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The map label for this gene is hisC [H]

Identifier: 123965450

GI number: 123965450

Start: 194467

End: 195576

Strand: Reverse

Name: hisC [H]

Synonym: P9515_02151

Alternate gene names: 123965450

Gene position: 195576-194467 (Counterclockwise)

Preceding gene: 123965451

Following gene: 123965443

Centisome position: 11.48

GC content: 28.65

Gene sequence:

>1110_bases
ATGAGTGAATTTAATAAAATAAATAATCTTCCCCCTACTCCAAGAAAGGAAATAATAAATATGCAATCTTATTCTGCACC
ATTAGAAAACAGAAGAAATTTATTGCGTTTAGATTTTAATGAAAATACTTTAGGACCAAGTCAAAAAGTATATGAAGCCA
TCAAAGATATAAAGTTAAATCAAATTTCAATCTATCCAGAATATAACTTATTAAAAAATTTTCTATCTCATAACTACTAT
GAATCAAGGCAATTTGATTCTGAAGAAATAGGTTTATTTAATGGAGCTGATGCTGTAATAAATGCGATATTTCATTCTTT
TGGCGATAGAGATGAAATATTCCTAACCACAAATCCGACTTTTGGATATTATTCACCTTGCTCGGAAATACAAGGAATGA
AAAAAATAACTTGTTCCTACGAAGGAGAACACTTTCTTTTCCCAATCAAGAGATTTGAAGAAAAAATTATTAAACATAAA
CCTAAATTAATATTTATTTGTAATCCGAATAATCCTACTGGTACTGTTTTAAGTGCTCAAGAAATAATTAAATTAGCAAA
TCTGAACAAAAGTTCATTAATCGTCGTTGACGAACTTTATGAGAAATTTAACGGCGATAGTCTTCTTCCTAAAATAGATT
TTCAAGAAATTAAAAATATAGTAATTATTCAATCACTTTCAAAAACTGCTGGTTTAGCTGGTTTACGAATTGGCTTTGCA
TTTGGAAATAAAAGCATAATCCAATATATCAATAAAGTCACGGGGCCATACGATGTGAACAGTTTTGCAGTTACTGCTGC
ATTAGCTGCTTTAAATGATAAATCTTATATAGATAATTATGTTACAGAAGTAAACAAAGCAAGATTATTTATTGAGAAAA
AGTTTGAATCCTTATCAATAAGGACACATTTTGGTGCGGGAAATTATTTTTTAATTTGGCCAAATCAAAATCCCGAAATT
TTGACAAGAAAAATGAGAGAAAGAGGTATCTTAATAAGAGAGATGAAAAATAAAAAAGATATTGAGAATTCTGTAAGGGT
TAGCATAGGAACTCAAGAACAAATGCTTCGTTTCTGGAGTACTTATAAAGAACTAGATCTTAATAATTAA

Upstream 100 bases:

>100_bases
TGAATACAAAGATTTCAAGACTTACATTATGTGCTTTGACTGAAAAGACTTTAAAATTAAGTTTAGAACTTCTTGGAATT
GATTCCTTAGAGAGAATGTA

Downstream 100 bases:

>100_bases
TCTTTGAAAATATAAATAGTATTTTTATCAATTCTTTTTGAATTTATTTCAAAGTTTTTACCAAGATATTTAACTTTAAA
ATCTTGCATATTTTCAAGAA

Product: aminotransferases class-I

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase [H]

Number of amino acids: Translated: 369; Mature: 368

Protein sequence:

>369_residues
MSEFNKINNLPPTPRKEIINMQSYSAPLENRRNLLRLDFNENTLGPSQKVYEAIKDIKLNQISIYPEYNLLKNFLSHNYY
ESRQFDSEEIGLFNGADAVINAIFHSFGDRDEIFLTTNPTFGYYSPCSEIQGMKKITCSYEGEHFLFPIKRFEEKIIKHK
PKLIFICNPNNPTGTVLSAQEIIKLANLNKSSLIVVDELYEKFNGDSLLPKIDFQEIKNIVIIQSLSKTAGLAGLRIGFA
FGNKSIIQYINKVTGPYDVNSFAVTAALAALNDKSYIDNYVTEVNKARLFIEKKFESLSIRTHFGAGNYFLIWPNQNPEI
LTRKMRERGILIREMKNKKDIENSVRVSIGTQEQMLRFWSTYKELDLNN

Sequences:

>Translated_369_residues
MSEFNKINNLPPTPRKEIINMQSYSAPLENRRNLLRLDFNENTLGPSQKVYEAIKDIKLNQISIYPEYNLLKNFLSHNYY
ESRQFDSEEIGLFNGADAVINAIFHSFGDRDEIFLTTNPTFGYYSPCSEIQGMKKITCSYEGEHFLFPIKRFEEKIIKHK
PKLIFICNPNNPTGTVLSAQEIIKLANLNKSSLIVVDELYEKFNGDSLLPKIDFQEIKNIVIIQSLSKTAGLAGLRIGFA
FGNKSIIQYINKVTGPYDVNSFAVTAALAALNDKSYIDNYVTEVNKARLFIEKKFESLSIRTHFGAGNYFLIWPNQNPEI
LTRKMRERGILIREMKNKKDIENSVRVSIGTQEQMLRFWSTYKELDLNN
>Mature_368_residues
SEFNKINNLPPTPRKEIINMQSYSAPLENRRNLLRLDFNENTLGPSQKVYEAIKDIKLNQISIYPEYNLLKNFLSHNYYE
SRQFDSEEIGLFNGADAVINAIFHSFGDRDEIFLTTNPTFGYYSPCSEIQGMKKITCSYEGEHFLFPIKRFEEKIIKHKP
KLIFICNPNNPTGTVLSAQEIIKLANLNKSSLIVVDELYEKFNGDSLLPKIDFQEIKNIVIIQSLSKTAGLAGLRIGFAF
GNKSIIQYINKVTGPYDVNSFAVTAALAALNDKSYIDNYVTEVNKARLFIEKKFESLSIRTHFGAGNYFLIWPNQNPEIL
TRKMRERGILIREMKNKKDIENSVRVSIGTQEQMLRFWSTYKELDLNN

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=315, Percent_Identity=24.4444444444444, Blast_Score=102, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6322075, Length=378, Percent_Identity=25.3968253968254, Blast_Score=118, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 42491; Mature: 42360

Theoretical pI: Translated: 8.87; Mature: 8.87

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEFNKINNLPPTPRKEIINMQSYSAPLENRRNLLRLDFNENTLGPSQKVYEAIKDIKLN
CCCCHHCCCCCCCCHHHHHCCHHCCCCHHCCCCEEEEECCCCCCCCHHHHHHHHHCCCCC
QISIYPEYNLLKNFLSHNYYESRQFDSEEIGLFNGADAVINAIFHSFGDRDEIFLTTNPT
EEEECCCHHHHHHHHHCCCHHHCCCCCHHCCCCCCHHHHHHHHHHHCCCCCEEEEEECCC
FGYYSPCSEIQGMKKITCSYEGEHFLFPIKRFEEKIIKHKPKLIFICNPNNPTGTVLSAQ
CCCCCCHHHHCCCCEEEEEECCCEEEECHHHHHHHHHHCCCCEEEEECCCCCCCCEECHH
EIIKLANLNKSSLIVVDELYEKFNGDSLLPKIDFQEIKNIVIIQSLSKTAGLAGLRIGFA
HHHHHHCCCCCCEEEHHHHHHHCCCCCCCCCCCHHHHCCEEEEEEHHHHCCCCEEEEEEE
FGNKSIIQYINKVTGPYDVNSFAVTAALAALNDKSYIDNYVTEVNKARLFIEKKFESLSI
ECCHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHEEE
RTHFGAGNYFLIWPNQNPEILTRKMRERGILIREMKNKKDIENSVRVSIGTQEQMLRFWS
EEEECCCCEEEEECCCCHHHHHHHHHHCCHHHHHHHCHHCCCCCEEEEECCHHHHHHHHH
TYKELDLNN
HHHHCCCCC
>Mature Secondary Structure 
SEFNKINNLPPTPRKEIINMQSYSAPLENRRNLLRLDFNENTLGPSQKVYEAIKDIKLN
CCCHHCCCCCCCCHHHHHCCHHCCCCHHCCCCEEEEECCCCCCCCHHHHHHHHHCCCCC
QISIYPEYNLLKNFLSHNYYESRQFDSEEIGLFNGADAVINAIFHSFGDRDEIFLTTNPT
EEEECCCHHHHHHHHHCCCHHHCCCCCHHCCCCCCHHHHHHHHHHHCCCCCEEEEEECCC
FGYYSPCSEIQGMKKITCSYEGEHFLFPIKRFEEKIIKHKPKLIFICNPNNPTGTVLSAQ
CCCCCCHHHHCCCCEEEEEECCCEEEECHHHHHHHHHHCCCCEEEEECCCCCCCCEECHH
EIIKLANLNKSSLIVVDELYEKFNGDSLLPKIDFQEIKNIVIIQSLSKTAGLAGLRIGFA
HHHHHHCCCCCCEEEHHHHHHHCCCCCCCCCCCHHHHCCEEEEEEHHHHCCCCEEEEEEE
FGNKSIIQYINKVTGPYDVNSFAVTAALAALNDKSYIDNYVTEVNKARLFIEKKFESLSI
ECCHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHEEE
RTHFGAGNYFLIWPNQNPEILTRKMRERGILIREMKNKKDIENSVRVSIGTQEQMLRFWS
EEEECCCCEEEEECCCCHHHHHHHHHHCCHHHHHHHCHHCCCCCEEEEECCHHHHHHHHH
TYKELDLNN
HHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]