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The map label for this gene is nadC [H]

Identifier: 123965452

GI number: 123965452

Start: 197412

End: 198278

Strand: Reverse

Name: nadC [H]

Synonym: P9515_02171

Alternate gene names: 123965452

Gene position: 198278-197412 (Counterclockwise)

Preceding gene: 123965453

Following gene: 123965451

Centisome position: 11.63

GC content: 29.41

Gene sequence:

>867_bases
GTGGACTTTTACTCTCCAAACATATCTAGAATTATTGATTATTGGATTGAAGAAGATATCGGAAAAGGTGATCTTACATC
TTCGGCAATTACAGAAAATATTGGAAAAGCCCATTGGTTAGCAAAGGAAAAAGGAATATTTTGTGGCGTTGAAATAATAA
AGACAATTTTAAATAAAATTGATGAAAACATAGATTGTAGATTTTTTATTAAGGATGGCGAAACATTTTTGAAAGATCAA
AAACTTCTGGAACTATGTGGACCCTCAAGAAGCCTATTGGCAAGTGAAAGAATAAGTCTCAATATATCTATGCATTTATC
AGGAATATCGACTTATACAAAAAATATTGTAGATGTTTTAAAAGGTACAAATATAAAGTTAGCAGATACAAGAAAAACTA
CTCCTGGTTTGAGAATATTTGAAAAGTATGCTTTTAAATGTGGTGGAGGTATTAATCATAGAATGGGACTGTACGATGCT
GCAATGATTAAAGAAAACCATATTGCATGGACTGATAACTTAAACAATGCAGTAAAAAAAATTAGATTGAATACTCCATT
TACAACACATATTATTATTGAAGCTGAAAATATGAAGCAAGCAAAAGATGCAGTTCTAGCAGGTGCAGATAGTATTTTAT
TAGATGAATTTAATCCTGAATTGCTCGAAAAATGTATTAAAGAATTAAGAGAGTTATCAATAAATAGCTCTAAAAGAACA
AAGAGAAATAACTTGATCATAGAGGTCTCTGGGATTAATCCAAGAGACATTAGTAACTATTTAATTGATGGAGTTGATTT
CATATCGACAAGTTCTTCAATTACTAAAAGTAATTGGATTGATTTTAGTATGCGTTATATTAATTAA

Upstream 100 bases:

>100_bases
CTAAATTTTGCATAGGTAAATAAATTTTTAATTAAATGACATAAATATATAAAGTAAACTTTAAAAGTTAAAATAAAATT
CATTATCTATTACAAGTTTT

Downstream 100 bases:

>100_bases
ATGAATCGAATTGTACTTTAATAATTCATGCAGGTAATTTATCAAGAATTAACTAAAAGATTTGAAGAAACCCTTCTAGA
AAGTCTTATAAAAAATGAGA

Product: nicotinate-nucleotide pyrophosphorylase:quinolinate phosphoriobsyl transferase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 288; Mature: 288

Protein sequence:

>288_residues
MDFYSPNISRIIDYWIEEDIGKGDLTSSAITENIGKAHWLAKEKGIFCGVEIIKTILNKIDENIDCRFFIKDGETFLKDQ
KLLELCGPSRSLLASERISLNISMHLSGISTYTKNIVDVLKGTNIKLADTRKTTPGLRIFEKYAFKCGGGINHRMGLYDA
AMIKENHIAWTDNLNNAVKKIRLNTPFTTHIIIEAENMKQAKDAVLAGADSILLDEFNPELLEKCIKELRELSINSSKRT
KRNNLIIEVSGINPRDISNYLIDGVDFISTSSSITKSNWIDFSMRYIN

Sequences:

>Translated_288_residues
MDFYSPNISRIIDYWIEEDIGKGDLTSSAITENIGKAHWLAKEKGIFCGVEIIKTILNKIDENIDCRFFIKDGETFLKDQ
KLLELCGPSRSLLASERISLNISMHLSGISTYTKNIVDVLKGTNIKLADTRKTTPGLRIFEKYAFKCGGGINHRMGLYDA
AMIKENHIAWTDNLNNAVKKIRLNTPFTTHIIIEAENMKQAKDAVLAGADSILLDEFNPELLEKCIKELRELSINSSKRT
KRNNLIIEVSGINPRDISNYLIDGVDFISTSSSITKSNWIDFSMRYIN
>Mature_288_residues
MDFYSPNISRIIDYWIEEDIGKGDLTSSAITENIGKAHWLAKEKGIFCGVEIIKTILNKIDENIDCRFFIKDGETFLKDQ
KLLELCGPSRSLLASERISLNISMHLSGISTYTKNIVDVLKGTNIKLADTRKTTPGLRIFEKYAFKCGGGINHRMGLYDA
AMIKENHIAWTDNLNNAVKKIRLNTPFTTHIIIEAENMKQAKDAVLAGADSILLDEFNPELLEKCIKELRELSINSSKRT
KRNNLIIEVSGINPRDISNYLIDGVDFISTSSSITKSNWIDFSMRYIN

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=284, Percent_Identity=28.169014084507, Blast_Score=124, Evalue=8e-29,
Organism=Escherichia coli, GI1786299, Length=288, Percent_Identity=35.4166666666667, Blast_Score=157, Evalue=9e-40,
Organism=Saccharomyces cerevisiae, GI6321162, Length=281, Percent_Identity=33.0960854092527, Blast_Score=152, Evalue=6e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 32544; Mature: 32544

Theoretical pI: Translated: 7.46; Mature: 7.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFYSPNISRIIDYWIEEDIGKGDLTSSAITENIGKAHWLAKEKGIFCGVEIIKTILNKI
CCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHCCHHHHHHHCCCCEECHHHHHHHHHHH
DENIDCRFFIKDGETFLKDQKLLELCGPSRSLLASERISLNISMHLSGISTYTKNIVDVL
CCCCCEEEEEECCHHHHHHHHHHHHHCCCHHHHHHCCEEEEEEEEECCHHHHHHHHHHHH
KGTNIKLADTRKTTPGLRIFEKYAFKCGGGINHRMGLYDAAMIKENHIAWTDNLNNAVKK
CCCCEEEECCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCEEEECCHHHHHHE
IRLNTPFTTHIIIEAENMKQAKDAVLAGADSILLDEFNPELLEKCIKELRELSINSSKRT
EECCCCCEEEEEEEECCHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHCCCCCCCCC
KRNNLIIEVSGINPRDISNYLIDGVDFISTSSSITKSNWIDFSMRYIN
CCCCEEEEEECCCCHHHHHHHHCCHHHHCCCCCCCCCCCEEEEEEECC
>Mature Secondary Structure
MDFYSPNISRIIDYWIEEDIGKGDLTSSAITENIGKAHWLAKEKGIFCGVEIIKTILNKI
CCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHCCHHHHHHHCCCCEECHHHHHHHHHHH
DENIDCRFFIKDGETFLKDQKLLELCGPSRSLLASERISLNISMHLSGISTYTKNIVDVL
CCCCCEEEEEECCHHHHHHHHHHHHHCCCHHHHHHCCEEEEEEEEECCHHHHHHHHHHHH
KGTNIKLADTRKTTPGLRIFEKYAFKCGGGINHRMGLYDAAMIKENHIAWTDNLNNAVKK
CCCCEEEECCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCEEEECCHHHHHHE
IRLNTPFTTHIIIEAENMKQAKDAVLAGADSILLDEFNPELLEKCIKELRELSINSSKRT
EECCCCCEEEEEEEECCHHHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHCCCCCCCCC
KRNNLIIEVSGINPRDISNYLIDGVDFISTSSSITKSNWIDFSMRYIN
CCCCEEEEEECCCCHHHHHHHHCCHHHHCCCCCCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]