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The map label for this gene is hisS

Identifier: 123965923

GI number: 123965923

Start: 624965

End: 626254

Strand: Direct

Name: hisS

Synonym: P9515_06881

Alternate gene names: 123965923

Gene position: 624965-626254 (Clockwise)

Preceding gene: 123965921

Following gene: 123965924

Centisome position: 36.67

GC content: 30.7

Gene sequence:

>1290_bases
TTGAATAACCTTAAAAATCTTAGAGGAACAGTTGATCTTTTGCCTGACAACTTAATAAAGTGGCAAAATGTTGAAAAAAT
AATATTAGAGCTGCTTTTAAGAGCCTCTGTGAAGGAAATTAGAACTCCTATATTAGAAATGACTGAATTATTTATGCGAG
GTATTGGAGAGGGTACCGATGTCGTTAGCAAAGAGATGTATACATTTTTAGATAGAGGTGAAAGGTCATGCACTTTAAGA
CCAGAGGGGACTGCCTCCGTTGCAAGAGCAATAATACAAAATGGAATATCAAGTAAATCCTTACAAAAACTTTGGTACAT
GGGGCCAATGTTTAGATATGAGAGACCTCAAGCAGGCAGGCAAAGGCAATTTCATCAGTTAGGAGTTGAATTTATTGGTT
ATGATTCGGTAAGGAGTGATATCGAGATAATTGCTTTGGCTTGGGATATTTTGGAGAAATTAGGAATAAAAGAGCTAAAT
CTTGAAATTAATACTTTAGGTGACTTTAATGACAGGTCAAATTTTCAGAAAGCTTTCTTAAAATGGTTAGAAGTTAACAA
AAATGACTTAGATTTGGATTCTCAAAATAGAATAGTTAAGAACCCTTTAAGAATTTTTGATACTAAGAATGCGAAAACAA
AAAGCATTCTTGAAGATGCTCCAAAATTATTTGACTTTTTGTCTGAAAAAAGTCTTAAGAGATATATAAATATTAAAGAA
ATGTTAAAGCTTCTTAAAATACCTTTTATAGAAAATTTCAATTTAGTAAGAGGGTTGGATTATTACACACATACTGCATT
TGAAATTACAAGTGGTGCACTTGGCTCGCAAGCTACAGTTTGCGGGGGAGGCAGATATGATAATTTGATTAATCAAATGG
GAGGAACAGAAACTCCAGCAATTGGATTTGCAATTGGATTAGAGAGACTTATTCTTTTGGCGGGTAAAGATCTTGAAGAA
AGTAGAGAAACTGATATTTATATTGTTAATAAAGGGTTTCAAGCTGAAATATTGGCTATTGACTTATCAAGGAAGCTAAG
AAATTATGATTTGATAATTGAATTAGATTTAAGTGGAGCATCATTTTCTAAGCAATTTAAAAAAGCTAATAAATTAAAAT
CAAAAAGTATTATTATAATTGGAGATGATGAAGCTTTAAAAAATGAATTTAAAATAAGGCTTTTTAATAATATCAATGTA
GAAAATCATGAAGCTAATATATCCTTTGAGGATGATATTAAATTAGAAAAGTGGTTAAAGACTAATTTTCTTTTAGATAA
AAACCTTTAG

Upstream 100 bases:

>100_bases
AATATTTTGTAAGAATGTTAGATTAAATTATGACATACAGAATCTCAGCAAAATTGAATTTCTATGTAAATTAAAAAATT
TGAATTATTAATTTAGAACT

Downstream 100 bases:

>100_bases
AATATGAAGATTGTATTATTTGTTTCTTTATTAGTTATGTTTTCATTTATATTTCTAAAATTTTACAAATATAAAAAAGC
TTTAAAAAAAAATAAAGATA

Product: histidyl-tRNA synthetase

Products: NA

Alternate protein names: Histidine--tRNA ligase; HisRS

Number of amino acids: Translated: 429; Mature: 429

Protein sequence:

>429_residues
MNNLKNLRGTVDLLPDNLIKWQNVEKIILELLLRASVKEIRTPILEMTELFMRGIGEGTDVVSKEMYTFLDRGERSCTLR
PEGTASVARAIIQNGISSKSLQKLWYMGPMFRYERPQAGRQRQFHQLGVEFIGYDSVRSDIEIIALAWDILEKLGIKELN
LEINTLGDFNDRSNFQKAFLKWLEVNKNDLDLDSQNRIVKNPLRIFDTKNAKTKSILEDAPKLFDFLSEKSLKRYINIKE
MLKLLKIPFIENFNLVRGLDYYTHTAFEITSGALGSQATVCGGGRYDNLINQMGGTETPAIGFAIGLERLILLAGKDLEE
SRETDIYIVNKGFQAEILAIDLSRKLRNYDLIIELDLSGASFSKQFKKANKLKSKSIIIIGDDEALKNEFKIRLFNNINV
ENHEANISFEDDIKLEKWLKTNFLLDKNL

Sequences:

>Translated_429_residues
MNNLKNLRGTVDLLPDNLIKWQNVEKIILELLLRASVKEIRTPILEMTELFMRGIGEGTDVVSKEMYTFLDRGERSCTLR
PEGTASVARAIIQNGISSKSLQKLWYMGPMFRYERPQAGRQRQFHQLGVEFIGYDSVRSDIEIIALAWDILEKLGIKELN
LEINTLGDFNDRSNFQKAFLKWLEVNKNDLDLDSQNRIVKNPLRIFDTKNAKTKSILEDAPKLFDFLSEKSLKRYINIKE
MLKLLKIPFIENFNLVRGLDYYTHTAFEITSGALGSQATVCGGGRYDNLINQMGGTETPAIGFAIGLERLILLAGKDLEE
SRETDIYIVNKGFQAEILAIDLSRKLRNYDLIIELDLSGASFSKQFKKANKLKSKSIIIIGDDEALKNEFKIRLFNNINV
ENHEANISFEDDIKLEKWLKTNFLLDKNL
>Mature_429_residues
MNNLKNLRGTVDLLPDNLIKWQNVEKIILELLLRASVKEIRTPILEMTELFMRGIGEGTDVVSKEMYTFLDRGERSCTLR
PEGTASVARAIIQNGISSKSLQKLWYMGPMFRYERPQAGRQRQFHQLGVEFIGYDSVRSDIEIIALAWDILEKLGIKELN
LEINTLGDFNDRSNFQKAFLKWLEVNKNDLDLDSQNRIVKNPLRIFDTKNAKTKSILEDAPKLFDFLSEKSLKRYINIKE
MLKLLKIPFIENFNLVRGLDYYTHTAFEITSGALGSQATVCGGGRYDNLINQMGGTETPAIGFAIGLERLILLAGKDLEE
SRETDIYIVNKGFQAEILAIDLSRKLRNYDLIIELDLSGASFSKQFKKANKLKSKSIIIIGDDEALKNEFKIRLFNNINV
ENHEANISFEDDIKLEKWLKTNFLLDKNL

Specific function: Unknown

COG id: COG0124

COG function: function code J; Histidyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Escherichia coli, GI1788861, Length=388, Percent_Identity=44.3298969072165, Blast_Score=338, Evalue=5e-94,
Organism=Saccharomyces cerevisiae, GI6325290, Length=464, Percent_Identity=23.0603448275862, Blast_Score=94, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYH_PROM5 (A2BVT6)

Other databases:

- EMBL:   CP000552
- RefSeq:   YP_001011004.1
- ProteinModelPortal:   A2BVT6
- SMR:   A2BVT6
- STRING:   A2BVT6
- GeneID:   4719566
- GenomeReviews:   CP000552_GR
- KEGG:   pmc:P9515_06881
- eggNOG:   COG0124
- HOGENOM:   HBG616575
- OMA:   VFEWVTT
- ProtClustDB:   PRK00037
- BioCyc:   PMAR167542:P9515ORF_0724-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00127
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR015807
- InterPro:   IPR004516
- Gene3D:   G3DSA:3.40.50.800
- PANTHER:   PTHR11476
- PIRSF:   PIRSF001549
- TIGRFAMs:   TIGR00442

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b; SSF52954 Anticodon_bd

EC number: =6.1.1.21

Molecular weight: Translated: 49156; Mature: 49156

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNLKNLRGTVDLLPDNLIKWQNVEKIILELLLRASVKEIRTPILEMTELFMRGIGEGTD
CCCCHHHCCHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
VVSKEMYTFLDRGERSCTLRPEGTASVARAIIQNGISSKSLQKLWYMGPMFRYERPQAGR
HHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHCCCCHHHHHHHHHCCCHHHCCCCCCHH
QRQFHQLGVEFIGYDSVRSDIEIIALAWDILEKLGIKELNLEINTLGDFNDRSNFQKAFL
HHHHHHHCHHHCCCHHHHCCHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCHHHHHHHH
KWLEVNKNDLDLDSQNRIVKNPLRIFDTKNAKTKSILEDAPKLFDFLSEKSLKRYINIKE
HHHHCCCCCCCCCCCCCHHHCCHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
MLKLLKIPFIENFNLVRGLDYYTHTAFEITSGALGSQATVCGGGRYDNLINQMGGTETPA
HHHHHCCCCCCCCCHHHCCHHHHHHHEEEECCCCCCCCEEECCCCHHHHHHHCCCCCCCH
IGFAIGLERLILLAGKDLEESRETDIYIVNKGFQAEILAIDLSRKLRNYDLIIELDLSGA
HHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCEEEEEEEHHHHHCCCEEEEEEECCCC
SFSKQFKKANKLKSKSIIIIGDDEALKNEFKIRLFNNINVENHEANISFEDDIKLEKWLK
HHHHHHHHHHHCCCCEEEEEECCHHHCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHHHH
TNFLLDKNL
HHCEECCCC
>Mature Secondary Structure
MNNLKNLRGTVDLLPDNLIKWQNVEKIILELLLRASVKEIRTPILEMTELFMRGIGEGTD
CCCCHHHCCHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
VVSKEMYTFLDRGERSCTLRPEGTASVARAIIQNGISSKSLQKLWYMGPMFRYERPQAGR
HHHHHHHHHHHCCCCEEEECCCCHHHHHHHHHHCCCCHHHHHHHHHCCCHHHCCCCCCHH
QRQFHQLGVEFIGYDSVRSDIEIIALAWDILEKLGIKELNLEINTLGDFNDRSNFQKAFL
HHHHHHHCHHHCCCHHHHCCHHHHHHHHHHHHHCCCEEEEEEEEECCCCCCCHHHHHHHH
KWLEVNKNDLDLDSQNRIVKNPLRIFDTKNAKTKSILEDAPKLFDFLSEKSLKRYINIKE
HHHHCCCCCCCCCCCCCHHHCCHHEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
MLKLLKIPFIENFNLVRGLDYYTHTAFEITSGALGSQATVCGGGRYDNLINQMGGTETPA
HHHHHCCCCCCCCCHHHCCHHHHHHHEEEECCCCCCCCEEECCCCHHHHHHHCCCCCCCH
IGFAIGLERLILLAGKDLEESRETDIYIVNKGFQAEILAIDLSRKLRNYDLIIELDLSGA
HHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCEEEEEEEHHHHHCCCEEEEEEECCCC
SFSKQFKKANKLKSKSIIIIGDDEALKNEFKIRLFNNINVENHEANISFEDDIKLEKWLK
HHHHHHHHHHHCCCCEEEEEECCHHHCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHHHH
TNFLLDKNL
HHCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA