Click here to switch to the map view.

The map label for this gene is gyrA [H]

Identifier: 123966386

GI number: 123966386

Start: 1003552

End: 1006143

Strand: Direct

Name: gyrA [H]

Synonym: P9515_11531

Alternate gene names: 123966386

Gene position: 1003552-1006143 (Clockwise)

Preceding gene: 123966381

Following gene: 123966387

Centisome position: 58.89

GC content: 36.07

Gene sequence:

>2592_bases
ATGTCCGATATTGTTGATTCTGGTGATTCTAGTTTGAGTGAAAATAACGAGCGAATCATTCAAACAGACTTGAGGAATGA
AATGTCACGATCATACTTAGAGTATGCAATGAGCGTCATTGTTGGTCGTGCTCTTCCTGATGCAAGAGATGGGCTAAAGC
CAGTTCACAGAAGGATTCTTTACGCAATGTATGAGCTTGGATTGACAAGCGGTAGGCCTTATAGAAAATGTGCAAGGGTT
GTAGGAGAAGTTTTAGGTAAGTATCATCCTCACGGAGACACTGCTGTTTACGATGCATTAGTACGAATGGCACAAGATTT
CTCGATGAGAATGCCACTCATTGATGGCCATGGAAATTTCGGCTCAGTAGATAATGATCCTCCCGCTGCGATGAGATATA
CAGAGTCACGTCTTCAATCCCTAACAGATGAAAGTTTACTTGAGGATATTGAATCTGAAACAGTTGATTTTTCCGATAAT
TTTGATGGATCACAACAAGAACCAACAGTTTTGCCAGCTAGAATACCCCAACTCCTTTTAAATGGATCATCAGGTATTGC
GGTAGGAATGGCCACTAATATTCCTCCTCATAATTTAGGAGAATTAATTAATGGTCTTAAATCGATAATCAAAAATCCTT
TAATGGAAGACAAAGAACTTTTTGAATTAATTAAAGGTCCTGATTTTCCAACTGGCGGACAGATCTTAGGCAGAGATGGA
ATTAAAGAGACTTTCAAGTCTGGGAGAGGATCTATAACCATGAGAGGGGTAGCAGATATTGAACAAATAAAATCCCCAGG
AAGAGCAGAAAAAGACGCTGTGATAATAACTGAACTTCCATTTCAAACTAACAAAGCAGCTTTAATAGAGAGAATTGCAG
ATTTAGTAAATGACAAAAAATTAGAGGGTATTTCTGACATTAGAGATGAAAGTGACAGGGACGGGATGAGAATTGTAATA
GAACTAAAGAGAGATGCCTATCCTCAAGTTGTCTTAAATAATTTATTTAAGTTAACACCTCTACAAAACAACTTTAGTGC
AAATATTTTAGCTCTTGTCAACGGAGAACCTACAACTCTTTCTCTAAGAAAAATGTTGGATGTATTTCTTGATTTTAGAA
TTGTAACGATTAAAAGAAGAACAACATTCTTATTGAAAAAAGCAGAGGAAAGAGATCACATTATAAAAGGACTTCTTTTA
GCGCTAGAAGCCATGGATAACATTATAAATTTAATAAGATCTGCAAAAGATACAACTTCTGCGAGAGAACAATTACAAAA
AGATCATGAATTATCTGTTATTCAGGCAGATGCTATTTTACAAATGCAATTAAGAAGATTAACCGCTTTAGAGGCAGATA
AAATCAAATCAGAGCATGATGAACTTACCCGGAAAATTACAGACTATAAAAATATATTGCAGGATAAAGACCGCATTAAT
GAAATAATTCTTGAAGAGTTGAGTAAAATAGATGAAAGATTTTCATCCCCAAGGAAAACTGAGATTCTTAATTTAGGGGG
TGGTTTAGATGATATTGACCTTATAGCTAACGAGAGATCAGTTGTTTTACTAACTTCAGCCGGTTATTTAAAAAGAATGC
CAGTTAGTGAATTCGAATCTACCAGCAGAGGTTCAAGAGGTAAAGCCGGAACAAAAAATCAAGAAGATGATGAAGTTAAT
TTATTTATAAGCTGTAATGATCATGACACTCTTTTACTTTTCAGTGATCGAGGGGTAGCTTATGCACTTCCAGCATATCG
AGTCCCTATGAGTAGCAGAACAGCCAAAGGTACTCCTTCTGTTCAACTACTTCCAATCCCAAGAGAAGAACAAATCACTT
CTATTGTTTCAGTAGAGTCTTTTGACAATGATCGTTATTTATTAATGCTTACTAAAGCTGGATTTATTAAAAGAACTCCA
TTATCAGCTTTTTCAAAAATACGTTCAAATGGTTTAATAGCAATTAACCTAGAAGAGGGAGATGCCTTAACTTGGGTCAG
ATTATCAAAAGAAGGCGATAGTGTATTAATTGGATCAAGCAAAGGAATGACGATTCATTTCAGGTTAGATAATAATGAAT
TAAGGCCTCTTGGCAGAACTGCGAGAGGTGTTAAATCTATGAACTTAAAGGATGGAGATAAACTTGTATCCATGGATGTT
TTAACTTCTGATCTAGTTGACCAATTAGCAAGTCTTGAGAATGAAAATGACGAAGATATTGAAAGCAATTCATCAAAGGG
GCCATGGGTTTTAGTAGCTAGTGCTTTTGGTCTAGGGAAGAGGGTCCCAGTAGCTCAATTTAGATTGCAAAAAAGAGCGG
GAATGGGTTTAAGAGCAATAAAATTCAGAATTAAAGATGATTCACTCGTAGGACTTAAGGTTCTTGGAGAAGGTGAAGAA
TTAATTTTTGTCACCGAGAGAGGAGTTATCGTAAGAACAAATGCCGATAAAATTTCGCAACAATCAAGAGCTGCTACAGG
AGTAAGATTACAACGGCTAGACGATGGTGATCATTTATCTGAAGTTGTGTTAGTTCCACATGAGCAAATCGATGATTCAG
ATCAATTAATGACTAAAGAAGAAGAGCTCTAA

Upstream 100 bases:

>100_bases
TTTATAATTTTGTAGAAATATGAGTATTTGAAAATTAATTATTAGCATTATTTTATTCATTCTGACAATGAGGGATTATT
ATTAAATAAAGGTTTTTAAT

Downstream 100 bases:

>100_bases
CAAAGTAGGAGATTAAACCGTTCCCATGGAAATACTTGATATTTTAATTTTAGGTTCTGGACCTGCAGCATTATGTTTAG
CCTCAGAATTAGCTAAACAA

Product: DNA gyrase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 863; Mature: 862

Protein sequence:

>863_residues
MSDIVDSGDSSLSENNERIIQTDLRNEMSRSYLEYAMSVIVGRALPDARDGLKPVHRRILYAMYELGLTSGRPYRKCARV
VGEVLGKYHPHGDTAVYDALVRMAQDFSMRMPLIDGHGNFGSVDNDPPAAMRYTESRLQSLTDESLLEDIESETVDFSDN
FDGSQQEPTVLPARIPQLLLNGSSGIAVGMATNIPPHNLGELINGLKSIIKNPLMEDKELFELIKGPDFPTGGQILGRDG
IKETFKSGRGSITMRGVADIEQIKSPGRAEKDAVIITELPFQTNKAALIERIADLVNDKKLEGISDIRDESDRDGMRIVI
ELKRDAYPQVVLNNLFKLTPLQNNFSANILALVNGEPTTLSLRKMLDVFLDFRIVTIKRRTTFLLKKAEERDHIIKGLLL
ALEAMDNIINLIRSAKDTTSAREQLQKDHELSVIQADAILQMQLRRLTALEADKIKSEHDELTRKITDYKNILQDKDRIN
EIILEELSKIDERFSSPRKTEILNLGGGLDDIDLIANERSVVLLTSAGYLKRMPVSEFESTSRGSRGKAGTKNQEDDEVN
LFISCNDHDTLLLFSDRGVAYALPAYRVPMSSRTAKGTPSVQLLPIPREEQITSIVSVESFDNDRYLLMLTKAGFIKRTP
LSAFSKIRSNGLIAINLEEGDALTWVRLSKEGDSVLIGSSKGMTIHFRLDNNELRPLGRTARGVKSMNLKDGDKLVSMDV
LTSDLVDQLASLENENDEDIESNSSKGPWVLVASAFGLGKRVPVAQFRLQKRAGMGLRAIKFRIKDDSLVGLKVLGEGEE
LIFVTERGVIVRTNADKISQQSRAATGVRLQRLDDGDHLSEVVLVPHEQIDDSDQLMTKEEEL

Sequences:

>Translated_863_residues
MSDIVDSGDSSLSENNERIIQTDLRNEMSRSYLEYAMSVIVGRALPDARDGLKPVHRRILYAMYELGLTSGRPYRKCARV
VGEVLGKYHPHGDTAVYDALVRMAQDFSMRMPLIDGHGNFGSVDNDPPAAMRYTESRLQSLTDESLLEDIESETVDFSDN
FDGSQQEPTVLPARIPQLLLNGSSGIAVGMATNIPPHNLGELINGLKSIIKNPLMEDKELFELIKGPDFPTGGQILGRDG
IKETFKSGRGSITMRGVADIEQIKSPGRAEKDAVIITELPFQTNKAALIERIADLVNDKKLEGISDIRDESDRDGMRIVI
ELKRDAYPQVVLNNLFKLTPLQNNFSANILALVNGEPTTLSLRKMLDVFLDFRIVTIKRRTTFLLKKAEERDHIIKGLLL
ALEAMDNIINLIRSAKDTTSAREQLQKDHELSVIQADAILQMQLRRLTALEADKIKSEHDELTRKITDYKNILQDKDRIN
EIILEELSKIDERFSSPRKTEILNLGGGLDDIDLIANERSVVLLTSAGYLKRMPVSEFESTSRGSRGKAGTKNQEDDEVN
LFISCNDHDTLLLFSDRGVAYALPAYRVPMSSRTAKGTPSVQLLPIPREEQITSIVSVESFDNDRYLLMLTKAGFIKRTP
LSAFSKIRSNGLIAINLEEGDALTWVRLSKEGDSVLIGSSKGMTIHFRLDNNELRPLGRTARGVKSMNLKDGDKLVSMDV
LTSDLVDQLASLENENDEDIESNSSKGPWVLVASAFGLGKRVPVAQFRLQKRAGMGLRAIKFRIKDDSLVGLKVLGEGEE
LIFVTERGVIVRTNADKISQQSRAATGVRLQRLDDGDHLSEVVLVPHEQIDDSDQLMTKEEEL
>Mature_862_residues
SDIVDSGDSSLSENNERIIQTDLRNEMSRSYLEYAMSVIVGRALPDARDGLKPVHRRILYAMYELGLTSGRPYRKCARVV
GEVLGKYHPHGDTAVYDALVRMAQDFSMRMPLIDGHGNFGSVDNDPPAAMRYTESRLQSLTDESLLEDIESETVDFSDNF
DGSQQEPTVLPARIPQLLLNGSSGIAVGMATNIPPHNLGELINGLKSIIKNPLMEDKELFELIKGPDFPTGGQILGRDGI
KETFKSGRGSITMRGVADIEQIKSPGRAEKDAVIITELPFQTNKAALIERIADLVNDKKLEGISDIRDESDRDGMRIVIE
LKRDAYPQVVLNNLFKLTPLQNNFSANILALVNGEPTTLSLRKMLDVFLDFRIVTIKRRTTFLLKKAEERDHIIKGLLLA
LEAMDNIINLIRSAKDTTSAREQLQKDHELSVIQADAILQMQLRRLTALEADKIKSEHDELTRKITDYKNILQDKDRINE
IILEELSKIDERFSSPRKTEILNLGGGLDDIDLIANERSVVLLTSAGYLKRMPVSEFESTSRGSRGKAGTKNQEDDEVNL
FISCNDHDTLLLFSDRGVAYALPAYRVPMSSRTAKGTPSVQLLPIPREEQITSIVSVESFDNDRYLLMLTKAGFIKRTPL
SAFSKIRSNGLIAINLEEGDALTWVRLSKEGDSVLIGSSKGMTIHFRLDNNELRPLGRTARGVKSMNLKDGDKLVSMDVL
TSDLVDQLASLENENDEDIESNSSKGPWVLVASAFGLGKRVPVAQFRLQKRAGMGLRAIKFRIKDDSLVGLKVLGEGEEL
IFVTERGVIVRTNADKISQQSRAATGVRLQRLDDGDHLSEVVLVPHEQIDDSDQLMTKEEEL

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=517, Percent_Identity=22.8239845261122, Blast_Score=79, Evalue=2e-14,
Organism=Homo sapiens, GI19913406, Length=342, Percent_Identity=23.6842105263158, Blast_Score=73, Evalue=9e-13,
Organism=Escherichia coli, GI1788562, Length=855, Percent_Identity=42.3391812865497, Blast_Score=666, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=613, Percent_Identity=37.1941272430669, Blast_Score=373, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI17535065, Length=175, Percent_Identity=30.2857142857143, Blast_Score=72, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI212645845, Length=227, Percent_Identity=27.7533039647577, Blast_Score=67, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6324241, Length=293, Percent_Identity=29.0102389078498, Blast_Score=85, Evalue=6e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 96107; Mature: 95976

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDIVDSGDSSLSENNERIIQTDLRNEMSRSYLEYAMSVIVGRALPDARDGLKPVHRRIL
CCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHH
YAMYELGLTSGRPYRKCARVVGEVLGKYHPHGDTAVYDALVRMAQDFSMRMPLIDGHGNF
HHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEECCCCC
GSVDNDPPAAMRYTESRLQSLTDESLLEDIESETVDFSDNFDGSQQEPTVLPARIPQLLL
CCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHC
NGSSGIAVGMATNIPPHNLGELINGLKSIIKNPLMEDKELFELIKGPDFPTGGQILGRDG
CCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCEECCCH
IKETFKSGRGSITMRGVADIEQIKSPGRAEKDAVIITELPFQTNKAALIERIADLVNDKK
HHHHHHCCCCCEEECCHHHHHHHCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCHH
LEGISDIRDESDRDGMRIVIELKRDAYPQVVLNNLFKLTPLQNNFSANILALVNGEPTTL
CCCHHHHCCCCCCCCCEEEEEECCCCCHHHHHHHHHEECCCCCCCCCEEEEEECCCCCCH
SLRKMLDVFLDFRIVTIKRRTTFLLKKAEERDHIIKGLLLALEAMDNIINLIRSAKDTTS
HHHHHHHHHHCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
AREQLQKDHELSVIQADAILQMQLRRLTALEADKIKSEHDELTRKITDYKNILQDKDRIN
HHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EIILEELSKIDERFSSPRKTEILNLGGGLDDIDLIANERSVVLLTSAGYLKRMPVSEFES
HHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHEECCCCEEEEECCCHHHCCCHHHHHH
TSRGSRGKAGTKNQEDDEVNLFISCNDHDTLLLFSDRGVAYALPAYRVPMSSRTAKGTPS
CCCCCCCCCCCCCCCCCCEEEEEEECCCCEEEEEECCCCEEECCCEECCCCCCCCCCCCC
VQLLPIPREEQITSIVSVESFDNDRYLLMLTKAGFIKRTPLSAFSKIRSNGLIAINLEEG
EEEEECCCHHHHHHHHHHCCCCCCCEEEEEECCCCEECCCHHHHHHHHCCCEEEEEECCC
DALTWVRLSKEGDSVLIGSSKGMTIHFRLDNNELRPLGRTARGVKSMNLKDGDKLVSMDV
CEEEEEEEECCCCEEEEECCCCEEEEEEECCCCCCCCCHHHHCCCCCCCCCCCCEEEHHH
LTSDLVDQLASLENENDEDIESNSSKGPWVLVASAFGLGKRVPVAQFRLQKRAGMGLRAI
HHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHCCCCEEEE
KFRIKDDSLVGLKVLGEGEELIFVTERGVIVRTNADKISQQSRAATGVRLQRLDDGDHLS
EEEECCCCEEEEEEECCCCEEEEEECCCEEEEECHHHHHHHHHHHCCCEEEECCCCCCCC
EVVLVPHEQIDDSDQLMTKEEEL
CEEEECCCCCCCCHHHHCCCCCC
>Mature Secondary Structure 
SDIVDSGDSSLSENNERIIQTDLRNEMSRSYLEYAMSVIVGRALPDARDGLKPVHRRIL
CCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHH
YAMYELGLTSGRPYRKCARVVGEVLGKYHPHGDTAVYDALVRMAQDFSMRMPLIDGHGNF
HHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEECCCCC
GSVDNDPPAAMRYTESRLQSLTDESLLEDIESETVDFSDNFDGSQQEPTVLPARIPQLLL
CCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHHHC
NGSSGIAVGMATNIPPHNLGELINGLKSIIKNPLMEDKELFELIKGPDFPTGGQILGRDG
CCCCCEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCEECCCH
IKETFKSGRGSITMRGVADIEQIKSPGRAEKDAVIITELPFQTNKAALIERIADLVNDKK
HHHHHHCCCCCEEECCHHHHHHHCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCHH
LEGISDIRDESDRDGMRIVIELKRDAYPQVVLNNLFKLTPLQNNFSANILALVNGEPTTL
CCCHHHHCCCCCCCCCEEEEEECCCCCHHHHHHHHHEECCCCCCCCCEEEEEECCCCCCH
SLRKMLDVFLDFRIVTIKRRTTFLLKKAEERDHIIKGLLLALEAMDNIINLIRSAKDTTS
HHHHHHHHHHCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
AREQLQKDHELSVIQADAILQMQLRRLTALEADKIKSEHDELTRKITDYKNILQDKDRIN
HHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EIILEELSKIDERFSSPRKTEILNLGGGLDDIDLIANERSVVLLTSAGYLKRMPVSEFES
HHHHHHHHHHHHHHCCCCCEEEEECCCCCCCHHHEECCCCEEEEECCCHHHCCCHHHHHH
TSRGSRGKAGTKNQEDDEVNLFISCNDHDTLLLFSDRGVAYALPAYRVPMSSRTAKGTPS
CCCCCCCCCCCCCCCCCCEEEEEEECCCCEEEEEECCCCEEECCCEECCCCCCCCCCCCC
VQLLPIPREEQITSIVSVESFDNDRYLLMLTKAGFIKRTPLSAFSKIRSNGLIAINLEEG
EEEEECCCHHHHHHHHHHCCCCCCCEEEEEECCCCEECCCHHHHHHHHCCCEEEEEECCC
DALTWVRLSKEGDSVLIGSSKGMTIHFRLDNNELRPLGRTARGVKSMNLKDGDKLVSMDV
CEEEEEEEECCCCEEEEECCCCEEEEEEECCCCCCCCCHHHHCCCCCCCCCCCCEEEHHH
LTSDLVDQLASLENENDEDIESNSSKGPWVLVASAFGLGKRVPVAQFRLQKRAGMGLRAI
HHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHCCCCEEEE
KFRIKDDSLVGLKVLGEGEELIFVTERGVIVRTNADKISQQSRAATGVRLQRLDDGDHLS
EEEECCCCEEEEEEECCCCEEEEEECCCEEEEECHHHHHHHHHHHCCCEEEECCCCCCCC
EVVLVPHEQIDDSDQLMTKEEEL
CEEEECCCCCCCCHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]