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The map label for this gene is uvrC [H]

Identifier: 123966197

GI number: 123966197

Start: 858529

End: 860463

Strand: Reverse

Name: uvrC [H]

Synonym: P9515_09641

Alternate gene names: 123966197

Gene position: 860463-858529 (Counterclockwise)

Preceding gene: 123966198

Following gene: 123966196

Centisome position: 50.49

GC content: 27.49

Gene sequence:

>1935_bases
ATGAATAATCCTTCAACTAAAGTATTGGATAAAAAATATAATTTTAAAATAGAATATAAACTTATCAATAATAAGCAATT
ATTAAAATCAAGATTATCAGAAATACCAAAGAGTTCTGGATGTTATCTTTTTAAGGATTTAGATAATAATTTACTTTATA
TAGGAAAATCAAAAACACTTCGAAATAGGGTAAGTAGTTACTTCAATAACTATGCTGATCTTTCACCAAGATTATGTTTA
ATGGTAAGACAGATAACTGAGATAGATATTATCGTCACGGACAGTGAGTATGAAGCTCTTAATTTAGAATCAAATTTAAT
AAAAACCAATAAACCATATTTTAATATTTTATTAAAAGATGATAAAAAATATCCATATCTTTGCATAACATGGAGTGAAA
AATATCCAAAAATATTTATAACTAGAAAAAGGAGGAATAGAAATAATTTAGATAGATATTACGGTCCTTATGTAGATGTT
GGTCTTTTAAGAAATACATTATTTTTAATAAAAAAAATTTTTCCGTTGAGACACAGTAAATTATCAAAATCCTTTTATCG
TGAAATTACAGGAGTAGATCTAGAAAAAATATCATCAGAGGAATACAAAAAAATAATGAAACAAGCGTCAATGGTATTTC
AAGGAAGAAACGATGATTTAATTAAAATTCTTGAAAAAAAAATGTCTTTTTATTCAACTGAACTTCAATATGAGAAAGCA
GCAAAAATTAGAGATCAAATTAACGGACTAAGATTATTAACTGAATCTCAAAAAATATCTATTCCTGATTCTTCCATAAA
TAGAGATATTTTCGGGATAGTTTCGGAAAAAAATATAGCTAGTATTCAAATCTTTCAGATGAGATCAGGTAAATTAATTG
GTCGTATTGGATATAGTCAAAAATTGAATGGGCTTCAAGAAAGTGAAATCCTTCAAAGAATTCTAGAAGAACATTATATA
AATGTTGAAGGGATAGAAATTCCCTCTGAAATATTAGTTCAATATAATTTCCAAAAAATAAAGATTATTGAAGAATGGCT
TAGTGAGATAAAACAAAAAAAAGTTAAAATAATTAATCCTAAAAGAAGTAATAAATTAAAAACAATTGAAATGGTTCAAA
AAAATGCAAGATTAGAACTAAATAGAATATTAAATGGAATACAAGATAATGAATCTGCTATTGAGGATTTATCTCAAATA
CTAGATTTGAGTATTCATCCAAGAAGATTAGAGGGCTACGATATAAGTCATATTCAAGGTACAGATCCAGTAGCATCACA
AGTTGTGTTTATAGATGGATTGCCATCGAAACAAAATTATAGAAAATATAAAATAAAAGACTCTAATGTTTACATAGGTC
ATAGCGACGATTACGCTTCAATATATGAGGTTATTCATAGAAGATTTAGAAAATGGTCTAGATATAAACAAAATGGAGGG
AATCTAAGTACCATAAATAATACTAAACAAAGTAGTCTTGATAATGAACTATTTTCTGACTGGCCTGATTTGGTAATGAT
TGATGGAGGTAAAGGGCAACTAAACTCCGCTTATAAGGCTTTGGAAGAACTTGATTTAGAAAAAGATGTTATTCTATGTT
CCTTAGCAAAAAAGAATGAAGAAATTTATGTACCTGGATTAACAAAACCTCTTAATACGGATATGAATCAAAAGGGAGTA
ATGCTCCTAAGAAGATTAAGAGATGAAGCACATAGATTTGCACTTTCATTTCATCGCAATAAGAGATCTAGGAGAATGAA
CAGGTCACAACTTACTCAGATACCAGGATTAGGTTCTTCAAGAATAAAGGATTTATTAGAGCATTTTAATTCTGTAGATG
CAATAAGAATTGCTAGTAAAGAAGAACTAATGAAAGTAAAGGGACTTGGGAGCAATACAGCAAAAGATATATATGATTAT
TTCAATTGCGATTAA

Upstream 100 bases:

>100_bases
TGTTTTTGTTGGAGAAGTTTTAACAGCATATTTAAATAATGATGTGGAATCTTTAAATTTAAATAGTACAGGATGGAATT
ATGGAGGTTAGAAACTATAG

Downstream 100 bases:

>100_bases
ATTTGGATATGAGAAATTATTTTAGAATTATTCATAGATGTTGATATTATTGTATTTTGTGTAAATTAATAAGTAGGATT
ATTTAAGTTGATAAATAAAA

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C [H]

Number of amino acids: Translated: 644; Mature: 644

Protein sequence:

>644_residues
MNNPSTKVLDKKYNFKIEYKLINNKQLLKSRLSEIPKSSGCYLFKDLDNNLLYIGKSKTLRNRVSSYFNNYADLSPRLCL
MVRQITEIDIIVTDSEYEALNLESNLIKTNKPYFNILLKDDKKYPYLCITWSEKYPKIFITRKRRNRNNLDRYYGPYVDV
GLLRNTLFLIKKIFPLRHSKLSKSFYREITGVDLEKISSEEYKKIMKQASMVFQGRNDDLIKILEKKMSFYSTELQYEKA
AKIRDQINGLRLLTESQKISIPDSSINRDIFGIVSEKNIASIQIFQMRSGKLIGRIGYSQKLNGLQESEILQRILEEHYI
NVEGIEIPSEILVQYNFQKIKIIEEWLSEIKQKKVKIINPKRSNKLKTIEMVQKNARLELNRILNGIQDNESAIEDLSQI
LDLSIHPRRLEGYDISHIQGTDPVASQVVFIDGLPSKQNYRKYKIKDSNVYIGHSDDYASIYEVIHRRFRKWSRYKQNGG
NLSTINNTKQSSLDNELFSDWPDLVMIDGGKGQLNSAYKALEELDLEKDVILCSLAKKNEEIYVPGLTKPLNTDMNQKGV
MLLRRLRDEAHRFALSFHRNKRSRRMNRSQLTQIPGLGSSRIKDLLEHFNSVDAIRIASKEELMKVKGLGSNTAKDIYDY
FNCD

Sequences:

>Translated_644_residues
MNNPSTKVLDKKYNFKIEYKLINNKQLLKSRLSEIPKSSGCYLFKDLDNNLLYIGKSKTLRNRVSSYFNNYADLSPRLCL
MVRQITEIDIIVTDSEYEALNLESNLIKTNKPYFNILLKDDKKYPYLCITWSEKYPKIFITRKRRNRNNLDRYYGPYVDV
GLLRNTLFLIKKIFPLRHSKLSKSFYREITGVDLEKISSEEYKKIMKQASMVFQGRNDDLIKILEKKMSFYSTELQYEKA
AKIRDQINGLRLLTESQKISIPDSSINRDIFGIVSEKNIASIQIFQMRSGKLIGRIGYSQKLNGLQESEILQRILEEHYI
NVEGIEIPSEILVQYNFQKIKIIEEWLSEIKQKKVKIINPKRSNKLKTIEMVQKNARLELNRILNGIQDNESAIEDLSQI
LDLSIHPRRLEGYDISHIQGTDPVASQVVFIDGLPSKQNYRKYKIKDSNVYIGHSDDYASIYEVIHRRFRKWSRYKQNGG
NLSTINNTKQSSLDNELFSDWPDLVMIDGGKGQLNSAYKALEELDLEKDVILCSLAKKNEEIYVPGLTKPLNTDMNQKGV
MLLRRLRDEAHRFALSFHRNKRSRRMNRSQLTQIPGLGSSRIKDLLEHFNSVDAIRIASKEELMKVKGLGSNTAKDIYDY
FNCD
>Mature_644_residues
MNNPSTKVLDKKYNFKIEYKLINNKQLLKSRLSEIPKSSGCYLFKDLDNNLLYIGKSKTLRNRVSSYFNNYADLSPRLCL
MVRQITEIDIIVTDSEYEALNLESNLIKTNKPYFNILLKDDKKYPYLCITWSEKYPKIFITRKRRNRNNLDRYYGPYVDV
GLLRNTLFLIKKIFPLRHSKLSKSFYREITGVDLEKISSEEYKKIMKQASMVFQGRNDDLIKILEKKMSFYSTELQYEKA
AKIRDQINGLRLLTESQKISIPDSSINRDIFGIVSEKNIASIQIFQMRSGKLIGRIGYSQKLNGLQESEILQRILEEHYI
NVEGIEIPSEILVQYNFQKIKIIEEWLSEIKQKKVKIINPKRSNKLKTIEMVQKNARLELNRILNGIQDNESAIEDLSQI
LDLSIHPRRLEGYDISHIQGTDPVASQVVFIDGLPSKQNYRKYKIKDSNVYIGHSDDYASIYEVIHRRFRKWSRYKQNGG
NLSTINNTKQSSLDNELFSDWPDLVMIDGGKGQLNSAYKALEELDLEKDVILCSLAKKNEEIYVPGLTKPLNTDMNQKGV
MLLRRLRDEAHRFALSFHRNKRSRRMNRSQLTQIPGLGSSRIKDLLEHFNSVDAIRIASKEELMKVKGLGSNTAKDIYDY
FNCD

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision [H]

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI87081999, Length=635, Percent_Identity=30.2362204724409, Blast_Score=288, Evalue=6e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305 [H]

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N [H]

EC number: NA

Molecular weight: Translated: 75097; Mature: 75097

Theoretical pI: Translated: 9.94; Mature: 9.94

Prosite motif: PS50151 UVR ; PS50164 UVRC_1 ; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNPSTKVLDKKYNFKIEYKLINNKQLLKSRLSEIPKSSGCYLFKDLDNNLLYIGKSKTL
CCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHCCCCCCCEEEEECCCCEEEEECCHHH
RNRVSSYFNNYADLSPRLCLMVRQITEIDIIVTDSEYEALNLESNLIKTNKPYFNILLKD
HHHHHHHHHHHCCCCHHHHHHHHHHCEEEEEEECCCCCEECCCCCCEECCCCEEEEEEEC
DKKYPYLCITWSEKYPKIFITRKRRNRNNLDRYYGPYVDVGLLRNTLFLIKKIFPLRHSK
CCCCCEEEEEECCCCCEEEEEECCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
LSKSFYREITGVDLEKISSEEYKKIMKQASMVFQGRNDDLIKILEKKMSFYSTELQYEKA
HHHHHHHHHCCCCHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
AKIRDQINGLRLLTESQKISIPDSSINRDIFGIVSEKNIASIQIFQMRSGKLIGRIGYSQ
HHHHHHHCCEEEEECCCEEECCCCCCCCCEEEEECCCCCCEEEEEEECCCCEEEECCCHH
KLNGLQESEILQRILEEHYINVEGIEIPSEILVQYNFQKIKIIEEWLSEIKQKKVKIINP
HHCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHEEECCHHHHHHHHHHHHHHHCCEEEECC
KRSNKLKTIEMVQKNARLELNRILNGIQDNESAIEDLSQILDLSIHPRRLEGYDISHIQG
CCCCCHHHHHHHHHCCCEEHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
TDPVASQVVFIDGLPSKQNYRKYKIKDSNVYIGHSDDYASIYEVIHRRFRKWSRYKQNGG
CCCHHCCEEEEECCCCCCCCCEEEEECCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCC
NLSTINNTKQSSLDNELFSDWPDLVMIDGGKGQLNSAYKALEELDLEKDVILCSLAKKNE
CEEECCCCHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHCCCCHHEEEEECCCCC
EIYVPGLTKPLNTDMNQKGVMLLRRLRDEAHRFALSFHRNKRSRRMNRSQLTQIPGLGSS
EEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCHH
RIKDLLEHFNSVDAIRIASKEELMKVKGLGSNTAKDIYDYFNCD
HHHHHHHHHCCCCEEEECCHHHHHHHHCCCCCHHHHHHHHCCCC
>Mature Secondary Structure
MNNPSTKVLDKKYNFKIEYKLINNKQLLKSRLSEIPKSSGCYLFKDLDNNLLYIGKSKTL
CCCCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHCCCCCCCEEEEECCCCEEEEECCHHH
RNRVSSYFNNYADLSPRLCLMVRQITEIDIIVTDSEYEALNLESNLIKTNKPYFNILLKD
HHHHHHHHHHHCCCCHHHHHHHHHHCEEEEEEECCCCCEECCCCCCEECCCCEEEEEEEC
DKKYPYLCITWSEKYPKIFITRKRRNRNNLDRYYGPYVDVGLLRNTLFLIKKIFPLRHSK
CCCCCEEEEEECCCCCEEEEEECCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
LSKSFYREITGVDLEKISSEEYKKIMKQASMVFQGRNDDLIKILEKKMSFYSTELQYEKA
HHHHHHHHHCCCCHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
AKIRDQINGLRLLTESQKISIPDSSINRDIFGIVSEKNIASIQIFQMRSGKLIGRIGYSQ
HHHHHHHCCEEEEECCCEEECCCCCCCCCEEEEECCCCCCEEEEEEECCCCEEEECCCHH
KLNGLQESEILQRILEEHYINVEGIEIPSEILVQYNFQKIKIIEEWLSEIKQKKVKIINP
HHCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHEEECCHHHHHHHHHHHHHHHCCEEEECC
KRSNKLKTIEMVQKNARLELNRILNGIQDNESAIEDLSQILDLSIHPRRLEGYDISHIQG
CCCCCHHHHHHHHHCCCEEHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
TDPVASQVVFIDGLPSKQNYRKYKIKDSNVYIGHSDDYASIYEVIHRRFRKWSRYKQNGG
CCCHHCCEEEEECCCCCCCCCEEEEECCCEEEECCCCHHHHHHHHHHHHHHHHHHHHCCC
NLSTINNTKQSSLDNELFSDWPDLVMIDGGKGQLNSAYKALEELDLEKDVILCSLAKKNE
CEEECCCCHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHCCCCHHEEEEECCCCC
EIYVPGLTKPLNTDMNQKGVMLLRRLRDEAHRFALSFHRNKRSRRMNRSQLTQIPGLGSS
EEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCHH
RIKDLLEHFNSVDAIRIASKEELMKVKGLGSNTAKDIYDYFNCD
HHHHHHHHHCCCCEEEECCHHHHHHHHCCCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12917642 [H]