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The map label for this gene is cysS

Identifier: 123966538

GI number: 123966538

Start: 1147164

End: 1148642

Strand: Direct

Name: cysS

Synonym: P9515_13051

Alternate gene names: 123966538

Gene position: 1147164-1148642 (Clockwise)

Preceding gene: 123966537

Following gene: 123966539

Centisome position: 67.31

GC content: 30.9

Gene sequence:

>1479_bases
ATGATCAAATTATTTAATACTTTAAGTAAAAACGTTGAAGTTTTTAAACCAATAGATGAAGAAGTAAAAATATATTGTTG
TGGCGTAACTGTTTATGATTTATGTCATCTTGGGCATGCAAGAAGTTATATAGCTTGGGATGTCTTGAGAAGATTCTTAA
TTTATAGTGATTACAAAGTTAAGTTCGTCCAGAATTTTACTGATATCGACGATAAGATTTTAAAAAGAGCAAAAGAAGAA
AATAGCTCTATGAAGCAGGTTTCAGAAAAAAATATTGCTGAATTCCATAAGGATATGGATGCCCTAGGGATTATGAGGCC
AGATAGTATGCCTAAAGCTACAAATCATATTTGCAATATTTGTTCATTTATAAAAGTACTTGAGAAAAAAGGTTTTGCAT
ATGCCAGAGGTGGAGATGTTTATTATTCTGTTTTTAAAAATAAAGATTATGGAAAACTAAGTAATCAAAATATCCTAGAG
CAAAATATAAATCAGCAAGGCAGGATGACTTCAGATGAAAGCAACAAAAAAAATAATCCCCAAGATTTTGCTCTATGGAA
AAAAGCAAAAGAGAATGAACCATCTTTCGATTCACCTTGGGGGAAAGGCAGACCTGGATGGCATATTGAATGTTCTGCGA
TGGTAAAAGATGAATTAGGAGAAACAATTGATATCCATTTAGGAGGGGCTGATCTTATTTTTCCTCACCATGAAAATGAG
ATTGCACAATCTGAATCAGCTAATAATAAAAAGCTTGCAAACTATTGGCTTCATAATGGGATGGTCAATGTAAATGGGCA
AAAGATGAGCAAATCTTTGAAAAACTTTACGACCATTAGAGATTTATTAGATTCAGGGACAAGTCCAATGACCTTAAGAT
ATTTTGTTTTAACCGTGAACTATAGAAAGCCACTCGATTTCACTGATGAGGCTTTGAAAAGTGCCTCCGAAGCATGGAAA
ACAATTAATGTCGCACTTTCTTTTTTCGATATTACTAAAAAAGAAAATCTATCGATTGAGGTAAACGAAACGAATGAATT
TGTTGAAGAAAAATATAAAGAAAAAATCAATTATGAAATATCTCAAAAAAAGATAAAATTTACTAATGCTTTAAATAACG
ACCTCAATACAGCAGGAGCAATTGCAATTATTTATGAATTAGCTAAGCCACTAAAAAACTTTATAAACCAATTCCAAAGA
ATTAAAAATCTTGACATTAATACTAATGAAAAATTTCATCTTAGAGAAACATTAAAAACATTAGAAGAACTTACCCAAGT
GCTTGGATTAAAAAAAGAAGAAATAATAATCGAAAACAAAATCACCGAAGAACAAATAATATCGCTTATTAATAAAAGAT
TGATCGCAAAAAAGGGAAGAGATTATGCAGAAGCCGATAAAATAAGAAATTCATTAAAGGAAAAAGGCATAGAACTTATA
GATCAATCCACTGAGCTAACAACATGGGTTAGGCTCTAA

Upstream 100 bases:

>100_bases
TGGAAGATTGTGTAAAATTAAAAGTACCACTTCTAGTGGATATTGGAGTTGGAAATAACTGGATGGAAACCAAATAATCT
TCAAATAAATACTTTTTAAT

Downstream 100 bases:

>100_bases
ATTTTAAGAAAAAACCCAATTTAAAATTTTTATTTTTTAAATTCACCTTTAAGTGGGAAAATATTATAAATATTAGAGAA
AATTGAAATACATCACTGTA

Product: cysteinyl-tRNA synthetase

Products: NA

Alternate protein names: Cysteine--tRNA ligase; CysRS

Number of amino acids: Translated: 492; Mature: 492

Protein sequence:

>492_residues
MIKLFNTLSKNVEVFKPIDEEVKIYCCGVTVYDLCHLGHARSYIAWDVLRRFLIYSDYKVKFVQNFTDIDDKILKRAKEE
NSSMKQVSEKNIAEFHKDMDALGIMRPDSMPKATNHICNICSFIKVLEKKGFAYARGGDVYYSVFKNKDYGKLSNQNILE
QNINQQGRMTSDESNKKNNPQDFALWKKAKENEPSFDSPWGKGRPGWHIECSAMVKDELGETIDIHLGGADLIFPHHENE
IAQSESANNKKLANYWLHNGMVNVNGQKMSKSLKNFTTIRDLLDSGTSPMTLRYFVLTVNYRKPLDFTDEALKSASEAWK
TINVALSFFDITKKENLSIEVNETNEFVEEKYKEKINYEISQKKIKFTNALNNDLNTAGAIAIIYELAKPLKNFINQFQR
IKNLDINTNEKFHLRETLKTLEELTQVLGLKKEEIIIENKITEEQIISLINKRLIAKKGRDYAEADKIRNSLKEKGIELI
DQSTELTTWVRL

Sequences:

>Translated_492_residues
MIKLFNTLSKNVEVFKPIDEEVKIYCCGVTVYDLCHLGHARSYIAWDVLRRFLIYSDYKVKFVQNFTDIDDKILKRAKEE
NSSMKQVSEKNIAEFHKDMDALGIMRPDSMPKATNHICNICSFIKVLEKKGFAYARGGDVYYSVFKNKDYGKLSNQNILE
QNINQQGRMTSDESNKKNNPQDFALWKKAKENEPSFDSPWGKGRPGWHIECSAMVKDELGETIDIHLGGADLIFPHHENE
IAQSESANNKKLANYWLHNGMVNVNGQKMSKSLKNFTTIRDLLDSGTSPMTLRYFVLTVNYRKPLDFTDEALKSASEAWK
TINVALSFFDITKKENLSIEVNETNEFVEEKYKEKINYEISQKKIKFTNALNNDLNTAGAIAIIYELAKPLKNFINQFQR
IKNLDINTNEKFHLRETLKTLEELTQVLGLKKEEIIIENKITEEQIISLINKRLIAKKGRDYAEADKIRNSLKEKGIELI
DQSTELTTWVRL
>Mature_492_residues
MIKLFNTLSKNVEVFKPIDEEVKIYCCGVTVYDLCHLGHARSYIAWDVLRRFLIYSDYKVKFVQNFTDIDDKILKRAKEE
NSSMKQVSEKNIAEFHKDMDALGIMRPDSMPKATNHICNICSFIKVLEKKGFAYARGGDVYYSVFKNKDYGKLSNQNILE
QNINQQGRMTSDESNKKNNPQDFALWKKAKENEPSFDSPWGKGRPGWHIECSAMVKDELGETIDIHLGGADLIFPHHENE
IAQSESANNKKLANYWLHNGMVNVNGQKMSKSLKNFTTIRDLLDSGTSPMTLRYFVLTVNYRKPLDFTDEALKSASEAWK
TINVALSFFDITKKENLSIEVNETNEFVEEKYKEKINYEISQKKIKFTNALNNDLNTAGAIAIIYELAKPLKNFINQFQR
IKNLDINTNEKFHLRETLKTLEELTQVLGLKKEEIIIENKITEEQIISLINKRLIAKKGRDYAEADKIRNSLKEKGIELI
DQSTELTTWVRL

Specific function: Unknown

COG id: COG0215

COG function: function code J; Cysteinyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI13375695, Length=318, Percent_Identity=41.1949685534591, Blast_Score=233, Evalue=4e-61,
Organism=Homo sapiens, GI303304987, Length=298, Percent_Identity=38.5906040268456, Blast_Score=206, Evalue=6e-53,
Organism=Homo sapiens, GI62240992, Length=298, Percent_Identity=38.9261744966443, Blast_Score=206, Evalue=6e-53,
Organism=Homo sapiens, GI10835051, Length=298, Percent_Identity=38.9261744966443, Blast_Score=205, Evalue=6e-53,
Organism=Homo sapiens, GI21269877, Length=325, Percent_Identity=37.2307692307692, Blast_Score=205, Evalue=6e-53,
Organism=Escherichia coli, GI1786737, Length=502, Percent_Identity=42.8286852589641, Blast_Score=362, Evalue=1e-101,
Organism=Caenorhabditis elegans, GI17509797, Length=257, Percent_Identity=38.5214007782101, Blast_Score=170, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17509795, Length=257, Percent_Identity=38.5214007782101, Blast_Score=170, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6324082, Length=223, Percent_Identity=43.9461883408072, Blast_Score=189, Evalue=1e-48,
Organism=Drosophila melanogaster, GI19922218, Length=390, Percent_Identity=34.8717948717949, Blast_Score=217, Evalue=2e-56,
Organism=Drosophila melanogaster, GI19922364, Length=305, Percent_Identity=37.7049180327869, Blast_Score=194, Evalue=1e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYC_PROM5 (A2BXK1)

Other databases:

- EMBL:   CP000552
- RefSeq:   YP_001011619.1
- ProteinModelPortal:   A2BXK1
- SMR:   A2BXK1
- STRING:   A2BXK1
- GeneID:   4718825
- GenomeReviews:   CP000552_GR
- KEGG:   pmc:P9515_13051
- eggNOG:   COG0215
- HOGENOM:   HBG327651
- OMA:   HIGNIRA
- ProtClustDB:   PRK00260
- BioCyc:   PMAR167542:P9515ORF_1364-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00041_B
- InterPro:   IPR015803
- InterPro:   IPR015273
- InterPro:   IPR014729
- InterPro:   IPR009080
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR10890
- PRINTS:   PR00983
- SMART:   SM00840
- TIGRFAMs:   TIGR00435

Pfam domain/function: PF09190 DALR_2; PF01406 tRNA-synt_1e; SSF47323 tRNAsyn_1a_bind

EC number: =6.1.1.16

Molecular weight: Translated: 56817; Mature: 56817

Theoretical pI: Translated: 8.31; Mature: 8.31

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: BINDING 271-271

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKLFNTLSKNVEVFKPIDEEVKIYCCGVTVYDLCHLGHARSYIAWDVLRRFLIYSDYKV
CCCHHHHHHCCCEEECCCCCCEEEEEECCHHHHHHHHCCHHHHHHHHHHHHHHHHCCCEE
KFVQNFTDIDDKILKRAKEENSSMKQVSEKNIAEFHKDMDALGIMRPDSMPKATNHICNI
EEHHHHCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
CSFIKVLEKKGFAYARGGDVYYSVFKNKDYGKLSNQNILEQNINQQGRMTSDESNKKNNP
HHHHHHHHHCCCEEECCCCEEEEEECCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCC
QDFALWKKAKENEPSFDSPWGKGRPGWHIECSAMVKDELGETIDIHLGGADLIFPHHENE
HHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEHHHHHHHCCCEEEEEECCEEEECCCCCCH
IAQSESANNKKLANYWLHNGMVNVNGQKMSKSLKNFTTIRDLLDSGTSPMTLRYFVLTVN
HHHCCCCCCHHHHHHHHHCCEEEECHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEEE
YRKPLDFTDEALKSASEAWKTINVALSFFDITKKENLSIEVNETNEFVEEKYKEKINYEI
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHCCCCH
SQKKIKFTNALNNDLNTAGAIAIIYELAKPLKNFINQFQRIKNLDINTNEKFHLRETLKT
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
LEELTQVLGLKKEEIIIENKITEEQIISLINKRLIAKKGRDYAEADKIRNSLKEKGIELI
HHHHHHHHCCCHHHEEECCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHH
DQSTELTTWVRL
CCCCCHHHEECC
>Mature Secondary Structure
MIKLFNTLSKNVEVFKPIDEEVKIYCCGVTVYDLCHLGHARSYIAWDVLRRFLIYSDYKV
CCCHHHHHHCCCEEECCCCCCEEEEEECCHHHHHHHHCCHHHHHHHHHHHHHHHHCCCEE
KFVQNFTDIDDKILKRAKEENSSMKQVSEKNIAEFHKDMDALGIMRPDSMPKATNHICNI
EEHHHHCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHH
CSFIKVLEKKGFAYARGGDVYYSVFKNKDYGKLSNQNILEQNINQQGRMTSDESNKKNNP
HHHHHHHHHCCCEEECCCCEEEEEECCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCC
QDFALWKKAKENEPSFDSPWGKGRPGWHIECSAMVKDELGETIDIHLGGADLIFPHHENE
HHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEHHHHHHHCCCEEEEEECCEEEECCCCCCH
IAQSESANNKKLANYWLHNGMVNVNGQKMSKSLKNFTTIRDLLDSGTSPMTLRYFVLTVN
HHHCCCCCCHHHHHHHHHCCEEEECHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEEEEE
YRKPLDFTDEALKSASEAWKTINVALSFFDITKKENLSIEVNETNEFVEEKYKEKINYEI
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHCCCCH
SQKKIKFTNALNNDLNTAGAIAIIYELAKPLKNFINQFQRIKNLDINTNEKFHLRETLKT
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
LEELTQVLGLKKEEIIIENKITEEQIISLINKRLIAKKGRDYAEADKIRNSLKEKGIELI
HHHHHHHHCCCHHHEEECCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHHH
DQSTELTTWVRL
CCCCCHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA