Click here to switch to the map view.

The map label for this gene is phrA [H]

Identifier: 123966755

GI number: 123966755

Start: 1353736

End: 1354872

Strand: Reverse

Name: phrA [H]

Synonym: P9515_15221

Alternate gene names: 123966755

Gene position: 1354872-1353736 (Counterclockwise)

Preceding gene: 123966758

Following gene: 123966754

Centisome position: 79.5

GC content: 27.79

Gene sequence:

>1137_bases
ATGACACAATTTCAGGATGCTCAAGAAAAGTGGGTCGATTTTTTAGAGAATAAAATTCAAAACTATGAAAAATTTCGTAA
TTTTGATTATGGACCAGAGAATGTTAGCTCGGTTTCGAAATTATCCCCTTACGTTTCGCATAGGATTTTATTAGAGTACG
AATTAATTGAGGAAGTTAAGAAGAAATATCAATCTCAAAAAATTAATAAATTTATAGAAGAAATTTATTGGAGAATTTAT
TGGAAAGGTTGGATGGAGAATAGACCGAATGTTTGGGTTGATTTTATTTCAGAAAAAAATTTTAAATATGATTTTGAAGC
CTATGAAAAAGCAATTAATGGAGATACAGATTTAAGCTTTTTTAATTCATGGGTTAATGAGTTAAAGACTCATAACTATT
TACACAACCATACTCGGATGTGGTTTGCTAGTACTTGGATATTTAATTTTGGACTGCCTTGGGAATTAGGTGCGAATTTT
TTCTTTAAACATTTATATGATGGGGATTCTGCCTCCAATATTTTGAGTTGGAGATGGGTTGCTGGATTACAAACAAAAGG
GAAGCAATATCTTTTTTCCCCCTCAAATCTTAGGAAATTTTCAAATAATAGGTTTAATGTTGAAAAAATTAATAATAAAC
AAATCTTTCTAGAAGAACTAAATCAAATTCCATTAACAGATGAGATTTATAAGAGCAATATGGAACAAAAGTCAGAATCA
CTCATATTATTTGAAAACGATTTACATGCTCCAACCCTTAAAAATATCTTTCAAAATTACAAACGAGTATTCATTATCCT
GCTAGGAAACGAACAAAGAAAGATAAAATTATCTTCAGCAGTTATGAGTTTCAAACAACAAATAGTTTCCGAATTTGTAG
CGCAATTTGATAATGTTACTCAACTTAATACTATAAGACTTCAAGAAAACTTTAAAGATATTAATCAGTTAGATATGATT
TATCCCGGCATAGGAGATAATAACGATTTTATAAAAAATTTTAAAATTTCAAATAATAAAGTTATCTTTAACTTAGTAAG
AGATCAAGACTTATTTGCTTGGAAGTTTGCCAAAAAAGGATTTTTTAAATTTAAAGAAAACATTCCAAAAATCAATAAAT
ATATTTTTCAAAATTAA

Upstream 100 bases:

>100_bases
AAAAAAATTTTATGAACTTCTATTCGTTAAGTGATTCCCTAAAAAAATTTAGTATTTACCTAGTTACAATTAAGAAAAAT
ATGTTCTAGCTTATGTAAAA

Downstream 100 bases:

>100_bases
TAATTGAAGATTTTTGAAAGGTAATATATTTTTATAAACTTGAACATTTAATATTCATTGCCATCTAAGTATATATACTT
AATTAAGGATCAGTTTGGTG

Product: DNA photolyase-like protein

Products: NA

Alternate protein names: DNA photolyase; Photoreactivating enzyme [H]

Number of amino acids: Translated: 378; Mature: 377

Protein sequence:

>378_residues
MTQFQDAQEKWVDFLENKIQNYEKFRNFDYGPENVSSVSKLSPYVSHRILLEYELIEEVKKKYQSQKINKFIEEIYWRIY
WKGWMENRPNVWVDFISEKNFKYDFEAYEKAINGDTDLSFFNSWVNELKTHNYLHNHTRMWFASTWIFNFGLPWELGANF
FFKHLYDGDSASNILSWRWVAGLQTKGKQYLFSPSNLRKFSNNRFNVEKINNKQIFLEELNQIPLTDEIYKSNMEQKSES
LILFENDLHAPTLKNIFQNYKRVFIILLGNEQRKIKLSSAVMSFKQQIVSEFVAQFDNVTQLNTIRLQENFKDINQLDMI
YPGIGDNNDFIKNFKISNNKVIFNLVRDQDLFAWKFAKKGFFKFKENIPKINKYIFQN

Sequences:

>Translated_378_residues
MTQFQDAQEKWVDFLENKIQNYEKFRNFDYGPENVSSVSKLSPYVSHRILLEYELIEEVKKKYQSQKINKFIEEIYWRIY
WKGWMENRPNVWVDFISEKNFKYDFEAYEKAINGDTDLSFFNSWVNELKTHNYLHNHTRMWFASTWIFNFGLPWELGANF
FFKHLYDGDSASNILSWRWVAGLQTKGKQYLFSPSNLRKFSNNRFNVEKINNKQIFLEELNQIPLTDEIYKSNMEQKSES
LILFENDLHAPTLKNIFQNYKRVFIILLGNEQRKIKLSSAVMSFKQQIVSEFVAQFDNVTQLNTIRLQENFKDINQLDMI
YPGIGDNNDFIKNFKISNNKVIFNLVRDQDLFAWKFAKKGFFKFKENIPKINKYIFQN
>Mature_377_residues
TQFQDAQEKWVDFLENKIQNYEKFRNFDYGPENVSSVSKLSPYVSHRILLEYELIEEVKKKYQSQKINKFIEEIYWRIYW
KGWMENRPNVWVDFISEKNFKYDFEAYEKAINGDTDLSFFNSWVNELKTHNYLHNHTRMWFASTWIFNFGLPWELGANFF
FKHLYDGDSASNILSWRWVAGLQTKGKQYLFSPSNLRKFSNNRFNVEKINNKQIFLEELNQIPLTDEIYKSNMEQKSESL
ILFENDLHAPTLKNIFQNYKRVFIILLGNEQRKIKLSSAVMSFKQQIVSEFVAQFDNVTQLNTIRLQENFKDINQLDMIY
PGIGDNNDFIKNFKISNNKVIFNLVRDQDLFAWKFAKKGFFKFKENIPKINKYIFQN

Specific function: Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand upon exposure to ul

COG id: COG0415

COG function: function code L; Deoxyribodipyrimidine photolyase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DNA photolyase domain [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6324962, Length=201, Percent_Identity=24.3781094527363, Blast_Score=63, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002081
- InterPro:   IPR018394
- InterPro:   IPR006050
- InterPro:   IPR005101
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00875 DNA_photolyase; PF03441 FAD_binding_7 [H]

EC number: =4.1.99.3 [H]

Molecular weight: Translated: 45544; Mature: 45413

Theoretical pI: Translated: 9.40; Mature: 9.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQFQDAQEKWVDFLENKIQNYEKFRNFDYGPENVSSVSKLSPYVSHRILLEYELIEEVK
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
KKYQSQKINKFIEEIYWRIYWKGWMENRPNVWVDFISEKNFKYDFEAYEKAINGDTDLSF
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHCCCCCHHHH
FNSWVNELKTHNYLHNHTRMWFASTWIFNFGLPWELGANFFFKHLYDGDSASNILSWRWV
HHHHHHHHHHHHHHHHHHHHEEEEEEHEECCCCHHHCHHHHHHHHCCCCCCCCEEEHHHH
AGLQTKGKQYLFSPSNLRKFSNNRFNVEKINNKQIFLEELNQIPLTDEIYKSNMEQKSES
HCCCCCCCEEEECCHHHHHHCCCCEEEEECCCCCHHHHHHCCCCCCHHHHHCCHHHCCCC
LILFENDLHAPTLKNIFQNYKRVFIILLGNEQRKIKLSSAVMSFKQQIVSEFVAQFDNVT
EEEEECCCCCHHHHHHHHHHHEEEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCC
QLNTIRLQENFKDINQLDMIYPGIGDNNDFIKNFKISNNKVIFNLVRDQDLFAWKFAKKG
HHEEEEEHHHHHHHHHHHHCCCCCCCCCCHHEEEEECCCEEEEEEECCCCHHHHHHHHHH
FFKFKENIPKINKYIFQN
HHHHHHCCCHHHHHHCCC
>Mature Secondary Structure 
TQFQDAQEKWVDFLENKIQNYEKFRNFDYGPENVSSVSKLSPYVSHRILLEYELIEEVK
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
KKYQSQKINKFIEEIYWRIYWKGWMENRPNVWVDFISEKNFKYDFEAYEKAINGDTDLSF
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHHCCCCCHHHH
FNSWVNELKTHNYLHNHTRMWFASTWIFNFGLPWELGANFFFKHLYDGDSASNILSWRWV
HHHHHHHHHHHHHHHHHHHHEEEEEEHEECCCCHHHCHHHHHHHHCCCCCCCCEEEHHHH
AGLQTKGKQYLFSPSNLRKFSNNRFNVEKINNKQIFLEELNQIPLTDEIYKSNMEQKSES
HCCCCCCCEEEECCHHHHHHCCCCEEEEECCCCCHHHHHHCCCCCCHHHHHCCHHHCCCC
LILFENDLHAPTLKNIFQNYKRVFIILLGNEQRKIKLSSAVMSFKQQIVSEFVAQFDNVT
EEEEECCCCCHHHHHHHHHHHEEEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCC
QLNTIRLQENFKDINQLDMIYPGIGDNNDFIKNFKISNNKVIFNLVRDQDLFAWKFAKKG
HHEEEEEHHHHHHHHHHHHCCCCCCCCCCHHEEEEECCCEEEEEEECCCCHHHHHHHHHH
FFKFKENIPKINKYIFQN
HHHHHHCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]