077 (Counterclockwise)

Preceding gene: 123966849

Following gene: 123966844

Centisome position: 82.9

GC content: 39.63

Gene sequence:

>1635_bases
ATGGCTAAAAGAATTATTTACAACGAGCAAGCTCGTAGAGCGCTCGAGAGAGGCATTGATATCCTTGCTGAGTCTGTGGC
TGTAACGCTTGGGCCTAAGGGAAGAAATGTTGTCCTAGAAAAAAAATTTGGAGCTCCTCAAATTATTAATGATGGGGTAA
CAATTGCAAAGGAAATCGAATTAGAGGACCATATTGAAAATACTGGTGTTGCTCTAATTAGACAAGCTGCTTCAAAGACA
AATGATGCGGCTGGTGACGGTACTACAACTGCTACTGTTCTTGCACATGCAATGGTAAAAGCTGGCCTACGAAATGTAGC
AGCTGGAGCTAATGCCATTACCTTAAAAAAAGGTATTGATAAAGCTACTGAATTCCTTGTAGGGAAGATAGAAGAAAATT
CAAAACCAATTAGTGATAGTACTGCAATAGCTCAATGCGGAACTATTGCTGCCGGCAATGATGAAGAAGTTGGTGAAATG
ATTGCCAATGCAATGGACAAGGTAGGTAAAGAAGGTGTCATCTCACTTGAAGAAGGCAAATCAATGACTACTGAGTTAGA
GGTCACTGAGGGAATGCGTTTTGATAAAGGTTACATTTCTCCCTACTTTGCAACAGATACTGAGCGAATGGAGGCAGTCT
TAGATGAGCCTTACATTTTACTAACTGATAAGAAGATTGCGTTAGTGCAAGATTTAGTGCCAGTCTTAGAGCAAATAGCC
AAAACAGGAAAGCCTCTTGTCATTATTGCTGAAGATATTGAAAAAGAAGCTCTAGCTACTCTAGTTGTTAATAGATTAAG
AGGTGTGCTGAATGTTGCTGCTGTTAAGGCTCCCGGATTTGGCGATAGAAGGAAAGCAATGCTTGAAGATATGGCTGTTT
TGACTAATGGTCAGTTAATAACTGAAGATGCAGGTTTGAAATTAGAAAATGCTACTTTAGAAATGTTAGGCACTGGTAGA
AGAATTACCATCAATAAAGAGACTACAACTATAGTCGCTGAGGGTAATGAAAAGGCAGTCAATTCAAGATGTGATCAGAT
TAAAAAACAAATGGAGGAAACAGATTCTTCCTACGACAAAGAAAAACTTCAAGAACGTTTAGCTAAGCTGGCTGGAGGAG
TTGCAGTTATTAAAGTTGGAGCTGCTACTGAAACTGAAATGAAGGATAAAAAACTTCGTTTAGAAGATGCTATCAATGCT
ACAAAAGCTGCTGTTGAAGAAGGGATAGTTCCAGGTGGTGGAACAACTCTTGCACATTTAGCTCCAATTCTTAAAGAATG
GGCTGATGCAACTTTATCTGGCGAGGAATTAATAGGAGCCAATATAGTTGAGGCATCATTAACTGCTCCTCTTATGAGAA
TTGCTGAGAATGCTGGTTCAAATGGAGCTGTAATTGCTGAAAATGTTAAATCCAAACCATTTAATGATGGATTTAATGCA
GCTACTGGAGAATATGTAGACATGTCTTCAGCAGGAATAGTTGATCCTGCAAAAGTCACACGTTCTGGACTACAGAATGC
CGCATCAATAGCAGGAATGGTACTTACTACTGAATGCATTGTTGCAGATATGCCTGAGAAAAAAGAATCAGCACCTGCTG
GAGCTCCAGGAATGGGTGGAGATTTTGACTACTAG

Upstream 100 bases:

>100_bases
TGAGTACGTCTTGCTTTCAGAAAAAGATATTTTGGCTGTTGTAAGCTAATTTATTTGTTTCAAAAATTATTAAAACTTAT
TATTAAATTACTTGCCTAAC

Downstream 100 bases:

>100_bases
ATAATTACATGTTCTAGTTCAAAAGGGATTGTTTTTACAATCCCTTTTTTTGTTCAAAAAATTATTTAAAGAAAAATAAA
TGTAATTTTAAAATACTAAA

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein 2; Protein Cpn60 2 [H]

Number of amino acids: Translated: 544; Mature: 543

Protein sequence:

