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The map label for this gene is pyrD [H]

Identifier: 123965463

GI number: 123965463

Start: 210471

End: 211640

Strand: Reverse

Name: pyrD [H]

Synonym: P9515_02281

Alternate gene names: 123965463

Gene position: 211640-210471 (Counterclockwise)

Preceding gene: 123965464

Following gene: 123965462

Centisome position: 12.42

GC content: 30.34

Gene sequence:

>1170_bases
ATGTTTGAACAGAAAGGGATGTTTATTAATATTTATAAGAATTTGGTCACTCCTATCCTTAAAAAAGATACTGGCATAGA
TGCAGAGTACCTGACAAATTTTTCTTTAAGTCTTCTTGCTTTTACTTCAAATAATAGAAACTGGCCCTTAATTAAAGGCA
TAATAAAGCGTTTAAATGATGAGTTTTGTGTGGTTGATAAAAGATTACATCAAAACATATGTGGGATAGATTTTTGTAAT
CCAGTAGGTTTAGCAGCTGGTTTTGATAAAAATGGTAATGCTGCAAATATTTGGGAAAATTTTGGATTTGGTTTCGCTGA
AATTGGAACAGTTACCAAATTTGCTCAATCTGGAAATCCTAAACCAAGATTATTTAGATTAGCTAAGGAGGAGGCGGCAT
TAAATAGAATGGGTTTTAATAATAATGGTGCTGAAAATCTTTTTAAAAACTTTTTAAAACAAGGTATTCCTTTAAAAAAG
AATAGAAAAAATAATTGTTTGGGCATAAATTTTGGAAAATCAAAAATTACAAGTTTATCCAAGGCTACAGAAGATTATTT
AACTTCTTTAAAACTTTTGATTCCTTATTGTGACTACGCTGCTATAAATGTAAGTTCACCTAATACTGAAGGTCTTAGAA
AGCTACAAGATCCTATTCTTTTACAAGAACTGCTTAGAGAAGTTAAAAAATTAGATAATTGTCCACCTTTATTCGTGAAA
ATTGCACCAGATTTAAGTTATAAAGATATTGAAGATATCTGCCAACTAATAATTGATGAAAATATTAATGGAATCATCGC
TACTAATACCAGCCTAGATAGATTAGGTCTTGAGCAAAGAAAAATAAAGCAAACAGGGCTATTACTCTCTGAAGAAAATG
GTGGATTAAGTGGCAGACCACTTCAACTAAAAGCAAATCAAATAATTCGTCATATTAATAATATTGATCAAAGTATTAAA
TTAATTGGAGTAGGGGGAATAGACAGCCCAGAATCTGCTTGGGAAAGGATATGTGCTGGAGCTTCTTTAGTACAAATATA
TACTGGATGGATTTATAAAGGTCCTCAACTAGTTCCAAATATTCTTAATGGGATCATAAAACAACTTAATAAACATCAAT
TATCAAATATAAAAGAAGCCATTGGATCAAACTTAAAATGGATTGAATGA

Upstream 100 bases:

>100_bases
AAAAATATGAATTATTTGAATGGCGGAATTGGAGATTAATTCCTAAAAATCAAAAATATTGGATAATAGAGAATAAACAC
GCTTAATCTTTAATATTTTT

Downstream 100 bases:

>100_bases
AACCTAAGATAAATTATGGATTCAAAATCAATAATTTGGAAAACGAAAGTATGAACGATGTGAACTTCAAGCATGGAGGA
AATATATTGACTCAGGCAAA

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 389; Mature: 389

Protein sequence:

>389_residues
MFEQKGMFINIYKNLVTPILKKDTGIDAEYLTNFSLSLLAFTSNNRNWPLIKGIIKRLNDEFCVVDKRLHQNICGIDFCN
PVGLAAGFDKNGNAANIWENFGFGFAEIGTVTKFAQSGNPKPRLFRLAKEEAALNRMGFNNNGAENLFKNFLKQGIPLKK
NRKNNCLGINFGKSKITSLSKATEDYLTSLKLLIPYCDYAAINVSSPNTEGLRKLQDPILLQELLREVKKLDNCPPLFVK
IAPDLSYKDIEDICQLIIDENINGIIATNTSLDRLGLEQRKIKQTGLLLSEENGGLSGRPLQLKANQIIRHINNIDQSIK
LIGVGGIDSPESAWERICAGASLVQIYTGWIYKGPQLVPNILNGIIKQLNKHQLSNIKEAIGSNLKWIE

Sequences:

>Translated_389_residues
MFEQKGMFINIYKNLVTPILKKDTGIDAEYLTNFSLSLLAFTSNNRNWPLIKGIIKRLNDEFCVVDKRLHQNICGIDFCN
PVGLAAGFDKNGNAANIWENFGFGFAEIGTVTKFAQSGNPKPRLFRLAKEEAALNRMGFNNNGAENLFKNFLKQGIPLKK
NRKNNCLGINFGKSKITSLSKATEDYLTSLKLLIPYCDYAAINVSSPNTEGLRKLQDPILLQELLREVKKLDNCPPLFVK
IAPDLSYKDIEDICQLIIDENINGIIATNTSLDRLGLEQRKIKQTGLLLSEENGGLSGRPLQLKANQIIRHINNIDQSIK
LIGVGGIDSPESAWERICAGASLVQIYTGWIYKGPQLVPNILNGIIKQLNKHQLSNIKEAIGSNLKWIE
>Mature_389_residues
MFEQKGMFINIYKNLVTPILKKDTGIDAEYLTNFSLSLLAFTSNNRNWPLIKGIIKRLNDEFCVVDKRLHQNICGIDFCN
PVGLAAGFDKNGNAANIWENFGFGFAEIGTVTKFAQSGNPKPRLFRLAKEEAALNRMGFNNNGAENLFKNFLKQGIPLKK
NRKNNCLGINFGKSKITSLSKATEDYLTSLKLLIPYCDYAAINVSSPNTEGLRKLQDPILLQELLREVKKLDNCPPLFVK
IAPDLSYKDIEDICQLIIDENINGIIATNTSLDRLGLEQRKIKQTGLLLSEENGGLSGRPLQLKANQIIRHINNIDQSIK
LIGVGGIDSPESAWERICAGASLVQIYTGWIYKGPQLVPNILNGIIKQLNKHQLSNIKEAIGSNLKWIE

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI45006951, Length=327, Percent_Identity=40.9785932721713, Blast_Score=226, Evalue=3e-59,
Organism=Escherichia coli, GI1787177, Length=303, Percent_Identity=46.2046204620462, Blast_Score=246, Evalue=2e-66,
Organism=Caenorhabditis elegans, GI17509475, Length=324, Percent_Identity=37.962962962963, Blast_Score=209, Evalue=2e-54,
Organism=Drosophila melanogaster, GI281361352, Length=334, Percent_Identity=40.1197604790419, Blast_Score=239, Evalue=2e-63,
Organism=Drosophila melanogaster, GI17137316, Length=334, Percent_Identity=40.1197604790419, Blast_Score=239, Evalue=2e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.5.2 [H]

Molecular weight: Translated: 43418; Mature: 43418

Theoretical pI: Translated: 9.32; Mature: 9.32

Prosite motif: PS00911 DHODEHASE_1 ; PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFEQKGMFINIYKNLVTPILKKDTGIDAEYLTNFSLSLLAFTSNNRNWPLIKGIIKRLND
CCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHCCCEEEEEEECCCCCCHHHHHHHHHCCC
EFCVVDKRLHQNICGIDFCNPVGLAAGFDKNGNAANIWENFGFGFAEIGTVTKFAQSGNP
CCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHCCCC
KPRLFRLAKEEAALNRMGFNNNGAENLFKNFLKQGIPLKKNRKNNCLGINFGKSKITSLS
CHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEEECCHHHHHHHH
KATEDYLTSLKLLIPYCDYAAINVSSPNTEGLRKLQDPILLQELLREVKKLDNCPPLFVK
HHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHCHHHHHHHHHHHHHHCCCCCEEEE
IAPDLSYKDIEDICQLIIDENINGIIATNTSLDRLGLEQRKIKQTGLLLSEENGGLSGRP
ECCCCCCCCHHHHHHHHHCCCCCEEEEECCCHHHHCCHHHHHHHHCCEEECCCCCCCCCC
LQLKANQIIRHINNIDQSIKLIGVGGIDSPESAWERICAGASLVQIYTGWIYKGPQLVPN
EEEHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHH
ILNGIIKQLNKHQLSNIKEAIGSNLKWIE
HHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MFEQKGMFINIYKNLVTPILKKDTGIDAEYLTNFSLSLLAFTSNNRNWPLIKGIIKRLND
CCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHCCCEEEEEEECCCCCCHHHHHHHHHCCC
EFCVVDKRLHQNICGIDFCNPVGLAAGFDKNGNAANIWENFGFGFAEIGTVTKFAQSGNP
CCEEHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHCCCC
KPRLFRLAKEEAALNRMGFNNNGAENLFKNFLKQGIPLKKNRKNNCLGINFGKSKITSLS
CHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEEECCHHHHHHHH
KATEDYLTSLKLLIPYCDYAAINVSSPNTEGLRKLQDPILLQELLREVKKLDNCPPLFVK
HHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHCHHHHHHHHHHHHHHCCCCCEEEE
IAPDLSYKDIEDICQLIIDENINGIIATNTSLDRLGLEQRKIKQTGLLLSEENGGLSGRP
ECCCCCCCCHHHHHHHHHCCCCCEEEEECCCHHHHCCHHHHHHHHCCEEECCCCCCCCCC
LQLKANQIIRHINNIDQSIKLIGVGGIDSPESAWERICAGASLVQIYTGWIYKGPQLVPN
EEEHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHH
ILNGIIKQLNKHQLSNIKEAIGSNLKWIE
HHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12917641 [H]