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The map label for this gene is elaC

Identifier: 123966743

GI number: 123966743

Start: 1344978

End: 1345916

Strand: Direct

Name: elaC

Synonym: P9515_15101

Alternate gene names: 123966743

Gene position: 1344978-1345916 (Clockwise)

Preceding gene: 123966741

Following gene: 123966744

Centisome position: 78.92

GC content: 35.14

Gene sequence:

>939_bases
GTGAATGTAACTTTCTTAGGAACCAGCTCGGGGGTTCCCACCTTAACAAGAAATGTCTCCTCTTTAGCCCTTAAATTATC
ACAAACGGCGGAAGTTTGGCTTTTTGACTGCGGAGAAGGGACTCAGCATCAATTAATGAAAAGTAATATTAAGTCTTCGC
AAATTAAGAAGATATTTATTACGCACATGCATGGTGATCACATATATGGTTTGCCAGGCCTTTTAGCCACCTTAGGGCTA
TCAGGAAACAGTAATGGTATTGAACTTTATGGCCCTTCAGAGTTAAAATTTTTTGTACTTTCTGCACTTAAAAGCAGCTA
TTGCAAGTTGTCATTTCCGTTGCGTTTTAAAGAAGTTGAAGATAAGGCCTCATTTAATAAAATTTTATTCGAAAACGATA
AGTTAAAAGTTCATTGTGCGTGTCTCAAACATAGACTACCTGCATATGGTTATCGTGTAAGCGAAAAAGATAAGCCTGGT
ATATTTGATATAAAAAAAGCAACAGATTTAAATATTCCGCCTGGACCTATATATTCAGAATTACAAGCCGGCAAAACAGT
TAAATTGAAGGATGGAAGATCTTTTAATGGGCAAGAGTTCTGTGGTCCTCCTCGAAAAGGTGAAAGTTTTGTTTATTGCA
CAGATACAGTTTTTAGTGAGTCGGCAATTAACCTATCAAAAAATGCTGATTTATTGGTCCATGAATCTACATTTTCAAAG
GAAGATGAAAAAATGGCTTACGAAAAATTACATTCGACAACAATAATGGCAGCAAAAACTGCACTCTTGGCCAACGCAAA
GAAATTAATTATCACACATATAAGTCCTAGATATACTCAAAAAAGCCTAATAAAGCCAAGCACTTTACTATTAGAAGCTC
AAAAAATTTTCCCCAATACTTATCTTGCAAAAGATTTCTTGACCGCAAAAATTAAATAA

Upstream 100 bases:

>100_bases
TTTAAAAATCACTATGTCTGAGAAACAAATTTTGTATTTGCCTTAGTTTGACTAAAAGTCTAGATTTAATCTAGATATAA
AAATAAAAATATTATAATAA

Downstream 100 bases:

>100_bases
ACTGCAACAGTTCGTGAGCAGTAGGGTTGTAAATGGCCAACCCATGAAATAATAGTCTTATGGTTTTTTTTAATTTGATG
TCGATCGAAATGGTTTCTAT

Product: metallo-beta-lactamase superfamily protein

Products: NA

Alternate protein names: RNase Z; tRNA 3 endonuclease; tRNase Z

Number of amino acids: Translated: 312; Mature: 312

Protein sequence:

>312_residues
MNVTFLGTSSGVPTLTRNVSSLALKLSQTAEVWLFDCGEGTQHQLMKSNIKSSQIKKIFITHMHGDHIYGLPGLLATLGL
SGNSNGIELYGPSELKFFVLSALKSSYCKLSFPLRFKEVEDKASFNKILFENDKLKVHCACLKHRLPAYGYRVSEKDKPG
IFDIKKATDLNIPPGPIYSELQAGKTVKLKDGRSFNGQEFCGPPRKGESFVYCTDTVFSESAINLSKNADLLVHESTFSK
EDEKMAYEKLHSTTIMAAKTALLANAKKLIITHISPRYTQKSLIKPSTLLLEAQKIFPNTYLAKDFLTAKIK

Sequences:

>Translated_312_residues
MNVTFLGTSSGVPTLTRNVSSLALKLSQTAEVWLFDCGEGTQHQLMKSNIKSSQIKKIFITHMHGDHIYGLPGLLATLGL
SGNSNGIELYGPSELKFFVLSALKSSYCKLSFPLRFKEVEDKASFNKILFENDKLKVHCACLKHRLPAYGYRVSEKDKPG
IFDIKKATDLNIPPGPIYSELQAGKTVKLKDGRSFNGQEFCGPPRKGESFVYCTDTVFSESAINLSKNADLLVHESTFSK
EDEKMAYEKLHSTTIMAAKTALLANAKKLIITHISPRYTQKSLIKPSTLLLEAQKIFPNTYLAKDFLTAKIK
>Mature_312_residues
MNVTFLGTSSGVPTLTRNVSSLALKLSQTAEVWLFDCGEGTQHQLMKSNIKSSQIKKIFITHMHGDHIYGLPGLLATLGL
SGNSNGIELYGPSELKFFVLSALKSSYCKLSFPLRFKEVEDKASFNKILFENDKLKVHCACLKHRLPAYGYRVSEKDKPG
IFDIKKATDLNIPPGPIYSELQAGKTVKLKDGRSFNGQEFCGPPRKGESFVYCTDTVFSESAINLSKNADLLVHESTFSK
EDEKMAYEKLHSTTIMAAKTALLANAKKLIITHISPRYTQKSLIKPSTLLLEAQKIFPNTYLAKDFLTAKIK

Specific function: Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA

COG id: COG1234

COG function: function code R; Metal-dependent hydrolases of the beta-lactamase superfamily III

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RNase Z family

Homologues:

Organism=Homo sapiens, GI8922122, Length=359, Percent_Identity=35.3760445682451, Blast_Score=209, Evalue=2e-54,
Organism=Escherichia coli, GI87082078, Length=309, Percent_Identity=43.042071197411, Blast_Score=251, Evalue=6e-68,
Organism=Drosophila melanogaster, GI24652403, Length=301, Percent_Identity=25.5813953488372, Blast_Score=68, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RNZ_PROM5 (A2BY56)

Other databases:

- EMBL:   CP000552
- RefSeq:   YP_001011824.1
- ProteinModelPortal:   A2BY56
- SMR:   A2BY56
- STRING:   A2BY56
- GeneID:   4720074
- GenomeReviews:   CP000552_GR
- KEGG:   pmc:P9515_15101
- eggNOG:   COG1234
- HOGENOM:   HBG648406
- OMA:   HSTSTMA
- ProtClustDB:   CLSK922157
- BioCyc:   PMAR167542:P9515ORF_1578-MONOMER
- HAMAP:   MF_01818
- InterPro:   IPR001279
- InterPro:   IPR013471
- TIGRFAMs:   TIGR02651

Pfam domain/function: PF00753 Lactamase_B

EC number: =3.1.26.11

Molecular weight: Translated: 34665; Mature: 34665

Theoretical pI: Translated: 9.79; Mature: 9.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVTFLGTSSGVPTLTRNVSSLALKLSQTAEVWLFDCGEGTQHQLMKSNIKSSQIKKIFI
CEEEEEECCCCCCHHHHCHHHHHEEECCCCEEEEEECCCCHHHHHHHHCCCHHHEEEEEE
THMHGDHIYGLPGLLATLGLSGNSNGIELYGPSELKFFVLSALKSSYCKLSFPLRFKEVE
EEECCCEEECCHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHHCCEEEECCEEEEHHH
DKASFNKILFENDKLKVHCACLKHRLPAYGYRVSEKDKPGIFDIKKATDLNIPPGPIYSE
HHHHHCCEEEECCCEEEEEEHHHCCCCCCCEEECCCCCCCEEEECCCCCCCCCCCCCHHH
LQAGKTVKLKDGRSFNGQEFCGPPRKGESFVYCTDTVFSESAINLSKNADLLVHESTFSK
HHCCCEEEEECCCCCCCCCCCCCCCCCCEEEEEECCHHCCCCCCCCCCCCEEEECCCCCC
EDEKMAYEKLHSTTIMAAKTALLANAKKLIITHISPRYTQKSLIKPSTLLLEAQKIFPNT
CHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHCCCHHHEEEHHHHCCCH
YLAKDFLTAKIK
HHHHHHEEEECC
>Mature Secondary Structure
MNVTFLGTSSGVPTLTRNVSSLALKLSQTAEVWLFDCGEGTQHQLMKSNIKSSQIKKIFI
CEEEEEECCCCCCHHHHCHHHHHEEECCCCEEEEEECCCCHHHHHHHHCCCHHHEEEEEE
THMHGDHIYGLPGLLATLGLSGNSNGIELYGPSELKFFVLSALKSSYCKLSFPLRFKEVE
EEECCCEEECCHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHHHHCCEEEECCEEEEHHH
DKASFNKILFENDKLKVHCACLKHRLPAYGYRVSEKDKPGIFDIKKATDLNIPPGPIYSE
HHHHHCCEEEECCCEEEEEEHHHCCCCCCCEEECCCCCCCEEEECCCCCCCCCCCCCHHH
LQAGKTVKLKDGRSFNGQEFCGPPRKGESFVYCTDTVFSESAINLSKNADLLVHESTFSK
HHCCCEEEEECCCCCCCCCCCCCCCCCCEEEEEECCHHCCCCCCCCCCCCEEEECCCCCC
EDEKMAYEKLHSTTIMAAKTALLANAKKLIITHISPRYTQKSLIKPSTLLLEAQKIFPNT
CHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHCCCHHHEEEHHHHCCCH
YLAKDFLTAKIK
HHHHHHEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA