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The map label for this gene is hisZ [H]

Identifier: 123966215

GI number: 123966215

Start: 878806

End: 879957

Strand: Direct

Name: hisZ [H]

Synonym: P9515_09821

Alternate gene names: 123966215

Gene position: 878806-879957 (Clockwise)

Preceding gene: 123966214

Following gene: 123966216

Centisome position: 51.57

GC content: 24.05

Gene sequence:

>1152_bases
ATGAGTGATATAAAAGAATTTAATTTAATAGATGTAAGGAATAATTCCACAATTGTTAATGATTTAAATAATGTATATAA
GCTTTGGGGTTACGAAGAAGTTTCACCTTCATTTATTAATAACCTTGACACAATTAAAGGTAGTGAAGTAATCAATGAGG
ATGAACTTATTGGAATAGTTAGTAATAATTCATTATGCTTAAGACCTGAAATGACAACATCAATTGTTAAGTTAACTTCA
ACAAGATTATTAAATAAGAAGAGACCAATAAGGCTTTATAACAGTGGTATTGTATTTAACAAAAAACAAAGCTATAAAAA
TACTTATAAATTTCAAGAAAATTTACAAAGTGGTATTGAACTAATTAGTTATGATACAAAATTTCCCGAAATTGAAGTAA
TAAATATATTATTTGATGCTATTGATAATATAAATTTAATAGAGAATAGTAATCTTACTCTCCTTGTCAGTACAACAAAA
ATAATGGATTTAATTTTATTTAATTATAAAAATAATAATTATGAGGAAATTAAAAAATGTATGGTTAACCTCGATCAAGA
ATCATTGAATAGATTAAATATTGATAAAAATGATCAAACTATATTAAAGGAGTTAATCTTTACGAGAGGAGAACCAGAAA
TCATACTTAAAAAGCTTAAAAATATTTACGGTTACAATGATGTTATTAAGGAACTTGAAAACTTTTTTAATACTTTATCT
AAAATTGCGAAAAGATATAATATTAAAATACAACTTGATCCTACATATCAACCTCATCTTAATTTATATGCAGGTATAGT
TTTCCAACTTATATGCGAAAATAGTTTTGTTAAAACAATTATTGCAAAAGGTGGAAGGTATGACGAATTAGTAAGGTACT
TCAATCCTAATGAAAAAATAATTAATGGAATTGGTTTTACAATCTCTATAGATAATTTAAGGGAATTAATTATTGACGAT
TCGCAATCTAAAAAGAAAGTATTGTTGTTATTTAAAGATTCTTGCTTATTAGATAAAGGTATAAACGAGCAAAAAGCTTT
GCAAAAAAAAGGAATAACTACAATATTACATTTGAATCCATGCAATGAAAATTCAAAAGCTAATATTCTTATGAAAGAAC
ATAATTGTACAGAAATACAATGGATAAAATAA

Upstream 100 bases:

>100_bases
TGCAGTCCAAAATTAGAAGAAGAACTTAAATTAGAACTAGGAAACGTAACTCCTTTTAATAAAAACATTTATACTTAAAA
ATGCAATTTATAATATTAAT

Downstream 100 bases:

>100_bases
AAATCTCTCTTTAAAATTTTTAAAGAATAAAAAACTAGAAACTTTTATTTGTTAATTCAATATTTTAAGTACGGACAATA
CTCCTGTTAATGGTTGATTA

Product: ATP phosphoribosyltransferase regulatory subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 383; Mature: 382

Protein sequence:

>383_residues
MSDIKEFNLIDVRNNSTIVNDLNNVYKLWGYEEVSPSFINNLDTIKGSEVINEDELIGIVSNNSLCLRPEMTTSIVKLTS
TRLLNKKRPIRLYNSGIVFNKKQSYKNTYKFQENLQSGIELISYDTKFPEIEVINILFDAIDNINLIENSNLTLLVSTTK
IMDLILFNYKNNNYEEIKKCMVNLDQESLNRLNIDKNDQTILKELIFTRGEPEIILKKLKNIYGYNDVIKELENFFNTLS
KIAKRYNIKIQLDPTYQPHLNLYAGIVFQLICENSFVKTIIAKGGRYDELVRYFNPNEKIINGIGFTISIDNLRELIIDD
SQSKKKVLLLFKDSCLLDKGINEQKALQKKGITTILHLNPCNENSKANILMKEHNCTEIQWIK

Sequences:

>Translated_383_residues
MSDIKEFNLIDVRNNSTIVNDLNNVYKLWGYEEVSPSFINNLDTIKGSEVINEDELIGIVSNNSLCLRPEMTTSIVKLTS
TRLLNKKRPIRLYNSGIVFNKKQSYKNTYKFQENLQSGIELISYDTKFPEIEVINILFDAIDNINLIENSNLTLLVSTTK
IMDLILFNYKNNNYEEIKKCMVNLDQESLNRLNIDKNDQTILKELIFTRGEPEIILKKLKNIYGYNDVIKELENFFNTLS
KIAKRYNIKIQLDPTYQPHLNLYAGIVFQLICENSFVKTIIAKGGRYDELVRYFNPNEKIINGIGFTISIDNLRELIIDD
SQSKKKVLLLFKDSCLLDKGINEQKALQKKGITTILHLNPCNENSKANILMKEHNCTEIQWIK
>Mature_382_residues
SDIKEFNLIDVRNNSTIVNDLNNVYKLWGYEEVSPSFINNLDTIKGSEVINEDELIGIVSNNSLCLRPEMTTSIVKLTST
RLLNKKRPIRLYNSGIVFNKKQSYKNTYKFQENLQSGIELISYDTKFPEIEVINILFDAIDNINLIENSNLTLLVSTTKI
MDLILFNYKNNNYEEIKKCMVNLDQESLNRLNIDKNDQTILKELIFTRGEPEIILKKLKNIYGYNDVIKELENFFNTLSK
IAKRYNIKIQLDPTYQPHLNLYAGIVFQLICENSFVKTIIAKGGRYDELVRYFNPNEKIINGIGFTISIDNLRELIIDDS
QSKKKVLLLFKDSCLLDKGINEQKALQKKGITTILHLNPCNENSKANILMKEHNCTEIQWIK

Specific function: Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine [H]

COG id: COG3705

COG function: function code E; ATP phosphoribosyltransferase involved in histidine biosynthesis

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004516 [H]

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 44372; Mature: 44241

Theoretical pI: Translated: 7.76; Mature: 7.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDIKEFNLIDVRNNSTIVNDLNNVYKLWGYEEVSPSFINNLDTIKGSEVINEDELIGIV
CCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCCCCCCCEEEEE
SNNSLCLRPEMTTSIVKLTSTRLLNKKRPIRLYNSGIVFNKKQSYKNTYKFQENLQSGIE
ECCCEEECCCHHHHHHHHHHHHHHCCCCCEEEECCCEEEECCHHHHHHHHHHHHHHHHHH
LISYDTKFPEIEVINILFDAIDNINLIENSNLTLLVSTTKIMDLILFNYKNNNYEEIKKC
EEECCCCCCCHHHHHHHHHHHCCCEEEECCCEEEEEEHHHHHHHHEEECCCCCHHHHHHH
MVNLDQESLNRLNIDKNDQTILKELIFTRGEPEIILKKLKNIYGYNDVIKELENFFNTLS
HHCCCHHHHHHCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
KIAKRYNIKIQLDPTYQPHLNLYAGIVFQLICENSFVKTIIAKGGRYDELVRYFNPNEKI
HHHHHEEEEEEECCCCCCCHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHCCCCHHH
INGIGFTISIDNLRELIIDDSQSKKKVLLLFKDSCLLDKGINEQKALQKKGITTILHLNP
CCCCCEEEEHHHHHHHHHCCCCCCCEEEEEEECCCHHCCCCCHHHHHHHCCCEEEEEEEC
CNENSKANILMKEHNCTEIQWIK
CCCCCCCEEEEEECCCCEEEEEC
>Mature Secondary Structure 
SDIKEFNLIDVRNNSTIVNDLNNVYKLWGYEEVSPSFINNLDTIKGSEVINEDELIGIV
CCCCCCCEEEECCCCCHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCCCCCCCEEEEE
SNNSLCLRPEMTTSIVKLTSTRLLNKKRPIRLYNSGIVFNKKQSYKNTYKFQENLQSGIE
ECCCEEECCCHHHHHHHHHHHHHHCCCCCEEEECCCEEEECCHHHHHHHHHHHHHHHHHH
LISYDTKFPEIEVINILFDAIDNINLIENSNLTLLVSTTKIMDLILFNYKNNNYEEIKKC
EEECCCCCCCHHHHHHHHHHHCCCEEEECCCEEEEEEHHHHHHHHEEECCCCCHHHHHHH
MVNLDQESLNRLNIDKNDQTILKELIFTRGEPEIILKKLKNIYGYNDVIKELENFFNTLS
HHCCCHHHHHHCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
KIAKRYNIKIQLDPTYQPHLNLYAGIVFQLICENSFVKTIIAKGGRYDELVRYFNPNEKI
HHHHHEEEEEEECCCCCCCHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHHCCCCHHH
INGIGFTISIDNLRELIIDDSQSKKKVLLLFKDSCLLDKGINEQKALQKKGITTILHLNP
CCCCCEEEEHHHHHHHHHCCCCCCCEEEEEEECCCHHCCCCCHHHHHHHCCCEEEEEEEC
CNENSKANILMKEHNCTEIQWIK
CCCCCCCEEEEEECCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12917642 [H]