BacMap

Definition	Prochlorococcus marinus str. MIT 9515, complete genome.
Accession	NC_008817
Length	1,704,176

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The map label for this gene is rot [H]

Identifier: 123966209

GI number: 123966209

Start: 873391

End: 873828

Strand: Reverse

Name: rot [H]

Synonym: P9515_09761

Alternate gene names: 123966209

Gene position: 873828-873391 (Counterclockwise)

Preceding gene: 123966210

Following gene: 123966207

Centisome position: 51.28

GC content: 36.07

Gene sequence:

>438_bases
ATGACAAAAGCTTTATTTGAAACTGATGCAGGCATTATTAATATTGAATTATTTACCAATGACGCACCTAATACAGTTAA
TAATTTCACAAAATTAATTACTGAAGGTTTTTATGACGGTTTGGCCTTTCACCGCGTCATCCCTGGCTTTATGGCTCAGG
GAGGTTGCCCTAATACCCGCGAAGGATCTTCAGGAATGCCTGGGACAGGGGGACCGGGATACAATATTAAATGCGAAATT
AATTCAAATAAACATCTTAAAGGTTCACTTTCTATGGCACATGCAGGTAAAGATACTGGTGGTAGCCAATTTTTTATAGT
CTATGAATCTCAACCTCATTTAGACGGAGTTCATACTGTCTTTGGAAAAACAGAAGATATGGATATTGTTTTAAAACTTA
CAAACGGATCAAAAATTATTAAAGCTAGCTTAGTCTAA

Upstream 100 bases:

>100_bases
TGAACATAAAGATGAAAATATTGATTTAAATTCCATTAAGGAGAATCTTGAAAAGCTTCTTTAACGTTTATTATGCAAAT
ATCAAAGTATAAAATTTAAA

Downstream 100 bases:

>100_bases
GCTAAATCTTTATTAAATATAATACTAAAAGTTTCTTTATCAAGATTAAATTTTCTAGTAGAGGAATATAAATAATCATT
TTTTATTGAAAACTTTGTAT

Product: cyclophilin-type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase; Rotamase [H]

Number of amino acids: Translated: 145; Mature: 144

Protein sequence:

>145_residues
MTKALFETDAGIINIELFTNDAPNTVNNFTKLITEGFYDGLAFHRVIPGFMAQGGCPNTREGSSGMPGTGGPGYNIKCEI
NSNKHLKGSLSMAHAGKDTGGSQFFIVYESQPHLDGVHTVFGKTEDMDIVLKLTNGSKIIKASLV

Sequences:

>Translated_145_residues
MTKALFETDAGIINIELFTNDAPNTVNNFTKLITEGFYDGLAFHRVIPGFMAQGGCPNTREGSSGMPGTGGPGYNIKCEI
NSNKHLKGSLSMAHAGKDTGGSQFFIVYESQPHLDGVHTVFGKTEDMDIVLKLTNGSKIIKASLV
>Mature_144_residues
TKALFETDAGIINIELFTNDAPNTVNNFTKLITEGFYDGLAFHRVIPGFMAQGGCPNTREGSSGMPGTGGPGYNIKCEIN
SNKHLKGSLSMAHAGKDTGGSQFFIVYESQPHLDGVHTVFGKTEDMDIVLKLTNGSKIIKASLV

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI64276486, Length=123, Percent_Identity=43.0894308943089, Blast_Score=95, Evalue=2e-20,
Organism=Homo sapiens, GI7706339, Length=121, Percent_Identity=41.3223140495868, Blast_Score=91, Evalue=3e-19,
Organism=Homo sapiens, GI19557636, Length=147, Percent_Identity=41.4965986394558, Blast_Score=90, Evalue=6e-19,
Organism=Homo sapiens, GI24308049, Length=135, Percent_Identity=41.4814814814815, Blast_Score=90, Evalue=8e-19,
Organism=Homo sapiens, GI10863927, Length=129, Percent_Identity=48.8372093023256, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI4758950, Length=136, Percent_Identity=43.3823529411765, Blast_Score=81, Evalue=3e-16,
Organism=Homo sapiens, GI256017253, Length=128, Percent_Identity=42.96875, Blast_Score=81, Evalue=4e-16,
Organism=Homo sapiens, GI221139811, Length=128, Percent_Identity=42.96875, Blast_Score=81, Evalue=4e-16,
Organism=Homo sapiens, GI256017251, Length=128, Percent_Identity=42.96875, Blast_Score=81, Evalue=4e-16,
Organism=Homo sapiens, GI4505991, Length=126, Percent_Identity=46.031746031746, Blast_Score=80, Evalue=7e-16,
Organism=Homo sapiens, GI209417936, Length=125, Percent_Identity=44.8, Blast_Score=77, Evalue=4e-15,
Organism=Homo sapiens, GI30102944, Length=125, Percent_Identity=44.8, Blast_Score=77, Evalue=4e-15,
Organism=Homo sapiens, GI219842199, Length=125, Percent_Identity=44.8, Blast_Score=77, Evalue=4e-15,
Organism=Homo sapiens, GI42560244, Length=151, Percent_Identity=37.0860927152318, Blast_Score=77, Evalue=5e-15,
Organism=Homo sapiens, GI4826932, Length=143, Percent_Identity=40.5594405594406, Blast_Score=77, Evalue=7e-15,
Organism=Homo sapiens, GI5031987, Length=136, Percent_Identity=43.3823529411765, Blast_Score=76, Evalue=9e-15,
Organism=Homo sapiens, GI150418007, Length=128, Percent_Identity=40.625, Blast_Score=76, Evalue=1e-14,
Organism=Homo sapiens, GI178057341, Length=125, Percent_Identity=44, Blast_Score=75, Evalue=2e-14,
Organism=Homo sapiens, GI310127646, Length=131, Percent_Identity=41.9847328244275, Blast_Score=75, Evalue=2e-14,
Organism=Homo sapiens, GI310114371, Length=131, Percent_Identity=41.9847328244275, Blast_Score=75, Evalue=2e-14,
Organism=Homo sapiens, GI310119221, Length=131, Percent_Identity=41.9847328244275, Blast_Score=75, Evalue=2e-14,
Organism=Homo sapiens, GI6631100, Length=124, Percent_Identity=41.9354838709677, Blast_Score=74, Evalue=4e-14,
Organism=Homo sapiens, GI310129267, Length=125, Percent_Identity=44, Blast_Score=74, Evalue=5e-14,
Organism=Homo sapiens, GI310120620, Length=125, Percent_Identity=44, Blast_Score=74, Evalue=5e-14,
Organism=Homo sapiens, GI310110104, Length=128, Percent_Identity=43.75, Blast_Score=74, Evalue=7e-14,
Organism=Homo sapiens, GI5174637, Length=138, Percent_Identity=40.5797101449275, Blast_Score=72, Evalue=1e-13,
Organism=Homo sapiens, GI45439316, Length=132, Percent_Identity=40.1515151515151, Blast_Score=72, Evalue=2e-13,
Organism=Homo sapiens, GI303305009, Length=132, Percent_Identity=40.1515151515151, Blast_Score=72, Evalue=2e-13,
Organism=Homo sapiens, GI20911035, Length=145, Percent_Identity=36.551724137931, Blast_Score=71, Evalue=3e-13,
Organism=Homo sapiens, GI5454154, Length=132, Percent_Identity=36.3636363636364, Blast_Score=68, Evalue=2e-12,
Organism=Homo sapiens, GI22547215, Length=118, Percent_Identity=34.7457627118644, Blast_Score=68, Evalue=3e-12,
Organism=Homo sapiens, GI22547212, Length=118, Percent_Identity=34.7457627118644, Blast_Score=68, Evalue=3e-12,
Organism=Homo sapiens, GI7657473, Length=118, Percent_Identity=34.7457627118644, Blast_Score=68, Evalue=3e-12,
Organism=Homo sapiens, GI169164185, Length=128, Percent_Identity=41.40625, Blast_Score=66, Evalue=9e-12,
Organism=Homo sapiens, GI169163623, Length=128, Percent_Identity=41.40625, Blast_Score=66, Evalue=9e-12,
Organism=Homo sapiens, GI169163387, Length=128, Percent_Identity=41.40625, Blast_Score=66, Evalue=1e-11,
Organism=Homo sapiens, GI310132444, Length=128, Percent_Identity=39.0625, Blast_Score=64, Evalue=3e-11,
Organism=Homo sapiens, GI310113152, Length=128, Percent_Identity=39.0625, Blast_Score=64, Evalue=3e-11,
Organism=Homo sapiens, GI169214050, Length=128, Percent_Identity=42.1875, Blast_Score=64, Evalue=6e-11,
Organism=Homo sapiens, GI239751853, Length=128, Percent_Identity=42.1875, Blast_Score=63, Evalue=8e-11,
Organism=Homo sapiens, GI113428306, Length=128, Percent_Identity=42.1875, Blast_Score=63, Evalue=8e-11,
Organism=Escherichia coli, GI1789763, Length=139, Percent_Identity=38.1294964028777, Blast_Score=74, Evalue=4e-15,
Organism=Escherichia coli, GI1786736, Length=105, Percent_Identity=40, Blast_Score=63, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17539496, Length=121, Percent_Identity=43.801652892562, Blast_Score=92, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI71997782, Length=125, Percent_Identity=42.4, Blast_Score=88, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71980594, Length=122, Percent_Identity=42.6229508196721, Blast_Score=88, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71980590, Length=120, Percent_Identity=43.3333333333333, Blast_Score=87, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17506307, Length=140, Percent_Identity=44.2857142857143, Blast_Score=80, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17532641, Length=123, Percent_Identity=37.3983739837398, Blast_Score=79, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17565860, Length=142, Percent_Identity=42.9577464788732, Blast_Score=78, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17539498, Length=131, Percent_Identity=44.2748091603053, Blast_Score=76, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17551282, Length=127, Percent_Identity=42.5196850393701, Blast_Score=76, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17551284, Length=127, Percent_Identity=42.5196850393701, Blast_Score=76, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17552780, Length=134, Percent_Identity=44.7761194029851, Blast_Score=75, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17506311, Length=142, Percent_Identity=39.4366197183099, Blast_Score=75, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17566266, Length=142, Percent_Identity=40.8450704225352, Blast_Score=71, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17532643, Length=135, Percent_Identity=39.2592592592593, Blast_Score=70, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17552782, Length=135, Percent_Identity=40.7407407407407, Blast_Score=70, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17559074, Length=144, Percent_Identity=38.1944444444444, Blast_Score=70, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17552784, Length=125, Percent_Identity=36, Blast_Score=64, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323562, Length=128, Percent_Identity=46.09375, Blast_Score=84, Evalue=9e-18,
Organism=Saccharomyces cerevisiae, GI6320359, Length=159, Percent_Identity=40.8805031446541, Blast_Score=80, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6321848, Length=133, Percent_Identity=44.3609022556391, Blast_Score=77, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6320510, Length=132, Percent_Identity=43.9393939393939, Blast_Score=75, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6323246, Length=131, Percent_Identity=41.2213740458015, Blast_Score=65, Evalue=5e-12,
Organism=Drosophila melanogaster, GI19922376, Length=116, Percent_Identity=43.9655172413793, Blast_Score=92, Evalue=8e-20,
Organism=Drosophila melanogaster, GI21357249, Length=138, Percent_Identity=39.1304347826087, Blast_Score=91, Evalue=3e-19,
Organism=Drosophila melanogaster, GI17986117, Length=131, Percent_Identity=39.6946564885496, Blast_Score=90, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24650807, Length=125, Percent_Identity=41.6, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI20130249, Length=134, Percent_Identity=43.2835820895522, Blast_Score=80, Evalue=5e-16,
Organism=Drosophila melanogaster, GI19922912, Length=136, Percent_Identity=39.7058823529412, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24664125, Length=130, Percent_Identity=44.6153846153846, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21357783, Length=130, Percent_Identity=44.6153846153846, Blast_Score=78, Evalue=2e-15,
Organism=Drosophila melanogaster, GI45549139, Length=130, Percent_Identity=43.0769230769231, Blast_Score=77, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24652460, Length=121, Percent_Identity=36.3636363636364, Blast_Score=76, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17647301, Length=121, Percent_Identity=42.9752066115703, Blast_Score=73, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24586038, Length=141, Percent_Identity=36.1702127659575, Blast_Score=66, Evalue=6e-12,
Organism=Drosophila melanogaster, GI17136360, Length=133, Percent_Identity=36.0902255639098, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 15512; Mature: 15381

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKALFETDAGIINIELFTNDAPNTVNNFTKLITEGFYDGLAFHRVIPGFMAQGGCPNTR
CCCCCEECCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
EGSSGMPGTGGPGYNIKCEINSNKHLKGSLSMAHAGKDTGGSQFFIVYESQPHLDGVHTV
CCCCCCCCCCCCCCEEEEEECCCCCEECCEEEEECCCCCCCCEEEEEECCCCCCCCHHHC
FGKTEDMDIVLKLTNGSKIIKASLV
CCCCCCCEEEEEECCCCEEEEEECC
>Mature Secondary Structure 
TKALFETDAGIINIELFTNDAPNTVNNFTKLITEGFYDGLAFHRVIPGFMAQGGCPNTR
CCCCEECCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
EGSSGMPGTGGPGYNIKCEINSNKHLKGSLSMAHAGKDTGGSQFFIVYESQPHLDGVHTV
CCCCCCCCCCCCCCEEEEEECCCCCEECCEEEEECCCCCCCCEEEEEECCCCCCCCHHHC
FGKTEDMDIVLKLTNGSKIIKASLV
CCCCCCCEEEEEECCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA