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The map label for this gene is glmU

Identifier: 123965911

GI number: 123965911

Start: 612487

End: 613830

Strand: Reverse

Name: glmU

Synonym: P9515_06761

Alternate gene names: 123965911

Gene position: 613830-612487 (Counterclockwise)

Preceding gene: 123965912

Following gene: 123965906

Centisome position: 36.02

GC content: 29.24

Gene sequence:

>1344_bases
ATGTTAACTGTCGCGATATTAGCTGCAGGTAAGGGTACTAGGATGGCAAGCTCACTGCCTAAAGTCTTACATAAATTATC
TGGAAAAACTCTTCTTCAAAGAGTTATCGATTCTTGCAATGAATTAAAACCTGATAAAATATTTATTATCGTTGGACACA
AATCAAAGGAGGTAAAAGATTCCGTATTTAAAAATAATAATATTCACTTTATTGTTCAAAAGCCACAAAAGGGAACTGGA
CACGCCGTTCAAGTTCTTTCTCAGAAAGTAAAAAAACATGACGGTAAATTGATTGTCCTTAATGGAGATGTGCCACTTAT
CAAAGGTGAGACTTTAAAAAAACTTATTCATTATCATGATTCACAAAAAGCCGATGTTTCCTTAATAACCACGAAGAAAA
AGAATCCACATGGTTATGGAAGAGTATTTGCTAAAGATAATTTAATTGAAATGATAATCGAGGAAAAAGATTGTAATAAC
GTTCAAAAATCCAATTTATTGATAAATGCAGGCATATACTGCTTTAATTGGAAAAGTTTATCAAAAATAATTAATACTAT
AAAAAGTAATAATAAACAAAACGAAATTTATCTAACCGACGCTATCTATTTGCTAAAAAAATCTTATAGCTTTGAAATTT
TAGATAATGGAGAACTTCAAGGAATAAATAATAGAGTTCAATTATCAAAATGCGAAGAAACCATCCAAAATTTAATTAAA
GAGAAACATATGCTTGGAGGAGTAACTTTTATTAATCCCGCAAGTTGTACAGTAAGTGAAGAATCAATAATCGGAAAAGA
TGTAATAATCGATGCAAATACTCATATAAGGGGAAACTCTAAAATTTCTAATAATTGTAAAATTGGTCCAAATACTTTCA
TAAAAGATACGATCATAAATGAAAATTGTGAAATTATAAATTCAACTATTTTTAATTCAGTTTTAATGGATTTTGTAAAT
ATAGGTCCTTACAGTCACATAAGACCTAATTGTGAAATATCTTCTTACAGCAGAATTGGGAATTTTGTTGAGATAAAAAA
TAGTCAATTAGATAAAGAAGTTAAAGTTAATCATTTAAGCTATATTGGCGATTCTACAGTTGGGAAACATACCAATATTG
GAGCAGGAACAATTACAGCAAATTTTGATGGTAAAAAGAAACATCCAACTTTTATTGGGGAAAATTCCAGTATAGGTGCC
AATACGGTTTTAATTGCGCCTATTAATCTTGGTGATTCAGTAACAACTGGAGCAGGCTCAGTAATTACTAAAGATTCTCA
AAATAATTCTTTAGCTATTGCAAGAACCAAACAAGTAAATATTGAAAATTGGAAAAAAAATTAA

Upstream 100 bases:

>100_bases
TTATGCTCTAATCTTATAACTCCAAAAGAATGGAGAGATAAATGGGGAATGACGAAATAGATCTTAAACAGTAAGATTTA
AATAAAATATCTTAATAAAT

Downstream 100 bases:

>100_bases
ATTCAAAAATTAATCAATTGATTTAAGAATACTTTCAAGCTGCCAATTTCGGCTACCTTTAACCAAGATAAAATCTCCTT
TTTTTGTATATTTATTTATA

Product: bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase

Number of amino acids: Translated: 447; Mature: 447

Protein sequence:

>447_residues
MLTVAILAAGKGTRMASSLPKVLHKLSGKTLLQRVIDSCNELKPDKIFIIVGHKSKEVKDSVFKNNNIHFIVQKPQKGTG
HAVQVLSQKVKKHDGKLIVLNGDVPLIKGETLKKLIHYHDSQKADVSLITTKKKNPHGYGRVFAKDNLIEMIIEEKDCNN
VQKSNLLINAGIYCFNWKSLSKIINTIKSNNKQNEIYLTDAIYLLKKSYSFEILDNGELQGINNRVQLSKCEETIQNLIK
EKHMLGGVTFINPASCTVSEESIIGKDVIIDANTHIRGNSKISNNCKIGPNTFIKDTIINENCEIINSTIFNSVLMDFVN
IGPYSHIRPNCEISSYSRIGNFVEIKNSQLDKEVKVNHLSYIGDSTVGKHTNIGAGTITANFDGKKKHPTFIGENSSIGA
NTVLIAPINLGDSVTTGAGSVITKDSQNNSLAIARTKQVNIENWKKN

Sequences:

>Translated_447_residues
MLTVAILAAGKGTRMASSLPKVLHKLSGKTLLQRVIDSCNELKPDKIFIIVGHKSKEVKDSVFKNNNIHFIVQKPQKGTG
HAVQVLSQKVKKHDGKLIVLNGDVPLIKGETLKKLIHYHDSQKADVSLITTKKKNPHGYGRVFAKDNLIEMIIEEKDCNN
VQKSNLLINAGIYCFNWKSLSKIINTIKSNNKQNEIYLTDAIYLLKKSYSFEILDNGELQGINNRVQLSKCEETIQNLIK
EKHMLGGVTFINPASCTVSEESIIGKDVIIDANTHIRGNSKISNNCKIGPNTFIKDTIINENCEIINSTIFNSVLMDFVN
IGPYSHIRPNCEISSYSRIGNFVEIKNSQLDKEVKVNHLSYIGDSTVGKHTNIGAGTITANFDGKKKHPTFIGENSSIGA
NTVLIAPINLGDSVTTGAGSVITKDSQNNSLAIARTKQVNIENWKKN
>Mature_447_residues
MLTVAILAAGKGTRMASSLPKVLHKLSGKTLLQRVIDSCNELKPDKIFIIVGHKSKEVKDSVFKNNNIHFIVQKPQKGTG
HAVQVLSQKVKKHDGKLIVLNGDVPLIKGETLKKLIHYHDSQKADVSLITTKKKNPHGYGRVFAKDNLIEMIIEEKDCNN
VQKSNLLINAGIYCFNWKSLSKIINTIKSNNKQNEIYLTDAIYLLKKSYSFEILDNGELQGINNRVQLSKCEETIQNLIK
EKHMLGGVTFINPASCTVSEESIIGKDVIIDANTHIRGNSKISNNCKIGPNTFIKDTIINENCEIINSTIFNSVLMDFVN
IGPYSHIRPNCEISSYSRIGNFVEIKNSQLDKEVKVNHLSYIGDSTVGKHTNIGAGTITANFDGKKKHPTFIGENSSIGA
NTVLIAPINLGDSVTTGAGSVITKDSQNNSLAIARTKQVNIENWKKN

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-GlcNAc. Responsible for the acetylation of Glc-N-1-P to give GlcNAc-1-P and for the uridyl transfer from UTP to GlcNAc-1-P which produces UDP-GlcNAc

COG id: COG1207

COG function: function code M; N-acetylglucosamine-1-phosphate uridyltransferase (contains nucleotidyltransferase and I-patch acetyltransferase domains)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family

Homologues:

Organism=Escherichia coli, GI1790168, Length=451, Percent_Identity=38.1374722838137, Blast_Score=323, Evalue=1e-89,
Organism=Caenorhabditis elegans, GI133931050, Length=328, Percent_Identity=25.3048780487805, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLMU_PROM5 (A2BVS4)

Other databases:

- EMBL:   CP000552
- RefSeq:   YP_001010992.1
- ProteinModelPortal:   A2BVS4
- SMR:   A2BVS4
- STRING:   A2BVS4
- GeneID:   4719554
- GenomeReviews:   CP000552_GR
- KEGG:   pmc:P9515_06761
- eggNOG:   COG1207
- HOGENOM:   HBG688195
- OMA:   GSKVNHL
- ProtClustDB:   PRK14360
- BioCyc:   PMAR167542:P9515ORF_0712-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01631
- InterPro:   IPR005882
- InterPro:   IPR005835
- InterPro:   IPR011004
- TIGRFAMs:   TIGR01173

Pfam domain/function: PF00483 NTP_transferase; SSF51161 Trimer_LpxA_like

EC number: =2.7.7.23; =2.3.1.157

Molecular weight: Translated: 49373; Mature: 49373

Theoretical pI: Translated: 9.86; Mature: 9.86

Prosite motif: PS00101 HEXAPEP_TRANSFERASES

Important sites: ACT_SITE 358-358 BINDING 73-73 BINDING 140-140 BINDING 154-154 BINDING 169-169 BINDING 418-418 BINDING 435-435

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTVAILAAGKGTRMASSLPKVLHKLSGKTLLQRVIDSCNELKPDKIFIIVGHKSKEVKD
CEEEEEEECCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHH
SVFKNNNIHFIVQKPQKGTGHAVQVLSQKVKKHDGKLIVLNGDVPLIKGETLKKLIHYHD
HHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCEECCHHHHHHHHHCC
SQKADVSLITTKKKNPHGYGRVFAKDNLIEMIIEEKDCNNVQKSNLLINAGIYCFNWKSL
CCCCCEEEEEECCCCCCCCEEEEECCCCEEEHCCCCCCCCCCCCCEEEECCEEEECHHHH
SKIINTIKSNNKQNEIYLTDAIYLLKKSYSFEILDNGELQGINNRVQLSKCEETIQNLIK
HHHHHHHHCCCCCCEEEEEHHEEEHHCCCEEEEEECCCCCCCCCCEEHHHHHHHHHHHHH
EKHMLGGVTFINPASCTVSEESIIGKDVIIDANTHIRGNSKISNNCKIGPNTFIKDTIIN
HHHHHCCEEEECCCCCEECHHHCCCCEEEEECCCEECCCCCCCCCCCCCCCCEEEHEEEC
ENCEIINSTIFNSVLMDFVNIGPYSHIRPNCEISSYSRIGNFVEIKNSQLDKEVKVNHLS
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHCCCEEEECCCCCCCHHEEEHHE
YIGDSTVGKHTNIGAGTITANFDGKKKHPTFIGENSSIGANTVLIAPINLGDSVTTGAGS
ECCCCCCCCCCCCCCEEEEECCCCCCCCCEEECCCCCCCCCEEEEEEECCCCCCCCCCCC
VITKDSQNNSLAIARTKQVNIENWKKN
EEEECCCCCEEEEEEEEEECCCCCCCC
>Mature Secondary Structure
MLTVAILAAGKGTRMASSLPKVLHKLSGKTLLQRVIDSCNELKPDKIFIIVGHKSKEVKD
CEEEEEEECCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHH
SVFKNNNIHFIVQKPQKGTGHAVQVLSQKVKKHDGKLIVLNGDVPLIKGETLKKLIHYHD
HHHCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCEEEEEECCCCEECCHHHHHHHHHCC
SQKADVSLITTKKKNPHGYGRVFAKDNLIEMIIEEKDCNNVQKSNLLINAGIYCFNWKSL
CCCCCEEEEEECCCCCCCCEEEEECCCCEEEHCCCCCCCCCCCCCEEEECCEEEECHHHH
SKIINTIKSNNKQNEIYLTDAIYLLKKSYSFEILDNGELQGINNRVQLSKCEETIQNLIK
HHHHHHHHCCCCCCEEEEEHHEEEHHCCCEEEEEECCCCCCCCCCEEHHHHHHHHHHHHH
EKHMLGGVTFINPASCTVSEESIIGKDVIIDANTHIRGNSKISNNCKIGPNTFIKDTIIN
HHHHHCCEEEECCCCCEECHHHCCCCEEEEECCCEECCCCCCCCCCCCCCCCEEEHEEEC
ENCEIINSTIFNSVLMDFVNIGPYSHIRPNCEISSYSRIGNFVEIKNSQLDKEVKVNHLS
CCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHCCCEEEECCCCCCCHHEEEHHE
YIGDSTVGKHTNIGAGTITANFDGKKKHPTFIGENSSIGANTVLIAPINLGDSVTTGAGS
ECCCCCCCCCCCCCCEEEEECCCCCCCCCEEECCCCCCCCCEEEEEEECCCCCCCCCCCC
VITKDSQNNSLAIARTKQVNIENWKKN
EEEECCCCCEEEEEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA