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The map label for this gene is tmk

Identifier: 123965393

GI number: 123965393

Start: 144439

End: 145071

Strand: Reverse

Name: tmk

Synonym: P9515_01581

Alternate gene names: 123965393

Gene position: 145071-144439 (Counterclockwise)

Preceding gene: 123965394

Following gene: 123965392

Centisome position: 8.51

GC content: 31.44

Gene sequence:

>633_bases
ATGAAAGGTAAATTTATTGTTATTGAAGGAATAGATGGTTGTGGGAAAACAACCCAAATTGATGAGATTTCAAGATGGCT
ACCTACTAGTGGTCTAATGGGAAAGAATTCAAAATTAATAAAAACTAGGGAACCTGGGGGAAGCTTATTAGGTAAAAAAC
TTAGAAATTTAATACTTGACAACAATAAAAATAATAAGCCTTCATCACTTGCTGAGTTGTTACTTTATTCTGCAGATAGA
GCAGAACATGTTTCTAAAATAATTTCTCCTGCATTAAAAAAAGAGGACTGGGTAATTAGCGATAGATTTTCTGACTCTAC
ACTTGCTTATCAAGGCTATGGGAGACATATCAATCTAGAAATAATAAAAAATATCGAATCAATTGTTTGTCAAGGAGAAT
ATCCAGACCTTACTATTTTTCTGGAAATTTCAGCAGAGGAGAGTATTTTACGAAGAAAAAATTTTGTCCCTGACAGAATG
GAATCCGAAGGTATCAATTTTTTACAAAAAGTCAATGAAGGATTCAAGTTGATCGCTAAAGAAAAAAAGTGGAAAGTAAT
ATCTGCGACCCAAAATATTACTGCTATTTCTAATGAAATTAAAGAAACGTTACTAAAAACTTTTCGTAACTAA

Upstream 100 bases:

>100_bases
TTTTCCTAAATATGGCATTCTTCTAACACCTTCTATCGCAGCATTATTAATGGCAACAAGTTCCATAACCGTTGTAATCA
ATGCTTTATCTTTAGAATAA

Downstream 100 bases:

>100_bases
AGAATGATTAATCTTGAAAATGATAATCTTTTGATTAATAAAGAAGTCAATCAAATTTTAGAAAATATACTTCAAACAAA
AGTATTTTCTAACGGTTATA

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase

Number of amino acids: Translated: 210; Mature: 210

Protein sequence:

>210_residues
MKGKFIVIEGIDGCGKTTQIDEISRWLPTSGLMGKNSKLIKTREPGGSLLGKKLRNLILDNNKNNKPSSLAELLLYSADR
AEHVSKIISPALKKEDWVISDRFSDSTLAYQGYGRHINLEIIKNIESIVCQGEYPDLTIFLEISAEESILRRKNFVPDRM
ESEGINFLQKVNEGFKLIAKEKKWKVISATQNITAISNEIKETLLKTFRN

Sequences:

>Translated_210_residues
MKGKFIVIEGIDGCGKTTQIDEISRWLPTSGLMGKNSKLIKTREPGGSLLGKKLRNLILDNNKNNKPSSLAELLLYSADR
AEHVSKIISPALKKEDWVISDRFSDSTLAYQGYGRHINLEIIKNIESIVCQGEYPDLTIFLEISAEESILRRKNFVPDRM
ESEGINFLQKVNEGFKLIAKEKKWKVISATQNITAISNEIKETLLKTFRN
>Mature_210_residues
MKGKFIVIEGIDGCGKTTQIDEISRWLPTSGLMGKNSKLIKTREPGGSLLGKKLRNLILDNNKNNKPSSLAELLLYSADR
AEHVSKIISPALKKEDWVISDRFSDSTLAYQGYGRHINLEIIKNIESIVCQGEYPDLTIFLEISAEESILRRKNFVPDRM
ESEGINFLQKVNEGFKLIAKEKKWKVISATQNITAISNEIKETLLKTFRN

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family

Homologues:

Organism=Escherichia coli, GI1787340, Length=208, Percent_Identity=36.0576923076923, Blast_Score=127, Evalue=8e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KTHY_PROM5 (A2BUA6)

Other databases:

- EMBL:   CP000552
- RefSeq:   YP_001010474.1
- ProteinModelPortal:   A2BUA6
- STRING:   A2BUA6
- GeneID:   4720294
- GenomeReviews:   CP000552_GR
- KEGG:   pmc:P9515_01581
- eggNOG:   COG0125
- HOGENOM:   HBG626009
- OMA:   KGHIVIS
- ProtClustDB:   PRK13974
- BioCyc:   PMAR167542:P9515ORF_0165-MONOMER
- HAMAP:   MF_00165
- InterPro:   IPR018095
- InterPro:   IPR018094
- PANTHER:   PTHR10344
- TIGRFAMs:   TIGR00041

Pfam domain/function: PF02223 Thymidylate_kin

EC number: =2.7.4.9

Molecular weight: Translated: 23741; Mature: 23741

Theoretical pI: Translated: 9.76; Mature: 9.76

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGKFIVIEGIDGCGKTTQIDEISRWLPTSGLMGKNSKLIKTREPGGSLLGKKLRNLILD
CCCCEEEEECCCCCCCCCCHHHHHHHCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHCC
NNKNNKPSSLAELLLYSADRAEHVSKIISPALKKEDWVISDRFSDSTLAYQGYGRHINLE
CCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEECCCCCCEEEEECCCCEEEHH
IIKNIESIVCQGEYPDLTIFLEISAEESILRRKNFVPDRMESEGINFLQKVNEGFKLIAK
HHHHHHHHEECCCCCCEEEEEEECCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHEECC
EKKWKVISATQNITAISNEIKETLLKTFRN
CCCEEEEECCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKGKFIVIEGIDGCGKTTQIDEISRWLPTSGLMGKNSKLIKTREPGGSLLGKKLRNLILD
CCCCEEEEECCCCCCCCCCHHHHHHHCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHCC
NNKNNKPSSLAELLLYSADRAEHVSKIISPALKKEDWVISDRFSDSTLAYQGYGRHINLE
CCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEECCCCCCEEEEECCCCEEEHH
IIKNIESIVCQGEYPDLTIFLEISAEESILRRKNFVPDRMESEGINFLQKVNEGFKLIAK
HHHHHHHHEECCCCCCEEEEEEECCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHEECC
EKKWKVISATQNITAISNEIKETLLKTFRN
CCCEEEEECCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA