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The map label for this gene is ppx [H]

Identifier: 123965755

GI number: 123965755

Start: 466456

End: 468051

Strand: Direct

Name: ppx [H]

Synonym: P9515_05201

Alternate gene names: 123965755

Gene position: 466456-468051 (Clockwise)

Preceding gene: 123965752

Following gene: 123965757

Centisome position: 27.37

GC content: 31.45

Gene sequence:

>1596_bases
ATGATACAAGAAAACGAATTAAGTAATTTGCAAGAAAAAAATATTTTAGTAGCCTCAATCGATATAGGAACAAATTCTAC
TCATCTTTTGATTTCAGAAGTTAATTTAGATCTCAAATCCTTTTCAATAAAATTTACTGATAAATCTACAACCCGCTTAG
GAGAGAAAGATGAAGAGGGAAATCTTACTGAAGAATCAATTCAAAGAGTTTTATATACCCTTAAGCGGTTTAAGGAATAT
TGCAATAGTAATGGTGTTAATCAAATAGTAACTGCAGCGACAAGTGCTGTTAGGGAAGCTCCAAACGGTCGAGACTTTCT
TAATAGAGTTCAAAAGGAATTAGGTATTCAAATAGAACTAATAAGCGGATCTGAGGAGGCTAGGTTAATTTATCTTGGAG
TATTGTCTGGAATGGCTTTTGAAGATGAGTCCTACGTAATTATTGATATTGGTGGTGGCTCTACAGAGTTAATACTTGCA
GATAAAAAAGACGCAATAGCTCTTACAAGTTCAAGAGTTGGAGCAGTTAGGCTTAAAAATGATTTTCTTAATGAAGAACC
CATCAGTAATGAAAGATCTAAGTTTTTGAAGACTTTTATTAGAGGGTCTTTAGAACCATCTGTTGAAAAAATAAAAAGGA
GACTACATAAAGAAAAAAGTGTTGCAATGATTGCTACAAGCGGAACTGCGATCTCACTAGGGAATTTGATTTTGTCTGAT
CTTAGTCAGCCAAAACAGAAAATGCATGGTTATAAATTTAAAAAAGATAATTTAGAGGTTATTTTGGAAAAATTAATTAA
AATGCCCATCACTGAAATAAAGAAAATTCCATCATTGAGTGAAAGAAGAGCAGAAATAATAATCCCAGGAGCATTAATTC
TTAATACTTCAATGGATATGCTGGATTTTAATGAGTTAACAATAAGTGAGAGGGCTCTAAGGGAAGGTTTAGTAGTTGAT
TGGATGCTTCGCCAAGGAATAATTAAAAACGAATTTAATATTCAAAGTAATATTAGAAAAACCACCATAGTTCATCAGGC
TAGAAAGTTTGGTGTTGATAAAAATAGATCTGAAAAAGTTACTAATATCGCTTTTCAAATATACGACCAAACTAAAAATA
TCTTTCACAGCGATACTGACTCAAAAGCAAAAAAGCTCCTTTGGGCAGCTTGTCATCTTTATAGCTGTGGAAAATATGTA
AACATAAATTCGTACCATAAACATTCTTGGTATTTAATAAAACATTGTGAATTATTAGGTTATTCTCAATTGGAAACAAA
TATTATTGCTTCGATTGCTAGATATCATCGAAAGACTTTGCCTAAAAAAAGACATGAATCGTGGCAAAGTTTAATTTCAA
AAGAAGAAAAAACAATAGTACTTGAAATGTCCTTGATTTTAAGATTAGCGGCGTCCTTGGATCAAAGACCTGAGAATGTA
ATATCATCAATAAAAATTAAATTACAAAAAAATGCTCTTTCAATGGAAATAATACCTTTTAATTCAAATCAAGATCTTCT
TCTTGAGAAATGGAGCTTAGAATCATGTCGCAATGCGATTAAAGAACTCAAAAACTTAGAGTTAAAAGTGGTTTGA

Upstream 100 bases:

>100_bases
TAAATAATCTAACTAGTATTTAATTAATTCTATAATTTAATAATCAATTTTAAGTATATTAATTACGGTATTTAGGATCT
CTGTTTTTTAGAGAATAAAA

Downstream 100 bases:

>100_bases
TTTTTCTTTTTAAGTTCTTGTTTTGGAATTTGATTTTGGAAAGAGTTTGAAATGACATTAAAAATTAGAGAGGAGGCTAA
AAGGCCTAAAATTCCCGATA

Product: putative exopolyphosphatase

Products: NA

Alternate protein names: ExopolyPase; Metaphosphatase [H]

Number of amino acids: Translated: 531; Mature: 531

Protein sequence:

>531_residues
MIQENELSNLQEKNILVASIDIGTNSTHLLISEVNLDLKSFSIKFTDKSTTRLGEKDEEGNLTEESIQRVLYTLKRFKEY
CNSNGVNQIVTAATSAVREAPNGRDFLNRVQKELGIQIELISGSEEARLIYLGVLSGMAFEDESYVIIDIGGGSTELILA
DKKDAIALTSSRVGAVRLKNDFLNEEPISNERSKFLKTFIRGSLEPSVEKIKRRLHKEKSVAMIATSGTAISLGNLILSD
LSQPKQKMHGYKFKKDNLEVILEKLIKMPITEIKKIPSLSERRAEIIIPGALILNTSMDMLDFNELTISERALREGLVVD
WMLRQGIIKNEFNIQSNIRKTTIVHQARKFGVDKNRSEKVTNIAFQIYDQTKNIFHSDTDSKAKKLLWAACHLYSCGKYV
NINSYHKHSWYLIKHCELLGYSQLETNIIASIARYHRKTLPKKRHESWQSLISKEEKTIVLEMSLILRLAASLDQRPENV
ISSIKIKLQKNALSMEIIPFNSNQDLLLEKWSLESCRNAIKELKNLELKVV

Sequences:

>Translated_531_residues
MIQENELSNLQEKNILVASIDIGTNSTHLLISEVNLDLKSFSIKFTDKSTTRLGEKDEEGNLTEESIQRVLYTLKRFKEY
CNSNGVNQIVTAATSAVREAPNGRDFLNRVQKELGIQIELISGSEEARLIYLGVLSGMAFEDESYVIIDIGGGSTELILA
DKKDAIALTSSRVGAVRLKNDFLNEEPISNERSKFLKTFIRGSLEPSVEKIKRRLHKEKSVAMIATSGTAISLGNLILSD
LSQPKQKMHGYKFKKDNLEVILEKLIKMPITEIKKIPSLSERRAEIIIPGALILNTSMDMLDFNELTISERALREGLVVD
WMLRQGIIKNEFNIQSNIRKTTIVHQARKFGVDKNRSEKVTNIAFQIYDQTKNIFHSDTDSKAKKLLWAACHLYSCGKYV
NINSYHKHSWYLIKHCELLGYSQLETNIIASIARYHRKTLPKKRHESWQSLISKEEKTIVLEMSLILRLAASLDQRPENV
ISSIKIKLQKNALSMEIIPFNSNQDLLLEKWSLESCRNAIKELKNLELKVV
>Mature_531_residues
MIQENELSNLQEKNILVASIDIGTNSTHLLISEVNLDLKSFSIKFTDKSTTRLGEKDEEGNLTEESIQRVLYTLKRFKEY
CNSNGVNQIVTAATSAVREAPNGRDFLNRVQKELGIQIELISGSEEARLIYLGVLSGMAFEDESYVIIDIGGGSTELILA
DKKDAIALTSSRVGAVRLKNDFLNEEPISNERSKFLKTFIRGSLEPSVEKIKRRLHKEKSVAMIATSGTAISLGNLILSD
LSQPKQKMHGYKFKKDNLEVILEKLIKMPITEIKKIPSLSERRAEIIIPGALILNTSMDMLDFNELTISERALREGLVVD
WMLRQGIIKNEFNIQSNIRKTTIVHQARKFGVDKNRSEKVTNIAFQIYDQTKNIFHSDTDSKAKKLLWAACHLYSCGKYV
NINSYHKHSWYLIKHCELLGYSQLETNIIASIARYHRKTLPKKRHESWQSLISKEEKTIVLEMSLILRLAASLDQRPENV
ISSIKIKLQKNALSMEIIPFNSNQDLLLEKWSLESCRNAIKELKNLELKVV

Specific function: Degradation of inorganic polyphosphates. Orthophosphate is released progressively from the ends of polyphosphate [H]

COG id: COG0248

COG function: function code FP; Exopolyphosphatase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gppA/ppx family [H]

Homologues:

Organism=Escherichia coli, GI1788848, Length=428, Percent_Identity=27.3364485981308, Blast_Score=161, Evalue=8e-41,
Organism=Escherichia coli, GI48994966, Length=419, Percent_Identity=27.6849642004773, Blast_Score=151, Evalue=8e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022371
- InterPro:   IPR003695 [H]

Pfam domain/function: PF02541 Ppx-GppA [H]

EC number: =3.6.1.11 [H]

Molecular weight: Translated: 60393; Mature: 60393

Theoretical pI: Translated: 9.48; Mature: 9.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIQENELSNLQEKNILVASIDIGTNSTHLLISEVNLDLKSFSIKFTDKSTTRLGEKDEEG
CCCCCHHHCHHHCCEEEEEEECCCCCCEEEEEEECCCEEEEEEEECCCCHHHCCCCCCCC
NLTEESIQRVLYTLKRFKEYCNSNGVNQIVTAATSAVREAPNGRDFLNRVQKELGIQIEL
CCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCEEEEE
ISGSEEARLIYLGVLSGMAFEDESYVIIDIGGGSTELILADKKDAIALTSSRVGAVRLKN
ECCCCCCEEEEEEECCCCEECCCCEEEEEECCCCEEEEEECCCCCEEEECCCCCEEEEEH
DFLNEEPISNERSKFLKTFIRGSLEPSVEKIKRRLHKEKSVAMIATSGTAISLGNLILSD
HCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCEEEEEECCCEEHHHHHHHHH
LSQPKQKMHGYKFKKDNLEVILEKLIKMPITEIKKIPSLSERRAEIIIPGALILNTSMDM
HHHHHHHHCCCCCCCCCHHHHHHHHHHCCHHHHHHCCCCCCCCCEEEECCEEEECCCCCC
LDFNELTISERALREGLVVDWMLRQGIIKNEFNIQSNIRKTTIVHQARKFGVDKNRSEKV
CCCCHHHHHHHHHHCCHHHHHHHHCCCCCCCCCHHHCCHHHHHHHHHHHCCCCCCCCHHH
TNIAFQIYDQTKNIFHSDTDSKAKKLLWAACHLYSCGKYVNINSYHKHSWYLIKHCELLG
HHHHEEEEHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCEEECCCCCCCCEEEEEHHHHHC
YSQLETNIIASIARYHRKTLPKKRHESWQSLISKEEKTIVLEMSLILRLAASLDQRPENV
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHCCCHHHH
ISSIKIKLQKNALSMEIIPFNSNQDLLLEKWSLESCRNAIKELKNLELKVV
HHHHEEEEECCCEEEEEEEECCCCCCEEECCCHHHHHHHHHHHHCCEEEEC
>Mature Secondary Structure
MIQENELSNLQEKNILVASIDIGTNSTHLLISEVNLDLKSFSIKFTDKSTTRLGEKDEEG
CCCCCHHHCHHHCCEEEEEEECCCCCCEEEEEEECCCEEEEEEEECCCCHHHCCCCCCCC
NLTEESIQRVLYTLKRFKEYCNSNGVNQIVTAATSAVREAPNGRDFLNRVQKELGIQIEL
CCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCEEEEE
ISGSEEARLIYLGVLSGMAFEDESYVIIDIGGGSTELILADKKDAIALTSSRVGAVRLKN
ECCCCCCEEEEEEECCCCEECCCCEEEEEECCCCEEEEEECCCCCEEEECCCCCEEEEEH
DFLNEEPISNERSKFLKTFIRGSLEPSVEKIKRRLHKEKSVAMIATSGTAISLGNLILSD
HCCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCEEEEEECCCEEHHHHHHHHH
LSQPKQKMHGYKFKKDNLEVILEKLIKMPITEIKKIPSLSERRAEIIIPGALILNTSMDM
HHHHHHHHCCCCCCCCCHHHHHHHHHHCCHHHHHHCCCCCCCCCEEEECCEEEECCCCCC
LDFNELTISERALREGLVVDWMLRQGIIKNEFNIQSNIRKTTIVHQARKFGVDKNRSEKV
CCCCHHHHHHHHHHCCHHHHHHHHCCCCCCCCCHHHCCHHHHHHHHHHHCCCCCCCCHHH
TNIAFQIYDQTKNIFHSDTDSKAKKLLWAACHLYSCGKYVNINSYHKHSWYLIKHCELLG
HHHHEEEEHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCEEECCCCCCCCEEEEEHHHHHC
YSQLETNIIASIARYHRKTLPKKRHESWQSLISKEEKTIVLEMSLILRLAASLDQRPENV
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHCCCHHHH
ISSIKIKLQKNALSMEIIPFNSNQDLLLEKWSLESCRNAIKELKNLELKVV
HHHHEEEEECCCEEEEEEEECCCCCCEEECCCHHHHHHHHHHHHCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10382967; 10984043 [H]