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The map label for this gene is cobD [H]

Identifier: 123965462

GI number: 123965462

Start: 209335

End: 210420

Strand: Reverse

Name: cobD [H]

Synonym: P9515_02271

Alternate gene names: 123965462

Gene position: 210420-209335 (Counterclockwise)

Preceding gene: 123965463

Following gene: 123965460

Centisome position: 12.35

GC content: 29.65

Gene sequence:

>1086_bases
ATGAACGATGTGAACTTCAAGCATGGAGGAAATATATTGACTCAGGCAAAAAATTTAAATCTATTGCCGTCTAAAATAAT
TGACTCAAGTGCATCATTAGTAGCTTTTAAGCCACCTAAAATACTTTTAGACTCCTTAAGATTAGAAATTAAAAAACTAG
GATTTCAATATTATCCTGAAAGGAATCTAAATGATTTAAGAGAGATAATTGGAGAATTTCATCAAATAAATCCCGATAAT
ATATTGCCTGGGAATGGGGCCTCTGAGTTAATAACTTGGGCAGGACATGAAGCCTCCAAATTTGGAGTAAGTTCTATTCC
TAGTCCTGGCTTCGTAGATTATGAAAGATCACTAAATTGCTGGGATGCAAAATACAATTACTCAGAATTACCAAGGAATT
GGAGTAATAGTTTCCCTCAACCCTTCCCACTGAAACCAATTTGTGATGTACTTTGGATAACAAACCCACATAACCCTACT
GGTCAATTATGGGACAAAAAGTCACTTGAAATAATTTTAAAGAAATATAAGCTAGTAATTTGTGATGAAGCTTTTTTAGC
AATAACACCAAATGGTGAAAAACAATCTTTAATCCCACTCACTAAAATTTATGATAATTTATTAGTTATAAGGAGTTTGA
CAAAATTATTTAACATAGCAGGTTTAAGATTAGGTTATGTTGTTGGATCCTCTGAAAAACTAAATAAATGGAATATTAAG
AGAGATCCTTGGCCATTAAATTGTTTTGCTATTAAAGCTGGAATAGAGCTATTAAGTAATAAAATTTTTTATAAGGAATG
GACAAAAAAGATTCATGATTGGGTAAGAACTGAGAAGGATTGGGTTTCTCATGAATTGTCGAAAATAAAAAATCTTAAAG
TACATAACTCTTCAACTAACTTTTTTTTAGTAGAAAGTAAATTCTCATTAAACTCAAATATTAAGTATTTAGAAAACAAA
GGGATCTTAATTAGAGAATGTACCTCATTTAGATGTCTTAATGAAAAATGGGCAAGAATAAGTTTGCAGAATAGAAAAAA
TAATAAAATTTTATGTAGAGAAATTCAAAATTCTTTTAAAAAATAA

Upstream 100 bases:

>100_bases
TATCAAATATAAAAGAAGCCATTGGATCAAACTTAAAATGGATTGAATGAAACCTAAGATAAATTATGGATTCAAAATCA
ATAATTTGGAAAACGAAAGT

Downstream 100 bases:

>100_bases
TTTATTAAATTTTTAATCTTATTTGTAGATTTTAAGGAAGTAAGATTTTTCATATTTTCTTTCATTAAATCTAAAATTTC
ATATGTAGGTTTACCTTTGT

Product: aminotransferases class-I

Products: NA

Alternate protein names: L-threonine-O-3-phosphate decarboxylase [H]

Number of amino acids: Translated: 361; Mature: 361

Protein sequence:

>361_residues
MNDVNFKHGGNILTQAKNLNLLPSKIIDSSASLVAFKPPKILLDSLRLEIKKLGFQYYPERNLNDLREIIGEFHQINPDN
ILPGNGASELITWAGHEASKFGVSSIPSPGFVDYERSLNCWDAKYNYSELPRNWSNSFPQPFPLKPICDVLWITNPHNPT
GQLWDKKSLEIILKKYKLVICDEAFLAITPNGEKQSLIPLTKIYDNLLVIRSLTKLFNIAGLRLGYVVGSSEKLNKWNIK
RDPWPLNCFAIKAGIELLSNKIFYKEWTKKIHDWVRTEKDWVSHELSKIKNLKVHNSSTNFFLVESKFSLNSNIKYLENK
GILIRECTSFRCLNEKWARISLQNRKNNKILCREIQNSFKK

Sequences:

>Translated_361_residues
MNDVNFKHGGNILTQAKNLNLLPSKIIDSSASLVAFKPPKILLDSLRLEIKKLGFQYYPERNLNDLREIIGEFHQINPDN
ILPGNGASELITWAGHEASKFGVSSIPSPGFVDYERSLNCWDAKYNYSELPRNWSNSFPQPFPLKPICDVLWITNPHNPT
GQLWDKKSLEIILKKYKLVICDEAFLAITPNGEKQSLIPLTKIYDNLLVIRSLTKLFNIAGLRLGYVVGSSEKLNKWNIK
RDPWPLNCFAIKAGIELLSNKIFYKEWTKKIHDWVRTEKDWVSHELSKIKNLKVHNSSTNFFLVESKFSLNSNIKYLENK
GILIRECTSFRCLNEKWARISLQNRKNNKILCREIQNSFKK
>Mature_361_residues
MNDVNFKHGGNILTQAKNLNLLPSKIIDSSASLVAFKPPKILLDSLRLEIKKLGFQYYPERNLNDLREIIGEFHQINPDN
ILPGNGASELITWAGHEASKFGVSSIPSPGFVDYERSLNCWDAKYNYSELPRNWSNSFPQPFPLKPICDVLWITNPHNPT
GQLWDKKSLEIILKKYKLVICDEAFLAITPNGEKQSLIPLTKIYDNLLVIRSLTKLFNIAGLRLGYVVGSSEKLNKWNIK
RDPWPLNCFAIKAGIELLSNKIFYKEWTKKIHDWVRTEKDWVSHELSKIKNLKVHNSSTNFFLVESKFSLNSNIKYLENK
GILIRECTSFRCLNEKWARISLQNRKNNKILCREIQNSFKK

Specific function: Decarboxylates L-threonine-O-3-phosphate to yield (R)-1- amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin [H]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=297, Percent_Identity=24.5791245791246, Blast_Score=80, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR005860
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.1.1.81 [H]

Molecular weight: Translated: 41707; Mature: 41707

Theoretical pI: Translated: 9.97; Mature: 9.97

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
0.3 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
0.3 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDVNFKHGGNILTQAKNLNLLPSKIIDSSASLVAFKPPKILLDSLRLEIKKLGFQYYPE
CCCCCCCCCCCEEEECCCCCCCHHHHHCCCCCEEEECCHHHHHHHHHHHHHHCCCCCCCC
RNLNDLREIIGEFHQINPDNILPGNGASELITWAGHEASKFGVSSIPSPGFVDYERSLNC
CCHHHHHHHHHHHHCCCCCCCCCCCCHHHHEEECCCCCHHCCCCCCCCCCCCCCCCCCCC
WDAKYNYSELPRNWSNSFPQPFPLKPICDVLWITNPHNPTGQLWDKKSLEIILKKYKLVI
CCCCCCHHHCCCCHHCCCCCCCCCCHHHHEEEECCCCCCCCCCCCCHHHHHHHHHHEEEE
CDEAFLAITPNGEKQSLIPLTKIYDNLLVIRSLTKLFNIAGLRLGYVVGSSEKLNKWNIK
ECCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCC
RDPWPLNCFAIKAGIELLSNKIFYKEWTKKIHDWVRTEKDWVSHELSKIKNLKVHNSSTN
CCCCCCEEEEHHHHHHHHHCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCEEEECCCCC
FFLVESKFSLNSNIKYLENKGILIRECTSFRCLNEKWARISLQNRKNNKILCREIQNSFK
EEEEEECCCCCCCCEEEECCCEEEEECCCHHHHCCHHHEEEEECCCCCCCHHHHHHHHHC
K
C
>Mature Secondary Structure
MNDVNFKHGGNILTQAKNLNLLPSKIIDSSASLVAFKPPKILLDSLRLEIKKLGFQYYPE
CCCCCCCCCCCEEEECCCCCCCHHHHHCCCCCEEEECCHHHHHHHHHHHHHHCCCCCCCC
RNLNDLREIIGEFHQINPDNILPGNGASELITWAGHEASKFGVSSIPSPGFVDYERSLNC
CCHHHHHHHHHHHHCCCCCCCCCCCCHHHHEEECCCCCHHCCCCCCCCCCCCCCCCCCCC
WDAKYNYSELPRNWSNSFPQPFPLKPICDVLWITNPHNPTGQLWDKKSLEIILKKYKLVI
CCCCCCHHHCCCCHHCCCCCCCCCCHHHHEEEECCCCCCCCCCCCCHHHHHHHHHHEEEE
CDEAFLAITPNGEKQSLIPLTKIYDNLLVIRSLTKLFNIAGLRLGYVVGSSEKLNKWNIK
ECCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCC
RDPWPLNCFAIKAGIELLSNKIFYKEWTKKIHDWVRTEKDWVSHELSKIKNLKVHNSSTN
CCCCCCEEEEHHHHHHHHHCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCEEEECCCCC
FFLVESKFSLNSNIKYLENKGILIRECTSFRCLNEKWARISLQNRKNNKILCREIQNSFK
EEEEEECCCCCCCCEEEECCCEEEEECCCHHHHCCHHHEEEEECCCCCCCHHHHHHHHHC
K
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]