>544_residues
MAKRIIYNEQARRALERGIDILAESVAVTLGPKGRNVVLEKKFGAPQIINDGVTIAKEIELEDHIENTGVALIRQAASKT
NDAAGDGTTTATVLAHAMVKAGLRNVAAGANAITLKKGIDKATEFLVGKIEENSKPISDSTAIAQCGTIAAGNDEEVGEM
IANAMDKVGKEGVISLEEGKSMTTELEVTEGMRFDKGYISPYFATDTERMEAVLDEPYILLTDKKIALVQDLVPVLEQIA
KTGKPLVIIAEDIEKEALATLVVNRLRGVLNVAAVKAPGFGDRRKAMLEDMAVLTNGQLITEDAGLKLENATLEMLGTGR
RITINKETTTIVAEGNEKAVNSRCDQIKKQMEETDSSYDKEKLQERLAKLAGGVAVIKVGAATETEMKDKKLRLEDAINA
TKAAVEEGIVPGGGTTLAHLAPILKEWADATLSGEELIGANIVEASLTAPLMRIAENAGSNGAVIAENVKSKPFNDGFNA
ATGEYVDMSSAGIVDPAKVTRSGLQNAASIAGMVLTTECIVADMPEKKESAPAGAPGMGGDFDY

Sequences:

>Translated_544_residues
MAKRIIYNEQARRALERGIDILAESVAVTLGPKGRNVVLEKKFGAPQIINDGVTIAKEIELEDHIENTGVALIRQAASKT
NDAAGDGTTTATVLAHAMVKAGLRNVAAGANAITLKKGIDKATEFLVGKIEENSKPISDSTAIAQCGTIAAGNDEEVGEM
IANAMDKVGKEGVISLEEGKSMTTELEVTEGMRFDKGYISPYFATDTERMEAVLDEPYILLTDKKIALVQDLVPVLEQIA
KTGKPLVIIAEDIEKEALATLVVNRLRGVLNVAAVKAPGFGDRRKAMLEDMAVLTNGQLITEDAGLKLENATLEMLGTGR
RITINKETTTIVAEGNEKAVNSRCDQIKKQMEETDSSYDKEKLQERLAKLAGGVAVIKVGAATETEMKDKKLRLEDAINA
TKAAVEEGIVPGGGTTLAHLAPILKEWADATLSGEELIGANIVEASLTAPLMRIAENAGSNGAVIAENVKSKPFNDGFNA
ATGEYVDMSSAGIVDPAKVTRSGLQNAASIAGMVLTTECIVADMPEKKESAPAGAPGMGGDFDY
>Mature_543_residues
AKRIIYNEQARRALERGIDILAESVAVTLGPKGRNVVLEKKFGAPQIINDGVTIAKEIELEDHIENTGVALIRQAASKTN
DAAGDGTTTATVLAHAMVKAGLRNVAAGANAITLKKGIDKATEFLVGKIEENSKPISDSTAIAQCGTIAAGNDEEVGEMI
ANAMDKVGKEGVISLEEGKSMTTELEVTEGMRFDKGYISPYFATDTERMEAVLDEPYILLTDKKIALVQDLVPVLEQIAK
TGKPLVIIAEDIEKEALATLVVNRLRGVLNVAAVKAPGFGDRRKAMLEDMAVLTNGQLITEDAGLKLENATLEMLGTGRR
ITINKETTTIVAEGNEKAVNSRCDQIKKQMEETDSSYDKEKLQERLAKLAGGVAVIKVGAATETEMKDKKLRLEDAINAT
KAAVEEGIVPGGGTTLAHLAPILKEWADATLSGEELIGANIVEASLTAPLMRIAENAGSNGAVIAENVKSKPFNDGFNAA
TGEYVDMSSAGIVDPAKVTRSGLQNAASIAGMVLTTECIVADMPEKKESAPAGAPGMGGDFDY

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=533, Percent_Identity=43.7148217636023, Blast_Score=450, Evalue=1e-126,
Organism=Homo sapiens, GI31542947, Length=533, Percent_Identity=43.7148217636023, Blast_Score=450, Evalue=1e-126,
Organism=Escherichia coli, GI1790586, Length=529, Percent_Identity=57.2778827977316, Blast_Score=584, Evalue=1e-168,
Organism=Caenorhabditis elegans, GI17555558, Length=530, Percent_Identity=44.9056603773585, Blast_Score=456, Evalue=1e-128,
Organism=Caenorhabditis elegans, GI193210679, Length=215, Percent_Identity=41.8604651162791, Blast_Score=168, Evalue=7e-42,
Organism=Saccharomyces cerevisiae, GI6323288, Length=526, Percent_Identity=48.6692015209125, Blast_Score=489, Evalue=1e-139,
Organism=Saccharomyces cerevisiae, GI6322524, Length=576, Percent_Identity=22.2222222222222, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24641193, Length=528, Percent_Identity=46.4015151515151, Blast_Score=469, Evalue=1e-132,
Organism=Drosophila melanogaster, GI24641191, Length=528, Percent_Identity=46.4015151515151, Blast_Score=469, Evalue=1e-132,
Organism=Drosophila melanogaster, GI45550936, Length=526, Percent_Identity=42.9657794676806, Blast_Score=431, Evalue=1e-121,
Organism=Drosophila melanogaster, GI45550132, Length=526, Percent_Identity=42.9657794676806, Blast_Score=431, Evalue=1e-121,
Organism=Drosophila melanogaster, GI45550935, Length=526, Percent_Identity=42.9657794676806, Blast_Score=431, Evalue=1e-121,
Organism=Drosophila melanogaster, GI17864606, Length=546, Percent_Identity=37.9120879120879, Blast_Score=372, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24584129, Length=530, Percent_Identity=34.7169811320755, Blast_Score=295, Evalue=4e-80,
Organism=Drosophila melanogaster, GI19921262, Length=530, Percent_Identity=34.7169811320755, Blast_Score=295, Evalue=4e-80,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 57519; Mature: 57388

Theoretical pI: Translated: 4.59; Mature: 4.59

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKRIIYNEQARRALERGIDILAESVAVTLGPKGRNVVLEKKFGAPQIINDGVTIAKEIE
CCCCEEECHHHHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCCCCEECCCCEEEEECC
LEDHIENTGVALIRQAASKTNDAAGDGTTTATVLAHAMVKAGLRNVAAGANAITLKKGID
HHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHH
KATEFLVGKIEENSKPISDSTAIAQCGTIAAGNDEEVGEMIANAMDKVGKEGVISLEEGK
HHHHHHHHHHCCCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCC
SMTTELEVTEGMRFDKGYISPYFATDTERMEAVLDEPYILLTDKKIALVQDLVPVLEQIA
CCEEEEEHHCCCEECCCCCCCEECCCHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHH
KTGKPLVIIAEDIEKEALATLVVNRLRGVLNVAAVKAPGFGDRRKAMLEDMAVLTNGQLI
HCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCEEE
TEDAGLKLENATLEMLGTGRRITINKETTTIVAEGNEKAVNSRCDQIKKQMEETDSSYDK
ECCCCCEECCCHHEEECCCCEEEEECCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCH
EKLQERLAKLAGGVAVIKVGAATETEMKDKKLRLEDAINATKAAVEEGIVPGGGTTLAHL
HHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
APILKEWADATLSGEELIGANIVEASLTAPLMRIAENAGSNGAVIAENVKSKPFNDGFNA
HHHHHHHHCCCCCCCHHHCCHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCC
ATGEYVDMSSAGIVDPAKVTRSGLQNAASIAGMVLTTECIVADMPEKKESAPAGAPGMGG
CCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCCCCCC
DFDY
CCCC
>Mature Secondary Structure 
AKRIIYNEQARRALERGIDILAESVAVTLGPKGRNVVLEKKFGAPQIINDGVTIAKEIE
CCCEEECHHHHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCCCCEECCCCEEEEECC
LEDHIENTGVALIRQAASKTNDAAGDGTTTATVLAHAMVKAGLRNVAAGANAITLKKGID
HHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHH
KATEFLVGKIEENSKPISDSTAIAQCGTIAAGNDEEVGEMIANAMDKVGKEGVISLEEGK
HHHHHHHHHHCCCCCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEECCCC
SMTTELEVTEGMRFDKGYISPYFATDTERMEAVLDEPYILLTDKKIALVQDLVPVLEQIA
CCEEEEEHHCCCEECCCCCCCEECCCHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHH
KTGKPLVIIAEDIEKEALATLVVNRLRGVLNVAAVKAPGFGDRRKAMLEDMAVLTNGQLI
HCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCEEE
TEDAGLKLENATLEMLGTGRRITINKETTTIVAEGNEKAVNSRCDQIKKQMEETDSSYDK
ECCCCCEECCCHHEEECCCCEEEEECCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCH
EKLQERLAKLAGGVAVIKVGAATETEMKDKKLRLEDAINATKAAVEEGIVPGGGTTLAHL
HHHHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
APILKEWADATLSGEELIGANIVEASLTAPLMRIAENAGSNGAVIAENVKSKPFNDGFNA
HHHHHHHHCCCCCCCHHHCCHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCC
ATGEYVDMSSAGIVDPAKVTRSGLQNAASIAGMVLTTECIVADMPEKKESAPAGAPGMGG
CCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCCCCCC
DFDY
CCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA