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The map label for this gene is mtnP [H]

Identifier: 123965569

GI number: 123965569

Start: 305898

End: 306797

Strand: Reverse

Name: mtnP [H]

Synonym: P9515_03341

Alternate gene names: 123965569

Gene position: 306797-305898 (Counterclockwise)

Preceding gene: 123965571

Following gene: 123965562

Centisome position: 18.0

GC content: 35.67

Gene sequence:

>900_bases
ATGAATAAACAGCATTTATTACCAATTAAAGAATCAAGATTAGGAGTAATTGGTGGGAGTGGTTTCTATTCAATTGACAA
AATAGAATGTCATGAAGAATTTGAGGTCAATACTCCTTATGGTAAACCTTCTGATTCAATTAGGCTCTTTAAAATTGGCA
ACTTAGAAATTGCTTTTATAGCAAGACATGGTAGAACACATAGTCTCAATCCAACAGATATCCCTTACAAAGCTAACATT
TGGGCTCTCCGATCTATTGGTGTGAGATGGATAATTGCTCCATCTGCAGTTGGCTCCCTTCAAGAACAAATTAGGCCCCT
TGATATTGTTATTCCCGATCAATTTATTGATCGAACTCATAAAAGACCTACAACATTTTTTAATGAAGGAGCAGTAGCTC
ATGTAACTATGGGTGATCCTTTCTGTAGGAATTTATCAGAAATCCTAGCCAATGTTGGAGAAAAAACTATACCGGGGGGA
AGACAATTACATAGAGGAGGAACATATCTAGCAATGGAAGGGCCGGCTTTCTCAACCAGAGCAGAATCTAACTTATATAG
AAGTTGGGGTTGTTCAATAATAGGTATGACTAATCACACTGAAGCAAGATTAGCTAAAGAAGCTGAGATAGCCTATTCTT
CACTATCCATGGTTACTGATTATGATTGCTGGCATCAAACTCATCAAGAAGTATCAGTAGAGATGGTTTTGGAAAATCTC
AGAACTAATACTGAAGTTGCTAATAAAATTGTCTTTGAAATAGCGAAAGTTATTGATAGAGATAGACCTAAAAGCAAATC
ACATTTTTCTTTGAAAGATGGTTTAATAACCCCAAAAGAAAATATCCCCAGCTCTACCAAAGAAAAGCTGAAGATATTAA
CAGACATATATTGGAGTTAG

Upstream 100 bases:

>100_bases
TGGCATTAATTTAGGATTCATCAACCATTTTCTCATCAAAAGAACATTTGTATGTCCTCCTCCAATTAGTACTAGATGAT
TAATAGTCATTTGTTTCACA

Downstream 100 bases:

>100_bases
ATTAACTATATGAGACAACTAAAAAGTAATGGATACTTTAGCCTGCTCCTACTCCTTGATATGATCCATAGAAAAATATA
CCCAATACAAAAATAACCGC

Product: 5'-methylthioadenosine phosphorylase

Products: NA

Alternate protein names: 5'-methylthioadenosine phosphorylase; MTA phosphorylase [H]

Number of amino acids: Translated: 299; Mature: 299

Protein sequence:

>299_residues
MNKQHLLPIKESRLGVIGGSGFYSIDKIECHEEFEVNTPYGKPSDSIRLFKIGNLEIAFIARHGRTHSLNPTDIPYKANI
WALRSIGVRWIIAPSAVGSLQEQIRPLDIVIPDQFIDRTHKRPTTFFNEGAVAHVTMGDPFCRNLSEILANVGEKTIPGG
RQLHRGGTYLAMEGPAFSTRAESNLYRSWGCSIIGMTNHTEARLAKEAEIAYSSLSMVTDYDCWHQTHQEVSVEMVLENL
RTNTEVANKIVFEIAKVIDRDRPKSKSHFSLKDGLITPKENIPSSTKEKLKILTDIYWS

Sequences:

>Translated_299_residues
MNKQHLLPIKESRLGVIGGSGFYSIDKIECHEEFEVNTPYGKPSDSIRLFKIGNLEIAFIARHGRTHSLNPTDIPYKANI
WALRSIGVRWIIAPSAVGSLQEQIRPLDIVIPDQFIDRTHKRPTTFFNEGAVAHVTMGDPFCRNLSEILANVGEKTIPGG
RQLHRGGTYLAMEGPAFSTRAESNLYRSWGCSIIGMTNHTEARLAKEAEIAYSSLSMVTDYDCWHQTHQEVSVEMVLENL
RTNTEVANKIVFEIAKVIDRDRPKSKSHFSLKDGLITPKENIPSSTKEKLKILTDIYWS
>Mature_299_residues
MNKQHLLPIKESRLGVIGGSGFYSIDKIECHEEFEVNTPYGKPSDSIRLFKIGNLEIAFIARHGRTHSLNPTDIPYKANI
WALRSIGVRWIIAPSAVGSLQEQIRPLDIVIPDQFIDRTHKRPTTFFNEGAVAHVTMGDPFCRNLSEILANVGEKTIPGG
RQLHRGGTYLAMEGPAFSTRAESNLYRSWGCSIIGMTNHTEARLAKEAEIAYSSLSMVTDYDCWHQTHQEVSVEMVLENL
RTNTEVANKIVFEIAKVIDRDRPKSKSHFSLKDGLITPKENIPSSTKEKLKILTDIYWS

Specific function: Catalyzes the formation of methylthio-D-ribose 1- phosphate (MTR-1-P) from methylthioadenosine (MTA) [H]

COG id: COG0005

COG function: function code F; Purine nucleoside phosphorylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PNP/MTAP phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI47132622, Length=245, Percent_Identity=44.0816326530612, Blast_Score=224, Evalue=5e-59,
Organism=Caenorhabditis elegans, GI71980569, Length=248, Percent_Identity=38.7096774193548, Blast_Score=177, Evalue=5e-45,
Organism=Saccharomyces cerevisiae, GI6323045, Length=303, Percent_Identity=38.2838283828383, Blast_Score=186, Evalue=3e-48,
Organism=Drosophila melanogaster, GI20130079, Length=251, Percent_Identity=41.0358565737052, Blast_Score=192, Evalue=2e-49,
Organism=Drosophila melanogaster, GI221459247, Length=252, Percent_Identity=34.1269841269841, Blast_Score=159, Evalue=2e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010044
- InterPro:   IPR000845
- InterPro:   IPR001369
- InterPro:   IPR018099 [H]

Pfam domain/function: PF01048 PNP_UDP_1 [H]

EC number: =2.4.2.28 [H]

Molecular weight: Translated: 33678; Mature: 33678

Theoretical pI: Translated: 8.03; Mature: 8.03

Prosite motif: PS01240 PNP_MTAP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKQHLLPIKESRLGVIGGSGFYSIDKIECHEEFEVNTPYGKPSDSIRLFKIGNLEIAFI
CCCCCCCCCCCCCEEEEECCCCEEECEEECCCCEECCCCCCCCCCCEEEEEECCEEEEEE
ARHGRTHSLNPTDIPYKANIWALRSIGVRWIIAPSAVGSLQEQIRPLDIVIPDQFIDRTH
EECCCCCCCCCCCCCEECCEEEEECCCEEEEECCHHHHHHHHHCCCEEEEECHHHHHHHC
KRPTTFFNEGAVAHVTMGDPFCRNLSEILANVGEKTIPGGRQLHRGGTYLAMEGPAFSTR
CCCCEEECCCCEEEEECCCHHHHHHHHHHHHCCCCCCCCCCEECCCCCEEEECCCCCCCH
AESNLYRSWGCSIIGMTNHTEARLAKEAEIAYSSLSMVTDYDCWHQTHQEVSVEMVLENL
HHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
RTNTEVANKIVFEIAKVIDRDRPKSKSHFSLKDGLITPKENIPSSTKEKLKILTDIYWS
CCCHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCCCCCCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MNKQHLLPIKESRLGVIGGSGFYSIDKIECHEEFEVNTPYGKPSDSIRLFKIGNLEIAFI
CCCCCCCCCCCCCEEEEECCCCEEECEEECCCCEECCCCCCCCCCCEEEEEECCEEEEEE
ARHGRTHSLNPTDIPYKANIWALRSIGVRWIIAPSAVGSLQEQIRPLDIVIPDQFIDRTH
EECCCCCCCCCCCCCEECCEEEEECCCEEEEECCHHHHHHHHHCCCEEEEECHHHHHHHC
KRPTTFFNEGAVAHVTMGDPFCRNLSEILANVGEKTIPGGRQLHRGGTYLAMEGPAFSTR
CCCCEEECCCCEEEEECCCHHHHHHHHHHHHCCCCCCCCCCEECCCCCEEEECCCCCCCH
AESNLYRSWGCSIIGMTNHTEARLAKEAEIAYSSLSMVTDYDCWHQTHQEVSVEMVLENL
HHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
RTNTEVANKIVFEIAKVIDRDRPKSKSHFSLKDGLITPKENIPSSTKEKLKILTDIYWS
CCCHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCCCCCCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA