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The map label for this gene is ecm27 [H]

Identifier: 123965867

GI number: 123965867

Start: 566283

End: 567362

Strand: Reverse

Name: ecm27 [H]

Synonym: P9515_06321

Alternate gene names: 123965867

Gene position: 567362-566283 (Counterclockwise)

Preceding gene: 123965869

Following gene: 123965865

Centisome position: 33.29

GC content: 31.2

Gene sequence:

>1080_bases
ATGAGTGAATTTATATTGCCAATAATGGAGATATTAATAGGAATAATATTACTTTTTGCCGGTGGAGAATTATTCATTCA
AGGGGCGATTTCTTTATCCTTAATTTTAGGTATACCTCAAATTGTAATAGGTTTAACTGTTGTTTCTTTAGGGACAAGTT
CTCCTGAATTATTAGTAAGTTTAAATTCAATCTTCAAAGGGAGTGACTCTCTAGCAGCAAGTAATGTAATTGGAAGCAAT
ATTTTTAATGTTCTTGTTGTATTAGGAATAAGCTCATTGATAACACCTTTAAAAGTAAAAAGCAGAATTGTAAGAAGAGA
TGTCCCTCTTCTAATAGCTATTTCATGTGCAGTTTGGGCAATGTCATCAACAGGTCTATTAACTTGGCAGGCAGGGATTT
TTTTAATATTTTGTTTAACTTTAAATACAATTTGGGAAATAAATACAATACAAGAGAATGAAGAGGAGACAAAAAAGGCT
GAGCCTGAGATTGAGGAATCTCAAGGAAGAGAGAGAAGCAAATTCAACATTATTTTTAAATTGATATCTGGAATTCTTCT
TCTAAGTTTTGGTTCAAATACTTTAGTAAATGGTTCTCAATCTTTAGCAACTCTATTAGGCGTAAATGAAATAATTATTG
GTCTCACGATAGTTGCTACGGGAACCTCACTGCCTGAACTCGTTACTTCCATAATTGCAGCATTAAAAGGTAAAACAGAT
CTTGCTATTGGTAACGTCATTGGAAGTAATTTACTCAATCAGCTTCTTATACTGGGAAGTTGCAGTATTTTTTCCGGATT
AAAAGGTCTAACAATTGATCAAAGCCTTATAAAAGTTGACCTACCATTCATGGTTTTGACTACTTTTGCGTGCCTTCCAA
TTTTTTGGACAAAAGGTAAGATTTCTAGAATTGAAGGCTTTATACTTTTGAATCTTTATATTTTTTACATCATGGATAAG
TTATTGTTCTTGAAAGAATTTAACAATCTCTATCAATTGAGGGTGTGTATTTTTATTTATTTTTCTTTATTCACAGTATA
TCTTTTTACACAAGAAAAGTTAAAAACATCTAGAAGATAA

Upstream 100 bases:

>100_bases
ATTATTTAATCTATTTTAACAGCAAATAAATTTTGACAATAGTTTTAAGATAATTATTGAATAAATTAAAGATATAATCA
TTTAAATAAGTCTTTTAAAT

Downstream 100 bases:

>100_bases
TTTCATCAGCCATACATAGTTACAAATTCCTCTGAAATAGTTGGATGCAAAGCCATAGTATTATCAAAATCCTTTTTAGT
TATTCCTGCATTTAAAGAGA

Product: CaCA family sodium/calcium exchanger

Products: Na (I) [Cytoplasm]; Ca (II) [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 359; Mature: 358

Protein sequence:

>359_residues
MSEFILPIMEILIGIILLFAGGELFIQGAISLSLILGIPQIVIGLTVVSLGTSSPELLVSLNSIFKGSDSLAASNVIGSN
IFNVLVVLGISSLITPLKVKSRIVRRDVPLLIAISCAVWAMSSTGLLTWQAGIFLIFCLTLNTIWEINTIQENEEETKKA
EPEIEESQGRERSKFNIIFKLISGILLLSFGSNTLVNGSQSLATLLGVNEIIIGLTIVATGTSLPELVTSIIAALKGKTD
LAIGNVIGSNLLNQLLILGSCSIFSGLKGLTIDQSLIKVDLPFMVLTTFACLPIFWTKGKISRIEGFILLNLYIFYIMDK
LLFLKEFNNLYQLRVCIFIYFSLFTVYLFTQEKLKTSRR

Sequences:

>Translated_359_residues
MSEFILPIMEILIGIILLFAGGELFIQGAISLSLILGIPQIVIGLTVVSLGTSSPELLVSLNSIFKGSDSLAASNVIGSN
IFNVLVVLGISSLITPLKVKSRIVRRDVPLLIAISCAVWAMSSTGLLTWQAGIFLIFCLTLNTIWEINTIQENEEETKKA
EPEIEESQGRERSKFNIIFKLISGILLLSFGSNTLVNGSQSLATLLGVNEIIIGLTIVATGTSLPELVTSIIAALKGKTD
LAIGNVIGSNLLNQLLILGSCSIFSGLKGLTIDQSLIKVDLPFMVLTTFACLPIFWTKGKISRIEGFILLNLYIFYIMDK
LLFLKEFNNLYQLRVCIFIYFSLFTVYLFTQEKLKTSRR
>Mature_358_residues
SEFILPIMEILIGIILLFAGGELFIQGAISLSLILGIPQIVIGLTVVSLGTSSPELLVSLNSIFKGSDSLAASNVIGSNI
FNVLVVLGISSLITPLKVKSRIVRRDVPLLIAISCAVWAMSSTGLLTWQAGIFLIFCLTLNTIWEINTIQENEEETKKAE
PEIEESQGRERSKFNIIFKLISGILLLSFGSNTLVNGSQSLATLLGVNEIIIGLTIVATGTSLPELVTSIIAALKGKTDL
AIGNVIGSNLLNQLLILGSCSIFSGLKGLTIDQSLIKVDLPFMVLTTFACLPIFWTKGKISRIEGFILLNLYIFYIMDKL
LFLKEFNNLYQLRVCIFIYFSLFTVYLFTQEKLKTSRR

Specific function: Unknown

COG id: COG0530

COG function: function code P; Ca2+/Na+ antiporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium/potassium/calcium exchanger family [H]

Homologues:

Organism=Homo sapiens, GI4759128, Length=84, Percent_Identity=35.7142857142857, Blast_Score=65, Evalue=8e-11,
Organism=Escherichia coli, GI1789587, Length=224, Percent_Identity=33.4821428571429, Blast_Score=109, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004481
- InterPro:   IPR004837 [H]

Pfam domain/function: PF01699 Na_Ca_ex [H]

EC number: NA

Molecular weight: Translated: 39321; Mature: 39190

Theoretical pI: Translated: 7.80; Mature: 7.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEFILPIMEILIGIILLFAGGELFIQGAISLSLILGIPQIVIGLTVVSLGTSSPELLVS
CCCHHHHHHHHHHHHHHHHCCCHHEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHEE
LNSIFKGSDSLAASNVIGSNIFNVLVVLGISSLITPLKVKSRIVRRDVPLLIAISCAVWA
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
MSSTGLLTWQAGIFLIFCLTLNTIWEINTIQENEEETKKAEPEIEESQGRERSKFNIIFK
HCCCCEEEEHHHHHHHHHHHHHHHHEEECCCCCHHHHHHCCCCCHHHCCCCHHHHHHHHH
LISGILLLSFGSNTLVNGSQSLATLLGVNEIIIGLTIVATGTSLPELVTSIIAALKGKTD
HHHHHHHHHCCCCCEECCHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHCCCCC
LAIGNVIGSNLLNQLLILGSCSIFSGLKGLTIDQSLIKVDLPFMVLTTFACLPIFWTKGK
HHHHHHHHHHHHHHHHHHCCCHHHCCCCCCEECHHHHHCCCHHHHHHHHHHHHHHCCCCC
ISRIEGFILLNLYIFYIMDKLLFLKEFNNLYQLRVCIFIYFSLFTVYLFTQEKLKTSRR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SEFILPIMEILIGIILLFAGGELFIQGAISLSLILGIPQIVIGLTVVSLGTSSPELLVS
CCHHHHHHHHHHHHHHHHCCCHHEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHEE
LNSIFKGSDSLAASNVIGSNIFNVLVVLGISSLITPLKVKSRIVRRDVPLLIAISCAVWA
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
MSSTGLLTWQAGIFLIFCLTLNTIWEINTIQENEEETKKAEPEIEESQGRERSKFNIIFK
HCCCCEEEEHHHHHHHHHHHHHHHHEEECCCCCHHHHHHCCCCCHHHCCCCHHHHHHHHH
LISGILLLSFGSNTLVNGSQSLATLLGVNEIIIGLTIVATGTSLPELVTSIIAALKGKTD
HHHHHHHHHCCCCCEECCHHHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHCCCCC
LAIGNVIGSNLLNQLLILGSCSIFSGLKGLTIDQSLIKVDLPFMVLTTFACLPIFWTKGK
HHHHHHHHHHHHHHHHHHCCCHHHCCCCCCEECHHHHHCCCHHHHHHHHHHHHHHCCCCC
ISRIEGFILLNLYIFYIMDKLLFLKEFNNLYQLRVCIFIYFSLFTVYLFTQEKLKTSRR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Periplasm]; Ca (II) [Cytoplasm] [C]

Specific reaction: Na (I) [Periplasm] + Ca (II) [Cytoplasm] = Na (I) [Cytoplasm] + Ca (II) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9278503 [H]