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The map label for this gene is dxr

Identifier: 123966539

GI number: 123966539

Start: 1148725

End: 1149954

Strand: Direct

Name: dxr

Synonym: P9515_13061

Alternate gene names: 123966539

Gene position: 1148725-1149954 (Clockwise)

Preceding gene: 123966538

Following gene: 123966540

Centisome position: 67.41

GC content: 34.55

Gene sequence:

>1230_bases
TTGAAATACATCACTGTACTTGGTTCAACAGGTTCAATAGGAACACAAACTCTGGAAATAGTAAGAGAACTTCCCAACAA
ATTCAAAGTGGTGGCTCTTTCAGCAGGGAGAAATATAGACTTATTGACGGAGCAAGTTAGTCAGCATAAACCAGAAGTAA
TTGCTATCGACGATGAAAATCTTTTAACAGATTTAAAAAATAATATTAACAATTTAGGAATAAGTAATCCTCCAATAGTT
TTAGGTGGCCGAGAGGCAATTAATTCAGTCGCAGCATGGGATTCTGCTGATACCGTAATTACTGGGATAGTAGGATGTGC
TGGACTTATTCCGACGATGTCAGCAATTAAGGCCAGTAAAAATATTGCTCTTGCCAATAAAGAAACATTAATTGCAGCGG
GCTCAGTTGTTATTCCTGCTTTAAAGGAAAACAAAAGTAGACTTTTGCCTGCAGACTCTGAGCATTCAGCTATATTTCAA
TGCATACAAGGATTACCTAATTATGAAAATGCCGATTTTGTAACAGGTCAAATCCCAAATGGTTTAAAAGCTATTCATTT
AACAGCCTCAGGAGGTGCTTTTAGAGATTGGGCAGTAGAAGATTTAAAAAATGTCACAGTAGAAGATGCAACTTCTCATC
CAAATTGGAGTATGGGGAGAAAAATAACTGTAGATTCTGCCACTCTTATGAACAAAGGATTAGAAGTTATTGAAGCACAT
TATCTATTTGGTACACCCTACCAAAATATTGAAATTGTCATACATCCTCAGAGTATCATTCATTCAATGATTGAGATGGA
AGATTCTTCTGTCTTAGCTCAATTAGGATGGCCTGATATGAAACTCCCAATTCTATATGCAATGAGTTGGCCAGAAAGAT
TCAGAACCAATTGGAAAAGATTTAATTTAACTGAGATTGGCCAACTTACATTTAAAAAACCAGATGAAGTAAAATATCCA
TGTATGGGACTTGCCTACTCAGCTGGAAAATGTTCAGGAACTATGCCTGCAGTTCTAAATGCTGCAAATGAAATGGCTGT
AGATCAATTTCTTAAAGAAAAAATTTCTTTTCAAGAAATCCCTACTTTTATAAATAAGACTTGTGAAGCACATATTAATA
AACTCAACTTAAATCCAAATTTAGAAGATATTCTAGAGGTCGATAATTGGGCAAGGATTTTTGTTCAAGAAGAAATCAAA
AAAGGTAAAAAATATATAAATGTAGAATAA

Upstream 100 bases:

>100_bases
ACATGGGTTAGGCTCTAAATTTTAAGAAAAAACCCAATTTAAAATTTTTATTTTTTAAATTCACCTTTAAGTGGGAAAAT
ATTATAAATATTAGAGAAAA

Downstream 100 bases:

>100_bases
ATCAAAATCTAATGATGGATACAAAAACAGCTATTTTTGGTAGAAGAACTATTCATGCCTTTAATTCCAACAAAGTACCC
GAGAAATTAATTTTTGATGC

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase

Number of amino acids: Translated: 409; Mature: 409

Protein sequence:

>409_residues
MKYITVLGSTGSIGTQTLEIVRELPNKFKVVALSAGRNIDLLTEQVSQHKPEVIAIDDENLLTDLKNNINNLGISNPPIV
LGGREAINSVAAWDSADTVITGIVGCAGLIPTMSAIKASKNIALANKETLIAAGSVVIPALKENKSRLLPADSEHSAIFQ
CIQGLPNYENADFVTGQIPNGLKAIHLTASGGAFRDWAVEDLKNVTVEDATSHPNWSMGRKITVDSATLMNKGLEVIEAH
YLFGTPYQNIEIVIHPQSIIHSMIEMEDSSVLAQLGWPDMKLPILYAMSWPERFRTNWKRFNLTEIGQLTFKKPDEVKYP
CMGLAYSAGKCSGTMPAVLNAANEMAVDQFLKEKISFQEIPTFINKTCEAHINKLNLNPNLEDILEVDNWARIFVQEEIK
KGKKYINVE

Sequences:

>Translated_409_residues
MKYITVLGSTGSIGTQTLEIVRELPNKFKVVALSAGRNIDLLTEQVSQHKPEVIAIDDENLLTDLKNNINNLGISNPPIV
LGGREAINSVAAWDSADTVITGIVGCAGLIPTMSAIKASKNIALANKETLIAAGSVVIPALKENKSRLLPADSEHSAIFQ
CIQGLPNYENADFVTGQIPNGLKAIHLTASGGAFRDWAVEDLKNVTVEDATSHPNWSMGRKITVDSATLMNKGLEVIEAH
YLFGTPYQNIEIVIHPQSIIHSMIEMEDSSVLAQLGWPDMKLPILYAMSWPERFRTNWKRFNLTEIGQLTFKKPDEVKYP
CMGLAYSAGKCSGTMPAVLNAANEMAVDQFLKEKISFQEIPTFINKTCEAHINKLNLNPNLEDILEVDNWARIFVQEEIK
KGKKYINVE
>Mature_409_residues
MKYITVLGSTGSIGTQTLEIVRELPNKFKVVALSAGRNIDLLTEQVSQHKPEVIAIDDENLLTDLKNNINNLGISNPPIV
LGGREAINSVAAWDSADTVITGIVGCAGLIPTMSAIKASKNIALANKETLIAAGSVVIPALKENKSRLLPADSEHSAIFQ
CIQGLPNYENADFVTGQIPNGLKAIHLTASGGAFRDWAVEDLKNVTVEDATSHPNWSMGRKITVDSATLMNKGLEVIEAH
YLFGTPYQNIEIVIHPQSIIHSMIEMEDSSVLAQLGWPDMKLPILYAMSWPERFRTNWKRFNLTEIGQLTFKKPDEVKYP
CMGLAYSAGKCSGTMPAVLNAANEMAVDQFLKEKISFQEIPTFINKTCEAHINKLNLNPNLEDILEVDNWARIFVQEEIK
KGKKYINVE

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family

Homologues:

Organism=Escherichia coli, GI1786369, Length=403, Percent_Identity=44.1687344913151, Blast_Score=324, Evalue=6e-90,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXR_PROM5 (A2BXK2)

Other databases:

- EMBL:   CP000552
- RefSeq:   YP_001011620.1
- ProteinModelPortal:   A2BXK2
- SMR:   A2BXK2
- STRING:   A2BXK2
- GeneID:   4718826
- GenomeReviews:   CP000552_GR
- KEGG:   pmc:P9515_13061
- eggNOG:   COG0743
- HOGENOM:   HBG430762
- OMA:   IHSMVEY
- ProtClustDB:   PRK05447
- BioCyc:   PMAR167542:P9515ORF_1365-MONOMER
- HAMAP:   MF_00183
- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF006205
- TIGRFAMs:   TIGR00243

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom

EC number: =1.1.1.267

Molecular weight: Translated: 45041; Mature: 45041

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: NA

Important sites: BINDING 127-127 BINDING 154-154 BINDING 190-190 BINDING 213-213 BINDING 235-235

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYITVLGSTGSIGTQTLEIVRELPNKFKVVALSAGRNIDLLTEQVSQHKPEVIAIDDEN
CEEEEEEECCCCCHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHCCCCEEEECCHH
LLTDLKNNINNLGISNPPIVLGGREAINSVAAWDSADTVITGIVGCAGLIPTMSAIKASK
HHHHHHHHHHHCCCCCCCEEECCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
NIALANKETLIAAGSVVIPALKENKSRLLPADSEHSAIFQCIQGLPNYENADFVTGQIPN
CEEEECCCEEEEECCEEEECHHCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCEEECCCCC
GLKAIHLTASGGAFRDWAVEDLKNVTVEDATSHPNWSMGRKITVDSATLMNKGLEVIEAH
CCEEEEEEECCCCCHHHHHHHHHCCCEECCCCCCCCCCCCEEEECHHHHHHCCHHHHEEE
YLFGTPYQNIEIVIHPQSIIHSMIEMEDSSVLAQLGWPDMKLPILYAMSWPERFRTNWKR
EEECCCCCCEEEEECCHHHHHHHHHCCCCHHHHHCCCCCCCCEEEEEECCCHHHHCCCCC
FNLTEIGQLTFKKPDEVKYPCMGLAYSAGKCSGTMPAVLNAANEMAVDQFLKEKISFQEI
CCHHHHCCEECCCCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCHHHH
PTFINKTCEAHINKLNLNPNLEDILEVDNWARIFVQEEIKKGKKYINVE
HHHHHHHHHHHHEEECCCCCHHHHHHHCCHHHHHHHHHHHCCCCEECCC
>Mature Secondary Structure
MKYITVLGSTGSIGTQTLEIVRELPNKFKVVALSAGRNIDLLTEQVSQHKPEVIAIDDEN
CEEEEEEECCCCCHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHCCCCEEEECCHH
LLTDLKNNINNLGISNPPIVLGGREAINSVAAWDSADTVITGIVGCAGLIPTMSAIKASK
HHHHHHHHHHHCCCCCCCEEECCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
NIALANKETLIAAGSVVIPALKENKSRLLPADSEHSAIFQCIQGLPNYENADFVTGQIPN
CEEEECCCEEEEECCEEEECHHCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCEEECCCCC
GLKAIHLTASGGAFRDWAVEDLKNVTVEDATSHPNWSMGRKITVDSATLMNKGLEVIEAH
CCEEEEEEECCCCCHHHHHHHHHCCCEECCCCCCCCCCCCEEEECHHHHHHCCHHHHEEE
YLFGTPYQNIEIVIHPQSIIHSMIEMEDSSVLAQLGWPDMKLPILYAMSWPERFRTNWKR
EEECCCCCCEEEEECCHHHHHHHHHCCCCHHHHHCCCCCCCCEEEEEECCCHHHHCCCCC
FNLTEIGQLTFKKPDEVKYPCMGLAYSAGKCSGTMPAVLNAANEMAVDQFLKEKISFQEI
CCHHHHCCEECCCCCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCHHHH
PTFINKTCEAHINKLNLNPNLEDILEVDNWARIFVQEEIKKGKKYINVE
HHHHHHHHHHHHEEECCCCCHHHHHHHCCHHHHHHHHHHHCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA