Click here to switch to the map view.

The map label for this gene is ispA [C]

Identifier: 123966393

GI number: 123966393

Start: 1013799

End: 1014701

Strand: Direct

Name: ispA [C]

Synonym: P9515_11601

Alternate gene names: 123966393

Gene position: 1013799-1014701 (Clockwise)

Preceding gene: 123966392

Following gene: 123966394

Centisome position: 59.49

GC content: 36.54

Gene sequence:

>903_bases
ATGACAGAAGTTATCGATAATATTTCAGATTTTGATAAATATCTAAAAGAGACAAAAAAAATCGTAGAAGAAGCTCTTGA
TTTATCCTTAGGTCCAGAAAATCCAGAAATACTTAGGGAATCAATGAGATATTCTCTCTTGGCTGGAGGTAAAAGAATAC
GTCCAATTTTATGTCTAGCGTCTTGTTCTTTAGCAGGAGGAGAACCATCTCTAGCTGTCCCTACAGCAGTGGCAATAGAA
ATGATTCATACCATGTCATTAATACATGATGATTTACCCGCTATGGACAATGATGACTTAAGAAGAGGAAGACCTACAAA
TCATAAAGTTTATGGAGATGCAATAGCTATACTTGCTGGAGATGCATTATTAACGAGAGCATTTGAAATGGTCTCATTAA
GAAGCCCTGGTGTTGATCCAAATAGATTATTAAATGTAATTGGAGAACTTTCCCTTGTAGCAGGAGCGCCTGGACTTGTT
GGAGGTCAAGTTGTTGATCTGGAATGTGAAGGAAAAGAAGTTGACTTAGAAACCCTCGAGTATATTCATCTTCATAAGAC
GGGTGCCTTACTAAAAGCTTGCGTGAGAACTGGTGCGATGATTGCAGGAGCTAATGATGAATTATTAAAAGCTCTAACCA
CATATGCAGAGGGAATAGGTTTGGCATTCCAAATAATAGATGACATACTTGATTTAACTTCAAGTAGTGAGAAACTCGGT
AAAACAGCGGGTAAAGATCTTTTAGCAGATAAAACTACCTATCCAAAGTTACTTGGAATGGAAGAATCAAAGAAGAGAGC
TTTTGATTTGGTTGATAAAGCAAAAAAAGCAATTGAGCCTTGGGGTTTAGATGCACAATATTTAATCTCCTTAGCTGATT
TCATTACAAATAGAGATAGGTAA

Upstream 100 bases:

>100_bases
ACTATTTTTAGTTGGCAAAAGCAATTTGTTTTATTATCAAGGCTTAGTGACCTTTTGCCATAAAGTCCACGATGCAGAAA
AAATTTACTCAATGTAAAAA

Downstream 100 bases:

>100_bases
AAAGTATTAAATTTATGTCAGAATTTTTAGCTTTCTTAGATAATTCAGTTCTTTTCTGGAGTTTAATATCTTGTTTATTA
GCTCAATTCTTTAAAATTAT

Product: polyprenyl synthetase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 300; Mature: 299

Protein sequence:

>300_residues
MTEVIDNISDFDKYLKETKKIVEEALDLSLGPENPEILRESMRYSLLAGGKRIRPILCLASCSLAGGEPSLAVPTAVAIE
MIHTMSLIHDDLPAMDNDDLRRGRPTNHKVYGDAIAILAGDALLTRAFEMVSLRSPGVDPNRLLNVIGELSLVAGAPGLV
GGQVVDLECEGKEVDLETLEYIHLHKTGALLKACVRTGAMIAGANDELLKALTTYAEGIGLAFQIIDDILDLTSSSEKLG
KTAGKDLLADKTTYPKLLGMEESKKRAFDLVDKAKKAIEPWGLDAQYLISLADFITNRDR

Sequences:

>Translated_300_residues
MTEVIDNISDFDKYLKETKKIVEEALDLSLGPENPEILRESMRYSLLAGGKRIRPILCLASCSLAGGEPSLAVPTAVAIE
MIHTMSLIHDDLPAMDNDDLRRGRPTNHKVYGDAIAILAGDALLTRAFEMVSLRSPGVDPNRLLNVIGELSLVAGAPGLV
GGQVVDLECEGKEVDLETLEYIHLHKTGALLKACVRTGAMIAGANDELLKALTTYAEGIGLAFQIIDDILDLTSSSEKLG
KTAGKDLLADKTTYPKLLGMEESKKRAFDLVDKAKKAIEPWGLDAQYLISLADFITNRDR
>Mature_299_residues
TEVIDNISDFDKYLKETKKIVEEALDLSLGPENPEILRESMRYSLLAGGKRIRPILCLASCSLAGGEPSLAVPTAVAIEM
IHTMSLIHDDLPAMDNDDLRRGRPTNHKVYGDAIAILAGDALLTRAFEMVSLRSPGVDPNRLLNVIGELSLVAGAPGLVG
GQVVDLECEGKEVDLETLEYIHLHKTGALLKACVRTGAMIAGANDELLKALTTYAEGIGLAFQIIDDILDLTSSSEKLGK
TAGKDLLADKTTYPKLLGMEESKKRAFDLVDKAKKAIEPWGLDAQYLISLADFITNRDR

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=260, Percent_Identity=30, Blast_Score=88, Evalue=9e-18,
Organism=Escherichia coli, GI1786623, Length=302, Percent_Identity=45.6953642384106, Blast_Score=204, Evalue=5e-54,
Organism=Escherichia coli, GI1789578, Length=300, Percent_Identity=30.6666666666667, Blast_Score=124, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17505681, Length=190, Percent_Identity=30.5263157894737, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24651612, Length=279, Percent_Identity=28.673835125448, Blast_Score=92, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 32516; Mature: 32385

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEVIDNISDFDKYLKETKKIVEEALDLSLGPENPEILRESMRYSLLAGGKRIRPILCLA
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHH
SCSLAGGEPSLAVPTAVAIEMIHTMSLIHDDLPAMDNDDLRRGRPTNHKVYGDAIAILAG
HHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCEEHHCCHHHHHH
DALLTRAFEMVSLRSPGVDPNRLLNVIGELSLVAGAPGLVGGQVVDLECEGKEVDLETLE
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCHHHHH
YIHLHKTGALLKACVRTGAMIAGANDELLKALTTYAEGIGLAFQIIDDILDLTSSSEKLG
HHHHHHHHHHHHHHHHHCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
KTAGKDLLADKTTYPKLLGMEESKKRAFDLVDKAKKAIEPWGLDAQYLISLADFITNRDR
HHHCHHHHCCCCCCHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TEVIDNISDFDKYLKETKKIVEEALDLSLGPENPEILRESMRYSLLAGGKRIRPILCLA
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHH
SCSLAGGEPSLAVPTAVAIEMIHTMSLIHDDLPAMDNDDLRRGRPTNHKVYGDAIAILAG
HHCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCCEEHHCCHHHHHH
DALLTRAFEMVSLRSPGVDPNRLLNVIGELSLVAGAPGLVGGQVVDLECEGKEVDLETLE
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCHHHHH
YIHLHKTGALLKACVRTGAMIAGANDELLKALTTYAEGIGLAFQIIDDILDLTSSSEKLG
HHHHHHHHHHHHHHHHHCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
KTAGKDLLADKTTYPKLLGMEESKKRAFDLVDKAKKAIEPWGLDAQYLISLADFITNRDR
HHHCHHHHCCCCCCHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8486607; 7918490 [H]