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The map label for this gene is csgA [H]

Identifier: 123965710

GI number: 123965710

Start: 423447

End: 424151

Strand: Direct

Name: csgA [H]

Synonym: P9515_04751

Alternate gene names: 123965710

Gene position: 423447-424151 (Clockwise)

Preceding gene: 123965709

Following gene: 123965713

Centisome position: 24.85

GC content: 30.64

Gene sequence:

>705_bases
ATGAAAGGGTTAGCCTTAATTGTAGGCGCGGGTGGAATTGGAACGCAAATAGCTAAAGATTTGAGTGAAAATGAAAAAGA
CTTGGAGGTTATTTTGTGTGGAAGAAAAAGTGAATTTAATTCTTTTTGGGAACTAGATATAGAGGATTCTCAATCTCTTT
TGCAGTTGAAAAATAAAATATCAAATCATCCTTCAAAATTAAGGTTAGTTGTTAATGCTACAGGGAGACTTCATAGTGAT
TCACTTCAACCAGAAAAAAGATTACAACATCTTGATAAAAAAAATATGATGGAAAGTTTCTCAATTAATGCCTTTTCTCC
TATTTTGTTAGCTAAAGCAATTGAAGAATTTATCCCAAAAGATTTTTATTTTAATTTTGCAAGTATAAGTGCAAGAGTGG
GAAGCATTGGAGATAATCAAACTGGAGGTTGGTATTCATATAGAGCTGCAAAATCTGCCCAAAATCAATTTTTTAAATCT
TTAAGTATTGAGTGGACTAGACGTTTCCCAAAGGCTACTATTACGTTGCTTCATCCAGGAACAGTTGATACTGATTTATC
TAGACCTTTTCATAAATTTGTTCCAAAACATAAATTATTTACTAAAGAAAAATCATCCAAATTTTTGATCAATATTATTA
AAAATCAAACTCCAGAATTTACTGGAAAATTTATTGCATGGGATAGCTCAGAAATAATATGGTAA

Upstream 100 bases:

>100_bases
AAAAGCAAATCTAAATAAAATTTTCTAATCATATAAGAAATATCTTTACTCAAATCATAAGAAAAGTTTCTTAGAATCAA
TAAAGTTATTTTTTAATAAA

Downstream 100 bases:

>100_bases
ATCAAATTACTGTTGTTGAAACGGATAGAAAAGGATGAAAATATAAAATTGTAAATTGTTATCCAGATAAAGATCCTAAA
AAATCGATAATTAAGACAAT

Product: putative short chain dehydrogenase

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: C signal [H]

Number of amino acids: Translated: 234; Mature: 234

Protein sequence:

>234_residues
MKGLALIVGAGGIGTQIAKDLSENEKDLEVILCGRKSEFNSFWELDIEDSQSLLQLKNKISNHPSKLRLVVNATGRLHSD
SLQPEKRLQHLDKKNMMESFSINAFSPILLAKAIEEFIPKDFYFNFASISARVGSIGDNQTGGWYSYRAAKSAQNQFFKS
LSIEWTRRFPKATITLLHPGTVDTDLSRPFHKFVPKHKLFTKEKSSKFLINIIKNQTPEFTGKFIAWDSSEIIW

Sequences:

>Translated_234_residues
MKGLALIVGAGGIGTQIAKDLSENEKDLEVILCGRKSEFNSFWELDIEDSQSLLQLKNKISNHPSKLRLVVNATGRLHSD
SLQPEKRLQHLDKKNMMESFSINAFSPILLAKAIEEFIPKDFYFNFASISARVGSIGDNQTGGWYSYRAAKSAQNQFFKS
LSIEWTRRFPKATITLLHPGTVDTDLSRPFHKFVPKHKLFTKEKSSKFLINIIKNQTPEFTGKFIAWDSSEIIW
>Mature_234_residues
MKGLALIVGAGGIGTQIAKDLSENEKDLEVILCGRKSEFNSFWELDIEDSQSLLQLKNKISNHPSKLRLVVNATGRLHSD
SLQPEKRLQHLDKKNMMESFSINAFSPILLAKAIEEFIPKDFYFNFASISARVGSIGDNQTGGWYSYRAAKSAQNQFFKS
LSIEWTRRFPKATITLLHPGTVDTDLSRPFHKFVPKHKLFTKEKSSKFLINIIKNQTPEFTGKFIAWDSSEIIW

Specific function: Cell-cell signaling protein required for fruiting body morphogenesis. Necessary for cellular aggregation, for spore differentiation, and for gene expression that is initiated after 6 hour of starvation [H]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: To yeast YKL071W [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 26583; Mature: 26583

Theoretical pI: Translated: 10.07; Mature: 10.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGLALIVGAGGIGTQIAKDLSENEKDLEVILCGRKSEFNSFWELDIEDSQSLLQLKNKI
CCCEEEEEECCCCHHHHHHHHHCCCCCEEEEEECCCCCCCCEEEECCCCHHHHHHHHHHH
SNHPSKLRLVVNATGRLHSDSLQPEKRLQHLDKKNMMESFSINAFSPILLAKAIEEFIPK
CCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCH
DFYFNFASISARVGSIGDNQTGGWYSYRAAKSAQNQFFKSLSIEWTRRFPKATITLLHPG
HHEEHHHHHHHHHCCCCCCCCCCEEEHHHHHHHHHHHHHHHCHHHHHCCCCEEEEEEECC
TVDTDLSRPFHKFVPKHKLFTKEKSSKFLINIIKNQTPEFTGKFIAWDSSEIIW
CCCCCCCCHHHHHCCCHHHHHCCCCCHHHHHHHHCCCCCCCCEEEEECCCCCCC
>Mature Secondary Structure
MKGLALIVGAGGIGTQIAKDLSENEKDLEVILCGRKSEFNSFWELDIEDSQSLLQLKNKI
CCCEEEEEECCCCHHHHHHHHHCCCCCEEEEEECCCCCCCCEEEECCCCHHHHHHHHHHH
SNHPSKLRLVVNATGRLHSDSLQPEKRLQHLDKKNMMESFSINAFSPILLAKAIEEFIPK
CCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCH
DFYFNFASISARVGSIGDNQTGGWYSYRAAKSAQNQFFKSLSIEWTRRFPKATITLLHPG
HHEEHHHHHHHHHCCCCCCCCCCEEEHHHHHHHHHHHHHHHCHHHHHCCCCEEEEEEECC
TVDTDLSRPFHKFVPKHKLFTKEKSSKFLINIIKNQTPEFTGKFIAWDSSEIIW
CCCCCCCCHHHHHCCCHHHHHCCCCCHHHHHHHHCCCCCCCCEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2152896; 2107980; 2118510; 1372277 [H]