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The map label for this gene is proC [H]

Identifier: 123965693

GI number: 123965693

Start: 406914

End: 407726

Strand: Direct

Name: proC [H]

Synonym: P9515_04581

Alternate gene names: 123965693

Gene position: 406914-407726 (Clockwise)

Preceding gene: 123965692

Following gene: 123965698

Centisome position: 23.88

GC content: 31.12

Gene sequence:

>813_bases
GTGACAAGTAAAATCGCAGTTATTGGTTTTGGAAATATTGCAAAAGCTATAATCACGCCTCTATTTGATAAAAAGATACT
AAATCCAAAAGATTTTTATTGTTTAGTTAATACGAAAAAAAGTTTAGAAAATATTAGAAATAACTATAAATATAATATTA
ATATTTTTCAGGCGAACTCTAAAGATTCAGAGATTATTTGGGATTGCCCAGTTAAAATTCTATCTGTTAAGCCCCAGCAA
CTTAAAAACATAATTGAATTAGAAAAAAATAAAAATAATAGAAATTTATTGGTATCTATTTTAGCTGGTGTTTCTCTCGA
AAAACTTATCAAAAGATTCCCAAATCATAAATGTGTTAGGGTCGTGACTAATATTCCAATAACAATTGGTAAAGGTTCAA
CTGGAATTGCTTGGGGTGATGAAATATCGGAAAATCAGAAGGAAGCTGTCAGAAGATTATTTGAAAATACTAGTAAAATA
AATGAATTTCCTGAAGATCTACTCGATATTTTTTTAGCATTAACATCTTCGGGACCCGCTATAATTGCATTGATTATCGA
AGCTCTAAGTGACGGAGGGTTAAGCGGTGGATTGCCAAAACAACTGTCTGAAGAACTTGTGATGGATATGATCTTAGGAA
CTATAAGTTTAATAAGAGAAACTAATTTAACAACTACTGAGCTTAAGAATATGGTTACTTCTCCTGGGGGTACAACAATA
TCAGCACTAAGGGTGTTAGAAAATAAGAGTTTAAGATCTGCTTTGATTGAGGCAGTTGTCTCTGCAAGTAATCGTAGTAA
AGAATTTCGTTAA

Upstream 100 bases:

>100_bases
ATTTCAAGTAAAAAGACCTCTCCATATAGTTTAGAAACTAATACAACTCCAGAACCAGCTTGGGGTGAATCTAAATTATC
TGCATTTTCTTAATTAATCT

Downstream 100 bases:

>100_bases
ACTTTAGATGCTTTTATAATGTCTAAGTAAAGTTGTTCGAGAGCTTGGATGTTTTTTTTAATGGTATATCTTTCAATTAC
TCTCGCACGTCCCTTTTCCC

Product: Delta 1-pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 270; Mature: 269

Protein sequence:

>270_residues
MTSKIAVIGFGNIAKAIITPLFDKKILNPKDFYCLVNTKKSLENIRNNYKYNINIFQANSKDSEIIWDCPVKILSVKPQQ
LKNIIELEKNKNNRNLLVSILAGVSLEKLIKRFPNHKCVRVVTNIPITIGKGSTGIAWGDEISENQKEAVRRLFENTSKI
NEFPEDLLDIFLALTSSGPAIIALIIEALSDGGLSGGLPKQLSEELVMDMILGTISLIRETNLTTTELKNMVTSPGGTTI
SALRVLENKSLRSALIEAVVSASNRSKEFR

Sequences:

>Translated_270_residues
MTSKIAVIGFGNIAKAIITPLFDKKILNPKDFYCLVNTKKSLENIRNNYKYNINIFQANSKDSEIIWDCPVKILSVKPQQ
LKNIIELEKNKNNRNLLVSILAGVSLEKLIKRFPNHKCVRVVTNIPITIGKGSTGIAWGDEISENQKEAVRRLFENTSKI
NEFPEDLLDIFLALTSSGPAIIALIIEALSDGGLSGGLPKQLSEELVMDMILGTISLIRETNLTTTELKNMVTSPGGTTI
SALRVLENKSLRSALIEAVVSASNRSKEFR
>Mature_269_residues
TSKIAVIGFGNIAKAIITPLFDKKILNPKDFYCLVNTKKSLENIRNNYKYNINIFQANSKDSEIIWDCPVKILSVKPQQL
KNIIELEKNKNNRNLLVSILAGVSLEKLIKRFPNHKCVRVVTNIPITIGKGSTGIAWGDEISENQKEAVRRLFENTSKIN
EFPEDLLDIFLALTSSGPAIIALIIEALSDGGLSGGLPKQLSEELVMDMILGTISLIRETNLTTTELKNMVTSPGGTTIS
ALRVLENKSLRSALIEAVVSASNRSKEFR

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI198041662, Length=268, Percent_Identity=27.9850746268657, Blast_Score=128, Evalue=6e-30,
Organism=Homo sapiens, GI21361454, Length=271, Percent_Identity=30.6273062730627, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI24797097, Length=212, Percent_Identity=33.9622641509434, Blast_Score=119, Evalue=3e-27,
Organism=Homo sapiens, GI24797095, Length=212, Percent_Identity=33.9622641509434, Blast_Score=119, Evalue=3e-27,
Organism=Escherichia coli, GI1786585, Length=271, Percent_Identity=27.6752767527675, Blast_Score=122, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI17569021, Length=267, Percent_Identity=28.4644194756554, Blast_Score=117, Evalue=8e-27,
Organism=Caenorhabditis elegans, GI17540664, Length=277, Percent_Identity=30.6859205776173, Blast_Score=115, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6320861, Length=297, Percent_Identity=27.9461279461279, Blast_Score=117, Evalue=2e-27,
Organism=Drosophila melanogaster, GI21358587, Length=271, Percent_Identity=26.5682656826568, Blast_Score=123, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24648116, Length=280, Percent_Identity=29.2857142857143, Blast_Score=112, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24647700, Length=156, Percent_Identity=31.4102564102564, Blast_Score=101, Evalue=6e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 29854; Mature: 29723

Theoretical pI: Translated: 9.80; Mature: 9.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSKIAVIGFGNIAKAIITPLFDKKILNPKDFYCLVNTKKSLENIRNNYKYNINIFQANS
CCCCEEEEECCHHHHHHHHHHHHHHCCCCCCEEEEEECHHHHHHHHCCCEEEEEEEECCC
KDSEIIWDCPVKILSVKPQQLKNIIELEKNKNNRNLLVSILAGVSLEKLIKRFPNHKCVR
CCCCEEEECCCCEEECCHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHCCCCCEEE
VVTNIPITIGKGSTGIAWGDEISENQKEAVRRLFENTSKINEFPEDLLDIFLALTSSGPA
EEECCCEEECCCCCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
IIALIIEALSDGGLSGGLPKQLSEELVMDMILGTISLIRETNLTTTELKNMVTSPGGTTI
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHH
SALRVLENKSLRSALIEAVVSASNRSKEFR
HHHHHHHCHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
TSKIAVIGFGNIAKAIITPLFDKKILNPKDFYCLVNTKKSLENIRNNYKYNINIFQANS
CCCEEEEECCHHHHHHHHHHHHHHCCCCCCEEEEEECHHHHHHHHCCCEEEEEEEECCC
KDSEIIWDCPVKILSVKPQQLKNIIELEKNKNNRNLLVSILAGVSLEKLIKRFPNHKCVR
CCCCEEEECCCCEEECCHHHHHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHCCCCCEEE
VVTNIPITIGKGSTGIAWGDEISENQKEAVRRLFENTSKINEFPEDLLDIFLALTSSGPA
EEECCCEEECCCCCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
IIALIIEALSDGGLSGGLPKQLSEELVMDMILGTISLIRETNLTTTELKNMVTSPGGTTI
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHH
SALRVLENKSLRSALIEAVVSASNRSKEFR
HHHHHHHCHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]